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PubMedDate not supplied

Reuse of disposable syringe-needle units in the diabetic patient.

A comparison was made between reuse of plastic disposable needle-syringe units and glass syringes with daily new needles in diabetic patients who take daily insulin injections. Parameters studied were incidence of infection, clarity of syringe readings, ability to use syringe, and sharpness of needle. The plastic disposable units could be reused with safety and patient satisfaction by most patients for at least 3 days. Considerable cost benefit could accrue if disposable units were used more than one time for insulin injections.

Diabetes Mellitus↗
PubMed1998

From ideology to logistics: the organizational aspects of syringe exchange in a period of institutional consolidation.

The initial period in the establishment of syringe exchange projects is often characterized by overt conflict: between community AIDS activists, on the one hand, and public officials and political leaders who remain ideologically opposed to the introduction of measures perceived as condoning illicit drug use. In this context, professionals concerned with legitimating the new institutions of syringe exchange may sometimes neglect aspects of their everyday logistics and social organization, obscuring the important choices which have to be made to carry these initiatives forward. In particular, the contrast between formally-constituted institutions-the "storefront" or "community-based" syringe exchange programs (SEPs)-and the model of low-threshold syringe availability through pharmacies, vending machines, and user networks, is here presented not as an either/or choice but rather as a pair of complementary strategies which respond to diverse needs and target different populations. The advantages and disadvantages of each particular approach make it likely that maximum effectiveness will be achieved through a combination of every possible form of needle distribution, each tailored to specific and cultural circumstances. The case is here examined in the light of the experience of the SEPs in New York City, from their clandestine origins in 1990 through their first years of official functioning in 1992-1996.

Attitude of Health Personnel↗
PubMed2001

Update: syringe exchange programs--United States, 1998.

Syringe exchange programs (SEPs) provide sterile syringes in exchange for used syringes to reduce the transmission of human immunodeficiency virus (HIV) and other bloodborne infections associated with the reuse of potentially blood-contaminatedsyringes among injection drug users (IDUs) (1). This report summarizes a survey of 1998 SEP activities in the United States and compares them with 1994-1997 SEP activity surveys (1-3). SEPs are an increasingly common HIV prevention approach that offer a range of public health services in addition to syringe exchange.

Needle-Exchange Programs↗
PubMed2003

[The syringe pump as actuator--a practical application problem of feedback control systems].

Based on a computer simulation programme, the accuracy of the Graseby 3400 syringe pump was tested for its use in a feedback control system of the neuromuscular block. Firstly, a calculation of errors to determine the difference between the target and actual flow rates was carried out. Next, the characteristic curves of the syringe pump were determined under different flow and sampling rates to correct the application software of the feedback controller with a view to obtaining the correct flow rates online. It was discovered that, particularly with short 12 s sampling rates, dose-dependent errors of almost 100% were provable. Therefore, the application of a robust controller and integration of the characteristic curves at the outlet of the controller software are required. For the adoption of syringe pumps in medical feedback control systems, definite determination of the actual infusion quantity using an exact calculation of errors is required. Especially in cases of short sampling rates in combination with low infusion quantities, the syringe pump comes almost to a standstill, which results in extreme differences between target and actual flow rates.

Computer Simulation↗
PubMed1987

The effect of syringeal deafferentation on the stimulated vocalization in the domestic chick (Gallus gallus).

The rôle of syringeal feedback on the electrically elicited vocalization in chickens (Gallus gallus) was studied. The vocalization patterns elicited by stimulating the low-threshold "calling areas" in the midbrain, was examined before and after syringeal deafferentation obtained by cutting the X-XII anastomosis on either the left and right side. The results show that section of the X-XII anastomosis on the left side produces consistently a clear-cut lowering of the threshold for vocalization and an increase of the amplitude of the individual calls with no change in the repetition rate of the call sequences. All these effects are enhanced when the contralateral anastomosis is also severed. These results show that the bilateral syringeal deafferentation does not change the overall song pattern performance, that remains stereotyped both in duration and complexity, consistent with the hypothesis that, in adult birds, stable song patterns are not dependent on peripheral sources of feedback, but are ruled by a learned central control program. However the modification of vocalization threshold and amplitude suggests the hypothesis that the syringeal feedback plays an inhibitory rôle on vocalization by modulating the excitability of the central structures involved in the vocalization activity.

Afferent Pathways↗
PubMed1986

Bilateral syringeal coupling during phonation of a songbird.

The syrinx of oscine birds ("true songbirds") is a double vocal organ, and each side has generally been presumed to function independently under separate neural control during phonation. A significant counterexample is demonstrated here in the production of a common vocalization by the black-capped chickadee (Parus atricapillus), in which the 2 acoustic sources of the syrinx interact in a nonlinear fashion. The chickadee produces a sound with multiple frequency components that superficially resemble harmonics. An analysis of vocal production after unilateral and bilateral syringeal denervation shows instead that these frequency components are sum and difference frequencies, or heterodyne frequencies, resulting from cross-modulation between the 2 syringeal sides. A limited form of this bilateral coupling may be achieved after unilateral denervation of either syringeal side but not after bilateral denervation. Unilaterally denervated birds are capable of significant improvement in coupling after 10 d, too short a period for neural regrowth. These results suggest that coupling arises from a passive physical interaction between the 2 syringeal sources which is activated or regulated in some fashion by neural control from either side.

Animals↗
PubMed1995

Notification of syringe-sharing and sex partners of HIV-infected persons--Pennsylvania, 1993-1994.

In April 1993, a man incarcerated in a prison in Berks County in eastern Pennsylvania voluntarily requested testing for human immunodeficiency virus (HIV) antibody and was diagnosed with HIV infection. Following an interview and counseling by Pennsylvania Department of Health HIV Prevention Program (HIVPP) staff (1), he provided contact information about four persons with whom he had shared syringes to inject drugs before incarceration. As a result of follow-up investigation, HIV infection was diagnosed in two of these four persons. One of these two persons provided contact information about 47 partners, including 41 partners with whom he had shared syringes only and six with whom he had had sex and shared syringes. By May 1994, partner notification follow-up of the four partners of the index patient and all subsequently identified partners of HIV-infected persons identified a social network of 124 persons linked by syringe-sharing and/or sex. This report describes the findings of the investigation of this network during April 1993-May 1994 and limited additional information from June-September 1994.

AIDS Serodiagnosis↗
PubMed1998

Update: syringe exchange programs--United States, 1997.

As of December 1997, more than one third (36%) of the 641,086 cases of acquired immunodeficiency syndrome (AIDS) reported to CDC were directly or indirectly associated with injecting-drug use. Syringe exchange programs (SEPs) are one of the strategies employed to prevent infection with human immunodeficiency virus (HIV) among injecting-drug users (IDUs). The goal of SEPs is to reduce the transmission of HIV and other bloodborne infections associated with reuse of blood-contaminated syringes for drug injection by providing sterile syringes in exchange for used, potentially contaminated syringes. This report summarizes a survey of U.S. SEP activities during January-December 1997 and compares the findings with those of two previous surveys during 1994-1995 and 1996. The findings indicate continued expansion in the number, geographic coverage, and activity of SEPs in the United States.

Humans↗
PubMed1980

A flute syringe for vitreous surgery.

We have devised a method whereby an inexpensive, disposable tuberculin syringe may be used as a flute syringe with retrograde flushing capability. This syringe is particularly useful in vitreous surgery and alleviates problems that occur with commercially available instruments of this type.

Humans↗
PubMed1989

The rate of sulfur hexafluoride escape from a plastic syringe.

Sulfur hexafluoride (SF6) gas is widely used for internal tamponade during retinal reattachment surgery and is commonly injected into the eye from a 10-mL plastic syringe. The rate of diffusion of SF6 out of a plastic syringe has not bee studied. We measured the percentage of SF6 gas in a 10-mL plastic syringe by gas chromatography, confirmed by infrared spectrometry. Measurements were obtained immediately after aspiration, and at 30 s and 10, 15, 60, 90, and 120 minutes, and 18 hours. A marked decrease in SF6 concentration, from 97% at 30 s to 76% at 60 minutes and 2% at 18 hours, was noted. The results were highly reproducible. Sulfur hexafluoride gas should be injected into the patient's eye as soon as possible after aspiration from the tank to ensure accurate concentrations.

Chromatography, Gas↗
PubMed1990

CO2 power-assisted hand-held syringe: better visualization during diagnostic and interventional angiography.

Recent technology has produced high-flow and large-lumen catheters as well as other angiographic accessories to enhance the visualization of the coronary arteries during diagnostic and percutaneous transluminal coronary angioplasty (PTCA) procedures. In spite of these technological advances, there are still many cases in which the quality of the coronary angiography could be significantly improved. This paper reports on a clinical evaluation of a hand-held power syringe. The syringe offers the ability to power inject contrast safely and effectively during routine angiograms as well as through guiding catheters with the balloon catheter present during PTCA. At the same time, control of the injection is equal to that associated with manual syringes.

Angiography↗
PubMed2004

Microextraction in packed syringe (MEPS) for liquid and gas chromatographic applications. Part II--Determination of ropivacaine and its metabolites in human plasma samples using MEPS with liquid chromatography/tandem mass spectrometry.

A new technique for sample preparation on-line with liquid chromatographic/tandem mass spectrometric (LC/MS/MS) assay was developed. Microextraction in a packed syringe (MEPS) is a new miniaturized, solid-phase extraction technique that can be connected on-line to gas or liquid chromatography without any modifications. In MEPS approximately 1 mg of the solid packing material is inserted into a syringe (100-250 microl) as a plug. Sample preparation takes place on the packed bed. The bed can be coated to provide selective and suitable sampling conditions. The new method is very promising, very easy to use, fully automated, of low cost and rapid in comparison with previously used methods. This paper presents the development and validation of a method for MEPS on-line with LC/MS/MS. Ropivacaine and its metabolites (PPX and 3-OH-ropivacaine) in human plasma samples were used as model substances. The method was validated and the calibration curves were evaluated by means of quadratic regression and weighted by the inverse of the concentration, 1/x, for the calibration range 2-2000 nM. The applied polymer could be used more than 100 times before the syringe was discarded. The extraction recovery was between 40 and 60%. The results showed high correlation coefficients (R(2) > 0.999) for all analytes in the calibration range studied. The accuracy, expressed as a percentage variation from the nominal concentration values, ranged from 0 to 6%. The precision, expressed as the relative standard deviation, at three different concentrations (quality control samples) was consistently about 2-10%. The limit of quantification was 2 nM.

Blood Chemical Analysis↗
PubMed1980

An instrument for checking the radioactivity in shielded syringes.

A description is given of an instrument that can be used for checking, to within ten percent, the radioactivity in shielded syringes. The unit is simple in design and construction and easy to use. The lead shield of the syringe does not have to be removed, since only radiation emitted along the direction of the barrel is detected. A range of syringe sizes can be accommodated and, whilst the instrument is calibrated for 99Tcm with activities in the range 1-10 mCi, both higher and lower activities and other radionuclides can be used. Each measurement takes only a few seconds and the activity of radiopharmaceuticals can be routinely checked immediately before injection.

Radiometry↗
PubMed1994

Characteristics of users of syringe vending machines in Berlin.

Vending machines providing sterile injection equipment are part of the AIDS prevention measures for injecting drug users (IDU) in Berlin. A study was carried out to assess characteristics (history of iv drug use, frequency of use of the machines, contact with counselling units for IDU, attitudes towards the machines, HIV serostatus) in users of syringe vending machines. Of the 313 individuals surveyed, 77% reported using the vending machines regularly (more than four times a week). Compared to other studies of IDU in Berlin (eg at syringe exchange programmes) the users of the vending machines had a significantly shorter history of iv drug use. Overall, 72% of the IDU had had contacts at some time with specialised agencies for counselling on drug abuse and AIDS; however, only 33% had such contacts currently. Sixty-five percent of the IDU commented critically on the machines or made suggestions for improvement; 18% had experienced that the machines did not always work well, 14% called for more machines. HIV seroprevalence based on self-reported test results (N = 252) was 20%. In multivariate statistical analysis positive HIV serostatus was associated with site of interview, longer history of intravenous drug use, and current contact with counselling agencies. Despite the ready availability of syringes and needles, 25% of the participants reported borrowing injection equipment from other IDU in the previous six months. This proportion was significantly higher in IDU younger than 25 years (39%).(ABSTRACT TRUNCATED AT 250 WORDS)

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Fine needle biopsy without syringe aspiration.

Aspiration biopsies of fresh disease-free bovine hepatic liver were performed with three commercially available, small-gauge biopsy needles. A syringe was used to create a negative pressure when using Chiba and Sure-cut needles. A syringe was not used when using PercuCut needles which create an internal negative pressure equivalent to a 1.5 ml syringe when the stylet is partially withdrawn. The PercuCut and Chiba needle yielded a significantly larger specimen size than the Sure-Cut needle. There was no significant difference in sample size between the PercuCut and Chiba needles. All samples were of diagnostic quality.

Animals↗
PubMed1990

A hematologist's view of contrast media, clotting in angiography syringes and thrombosis during coronary angiography.

While ionic contrast media (CM) are stronger anticoagulants and antiplatelet agents, both nonionic and ionic CM retard clotting, fibrinopeptide A generation and platelet aggregation (at least by Born-O'Brien aggregometry). Thus, nonionic CM do not cause clots and thrombi. Rather, the driving force for clot or thrombus formation, when it occurs, is blood contact with and activation by the foreign surface of a syringe or catheter itself. A marked enhancement of clotting by glass syringes in comparison to plastic ones supports this view. Blood in any syringe or catheter, therefore, will clot more slowly in the presence of nonionic or ionic CM, the inhibitory effects of the latter being more profound. With respect to models of thrombosis at sites of vascular injury or stenosis, the antithrombotic effects of CM may either be transient owing to the dynamic nature of blood flow (local endothelial cell denudation model), or as in the case of ionic CM, actually to enhance local platelet aggregation (stenosis model). In these situations, preservation of the antithrombotic functions of endothelium with nonionic CM may be quite critical.

Angiography↗
PubMed1986

Studies on microbial contamination of reused disposable plastic insulin syringes.

The microbial contamination of reused disposable insulin syringes and bottles was studied. Fourteen patients, aged 16-64 years, took part in the study. 50 syringes and 52 bottles were examined for sterility at different stages of use. Twelve (24%) syringes and 4 (8%) bottles were found to be contaminated by micro-organisms, although only in low numbers. The micro-organisms recovered belonged to the normal skin flora of man.

Adolescent↗
PubMedDate not supplied

Experimental determination of calibration settings for plastic syringes containing solutions of 90Y using commercial radionuclide calibrators.

Calibration factors for several makes (Capintec, AtomLab, and PTW) and models of commercially available re-entrant ionization chambers ("dose calibrators") were determined for solutions of 90Y using 10 ml plastic syringes that are used in the administration of the recently approved radioimmunotherapy drug Zevalin. Effects of filling volume on chamber response were studied for the anticipated prescription volume range of 3-9 ml in those syringes. A series of syringes were prepared over that range with accurately known volumes using a "standard" solution containing 90YCl3 in 1 moll(-1) HCl and approximately 50 microg of nonradioactive YCl3 per gram of solution. The respective calibration factors for the Capintec and AtomLab chambers required to give the correct activity reading were found to be "55+/-2 x 10" and 393+/-6, where the uncertainties are expanded (k = 2) uncertainties. The results indicated no significant effect of filling volume on the calibration setting to within the uncertainty on the activity measurement for all but the PTW chamber. In that case, a variation of about 5% was observed over the filling range. A direct comparison was also made between the actual 90Y Zevalin drug and the "standard" solution, with no differences in determined calibration settings observed within the uncertainties on the activity calibration.

Calibration↗