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PubMed1998

Effects of propofol and pentobarbital on ligand binding to GABAA receptors suggest a similar mechanism of action.

The GABAA receptor is allosterically modulated by a number of anesthetics and barbiturates. We have examined the effects of propofol and pentobarbital on the binding of the receptor agonist [3H]muscimol and the benzodiazepine modulators [3H]flunitrazepam and [3H]Ro15-4513 to bovine brain membranes. Both agents potentiated the binding of [3H]muscimol (5 nM), with EC50 values of 18.7 and 276 microM, respectively. The binding of [3H]muscimol is heterogeneous, suggesting the presence of both high (Kd approximately 10 nM) and low (Kd approximately 0.1-1.0 microM) affinity sites. The major effect of both propofol and pentobarbital was to increase the affinity of the lower affinity sites without changing the total binding capacity. In contrast, the steroid anesthetic alphaxalone did not affect the affinity of these sites, suggesting that this drug has distinct effects on the GABAA receptor. Propofol and pentobarbital also increased the binding of the benzodiazepine agonist [3H]flunitrazepam and decreased the binding of the inverse agonist [3H]Ro15-4513. The results of these studies demonstrate that propofol and pentobarbital modulate the binding of ligands to the GABAA receptor in a similar manner, suggesting that these drugs may have a common mechanism of action.

Allosteric Site↗
PubMed1998

The inductive properties of mesoderm suggest that the neural crest cells are specified by a BMP gradient.

We have analyzed the role of mesoderm in the induction of the neural crest in Xenopus using expression of neural plate (Xsox-2) and neural crest (Xslug and ADAM). Conjugation experiments using different kinds of mesoderm together with embryonic dissection experiments suggest that the dorsolateral mesoderm is capable of specifically inducing neural crest cells. Neural crest markers can be induced in competent ectoderm at varying distances from the inducing mesoderm, with dorsal tissue inducing neural crest at a distance while dorsolateral tissue only induces neural crest directly in adjacent ectoderm. The results suggest that dorsal mesoderm has a high level of inducer and dorsolateral mesoderm has a lower level, consistent with a inductive gradient. We explored the possible role of BMP and noggin in the generation of such a hypothetical gradient and found that: (1) progressively higher levels of BMP activity are sufficient for the specification of neural plate, neural crest, and nonneural cells, respectively; (2) progressively higher levels of noggin are able to induce neural crest at greater distances from the source of inducer; and (3) modification of the levels of BMP activity causes induction of the neural crest in absence of neural plate, suggesting independent induction of these two tissues. We propose a model in which a gradient of BMP activity is established in the ectoderm by interaction between BMP in the ectoderm and BMP inhibitors in the mesoderm. Neural crest is induced when a threshold level of BMP is attained in the ectoderm. The dorsolateral mesoderm produces either BMP inhibitors or a specific neural crest inducer, with low BMP activity inducing neural plate while high BMP activity induces epidermis.

Animals↗
PubMed1998

Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens.

The dramatic shift in the pathological presentation of lung cancer [the proportional decrease in squamous cell carcinoma (SCC) and increase in adenocarcinoma (AC)] observed in the United States after the 1950s may have taken place as the result of the reduction in polycyclic aromatic hydrocarbons (PAHs) and the increase in N-nitrosamines in inhaled smoke from filtered low-yield cigarettes. The predominant mutation patterns of these tumors also suggest differences in their etiology. We tested the hypothesis that genetic susceptibility to PAHs, as determined by polymorphisms in CYP1A1 and GSTM1, predominantly causes lung SCCs, and susceptibility to nitrosamines, as determined by polymorphisms in CYP2E1, predominantly causes lung ACs. CYP1A1 and GSTM1 play a major role in the metabolic activation and detoxification of PAHs, respectively, and CYP2E1 plays a major role in the metabolic activation of nitrosamines. We conducted a population-based case-control study among 341 incident lung cancer cases and 456 controls of Caucasian, Japanese, or Hawaiian origin. In-person interviews collected detailed information on lifestyle risk factors, and DNA extracted from peripheral leukocytes was used in PCR-based genotyping assays. Logistic regression analyses were used to compute odds ratios and 95% confidence intervals (CIs) for each cell type, adjusting for smoking and dietary variables. The presence of at least one copy of the CYP1A1 MspI variant allele was found to be associated with a 2.4-fold (95% CI, 1.2-4.7) increase in the risk of SCC when this gene was considered singly and a 3.1-fold (95% CI, 1.2-7.9) increase in the risk of SCC when combined with a GSTM1 deletion. No significant association was found between MspI and all lung cancers or other cell types or with the CYP1A1 exon 7 polymorphism. In contrast, the CYP2E1 RsaI and DraI polymorphisms were not clearly related to SCC risk, but these homozygous variant genotypes were associated with a 10-fold (95% CI, 0.0-0.5) decrease in the risk of overall lung cancer (RsaI variant) and AC (DraI variant) compared to the homozygous wild-type genotypes. Inverse associations with these two closely linked CYP2E1 polymorphisms were also suggested for small cell carcinoma. In agreement with past experimental and epidemiological data, the associations found in this study between CYP1A1 and lung SCC and between CYP2E1 and lung AC suggest a certain specificity of tobacco smoke PAHs for lung SCC and tobacco-specific nitrosamines for lung ACs.

Adult↗
PubMed1998

Developmental and regional-specific expression of FLRFamide peptides in the tobacco hornworm, Manduca sexta, suggests functions at ecdysis.

The developmental profile of a family of three FLRFamide (Phe-Leu-Arg-Phe-NH2) peptides in the tobacco hornworm, Manduca sexta, revealed regional-specific expression patterns within the segmental ganglia. Levels of the three peptides-F7G (GNSFLRF-amide), F7D (DPSFLRFamide), and F10 (pEDVVHS-FLRFamide)-were always higher in the thoracic than abdominal ganglia. The predominant peptide also differed regionally, with F7G being highest in the thoracic ganglia and F7G and F100 being equivalent in the abdominal ganglia. Furthermore, we found regional-specific transient declines in ganglion peptide levels temporally correlated to ecdysis. Thoracic ganglion peptide levels declined at each molt, while abdominal ganglion levels declined over a period of 2 days after ecdysis. The decline in central levels was accompanied by an increase in levels in peripheral neurohemal sites, the transverse nerves (TNs). These observations suggest peptides were released from neurosecretory cells (NSCs) at ecdysis. Distinct sets of thoracic and abdominal NSCs and their processes in peripheral neurohemal sites were immunoreactive, supporting the biochemical data. These results also suggest the regional differences may arise from cellular-specific expression patterns for this family of peptides. In addition, fine immunoreactive processes were observed traveling between TNs and skeletal muscles, suggestive of myotropic actions. We propose that the release of different M. sexta FLRFamides from regionally distinct NSCs leads to a coordinated modulation of skeletal and visceral muscles that facilitate ecdysis.

Amino Acid Sequence↗
PubMed1996

Suggestion: metaphor and meaning.

This paper examines the metaphor of "suggestion" with reference to its origins and construction in the late nineteenth century in France. In addition to some general properties of the metaphorical mode, specific features of the "suggestion" metaphor are identified. It is shown how a network of meanings from a pathological situation (hypnosis) came to be applied to the behavior of crowds. The work of Le Bon was central in this process. This examination shows how metaphorical discourse was an important indicator of the orientation of early social psychology, namely the focus on interpersonal influence.

France↗
PubMed1983

A comparison of self-devaluation and somatic suggestion content in depressive mood manipulation.

The Velten Mood Induction Procedure (VMIP), often used to manipulate depressive mood, has its effectiveness attributed to the self-devaluative content of its statements; this finding supports cognitive theories of depression. Recent research has suggested that somatic content is more important than self-devaluation content in producing depressive mood variations. To study this using the VMIP, a neutral condition and two modified depression conditions were used: Somatic and self-devaluation (N = 302). The results indicate that self-devaluative statements resulted in significantly more depressed affect than neutral Ss, but no more than somatic statements; this latter group, however, did not differ from neutral Ss. The results of the previous research indicating the importance of the somatic suggestion manipulations as having more influence than negative self-evaluative statements is questioned.

Adult↗
PubMed1976

The concept of suggestion in the early history of advertising psychology.

As early as 1896, experimental psychologists began studying the mental processes involved in advertising. The first psychological theory of advertising maintained, in effect, that the consumer was a nonrational, suggestible creature under the hypnotic influence of the advertising copywriter. Walter Dill Scott was the major proponent of this theory, and it was largely through his writings that advertising men learned about the psychology of suggestion. Scott's theory was consistent with a growing trend in the advertising profession toward viewing consumer behavior as irrational. Scott's efforts might also be viewed as part of the trend in the advertising profession toward seeking a scientific basis for copywriting theory and practice.

Advertising↗
PubMed1982

Hysterical seizures: suggestion as a provocative EEG test.

We studied 57 patients with poorly controlled or atypical seizures to identify hysterical attacks with a provocative test consisting of initiation and termination of an attack with suggestion and saline injection during electroencephalographic (EEG) monitoring. Using this method, we diagnosed 48 patients as having hysterical attacks. Three additional patients had spontaneous hysterical attacks during routine recordings. Of the 51 patients with hysterical attacks, 78% were female. Two-thirds of the patients were between the ages of 20 and 35 years. Thirty-two patients had taken anticonvulsants before the study. Each patient's hysterical attack, aura, and postictum was stereotyped, and the 6 patients subject to both hysterical and organic seizures described the two types of attacks as different stereotyped behaviors. Tongue laceration, urinary incontinence, and postictal confusion were common. Twelve patients had evidence of past or present neurological disease. Abnormal EEGs were recorded in 37% but only 12% had spike or spike and wave discharges. The provocative EEG test employing saline and suggestion is a useful tool in the diagnosis of hysterical "seizures."

Adolescent↗
PubMed1994

Predictive value of induction of psychogenic seizures by suggestion.

Induction by suggestion has previously been reported to be effective in the diagnosis of psychogenic seizures (PS). However, the sensitivity and specificity of this procedure has not previously been studied. Results of induction of PS by suggestion were analyzed in 93 patients with purely PS. The diagnosis of PS was based on the recording of a clinical event on video-electroencephalography, the absence of clinical or electroencephalography the absence of clinical or electroencephalographic evidence of epilepsy, and the subsequent followup and withdrawal of anticonvulsants supporting the diagnosis of PS. A control-group was composed of 20 patients with epilepsy in which induction was tried. Both groups were comparable for age, sex, and educational level. Induction was performed following a standardized protocol. The test was carried out placing a colored patch on the neck. The test was considered positive when the induced clinical events were typical, according to a witness familiar with the patient's seizures. Induction was positive in 72 of 93 cases with PS and in none with epilepsy. Sensitivity of this test for the diagnosis of PS was 77.4%, specificity 100%, positive predictive value 100%, and negative predictive value 48.7%.

Adolescent↗
PubMed2004

Thirteen days: Joseph Delboeuf versus Pierre Janet on the nature of hypnotic suggestion.

The problem of post-hypnotic suggestion was introduced in 1884. Give a hypnotic subject the post-hypnotic command to return in 13 days. Awake, the subject remembers nothing yet nonetheless fulfills the command to return. How then does the subject count 13 days without knowing it? In 1886, Pierre Janet proposed the concept of dissociation as a solution, arguing that a second consciousness kept track of time outside of the subject's main consciousness. Joseph Delboeuf, in 1885, and Hippolyte Bernheim, in 1886, proposed an alternative solution, arguing that subjects occasionally drifted into a hypnotic state in which they were reminded of the suggestion. This article traces the development of these competing solutions and describes some of Delboeuf's final reflections on the problem of simulation and the nature of hypnosis.

Consciousness↗
PubMed1978

Effects of cannabis intoxication on primary suggestibility.

Thirty-five subjects of known hypnotizability were tested for primary suggestibility in the waking state with and without marijuana intoxication. The drug caused an increase in suggestibility similar to that produced by the induction of hypnosis. The effect did not persist when subjects were retested one week later in their normal waking state.

Adolescent↗
PubMed1996

Where to look first for suggestibility in young children.

Preschoolers' suggestibility following exposure to biased information has often been interpreted as indicating that memory traces have been genuinely altered. However, young children may not recognize that the purpose and relevance of questions in experiments on suggestibility is to determine whether they can ignore misinformation in remembering the original details of stories. Instead, children may be prompted to regard the original story details as trivial by experimenters who are perceived as having portrayed these details as unimportant or irrelevant in that they themselves did not bother to get these right. Under such conditions, children may interpret the biased information to mean that a biased alternative was an acceptable, or even a preferred, test choice when compared to the original details. We report the results of an investigation with 3- to 5-year-olds in which children heard a story followed the next day by either biased, unbiased, or no information. The children were able to identify the original story details 6 days later when the questions were phrased in an explicit manner that referred to the time of the information to be recalled.

Attention↗
PubMed1995

"Is this man your daddy?" suggestibility in children's eyewitness identification of a family member.

Studies of natural language development suggest that overextension of family memberships terms, such as daddy or papa, occurs in children in the second year of life, but rarely persists thereafter. However, in British Courts it is common for the testimony of 3- and even 4-year-olds to be dismissed on the grounds that these children may not be reliably identifying their father or stepfather when they claim that daddy was the perpetrator of abuse. This study examined whether 3-year-olds could be persuaded to confirm that a stranger who was labelled as daddy was their own father. A mock interview with experienced disclosure interviewers was conducted. Five of the 17 children--all from blue-collar families--misidentified a photograph of their own father when an identification question was repeated. Rather than undermining the validity of all preschoolers testimony, it is suggested that the responses of some children to apparently mundane questions of fact are influenced by contextual factors, including repetition of the question and the perceived omniscience of the interviewer.

Child Abuse↗
PubMed2005

The strategic regulation of children's memory performance and suggestibility.

We report two empirical studies that investigated previously reported benefits of a high accuracy motivation, and thus a high threshold, for children's and adults' event recall and for their ability to resist false suggestions. In the studies, 6-, 7-, and 8-year-olds, as well as adults, were shown a brief video about an event and were later asked unbiased and misleading questions about it. In Study 1, participants were either (a) given the typical accuracy instructions (including the option to answer with "I don't know"), (b) reminded of the accuracy instructions during the interview, or (c) immediately given feedback and a token for every correct answer. The results showed that the reminders were ineffective in stimulating strategic control behavior in children, independent of age. In Study 2, the confounding effects of feedback and incentives were disentangled by contrasting (a) free report, (b) feedback only, (c) incentives only, and (d) feedback plus incentives. Analyses on recall performance and suggestibility revealed that both feedback and incentives are necessary to increase children's accurate memory reports.

Child↗
PubMed2002

Memory and suggestibility in maltreated children: age, stress arousal, dissociation, and psychopathology.

The present study was designed to assess children's memory and suggestibility in the context of ongoing child maltreatment investigations. One hundred eighty-nine 3-17-year-olds involved in evaluations of alleged maltreatment were interviewed with specific and misleading questions about an anogenital examination and clinical assessment. For the anogenital examination, children's stress arousal was indexed both behaviorally and physiologically. For all children, individual-difference data were gathered on intellectual and short-term memory abilities, general psychopathology, and dissociative tendencies. Interviewers' ratings were available for a subset of children concerning the amount of detail provided in abuse disclosures. Results indicated that general psychopathology, short-term memory, and intellectual ability predicted facets of children's memory performance. Older compared to younger children evinced fewer memory errors and greater suggestibility resistance. Age was also significantly related to the amount of detail in children's abuse disclosures. Neither dissociation nor stress arousal significantly predicted children's memory. Implications for understanding maltreated children's eyewitness memory are discussed.

Adolescent↗
PubMedDate not supplied

Suggestibility in hypochondriacal patients and healthy control subjects. An experimental case-control study.

This study examined suggestibility to bodily sensations in hypochondriacal patients and healthy subjects. Both groups participated in an experiment in which electrical current was announced but not delivered. Suggestibility was measured by the number of responses and by response latencies. The authors hypothesized that the hypochondriacal patients would be more easily influenced by the expectation of a forthcoming stimulus, leading to higher and quicker "stimulus detection" rates than those experienced by the healthy subjects. In contrast to these expectations, the healthy subjects showed higher response frequencies and lower response latencies. Thus, the hypochondriacal patients appeared to be less influenced by the expectation that was raised. The theoretical and clinical implications of the results are discussed.

Adult↗
PubMed2000

Child characteristics which impact accuracy of recall and suggestibility in preschoolers: is age the best predictor?

OBJECTIVE: The purpose of the present study was to determine whether individual difference factors of metamemory, intelligence, and temperament can improve the ability to predict accuracy of recall and suggestibility in preschoolers. METHOD: Fifty-six children ranging in age from 43 months to 83 months (M = 61, SD = 9) were recruited from 13 child care centers in a rural southeastern town. Children participated in a "Circus Day" event conducted by two female undergraduate psychology students dressed as clowns. Approximately 10 days (M = 10; SD = 2) after the event, children were interviewed regarding their experiences. RESULTS AND CONCLUSIONS: Bivariate correlations and multiple regression analyses were performed in order to determine which factors were related and unique contributors to accuracy of recall and suggestibility. Of principal importance is the finding that child characteristics such as metamemory ability, intellectual functioning, and temperament may indeed be helpful in determining a child's capacity to accurately recall information in an interview, although for the most part age is the best predictor. Findings also underscore the importance of considering a child's SES and race when planning and conducting interviews with young children. Possible explanations for these findings as well as implications for future research and clinical application are discussed.

Child↗
PubMed2002

The effects of a caffeine placebo and suggestion on blood pressure, heart rate, well-being and cognitive performance.

We studied the effect of suggestion and different instructions in a balanced placebo design. One hundred and fifty-nine subjects were randomized into a 2*4 factorial design. All subjects except a control group received a caffeine placebo. Subjects were randomized to a condition which was identical to an earlier study, or received an information about scientifically proven effects of caffeine (factor 1). The second factor varied instructions: subjects were either made to expect coffee, no coffee or were in a double blind condition and were told either coffee or placebo would be applied. Dependent measures were blood pressure, heart rate, well-being and a cognitive task. There was one main effect of the instruction factor (P=0.03) on diastolic blood pressure, with the group 'told caffeine' reporting significantly smaller decrease in diastolic blood pressure than controls and subjects in the double blind condition. There were no other main effects on both the instruction or suggestion factor, and no interactions. Contrary to the literature, instruction effects were very small. This was apparently due to the fact that placebo-caffeine in the dose used in this study--one cup of strong 'coffee'--did not produce expectancy effects strong enough to affect the parameters measured. It is concluded that the placebo-caffeine research paradigm is not suitable for researching instruction effects in Germany, and that reported effects should be reproduced with tighter controls.

Adolescent↗