Twenty-first rheumatism review. Review of American and English literature for the years 1971 and 1972.
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Ketoconazole, an imidazole derivative, is the first encouraging new oral antimycotic in 20 years. Ketoconazole currently lacks Food and Drug Administration approval for treatment of dermatophytosis; however, it has demonstrated usefulness against a variety of fungal diseases, including tinea pedis, when griseofulvin has failed. The authors provide the reader with data from several studies on the medicinal therapy for dermatomycosis and onychomycosis, particularly where ketoconazole was utilized. Several studies utilizing other treatment modalities are also cited.
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