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PubMed1995

Effects of bilateral adrenalectomy on initiation of fur growth cycles in the deer mouse (Peromyscus maniculatus).

The objectives of this study were to determine the effects of bilateral adrenalectomy on the initiation of hair growth in the deer mouse and the duration of the actively growing phase of the hair growth cycle (anagen). Bilateral adrenalectomy plus deoxycorticosterone supplementation of adult deer mice resulted in the onset of hair growth 4 days earlier than in sham-operated mice supplemented with deoxycorticosterone. The duration of hair growth (anagen), based on guard hair measurements, was estimated to be approximately 12 days in both groups. As was expected for this species, the portion of the sheared test area in which new hair grew was incomplete in all control mice. In contrast, all adrenalectomized mice had hair growth over the entire sheared area. This suggests that normal, incomplete pelage replacement in adults was abolished and that adrenalectomy had a systemic effect, causing a greater number of hair follicles to become activated concurrently. These findings support the hypothesis that adrenal hormones exert an inhibitory effect on the induction of anagen and may be part of the mechanism controlling the onset of hair growth cycles.

Adrenal Glands↗
PubMed1996

Histopathology of Peromyscus leucopus naturally infected with pathogenic NY-1 hantaviruses: pathologic markers of HPS viral infection in mice.

Hantavirus research is impeded by the absence of animal models of viral pathogenesis. We have studied the histopathology of mice (P. leucopus) naturally infected with the NY-1 hantavirus on Shelter Island, New York. Five mice were determined to be seropositive in Western blotting to Four Corners Virus nucleocapsid protein and had serum antibodies to Seoul and Puumala hantavirus antigens by immunofluorescence assay. Hantavirus gene segments of the NY-1 hantavirus were identified in these mice and shown to be 99% identical to hantavirus genes isolated from the Rhode Island patient with hantavirus pulmonary syndrome. In ultrastructural examinations, we identified hantavirus particles in pulmonary endothelial cells. Morphologically, these mice demonstrate lymphohistocytic infiltrates in hepatic portal zones and slightly increased numbers of immunoblasts in splenic red pulp. Additionally, the alveolar septa in the lungs of infected mice are edematous with hyperplasia of type 1 pneumocytes. Naturally infected P. leucopus may serve as potentially useful animal models of hantavirus pulmonary syndrome disease.

Animals↗