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Results for “Parathyroid Neoplasms”

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At least 523 records · Page 29Linked to original sources
PubMed1979

The MEA-I syndrome: an all or none phenomenon?

Studies of two kindreds with the MEA-I syndrome prompted us to challenge the long-standing concept that endocrine involvement in this syndrome may be limited to one or two endocrine glands. Evaluation of medical histories, autopsies, or biochemical screening of 72 family members from five generations suggests that individuals inheriting the trait will develop endocrinopathy in all three endocrine systems characteristically involved in this syndrome, i.e., parathyroids, islets of Langerhans, and pituitary. Thirty-six surgical procedures have been performed on 21 family members. Gastrointestinal bleeding was the cause of death in 10 of 11 affected individuals. Only two individuals who inherited the trait have lived beyond 54 years, one with a total gastrectomy and one taking Cimetidine. In each instance, when tissue from one of the three endocrine systems was obtained (surgery or autopsy), abnormalities were documented. A search of the English-language literature (1953 to 1978) for reports of complete autopsies of MEA-I-affected individuals indicated pathology in all three endocrine systems in 29 of 32 cases. Medical and surgical management of this inherited disorder should be based on the concept that pathological changes will develop in the parathyroids, pancreatic islets, and the pituitary.

Adrenal Gland Neoplasms↗
PubMed1963

[HYPERPARATHYROIDISM].

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Calcium Metabolism Disorders↗
PubMed1997

Parathyroid adenomas and malignant neoplasms: coincidence or etiological association?

OBJECTIVE: To evaluate the possible association between primary hyperparathyroidism and malignant neoplasms. DESIGN: An historical cohort study. SETTING: The only Regional General Hospital of the Province of Udine, Italy (population = 500.000). PARTICIPANTS: All the 101 patients with surgically treated parathyroid adenomas. MAIN OUTCOME MEASURE: The incidence rate of malignant tumor was calculated for this cohort based on the number of incidence cases and the person-years at risk. Standardized morbidity rate ratios (SMR) were calculated to infer the cancer relative risk of the study cohort as compared with the general population. RESULTS: A total of 13 cases of malignant neoplasms were ascertained among cohort members. The overall number of observed cases of malignancy did not exceed the number of expected cases (SMR = 1.0). However, strong and statistically significant direct associations were found with bladder cancer (SMR = 5.1) and polycythemia vera (SMR = 62.5). CONCLUSIONS: Due to the magnitude of the associations between parathyroid and bladder cancer and polycythemia vera, it is unlikely that they might be explained completely by bias or chance. Rather, biologically plausible explanations were identified. Particularly, non-paraneoplastic hypercalcemia due to primary hyperparathyroidism may increase the risk of these malignancies.

Journal Article↗
PubMed1992

Normocalcemic hyperparathyroidism. Biochemical and symptom profiles before and after surgery.

Patients with normocalcemic hyperparathyroidism represent a diagnostic and therapeutic challenge. It is unclear to what extent these patients benefit from surgery in terms of correction of their serum chemistry abnormalities and their symptoms. We studied 142 patients: 23 with normocalcemic hyperparathyroidism (serum calcium levels below 2.62 mmol/L), 35 with intermittent hypercalcemia, and 84 with hypercalcemic hyperparathyroidism. Serum chemistry analyses and a standardized questionnaire of symptoms were completed before and after surgery. Overall, patients in the normocalcemic group reported a similar frequency of preoperative symptoms; had a similar reduction in postoperative symptoms; and had a similar normalization of serum calcium, parathormone, and phosphate levels as those in the two control groups. This study indicates that factors other than elevated serum calcium levels are in large part responsible for the symptoms of hyperparathyroidism and that these patients benefit from operation.

Adenoma↗
PubMed1975

Medullary carcinoma of the thyroid gland.

One hundred thirty-nine surgically treated patients with medullary carcinoma of the thyroid gland (MTC) were seen in our institution between January, 1926 and December, 1973. The incidence of this tumor among all thyroid cancers was 8%. Twenty-nine patients had the familial form of MTC; they were subclassified, on the basis of the phenotype, into a group of 15 patients with Sipple syndrome (or multiple endocrine neoplasia (MEN) Type 2A) and a group of 14 patients with mucosal-neuroma phenotype (or MEN type 2B). Better survivorship was seen in the younger patients, in those with bilateral tumors, in familial MTC, and in patients whose tumor was confined to the thyroid gland at the initial surgery. The incidence of tumor recurrence was 34%. However, in those with adequate surgical treatment, the recurrence was only 23%. The 5- and 10-year survivorships were 80% and 67%, respectively. The best chance of cure lies in early diagnosis through the use of immunoreactive calcitonin measurement in family members at risk, and an aggressive surgical attack on the primary tumor and any cervical metastases.

Adolescent↗