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At least 523 records · Page 29Linked to original sources
PubMed1975

[Clinical trial by perexiline maleate in treatment of angina pectoris (author's transl)].

A controlled double blind clinical trial has been conducted in 16 patients with "angina pectoris" in order to investigate the effect of Perexiline maleate as compared with prenilamine. Perexiline at the dose of 400 mg/die and prenilamine at the dose of 120 mg/die have been administered over a period of 4 weeks each. Between these periods placebo has been administered for two weeks. The number of attacks of angina and the number of tablets of nitroglycerine used per week by the patient during each period has been used for the evaluation. Furthermore ECG at rest and after exercise has been performed every two weeks. Our results statistically evaluated show a definite antianginal effect of Perexiline. According to our experience Perexiline should be considered the drug of choise in the treatment of angina complicated by bradicardia, left ventricular failure, bronchospasm, and in angina unresponsive to other drugs.

Angina Pectoris↗
PubMed1975

[The calcium-antagonistic fundamental effects of Verapamil on myocardial fibers and smooth muscle cells of the blood vessels].

Ca ions regulate the amount of ATP which is metabolized in the contractile system to produce mechanical energy. Since the consumption of ATP quantitatively determines the myocardial respiration rate, oxygen consumption is also Ca-dependent. Therefore, Ca-antagonistic compounds such as verapamil, D600 or nifedipine, by reducing the Ca supply to the beating heart, not only restrict ATP breakdown and mechanical activity but also myocardial oxygen demand. Moreover, Ca-antagonistic drugs lower the tone of vascular smooth muscle. This action leads to coronary vasodilation and a reduction in heart load because the peripheral vascular resistance is also diminished. All these factors contribute to an improvement of the cardiac energy balance in patients with coronary disease.

Adenosine Triphosphate↗
PubMed1975

[Therapy of angina pectoris. A task of everyday practice].

The current state of the medicamentous treatment of angina pectoris is presented as a standardized programmed guideline for general practice: 1. Prequisite for proper initial therapy is an exact diagnosis of a true stenocardia. 2. The intermediate treatment of coronary heart disease aimed at an effective lasting prophylaxis of angina pectoris attacks is based on a combined therapy with nitrates and beta-blockers. The mode of action of nitrates and beta-blockers is mentioned, side effects and contraindications are presented as limiting factors. The effects of nitrates, beta-blockers, and so-called vasodilators are exemplified by the new coronary drugs Sensit, Adalat and Pexid. After corresponding spot testing and clinical trials in 150 ambulant patients, Sensit is considered especially suited for wide application in the general practice. In the majority of patients there was a convincingly positive effect on general performance. The exertion tolerance increased by an average of 25 watts. Frequency, duration, and severity of stenocardic attacks are reliably influenced. In 68% of the patients, a remarkable regression and even sometimes a complete compensation of pathological ECG changes are achieved. The first results are seen approximately 2 weeks after commencing therapy, the maximum after 4 to 6 weeks. This improvement could be maintained by continuing regular medication, especially as the drug showed an astonishingly low incidence of side effects.

Angina Pectoris↗
PubMed1975

[Catecholamine in the myocardium; a fluorescence histochemical study].

There has been many studies on myocardial catecholamine (CA) in congestive heart failure and ishemias heart disease. However, it has been mainly studied pharmacologically and biochemically and has not been elucidated completely the local change of CA of the myocardium. CA in sympathetic nerves was first stained fluorescence histochemically by Falck-Hillarp in 1962, and many observations were made on its distribution and morphologically concentration of CA in tissue was also observed. Furthermore, the fluorescence histochemical simplified method (cryostat method) by Laties and Jacobowitz was published in 1967. This cryostat method produced the same good preparation instead of the freezed dried method of Falck-Hillarp and could be used semi-quantitatively for the determination of CA concentration in tissue. The author examined fluorescent-histochemically the distribution of CA in sympathetic nerve endings of the myocardium of animals (mouses, rabbits and dogs). After the administration of several agents and in some pathologic conditions, those were in the hypertrophied heart and impending heart failure, in myocardial infarction and A-V block. Furthermore, the change of CA in the myocardium was examined biochemically by von Euler method and its results were compared with the results of fluorescence-histo chemical method.

Animals↗