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The hypothalamic and neurohypophysial oxytocic activities in stressed rats: independence from beta-adrenergic blockade.

A distinct decrease of oxytocin was found in the hypothalamus of immobilized rats but not of those exposed to cold. Similarly, the content of oxytocin was lower in the neurohypophysis of rats immobilized for 24 hr but, on the contrary, increased in animals exposed to cold for 24 hr. Propranolol did not modify the mentioned changes brought about by immobilization or exposure to cold.

Animals↗

Oxytocic drugs and anaesthesia. A controlled clinical trial of ergometrine, syntocinon and normal saline during evacuation of the uterus after spontaneous abortion.

A randomised controlled clinical trial compared ergometrine 0.25 mg, syntocinon 10 mg and normal saline injected intravenously during evacuation of the uterus after spontaneous abortion showed no difference between any drug with respect to uterine contraction, change in blood pressure, blood loss or postoperative vomiting.

Abortion, Spontaneous↗

Cervical contractions: the response of the cervix to oxytocic stimulation in the latent phase of labour.

OBJECTIVE: To assess the cervical response to myometrial activity in early labour. DESIGN: Prospective observational study. SUBJECTS: Women requiring oxytocin stimulation in induced and spontaneous labours. SETTING: A teaching hospital in Birmingham. MAIN OUTCOME MEASURES: Simultaneous comparison of the cervical response to myometrial contractions was made on a cycle by cycle basis to deduce the properties of the cervix in early labour. RESULTS: Sixty-seven patients have been monitored, of whom 63 had satisfactory cervimetry data. Thirty (47.6%) women exhibited cervical contractions in response to myometrial activity. This response was only observed at dilatations up to 4 cm. The change in behaviour coincides with the transition from latent to active phases of dilatation. The length of the latent phase of labour was significantly longer in those women who exhibited cervical contractions (P < 0.001), although the active phase was similar in the two groups (P > 0.1). The group without cervical contractions exhibited a greater degree of effacement (P < 0.05) and tended to have more dilated cervices (P < 0.01) than those who showed cervical contractions. CONCLUSIONS: It is possible for the cervix to contract in early labour. This response may be the result of incomplete preparation of the cervix for the process of dilatation, and is seen during what is recognised as the latent phase in those women in whom the cervix is unaffected and undilated. These properties of the cervix may explain the poor results obtained from oxytocin stimulation of labour in the latent phase.

Adult↗

Postpartum hypertension and convulsion after oxytocic drugs.

An 18-year-old primipara developed acute hypertension leading to cerebral edema and convulsions following the IV injection of a bolus of 10 units of oxytocin with 0.2 mg methylergonovine maleate. Oxytocin in a dose of more than 2 units should not be administered IV in a single injection, as severe hypotension may result. If oxytocin is required, it can be injected either IM, or by IV pump or drip. The use of ergot in obstetrics should be limited to the treatment of life-threatening postpartum hemorrhage and be given only by the IM route. Ergot should not be administered to patients with cardiac, renal, or hypertensive disease, or in association with a vasoconstrictor.

Adolescent↗