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A unified paraxial approach to astigmatic optics.

In Gaussian optics properties such as dioptric power, lateral and angular magnification and thickness are simple scalar concepts. In linear optics, the optics of thick astigmatic systems, however, these concepts generalize to three-dimensional concepts in some cases (the dioptric power of thin systems, for example) and to four-dimensional concepts in general. As a result, the quantitative treatment of these properties in astigmatic systems presents challenges to the researcher in optometry, ophthalmology, and vision science. Considerable progress has been made only in the case of dioptric power. This paper presents a generalized approach to astigmatic optics which allows different physical properties to be treated in the same way: the theory is unified and, in a sense, complete. Mathematical and statistical methods developed for treating one concept become directly applicable to others. The paraxial optical properties of any optical system are completely defined by the 4 x 4 ray transfer matrix, called here the (ray) transference. The transference defines four fundamental properties of an optical system, tentatively called here positional magnification, optical thickness, divergence, and directional magnification. They are the four 2 x 2 submatrices A, B, C, and D of the transference. Each fundamental property is a modification of a familiar concept. Divergence is the negative of dioptric power expressed as the dioptric power matrix F. The four fundamental optical properties A, B, C, and D, and the derived property F, despite being different physically, all have the same underlying mathematical structure. This fact is exploited in developing a unified theory. The theory is complete in the sense that the fundamental properties fully characterize the paraxial optics of any system. The paper presents a general treatment that applies to any of the five properties. The implications are far reaching and extend beyond what can be described in the paper. Dioptric power of thin systems is treated as a particular application of the general theory. The result is the resolution of a number of issues of current interest to the researcher. It is shown, for example, that root-mean-squared (curvital) power, root-mean-squared torsional power, and length of the power vector (or dioptric strength) have a Pythagorean relationship, the power vector being the hypotenuse. Mean-squared curvital and torsional powers are in effect the area enclosed by polar profiles of curvital and torsional power, respectively. The full character of dioptric power cannot be represented by a single vector in the usual sense of the term. Two vectors are required: they are the meridional (vector) power and the orthogonal (vector) power, both of which are associated with the reference meridian. The power along a meridian (often thought of as a scalar or as two scalars) is a vector, the meridional power. This meridional power has components along (the meridional component of the meridional power) and perpendicular to (the orthogonal component of the meridional power) the meridian. In the literature, these components are the curvital power and the negative of the torsional power, respectively. The paper also examines the generalization of these results to the dioptric power of thick systems. Dioptric power is not a fundamental optical property but a derived property. Divergence, the negative of dioptric power, is the corresponding fundamental property. The theory described here is ray-based. The concept of the wavefront is unnecessary. The many formulas and concepts that apply in the context of dioptric power apply directly to the fundamental properties as well. The theory has the potential to provide a complete framework for future studies of astigmatic systems and could systematize the approach to and enhance the knowledge of astigmatism.

Astigmatism↗

Lens and peripheral retinal relationships during vitrectomy.

Relationships between the posterior surface of the crystalline lens and instruments introduced into the vitreous cavity through pars plana incisions were evaluated in ten eyes from cadavers. Instruments were introduced 3.0 mm, 3.5 mm, and 4.0 mm posterior to the anterior part of the limbus. The distance between an instrument oriented toward the center of the vitreous cavity and the peripheral edge of the lens in that meridian was 1.6 mm when the sclerotomy was 3.0 mm from the limbus and 2.8 mm when the sclerotomy was 4.0 mm from the limbus. The arc length from the sclerotomy where the instrument was introduced to the most distal meridian of the ora serrata that could be reached without touching the lens ranged from 2.8 to 3.8 clock hours as the distance between the sclerotomy and the limbus increased from 3.0 mm to 4.0 mm. The distance between the ora serrata and the most peripherally accessible point on the retina in the meridian 180 degrees from the sclerotomy decreased from 6.0 mm to 3.1 mm as the distance between the limbus and the sclerotomy increased from 3.0 mm to 4.0 mm.

Humans↗

Fucntional specialization and binocular interaction in the visual areas of rhesus monkey prestriate cortex.

If is is believed that neural mechanisms mediating stereoscopic vision may be localized in specific areas of the visual cortex, then it becomes necessary to be able to define these areas adequately. This is no easy matter in the rhesus monkey, an animal close to man, where the cytoarchitecturally uniform prestriate cortex is folded into deep sulci with secondary gyri. One way around this awkward problem is to use the callosal connections of the prestriate cortex as the anatomical landmarks. Callosal connections are restricted to regions at which the vertical meridian is represented. Since the visual fields, including the vertical meridian, are separately represented in each area, each has its own callosal connections. These are of great help in defining some of the boundaries of these areas, since the boundaries often coincide with the representation of the vertical meridian. With the visual areas thus defined anatomically, it becomes relatively easy to assign recordings to particular areas. Studies of binocular interactions in these areas reveal that most cells in all prestriate areas are binocularly driven. Hence, theoretically, all of the prestriate areas are candidates for stereoscopic mechanisms. The degree of binocular interaction varies from cell to cell. At the two extremes are cells which either respond to monocular stimulation only and are inhibited by binocular stimulation or ones which respond to binocular stimulation only. Changing, as opposed to fixed, disparity is signalled by two types of cells. In one category are cells activated in opposite directions for the two eyes. Such cells are always binocularly driven. In the other category are cells, some of which are monocularly activated, that are capable of responding to changing image size. In the monkey, both these categories of cells have so far been found in the motion area of the superior temporal sulcus only.

Animals↗

Self-rotation in electrocapillary flows.

The mechanism of appearance of swirl in a certain class of converging flows is investigated numerically. The analysis is motivated by the spontaneous generation of swirl, which has been observed in electrified menisci (Taylor cones). The electrical stress acting on the cone surface drives these electrified millimetric fluid flows. Numerical results show that the primarily swirl-free meridian flow is unstable within an interval of values of the Reynolds number based on the surface stress. For values of the Reynolds number outside this interval, which depends on the forcing conditions and the geometry of the flow, the nonswirling meridian flow is stable. The instability mechanism of circulation amplification, which has nothing to do with the well-known increase of swirl velocity due to the vortex stretching mechanism, is due to a convection-diffusion effect. The circulation accumulated at the axis zone by the converging meridian motion is pumped by diffusion toward the conical surface. This feedback loop mechanism shoots the circulation amplification for values of the Reynolds number larger than a critical one. The same instability mechanism of swirl amplification could also appear in other converging flows generated by body forces (natural convection, electrical forces, etc.).

Journal Article↗

Detecting the orientation of short lines in the periphery.

PURPOSE: Visual information processing in the human cortex is based on a highly ordered representation of the surrounding world. In addition to the retinotopic mapping of the visual field, systematic variations of the orientation tuning of neurons have been described in the primary visual cortex. As a step to understanding the relationship between position and orientation representation, we investigated psychophysically the minimum spatial requirements for the determination of orientation at various positions across the visual field. We know that the shortest line whose orientation can be resolved varies with eccentricity, such that its length corresponds to slightly less than 0.2 mm projected onto the cortical surface. Along the horizontal meridian horizontal lines are detected with higher precision than vertical or oblique lines. In the present experiments, we tested whether this is a preference for horizontal lines or for lines that are orientated radially away from the fovea. METHODS: Human observers were tested with lines positioned at one vertical, two horizontal and two oblique meridians at eccentricities between 5 and 25 degrees. RESULTS/CONCLUSION: Three of the four subjects were most sensitive for targets aligned with the meridian of presentation. This suggests that the visual system has the highest resolution in directions radiating from the fovea, which may be particularly useful for the analysis of flow fields resulting from forward translation.

Humans↗

Attentional selection and attentional gradients: an alternative method for studying transient visual-spatial attention.

In two experiments, I employed an alternative method for studying transient visual-spatial attention. Instead of using precues, attention was manipulated by presenting most stimuli sequentially at predictable locations. In Experiment 1, most stimuli appeared in a regular clockwise or counterclockwise order, but some were separated by one or both visual meridians from the expected location. In Experiment 2, most stimuli were presented successively along the horizontal meridian, and some stimuli were separated by one, two, or three positions from the expected location. Faster response times and larger posterior P1 and N1 components as well as enhanced negativities at midline electrodes were found for expected-location than for unexpected-location stimuli. These effects were partially modulated by the distance of unexpected stimuli from the current focus of attention, suggesting the existence of attentional gradients. Moreover, the data suggest that the direction of previous attentional shifts and the visual meridians play an important role for spatial attention.

Adult↗

An analysis of three meridional keratometric measurement of the anterior corneal surface.

Analysis of measurements taken in three meridians of a toroidal optical surface can produce a spherocylindrical result without having to locate the principal meridians. This technique is assessed for the anterior corneal surface using keratometry. Good agreement is found with measurements taken in the principal meridians making this a suitable method for the assessment of the eye's optical surfaces by Purkinje image measurement.

Adult↗

A comparison of the ARK-700A autokeratometer and Medmont E300 corneal topographer when measuring peripheral corneal curvature.

PURPOSE: The purpose of this study was to evaluate if corneal topogometry measurements as taken with the ARK-700A autokeratometer are comparable with those measured by the Medmont E300 videokeratoscope at corresponding locations. METHODS: Central and peripheral radius and eccentricity were measured in 122 right eyes of young normal subjects using autokeratometry and videokeratoscopy, obtained in a random order. RESULTS: Curvature measurements obtained with the ARK700A and Medmont E300 correlated well for the central cornea. Larger differences were observed between peripheral autokeratometry readings and the empirically determined corresponding locations with the videokeratoscope. Correlations between the instruments are inconsistent, resulting in unacceptable confidence intervals. Corneal eccentricity was significantly different between the instruments for the vertical (t = 2.4; p = 0.018) and for the horizontal meridians. In the first case, the difference between the averaged values was not clinically significant, but in the horizontal meridian the AK significantly overestimated eccentricity values (t = -11.5; p < 0.001) with differences which were clinically significant. CONCLUSIONS: Central corneal curvature data obtained by ARK700A and Medmont E300 can be interchanged but the same is not true of peripheral determinations of corneal shape. ARK700A probably measures peripheral corneal shape within an elliptical region between 5 and 7 mm in diameter, with the major axis in the vertical meridian.

Adult↗

The central-peripheral radius of the normal corneal curvature. A photokeratoscopic study.

Both eyes of 40 normal persons were examined with a photokeratoscope. A method for analyzing the photokeratoscopic data based on the principle of least square fitting is presented. It is demonstrated that the corneal flattening expressed as the relative change in the radius of the corneal curvature is proportional with the square of the chord distances from apex. The factor of proportionality RV is defined as the coefficient of radius variation, which, together with the radius of the apex curvature K, are characteristic constants for a given meridian in a given eye. Expressed as mean and SD, the study demonstrates for the horizontal meridian K = 7.86 mm (0.25) and RV = 0.71 X 10(-2) mm-2 (0.26 X 10(-2)), for the vertical meridian the corresponding dimension are K = 7.65 mm (0.24) and RV = 0.70 X 10(-2) mm-2 (0.38 X 10(-2)). These results imply a change in the radius of the corneal curvature 1 mm and 5 mm from apex at, respectively, 0.7% and 17.7%. The precisions expressed as SD, by which the 2 parameters may be determined, are for K 0.03 mm and RV 0.12 X 10(-2) mm-2.

Adolescent↗

The response characteristics of an inhibitory binocular interaction in human vision.

1. The contrast threshold level for visual detection of a linear grating consisting of parallel light and dark bars is increased by adaptation to a high contrast grating of spatial characteristics similar to those of the test grating (e.g. Blakemore & Campbell, 1969). This so-called contrast threshold elevation effect is significantly reduced if two adaptation gratings, with appropriate different spatial characteristics, are presented one to either eye (Ruddock & Wigley, 1976). We have studied the contrast threshold elevation effect obtained with a test and an adaptation grating presented to one eye and a second adaptation grating, referred to as the conditioning grating, presented to the other. 2. Preliminary data are presented for three subjects with normal stereoscopic vision. In each case, the contrast threshold elevation effect for a pair of spatially identical test and adaptation gratings is significantly reduced by a conditioning grating of spatial frequency in the range 1-5 c/deg. 3. Reduction in the contrast elevation effect is observed whether the conditioning and adaptation gratings are of the same or of different wave-lengths and the effect of the conditioning grating increases to a steady-state level over a period of some 30 sec following onset of its presentation. 4. Measurements were made with a 5 deg diameter circular test grating presented at retinal locations up to 8 deg in the horizontal and vertical meridians from a foveal fixation point. It was found that in the horizontal meridian, the amplitude of the suppression effect associated with the conditioning grating falls as the displacement angle of the test field from the fixation point increases. For displacements in the vertical meridian, however, the amplitude of the suppression effect is virtually independent of the retinal location of the test field. 5. Under experimental conditions which yield suppression of the contrast threshold elevation effect for subjects with normal stereoscopic vision, no suppression was found for three subjects who possessed neither global nor fine stereoscopic vision. Results for a subject who possessed fine, but not global stereoscopy, did, however, show the suppression effect.

Adaptation, Ocular↗

Electrophysiological evidence for interhemispheric transmission of visual information in man.

1. Electrophysiological evidence is presented of interactions between two stimuli (sinusoidal gratings of equal spatial frequency but different contrast, phase-reversed sinusoidally at different temporal frequencies) located on opposite side of, and within a few degrees from, the vertical meridian. 2. These interactions are revealed by a depression of the cortical visual evoked potential (VEP) evoked by the grating of lower contrast in the presence of the grating of higher contrast. They are similar to, albeit weaker than, those obtained with superimposed asynchronously modulated gratings. 3. The VEP reduction occurs also if the stimuli are presented dichoptically. 4. It does not occur if the gratings are located one above the other either on the same or on opposite sides of the vertical meridian. 5. The strength of the VEP reduction depends on the relative contrast of the two gratings and vanishes for spatial frequencies beyond 4 cycles/deg and temporal frequencies of the high-contrast grating beyond 10 Hz. 6. The results are in agreement with data on visual callosal connections in animals and confirm previous psychophysical findings (Berardi & Fiorentini, 1987) indicating the particular properties of the interhemispheric cross-talk between symmetric regions of the visual field astride the vertical meridian in man.

Brain↗

Monocular spatial distortions induced by marked accommodation.

Contraction of the ciliary muscle during marked accommodation causes the leading edge of the retina to advance as much as 0.5 centimeter. Near the posterior pole of the eye, the upward and downward extensional strains on the retina should be reasonably balanced. In the horizontal meridian an asymmetry is introduced because of the nasal location of the optic nerve head. Observers were asked to bisect the space between two parallel lines while fixating a movable line lying near the midpoint of the two lines. The test was conducted with the target far from and near the subject, in the horizontal and vertical meridians, and was repeated with accommodation paralyzed by a cycloplegic agent. Marked accommodation induced significant spatial distortions in the horizontal meridian. The effect is largely retinal.

Accommodation, Ocular↗

Comparison of two commercially available enzyme immunoassays for detection of Clostridium difficile in stool specimens.

Clostridium difficile is the cause of most cases of pseudomembranous colitis, the most severe form of antibiotic-associated diarrhea. Rapid diagnosis guides both the treatment and the control of nosocomial spread of infection. Two enzyme immunoassay (EIA) kits developed for the rapid detection of C. difficile toxin A in fecal specimens, Premier (Meridian Diagnostics, Cincinnati, Ohio) and Tox-A test (TechLab, Virginia Polytechnic Institute Research Park, Blacksburg), were evaluated by using 410 fecal specimens. Seventy-six specimens were positive for C. difficile toxin B by the cytotoxin assay (prevalence rate, 19%). The Meridian EIA was positive for 71 of the 76 samples, yielding a sensitivity of 93%. The TechLab EIA detected 75 of the 76 positive samples, yielding a sensitivity of 99%. The Meridian and TechLab EIAs had specificities of 100 and 93%, respectively. These data indicate that both EIAs are suitable alternatives to the cytotoxin assay in routine diagnostic laboratories. However, confirmation of TechLab EIA-positive test results by the cytotoxin assay remains necessary.

Adolescent↗

Use of acupressure to improve gastrointestinal motility in women after trans-abdominal hysterectomy.

The purpose of this study was to evaluate the effectiveness of acupressure on gastrointestinal (GI) motility in women after trans-abdominal hysterectomy (TAH). Patients were randomly assigned into two groups of 21 and 20 patients each. The experimental group received acupressure for 3 minutes at each of three meridian points: Neiguan (PC-6), Zusanli (ST-36) and Sanyinjiao (SP-6). The control group received 3 minutes of acupressure on sham points. Acupressure was performed twice a day. A questionnaire was used to determine patients' satisfaction prior to and after afternoon acupressure. GI contractions were measured with a multifunctional stethoscope before and after acupressure. Acupressure of these three meridian points significantly (p < 0.05) increased GI motility in the experimental group, but there was little change in the control group (p > 0.05). Our conclusions are that non-invasive acupressure of these meridian points can significantly improve GI motility and can be incorporated into the technical curriculum and clinical education program of nursing schools. Patients and their family members can be taught to continue this procedure at home to enhance GI motility in patients who have undergone TAH.

Abdominal Pain↗

Effect of electroacupuncture on pressor reflex during gastric distension.

The effect of electroacupuncture (EA) on the reflex cardiovascular response induced by mechanical distension of the stomach was studied in ventilated male Sprague-Dawley rats anesthetized by ketamine and alpha-chloralose. Repeated balloon inflation of the stomach to produce 20 mmHg tension on the gastric wall induced a consistent rise in mean arterial pressure, while heart rate (372 +/- 22 beats/min) was unchanged. This response was reversed by transection of the splanchnic nerves. Bilateral application of EA (1-2 mA, 2 Hz) at Neiguan-Jianshi acupoints (pericardial meridian, Pe 5-6) over the median nerve for 30 min significantly decreased the pressor response from 33 +/- 6 to 18 +/- 4 mmHg (n = 7, P < 0.05). This effect began after 10 min of EA and continued for 40 min after termination of EA. EA at Zusanli-Shangquxu acupoints (stomach meridian, St 36-37) over the deep peroneal nerve similarly inhibited the pressor response. The effect lasted for 10 min after EA was stopped (n = 6, P < 0.05), while EA at Guangming-Xuanzhong acupoints (gallbladder meridian, GB 37-39) over the superficial peroneal nerve did not inhibit the pressor response. Naloxone injected intravenously (n = 6) immediately after termination of EA or administered by microinjection into the rostral ventrolateral medulla (rVLM) 25 min after initiation of EA (n = 6) reversed the inhibition by EA, suggesting an opiate mechanism, including the rVLM, was involved.

Animals↗

Indirect, across-the-midline retinotectal projections and representation of ipsilateral visual field in superior colliculus of the cat.

1. In agreement with previous work, we have found that the ipsilateral visual field is represented in an extensive rostral portion--from one-third to one-half--of the superior colliculus (SC) of the cat. This representation is binocular. The SC representation of the ipsilateral visual field can be mediated both directly, by crossed retinotectal connections originating from temporal hemiretina, and indirectly, by across-the-midline connections relaying visual information from one-half of the brain to contralateral SC. 2. In order to study the indirect, across-the-midline visual input to the SC, we have recorded responses of SC neurons to visual stimuli presented to either the ipsilateral or the contralateral eye of cats with a midsagittal splitting of the optic chiasm. Units driven by the ipsilateral eye, presumably through the direct retinotectal input and/or corticotectal connections from ipsilateral visual cortex, were found throughout the SC, except at its caudal pole, which normally receives fibers from the extreme periphery of the contralateral nasal hemiretina. Units driven by the contralateral eye, undoubtedly through an indirect across-the-midline connection, were found only in the anterior portion of the SC, in which is normally represented the ipsilateral visual field. Receptive fields in both ipsilateral and contralateral eye had properties typical of SC receptive fields in cats with intact optic pathways. 3. All units having a receptive field in the contralateral eye had also a receptive field in the ipsilateral eye; for each of these units, the receptive fields in both eyes invariably abutted the vertical meridian of the visual field. The receptive field in one eye had about the same elevation relative to the horizontal meridian and the same vertical extension as the receptive field in the other eye; the two receptive fields of each binocular unit matched each other at the vertical meridian and formed a combined receptive field straddling the vertical midline of the horopter...

Animals↗

Importance of corpus callosum for visual receptive fields of single neurons in cat superior colliculus.

1. Section of the posterior two-thirds of the corpus callosum eliminates almost completely the response of superior colliculus (SC) neurons to stimulation of the contralateral eye in split-chiasm cats. On the contrary, the responsiveness of SC neurons to stimulation of the contralateral eye is not abolished by a transection of the posterior and tectal commissures leaving the corpus callosum intact. The callosal section also reduces the number of SC receptive fields abutting the vertical meridian in the ipsilateral eye of split-chiasm cats. 2. In cats with intact optic pathways, a similar callosal section abolishes the SC representation of the ipsilateral visual field in the ipsilateral eye and also reduces the number of receptive fields adjoining the vertical meridian in the same eye. In the contralateral eye, the SC representation of the ipsilateral visual field is reduced in extension to about one-fifth of that seen in cats with intact commissures. 3. The results suggest that the corpus callosum is the main pathway for cross-midline communication of visual information at not only the cortical, but also the midbrain level. The corpus callosum may subserve this function because it contains uninterrupted crossed corticotectal projections or because it transmits visual information from one hemisphere to contralateral cortical areas projecting ipsilaterally to SC. The latter hypothesis is more likely but, in any case, the findings imply that the lack of interhemispheric transfer of visual learning in cats with a chiasmatic and callosal section may depend on a midline disconnection of both subcortical and cortical visual centers. 4. The corpus callosum is also responsible for the representation of the ipsilateral visual field of the ipsilateral eye in the cat SC. The SC representation of the ipsilateral visual field in the contralateral eye is due, in minimal part, to direct retinotectal connections from temporal retina and, for the largest part, to the corpus callosum. 5. Finally, the corpus callosum contributes to the representation of the contralateral visual field near the vertical meridian of the temporal retina in both split-chiasm and normal cats. This is probably due to the scarcity of direct retinotectal projections from this part of the retina and to their supplementation by corticotectal neurons influenced by the callosal afferents.

Animals↗

Functional organization of neurons in cat striate cortex: variations in ocular dominance and receptive-field type with cortical laminae and location in visual field.

1. Binocularity and receptive-field type of cortical neurons were assessed relative to the cortical layer in which the neurons were recorded and to receptive-field position in the visual field. 2. Receptive fields were observed up to 2 degrees into the ipsilateral half of the visual field. In the region up to 2 degrees on either side of the vertical meridian, the relative contribution of the ipsilateral eye was reduced. This progression in ocular dominance from ipsilateral to contralateral visual field agrees well with the distribution of X-cells about the nasotemporal division. 3. The region of maximum binocularity in each hemifield was found to be a 12 degree wide vertical strip extending from the vertical meridian to 12 degrees contralateral. In the representation of the central 12 degree strip, most units in all cortical layers were binocular. 4. Low levels of binocularity were observed at a considerable distance before the monocular portion of the visual field was reached. 5. The decrease in binocularity for simple cells occurred closer to the vertical meridian than for complex cells. 6. The proportions of cells classified as simple or complex did not change with position in the visual field. 7. At all locations in the visual field, complex cells showed a higher percentage of binocularity than simple cells. 8. The proportions of two types of simple cells, I and II, and complex cells were variable between cortical layers. Layer IV contained predominantly simple II cells, whereas layer V contained predominantly complex cells. 9. The results are discussed in terms of visual perception and the dynamic pattern of visual stimulation around a moving animal, the optic flow field.

Animals↗