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Recurrent Klebsiella pneumoniae liver abscess in a diabetic patient followed by Streptococcus bovis endocarditis--occult colon tumor plays an important role.

Klebsiella pneumoniae is the leading cause of liver abscess in diabetic patients in Taiwan. We report the case of a diabetic patient with a history of four episodes of K. pneumoniae liver abscess within 3 years. The patient later developed Streptococcus bovis bacteremia originating from a colon tumor with complications of endocarditis, osteomyelitis, and silent splenic abscess. Occult colon tumor may have played an important role in our case, with recurrent infection arising from colonizers of the gastrointestinal tract. As our case shows, the possible association between occult colon tumor and K. pneumoniae liver abscess in diabetic patients should be surveyed.

Adenoma, Villous↗

[Case report: tenesmus in a cow with a liver abscess and nephritis].

A two-year-old Swiss Braunvieh cow was referred to our clinic because of tenesmus and weight loss. Clinical examination revealed a moderately abnormal general behaviour and condition, thin body condition and a rectal temperature of 40.1 degrees C. Tenesmus was evident, and rumen and intestinal motility were markedly reduced. All tests for a reticular foreign body were positive. On rectal examination, a round, smooth, firm, non-painful mass with a diameter of approximately 15 cm was palpated far cranially on the right side. Abnormal haematological and biochemical findings included marked anaemia, neutrophilic leucocytosis, markedly elevated concentration of fibrinogen and mildly elevated gamma-glutamyl-transferase activity. The clotting time of the glutaraldehyde test was one minute. Ultrasonographic examination revealed abscesses involving the liver and extending caudally into the right flank region. The liver parenchyma had diffuse changes. Because of a grave prognosis, the cow was euthanized. Postmortem findings substantiated ultrasonographic results; there were abscesses, caused by Fasciola hepatica infestation, originating in the liver and extending into the right flank. As well, there was severe, bilateral, multifocal, suppurative nephritis due to thromboembolism. Based on all the findings, a diagnosis of liver abscess caused by fascioliasis and bilateral suppurative nephritis was made.

Animals↗

Liver abscess. Case report.

A typical case of liver abscess is reported. The mortality rate of this surgical entity, previously very high, has been reduced markedly in recent years. The most important factors are the new diagnostic developments such as liver scans and coeliacography, making an early and exact diagnosis possible and thus forming the basis for an early and adequate surgical drainage.

Adult↗

Pyogenic liver abscesses complicated with abscess-duodenum fistula in a child: report of one case.

A 12-year-old girl with liver abscesses was confirmed to have a rare complication, abscess-duodenal fistula formation, which was demonstrated on performing fluoroscope-guided percutaneous drainage. She was successfully treated with percutaneous drainage and antibiotics. The incidence, etiology, diagnosis and clinical management of pyogenic liver abscess in children are discussed.

Anti-Bacterial Agents↗

[Diagnosis and treatment of a liver abscess with contrast-enhanced ultrasound].

We report on a patient with pyogenic liver abscess. Using a ultrasound contrast agent improves the characterization of pyogenic hepatic abscesses and facilitates repetitive therapeutic punctures. The use of ultrasound contrast agents opens new aspects in the diagnosis of liver abscesses and gives additional confidence in diagnostic and therapeutic procedures.

Aged, 80 and over↗

[Complicated amebic liver abscess--course and therapy].

We report on a case of an amoebic liver abscess acquired during a holiday in Bali. Transdiaphragmatic migration and consecutive atelectasis of the right lung caused respiratory insufficiency, requiring immediate surgical intervention. Complications consisted of massive bleeding into the colon concomitant with a reactivated CMV-infection. In addition, toxins of Clostridium difficile and enterohaemorrhagic E. coli were seen in the faeces. In contrast to the majority of uncomplicated cases of amoebic liver abscess, usually treated with amoebicidal drugs only, surgical intervention was clearly indicated in our patient.

Combined Modality Therapy↗

Simultaneous amebic liver abscess and hepatitis A.

A child with amebic colitis, liver abscess and hepatitis A is reported. Speculation as to why these two infectious agents have rarely been associated is presented. Diagnosis of hepatitis was not suspected in this case until physicians caring for the patient developed clinical hepatitis. The importance of suspecting hepatitis A in all patients with unexplained liver enzyme elevations is stressed.

Female↗

Pyogenic liver abscess.

Experience with 34 patients with pyogenic liver abscess is reviewed to evaluate the impact of percutaneous drainage and duration of antibiotic therapy on results of treatment. Patients with shock, adult respiratory distress syndrome, disseminated intravascular coagulation, jaundice, severe hypoalbuminemia, and diabetes had a poor prognosis. Percutaneous drainage was used successfully in 4 of 6 patients, but its use did not affect mortality rate or length of hospital stay. Percutaneous drainage may be the procedure of choice for selected patients. Half of our patients received antibiotics for 2 weeks or less with no abscess recurrences in this group. Long-term antibiotics may not be necessary after adequate surgical or percutaneous abscess drainage.

Adolescent↗

Amebic liver abscess: a therapeutic approach.

The clinical presentation of 48 patients with amebic liver abscess was no different than that reported in earlier studies. However, most patients were from countries endemic for parasitic disease. Failure to consider this diagnosis resulted in potentially avoidable surgery for six patients. Although metronidazole was successful primary therapy in 85% of 41 patients so treated, four of seven ruptured abscesses occurred in cases where metronidazole treatment failed. For assessment of factors that might predict metronidazole treatment failures, multiple parameters were analyzed. Of the factors evaluated, only timing of clinical response correlated with successful therapy. Ninety-four percent of metronidazole responders showed dramatic clinical improvement within 72 hours of initiation of therapy, whereas only 33% nonresponders had improved modestly during this time (P = .0014). Therefore, early diagnosis of amebic liver abscess in patients from endemic areas and treatment with metronidazole will result in successful therapy in 85% of cases. Surgical intervention or alternative medical therapy is indicated for those patients who do not respond after 72 hours of metronidazole therapy.

Adolescent↗

Bovine rumenitis - liver abscess complex: a bacteriological review.

Fusobacterium necrophorum is considered to be a member of the normal rumen flora and is the primary etiologic agent of bovine liver abscesses. Of the three biotypes of F. necrophorum, A, B, and C, only biotypes A and B have been implicated in the disease. Type B is the predominant biotype isolated from ruminal lesions and type A is the predominate biotype isolated from liver abscesses. Type A is usually found in pure culture in the liver abscesses; whereas, type B is usually found in mixed culture with either type A or with other bacterial species. Corynebacterium pyogenes, Streptococcus spp., Staphylococcus spp., and Bacteroides spp. are the most prevalent bacteria recovered from mixed cultures. Corynebacterium pyogenes is the most common species isolated and can cause disease synergistically with type B isolates.

Animals↗

Liver abscess after percutaneous ethanol injection (PEI) therapy for hepatocellular carcinoma. A case report.

We present a case of liver abscess after percutaneous ethanol injection (PEI) therapy for the treatment of recurrent hepatocellular carcinoma (HCC). The 56-year-old woman had a past history of cholecystoduodenostomy for cogenital dilatation of the bile duct, and pneumobilia was observed in the intrahepatic bile ducts prior to PEI. The abscess was successfully treated by percutaneous abscess drainage and antibiotic therapy. Klebsiella pneumonia, one of the most common causative organisms of biliary tract infection, was isolated from the abscess. Thus, biliary tract infection related to the previous biliary-enteric anastomosis operation may have been one of the causative factors in the liver abscess in this patient. The rare experience reported here suggests that a careful search for coexistent abscess at the time of PEI is important in HCC patients with biliary-enteric anastomosis, especially in those with pneumobilia.

Carcinoma, Hepatocellular↗

Ischemia in experimental acute amebic liver abscess in hamsters.

In experimental acute amebic liver abscess, produced in hamsters by the intraportal inoculation of 1 x 10(6) axenic trophozoites of Entamoeba histolytica strain HM-1, we examined the blood perfusion of the lesions 5, 10, 24 and 72 h after injection of the parasites. India ink introduced into the portal circulation filled all liver vessels but was systematically excluded from even the earlier amebic lesions. The absence of serum proteinase inhibitors from the lesions may allow the participation of amebic proteinases in the causation of tissue necrosis.

Acute Disease↗

An unusual presentation of spontaneous pneumoperitoneum secondary to the rupture of a gas-containing pyogenic liver abscess: report of a case.

We describe a rare case of spontaneous pneumoperitoneum secondary to the rupture of a gas-containing pyogenic liver abscess in a 59-year-old man. The patient was diagnosed as having a hollow viscus perforation based on a sudden onset of acute abdominal pain along with radiological evidence of bilateral subphrenic feee air (pneumoperitoneum), and underwent an emergency laparotomy. Contrary to expectations, the surgery revealed no perforations of the hollow viscus, but instead a ruptured liver abscess at the dome of the right hepatic lobe was identified associated with suppurative peritonitis. To the best of our knowledge, such a case of spontaneous pneumoperitoneum secondary to the rupture of a gas-containing liver abscess is extremely rare.

Abdomen, Acute↗

Reversible portal hypertension in amoebic liver abscess: a case report.

A fifty eight year old male patient, with an amoebic liver abscess showed reversal of portal hypertension demonstrated by radiological and endoscopic evidence of oesophageal varices, on successful treatment of abscess. This appears to be the first report of reversible oesophageal varices in amoebic liver abscess. The relevant features have been discussed with reference to available literature on the subject.

Drug Therapy, Combination↗

Clinical profile of multiple amoebic liver abscesses.

Of 70 consecutive patients with amoebic liver abscess admitted over a 3 year period, 15 (21.4%) had multiple abscesses. This condition, like solitary abscess, was a disease of the 2nd to 5th decade with a male preponderance. Multiple abscesses were more frequently associated with fever, jaundice, upper abdominal pain, pneumonitis and tender hepatomegaly. The left lobe of the liver was always enlarged in patients with multiple abscesses and 86% of patients required drainage of an abscess cavity. The presence of more severe clinical course, jaundice and left lobe hepatomegaly should raise the suspicion of multiple abscesses. After confirmation of the diagnosis by imaging technique, the abscess cavity should be aspirated for quick relief and cure.

Adolescent↗

Fate of Entamoeba histolytica during establishment of amoebic liver abscess analyzed by quantitative radioimaging and histology.

The protozoan parasite Entamoeba histolytica is the causative agent of amoebiasis, a human disease characterized by dysentery and liver abscess. The physiopathology of hepatic lesions can be satisfactorily reproduced in the hamster animal model by the administration of trophozoites through the portal vein route. Hamsters were infected with radioactively labeled amoebas for analysis of liver abscess establishment and progression. The radioimaging of material from parasite origin and quantification of the number inflammation foci, with or without amoebas, described here provides the first detailed assessment of trophozoite survival and death during liver infection by E. histolytica. The massive death of trophozoites observed in the first hours postinfection correlates with the presence of a majority of inflammatory foci without parasites. A critical point for success of infection is reached after 12 h when the lowest number of trophozoites is observed. The process then enters a commitment phase during which parasites multiply and the size of the infection foci increases fast. The liver shows extensive areas of dead hepatocytes that are surrounded by a peripheral layer of parasites facing inflammatory cells leading to acute inflammation. Our results show that the host response promotes massive parasite death but also suggest also that this is a major contributor to the establishment of inflammation during development of liver abscess.

Animals↗