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At least 523 records · Page 29Linked to original sources
PubMed2001

Evaluation of United States-licensed human immunodeficiency virus immunoassays for detection of group M viral variants.

Six Food and Drug Administration (FDA)-licensed human immunodeficiency virus type 1 (HIV-1) and HIV-1/2 immunoassays, including five enzyme immunoassays and one rapid test, were challenged with up to 250 serum samples collected from various global sites. The serum samples were from individuals known to be infected with variants of HIV-1 including group M subtypes A, B, B', C, D, E, F, and G and group O. All immunoassays detected the vast majority of samples tested. Three samples produced low signal over cutoff values in one or more tests: a clade B sample, an untypeable sample with a low antibody titer, and a group O sample. It is concluded that HIV-1 immunoassays used in the United States are capable of detecting most HIV-1 group M variants.

AIDS Serodiagnosis↗
PubMed2006

Essential elements of a licensed, mammalian plasmid origin of DNA synthesis.

We developed a mammalian plasmid replicon with a formerly uncharacterized origin of DNA synthesis, 8xRep*. 8xRep* functions efficiently to support once-per-cell-cycle synthesis of plasmid DNA which initiates within Rep*. By characterizing Rep*'s requirements for acting as an origin, we have uncovered several striking properties it shares with DS, the only other well-characterized, licensed, mammalian plasmid origin of DNA synthesis. Rep* contains a pair of previously unrecognized Epstein-Barr nuclear antigen 1 (EBNA1)-binding sites that are both necessary and sufficient in cis for its origin activity. These sites have an essential 21-bp center-to-center spacing, are bent by EBNA1, and recruit the origin recognition complex. The properties shared between DS and Rep* define cis and trans characteristics of a mammalian, extrachromosomal replicon. The role of EBNA1 likely reflects its evolution from cellular factors involved in the assembly of the initiation machinery.

Base Sequence↗
PubMed1986

Scotland's liquor licensing changes: an assessment.

The impact of the changes in Scotland's liquor licensing laws was assessed by comparing trends in alcohol related problems in Scotland with those in England and Wales. The study showed no appreciable effect on the level of alcohol related morbidity and mortality, though some improvements were noted in relation to the rates of convictions for drunkenness. The changes introduced since 1976 appeared to be popular and there was widespread perception that public drunkenness had become less common-place.

Alcohol Drinking↗
PubMed1994

European Medicines Evaluation Agency and the new licensing arrangements.

Since September 1971 the Medicines Act has provided the legal basis for controlling the manufacture, sale, supply and marketing of medicines in the UK. The law has been modified by Parliament and the incorporation of European directives, but until now its interpretation and implementation have remained matters for UK authorities. From 1 January 1995 the position changes with the establishment of the European Medicines Evaluation Agency (EMEA) and the introduction of marketing arrangements for medicines that will be binding across the European Union (EU). The EMEA, which will be based in London, will act as a coordinating centre, housing and servicing the Committee for Proprietary Medicinal Products (CPMP; equivalent to our Committee on Safety of Medicines), the body that will advise the European licensing authority (European Commission). The new arrangements will cover medicines and vaccines (including blood products and radiopharmaceuticals) for both human and veterinary use. This article outlines the workings of the new system and discusses how they might affect the provision of medicines for human use in the UK.

Animals↗
PubMed1983

Legislation covering the licensing of veterinary medicines in the United Kingdom.

The procedures used in the United Kingdom governing the licensing of veterinary medicines based on an advisory committee procedure are summarised. The article does not purport to cover all aspects of medicines legislation and must not be treated as a complete or authoritative statement of the law on any particular case. Reference should be made to the Medicines Act 1968 and regulations made under the Act. It does not cover EEC legislation.

Legislation, Drug↗
PubMed2007

DNA replication licensing factor minichromosome maintenance deficient 5 rescues p53-mediated growth arrest.

Inactivation of p53 signaling by mutation of p53 itself or abrogation of its normal function by other transfactors, such as MDM2, is a key event in the development of most human cancers. To identify novel regulators of p53, we have used a phenotype-based selection in which a total cDNA library in a retroviral vector has been introduced into TR9-7ER cells, which arrest when p53 is expressed from a tetracycline-regulated promoter. We have isolated several clones derived from cells that are not growth-arrested when p53 is overexpressed. In one clone, the levels of p53, p21, and MDM2 are comparable with those in TR9-7ER cells and, therefore, the abrogation of growth arrest by an exogenous cDNA is likely to be distal to p21. Using reverse transcription-PCR, we were able to isolate a cDNA of approximately 2.2 kb, which was found to have 99% identity to the nucleotides between about 80 and 2,288 of the open reading frame of a gene encoding DNA replication licensing factor. It encodes complete peptide of 734 residues of this protein also called minichromosome maintenance deficient 5 (MCM5) or cell division cycle 46 (Saccharomyces cerevisiae). Northern and Western blot analyses revealed that the expression of MCM5 and its transcriptional regulator, E2F1, is negatively regulated by p53. When MCM5 cDNA was reintroduced into fresh TR9-7ER cells, numerous colonies that grow in the absence of tetracycline were formed. This novel observation establishes a role for MCM5 in negating the growth arrest function of p53.

Cell Cycle Proteins↗
PubMed2006

Testing licensing by cue: a case of Russian palatalized coronals.

The hypothesis 'licensing by cue' by Steriade holds that phonological contrasts are maintained in environments that provide better acoustic cues to the contrasts and are neutralized in environments that provide poorer acoustic cues or no cues. This paper tests the hypothesis by examining the distribution of a phonological contrast--the Russian plain/palatalized coronal stops /t/ and /tj/ in various syllable-final contexts. The results of a series of acoustic and perceptual experiments presented in this paper provide some support for the hypothesis: the relative salience of releases in different word boundary contexts (_#k > _#n, _#s) correlates strongly with the general patterns of neutralization of the contrast in similar word-internal contexts (_k > _n, _s) in Russian and other related languages. At the same time, the relative salience of VC transitions in different vowel contexts (a_ > u_ > i_) has apparently little to do with attested patterns of neutralization. The results suggest that some perceptual cues are phonologically more relevant than others, providing evidence for interactions between phonetics and phonology more complex than predicted by the hypothesis.

Adult↗
PubMed2004

Institutionalization of a community action program targeting licensed premises in Stockholm, Sweden.

The objective of this article is to evaluate the level of institutionalization of a community action program targeting licensed premises in Stockholm. Five key factors were identified for institutionalization: adoption, sustainability, key leader support, structural changes, and compliance. A scale was developed to assess the strength of each factor. The results indicate a high degree of institutionalization (score 13 on a scale from 5 to 15). The authors conclude that the program activities have been sustained at a high level. A written agreement ensures that the participating organizations take responsibility for the continuing work.

Alcoholic Beverages↗
PubMed2006

Hospital demand for licensed practical nurses.

Despite evidence that hospital use of licensed practical nurses (LPNs) declined in the 1990s, the current registered nurse (RN) shortage has prompted interest in LPNs as substitutes for RNs. Hospitals, being the dominant employer of RNs, have an economic incentive to use less expensive LPNs as substitutes. Beside wages, there are several forces underlying hospital demand for LPNs. In this article, the authors model and estimate hospital demand for LPNs as a function of nurse wages and hospital, market, and patient characteristics using a longitudinal data set of short-term general hospitals in the United States. The authors find evidence that higher RN wages increase hospital demand for LPNs, both in levels and relative to RNs, suggesting that hospitals at least partially substitute RNs with LPNs.

Employment↗
PubMedDate not supplied

Investigating the educational needs of licensed nursing staff and certified nursing assistants in nursing homes regarding end-of-life care.

Nursing homes care for people at the end of life (EOL). There is evidence to suggest, however, that nursing staff in these settings is often unprepared to provide a high level of EOL care. This article reports the findings from three preliminary studies that investigated the needs of licensed staff and certified nursing assistants in nursing homes regarding EOL care. The studies involved needs assessment surveys, focus group interviews with staff members, and telephone interviews with nursing home administrators. Data show that the major needs included a lack of knowledge and skills in symptom management; communication difficulties; conflicts with families and physicians; and emotional distress in dealing with time constraints and attachment to residents. Implications for nursing home staff education are described.

Attitude of Health Personnel↗
PubMed2006

Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway.

Autoantibodies to proteinase 3 (PR3) are involved in the pathogenesis of autoimmune-mediated vasculitis in Wegener granulomatosis (WG). To address the question how the autoantigen PR3 becomes a target of adaptive immunity, we investigated the effect of PR3 on immature dendritic cells (iDCs) in patients with WG, healthy blood donors, and patients with Crohn disease (CD), another granulomatous disease. PR3 induces phenotypic and functional maturation of a fraction of blood monocyte-derived iDCs. PR3-treated DCs express high levels of CD83, a DC-restricted marker of maturation, CD80 and CD86, and HLA-DR. Furthermore, the DCs become fully competent antigen-presenting cells and can induce stimulation of PR3-specific CD4(+) T cells, which produce IFN-gamma. PR3-maturated DCs derived from WG patients induce a higher IFN-gamma response of PR3-specific CD4(+) T cells compared with patients with CD and healthy controls. The maturation of DCs mediated through PR3 was inhibited by a serine protease inhibitor, by antibodies directed against the protease-activated receptor-2 (PAR-2), and by inhibition of phospholipase C, suggesting that the interactions of PR3 with PAR-2 are involved in the induction of DC maturation. Wegener autoantigen interacts with a "gateway" receptor (PAR-2) on iDCs in vitro triggering their maturation and licenses them for a T helper 1 (Th1)-type response potentially favoring granuloma formation in WG.

Adult↗
PubMed2004

Practice patterns of naturopathic physicians: results from a random survey of licensed practitioners in two US States.

BACKGROUND: Despite the growing use of complementary and alternative medicine (CAM) by consumers in the U.S., little is known about the practice of CAM providers. The objective of this study was to describe and compare the practice patterns of naturopathic physicians in Washington State and Connecticut. METHODS: Telephone interviews were conducted with state-wide random samples of licensed naturopathic physicians and data were collected on consecutive patient visits in 1998 and 1999. The main outcome measures were: Sociodemographic, training and practice characteristics of naturopathic physicians; and demographics, reasons for visit, types of treatments, payment source and visit duration for patients. RESULT: One hundred and seventy practitioners were interviewed and 99 recorded data on a total of 1817 patient visits. Naturopathic physicians in Washington and Connecticut had similar demographic and practice characteristics. Both the practitioners and their patients were primarily White and female. Almost 75% of all naturopathic visits were for chronic complaints, most frequently fatigue, headache, and back symptoms. Complete blood counts, serum chemistries, lipids panels and stool analyses were ordered for 4% to 10% of visits. All other diagnostic tests were ordered less frequently. The most commonly prescribed naturopathic therapeutics were: botanical medicines (51% of visits in Connecticut, 43% in Washington), vitamins (41% and 43%), minerals (35% and 39%), homeopathy (29% and 19%) and allergy treatments (11% and 13%). The mean visit length was about 40 minutes. Approximately half the visits were paid directly by the patient. CONCLUSION: This study provides information that will help other health care providers, patients and policy makers better understand the nature of naturopathic care.

Adolescent↗
PubMedDate not supplied

The role of licensed nursing personnel in radiation oncology part B: integrating the ambulatory care nursing conceptual framework.

PURPOSE/OBJECTIVES: To describe the professional opportunities for licensed nursing personnel in radiation oncology within the conceptual framework developed for ambulatory care nurses by the American Academy of Ambulatory Care Nursing (AAACN). DATA SOURCES: Published articles and books. DATA SYNTHESIS: Using AAACN's framework, the researchers identified three roles that are part of every ambulatory care nurse's practice and can be readily customized to radiation oncology: an organizational/systems role, a professional role, and a clinical nursing role. Incorporating the described framework into a radiation oncology nurse's job description can lead to maximizing the use of the professional staff member within the radiation oncology department. This level of professional utilization and validation of the radiation oncology nurse will lead not only to improved patient outcomes but also to greater professional satisfaction, resulting in improved retention. CONCLUSIONS: The complexity of oncology therapies demands expert oncology nurses. This clearly is recognized in medical oncology, and patients with cancer who are being treated with radiation are no less important. To optimize patient care and therapeutic outcomes, the integration of nursing in all aspects of the radiation treatment continuum is essential. IMPLICATIONS FOR NURSING: Radiation oncology nursing is an evolving subspecialty. Nurses can use the information in this article to evaluate their current roles and individual potential for further professional growth.

Adult↗
PubMed2006

CpG oligonucleotides improve the protective immune response induced by the licensed anthrax vaccine.

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants, improving the response elicited by a coadministered vaccine. Combining CpG ODN with anthrax vaccine adsorbed (AVA, the licensed human vaccine) increases the speed, magnitude, and avidity of the resultant antibody response. IgG Abs against anthrax protective antigen (PA) protect mice, guinuea pigs, and rhesus macaques from infection.

Adjuvants, Immunologic↗
PubMed2002

Compliance of licensed child care centers with the American Academy of Pediatrics' recommendations for infant sleep positions.

Sudden Infant Death Syndrome is an elusive and tragic cause of infant mortality. In 1992, the American Academy of Pediatrics (AAP) recommended that healthy term infants be placed in the supine or lateral positions for sleep, based on research conducted in Europe, Australia, and New Zealand. The AAP modified its recommendation in 1994, indicating a preference for the supine position. Since the initial AAP proposal, national educational programs have worked to encourage parents and health care providers to utilize AAP guidelines. Studies have been done on parental use of the supine position. However, very little information exists about the procedures utilized in licensed child care facilities. A survey of child care providers was conducted to determine the risk for Sudden Infant Death Syndrome, as indicated by rates of compliance with AAP guidelines. Results show that although the majority of the child care providers knew the AAP recommendations, only 14.3% were in complete compliance. We make recommendations for the role of the public health nurse in facilitating compliance in child care centers along with suggestions for future research.

Catchment Area, Health↗
PubMed2006

Personality assessment training: view from a licensing board.

The literature contains numerous surveys about assessment training at the level of both doctoral programs and internships. There is minimal information about how such training is assessed by state and provincial regulatory bodies. In this article, we describe the process used by one state licensing board to assess a licensure candidate's transcript, conduct an oral examination, and potentially recommend remediation when the candidate is found to be deficient in specified skills. Our focus in this article is on the application of this evaluation process to personality assessment, although we also examined other areas of practice in a comparable manner.

Certification↗
PubMed2005

Neurologic symptoms in licensed private pesticide applicators in the agricultural health study.

Exposure to high levels of many pesticides has both acute and long-term neurologic consequences, but little is known about the neurotoxicity of chronic exposure to moderate levels of pesticides. We analyzed cross-sectional data from 18,782 white male licensed private pesticide applicators enrolled in the Agricultural Health Study in 1993-1997. Applicators provided information on lifetime pesticide use and 23 neurologic symptoms typically associated with pesticide intoxication. An indicator of more symptoms (> or = 10 vs. < 10) during the year before enrollment was associated with cumulative lifetime days of insecticide use: odds ratios (95% confidence intervals) were 1.64 (1.36-1.97) for 1-50 days, 1.89 (1.58-2.25) for 51-500 days, and 2.50 (2.00-3.13) for > 500 days, compared with never users. A modest association for fumigants [> 50 days, 1.50 (1.24-1.81)] and weaker relationships for herbicides [> 500 days, 1.32 (0.99-1.75)] and fungicides [> 50 days, 1.23 (1.00-1.50)] were observed. Pesticide use within the year before enrollment was not associated with symptom count. Only associations with insecticides and fumigants persisted when all four pesticide groups were examined simultaneously. Among chemical classes of insecticides, associations were strongest for organophosphates and organochlorines. Associations with cumulative exposure persisted after excluding individuals who had a history of pesticide poisoning or had experienced an event involving high personal pesticide exposure. These results suggest that self-reported neurologic symptoms are associated with cumulative exposure to moderate levels of fumigants and organophosphate and organochlorine insecticides, regardless of recent exposure or history of poisoning.

Adolescent↗