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Reproductive, perinatal, and environmental factors as predictors of the cognitive and language development of preterm and full-term infants.

The accuracy of a risk index based on reproductive and demographic factors to predict subsequent development was tested with 51 full-term and 53 preterm (birth weight less than 1,501 grams) infants. Stanford-Binet IQ and Reynell Language Expression and Comprehension at 3 years were significantly predicted by this risk index. Socioeconomic status, birth order, and, for the preterm group, severity of illness in the perinatal period were the most significant predictors of developmental outcome. The Home Observation for Measurement of the Environment (HOME) scores were significantly correlated, independently of SES and developmental level, with the 3-year Reynell and Stanford-Binet scores for the preterm, but not the full-term, group. Children who were classified as being at risk at 12 months but who had scores in the normal range at 3 years came from families with significantly higher scores on the HOME scale. Children not detected as being at risk in infancy but whose development was delayed at 3 years came from families with lower scores on the HOME scale. The combination system of perinatal, reproductive, and environmental variables allows the detection of infants at risk for subsequent developmental problems.

Birth Order↗

Development of language and speech perception in congenitally, profoundly deaf children as a function of age at cochlear implantation.

Like any other surgery requiring anesthesia, cochlear implantation in the first few years of life carries potential risks, which makes it important to assess the potential benefits. This study introduces a new method to assess the effect of age at implantation on cochlear implant outcomes: developmental trajectory analysis (DTA). DTA compares curves representing change in an outcome measure over time (i.e. developmental trajectories) for two groups of children that differ along a potentially important independent variable (e.g. age at intervention). This method was used to compare language development and speech perception outcomes in children who received cochlear implants in the second, third or fourth year of life. Within this range of age at implantation, it was found that implantation before the age of 2 resulted in speech perception and language advantages that were significant both from a statistical and a practical point of view. Additionally, the present results are consistent with the existence of a 'sensitive period' for language development, a gradual decline in language acquisition skills as a function of age.

Age Factors↗

Early intervention and language development in children who are deaf and hard of hearing.

OBJECTIVE: The primary purpose of this study was to examine the relationship between age of enrollment in intervention and language outcomes at 5 years of age in a group of deaf and hard-of-hearing children. METHOD: Vocabulary skills at 5 years of age were examined in a group of 112 children with hearing loss who were enrolled at various ages in a comprehensive intervention program. Verbal reasoning skills were explored in a subgroup of 80 of these children. Participants were evaluated using the Peabody Picture Vocabulary Test and a criterion-referenced measure, the Preschool Language Assessment Instrument, administered individually by professionals skilled in assessing children with hearing loss. A rating scale was developed to characterize the level of family involvement in the intervention program for children in the study. RESULTS: A statistically significant negative correlation was found between age of enrollment and language outcomes at 5 years of age. Children who were enrolled earliest (eg, by 11 months of age) demonstrated significantly better vocabulary and verbal reasoning skills at 5 years of age than did later-enrolled children. Regardless of degree of hearing loss, early-enrolled children achieved scores on these measures that approximated those of their hearing peers. In an attempt to understand the relationships among performance and factors, such as age of enrollment, family involvement, degree of hearing loss, and nonverbal intelligence, multiple regression models were applied to the data. The analyses revealed that only 2 of these factors explained a significant amount of the variance in language scores obtained at 5 years of age: family involvement and age of enrollment. Surprisingly, family involvement explained the most variance after controlling for the influence of the other factors (r =.615; F change = 58.70), underscoring the importance of this variable. Age of enrollment also contributed significantly to explained variance after accounting for the other variables in the regression (r = -.452; F change = 19.24). Importantly, there were interactions between the factors of family involvement and age of enrollment that influenced outcomes. Early enrollment was of benefit to children across all levels of family involvement. However, the most successful children in this study were those with high levels of family involvement who were enrolled early in intervention services. Late-identified children whose families were described as limited or average in involvement scored >2 standard deviations below their hearing peers at 5 years of age. Even in the best of circumstances (eg, early enrollment paired with high levels of family involvement), the children in this study scored within the low average range in abstract verbal reasoning compared with hearing peers, reflecting qualitative language differences in these groups of children. CONCLUSIONS: Consistent with the findings of Yoshinaga-Itano et al,(1) significantly better language scores were associated with early enrollment in intervention. High levels of family involvement correlated with positive language outcomes, and, conversely, limited family involvement was associated with significant child language delays at 5 years of age, especially when enrollment in intervention was late. The results suggest that success is achieved when early identification is paired with early interventions that actively involve families.

Age Factors↗

A longitudinal study of language development in two children with Williams syndrome.

Williams syndrome (WS) is often cited as the prime example within developmental disorders of the dissociation of language from other cognitive skills, particularly from visuo-motor skills. This claim has been responsible for the challenges posed by this population to cognitive theories and to models of language acquisition. Two Hebrew-speaking children with WS were followed longitudinally for 18 months, from the first occurrences of two word combinations. Y was 3.9-5.3 and BT was 4.2-5.8 during data collection. Both children had an MLU of 1.8-2.8. The children's linguistic profiles were compared to the profiles of typically-developing (TD) children of similar MLU as well as to the profiles of 11 children with a variety of neurodevelopmental disorders (ND), matched on MLU. The profiles exhibited by the children with WS throughout the period of the study differed from the profiles seen in both control groups.

Case-Control Studies↗

Brain event-related potentials (ERPs) measured at birth predict later language development in children with and without familial risk for dyslexia.

We report associations between brain event-related potentials (ERPs) measured from newborns with and without familial risk for dyslexia and these same children's later language and verbal memory skills at 2.5, 3.5, and 5 years of age. ERPs to synthetic consonant-vowel syllables (/ba/, /da/, /ga/; presented equiprobably with 3,910-7,285 msec interstimulus intervals) were recorded from 26 newborns at risk for familial dyslexia and 23 control infants participating in the Jyväskylä Longitudinal Study of Dyslexia. The correlation and regression analyses showed that the at-risk type of response pattern at birth (a slower shift in polarity from positivity to negativity in responses to /ga/ at 540-630 msec) in the right hemisphere was related to significantly poorer receptive language skills across both groups at the age of 2.5 years. The similar ERP pattern in the left hemisphere was associated with poorer verbal memory skills at the age of 5 years. These results demonstrate that ERPs of newborns may be valid predictors of later language and neurocognitive outcomes.

Brain↗