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PubMed1998

Construction and application of MCBL plate for facilitation of chromosome recombination in fungi.

A medium with camphor and benomyl MCBL plate was designed and constructed based on the proposed mechanism that d-camphor could induce the fusion of nuclear membrane while benomyl could induce the nondisjunctional recombination of chromosome in fungi. This so-called co-induction plate consisted of 0.1% d-camphor (W/V) and 0.5 microgram/L benomyl contained in Czapek's minimal medium. The precautions to be taken in the construction procedure of this plate was described in detail. One typical example of intergeneric fusion-cross, Aspergillus niger x Trichoderma reesei, was investigated, comparing the ratios of genotypes and phenotypes of fusant progenies produced by the co-induction of MCBL plate and by the step-by-step induction with camphor and benomyl separately. The results showed that the heterodiploid state was extremely transient and the recombinant haploid was hardly obtained when induced by the routine step-by-step method, whereas the ratios of apparent diplodization and nondisjunctional recombinant haplodization among all types of varied segregates on MCBL plate were greatly improved, compared with those on the routine plates containing single reagents, which indicated that the transient heterodiploid could be grasped and transformed further into nondisjunctional recombinant haploid when co-induced on the MCBL plate. The age of regenerated mycelium to be induced was found to have a dominant influence on the co-induction effects of MCBL plate. The mechanism of co-induction by MCBL plate and its promising applications were discussed.

Aspergillus niger↗
PubMed1994

Genotypic and Phenotypic Comparisons of Chromosomal Types within an Indigenous Soil Population of Rhizobium leguminosarum bv. trifolii.

The relative genetic similarities of 200 isolates of Rhizobium leguminosarum bv. trifolii recovered from an Oregon soil were determined at 13 enzyme loci by multilocus enzyme electrophoresis (MLEE). These isolates represented 13 antigenically distinct serotypes recovered from nodules formed on various clover species. The MLEE-derived levels of relatedness among isolates of R. leguminosarum bv. trifolii were found to be in good agreement with the levels of relatedness established by using repetitive (repetitive extragenic palindromic and enterobacterial repetitive intergeneric consensus) sequences and the PCR technique and with levels of relatedness from previously published DNA reassociation studies. BIOLOG substrate utilization patterns showed that isolates within an electrophoretic type (ET) were phenotypically more similar to each other than to isolates of other ETs. The soil isolates were represented by 53 ETs which could be clustered into seven groups (groups B, E, G, H1, H2, I, and J). Evidence for multilocus structure within the population was obtained, and group B was identified as the primary creator of the disequilibrium. Of 75 isolates belonging to the nodule-dominant serotype AS6 complex, 72 were found in group B. Isolates WS2-01 and WS2-02 representing nodule-dominant serotypes recovered from subclover grown at another Oregon site were also found in group B. Isolates representing the most numerous ETs in group B (ETs 2 and 3) were either suboptimally effective or completely ineffective at fixing nitrogen on six different clover species. Another four groups of isolates (groups A, C, D, and F) were identified when 32 strains of diverse origins were analyzed by MLEE and incorporated into the cluster analysis. Group A was most dissimilar in comparisons with other groups and contained strain USDA 2124 (T24), which produces trifolitoxin and has unique symbiotic characteristics.

Journal Article↗
PubMedDate not supplied

Adrenarche and the evolution of human life history.

Adrenarche, the prepubertal onset of adrenal production of dehydroepiandrosterone sulfate (DHEAS), is a distinctive aspect of the human life course. Yet its evolutionary origins remain unexplained. Production of DHEAS is associated with the development of the zona reticularis, a novel histological layer within the adrenal gland, derived from the fetal adrenal gland, and associated with primates more generally. Evidence that DHEAS is a neurosteroid, together with the fact that increases in DHEAS parallel patterns of cortical maturation from approximately age 6 years to the mid-20s, suggests that DHEAS may play an important role in extended brain maturation among humans. DHEAS has demonstrated effects on mood in humans, and acts at neuron receptor sites. I suggest three ways in which DHEAS may play a role in human brain maturation: 1) increasing activity of the amgydala; 2) increasing activity of the hippocampus; and 3) promoting synaptogenesis within the cortex. I propose that associated changes in fearfulness and anxiety, and memory, could act to increase social interaction with nonfamiliar individuals and shape cognitive development. Comparison with the African apes suggests that the timing of adrenarche in chimpanzees may be similar to that in humans, though the full course of age-related changes in DHEAS and their relationship to reproductive and brain maturation are not clear. The role of DHEAS as a physiological mechanism supporting increased brain development, extended life span, and decreased sexual dimorphism is most compatible with Kaplan et al.'s (2000) theory of the evolution of human life history and intergenerational transfers.

Adrenarche↗
PubMed2003

Institutionalization in Taiwan. The role of caregiver gender.

The role of caregiver gender in the likelihood of institutionalization of Taiwanese older adults was explored in this study. A sample of 78 male and 69 female primary caregivers of elderly patients who had experienced a stroke at least 6 months prior to the study were interviewed. Logistic regression analyses were applied to examine direct and interaction effects of the elderly adult's functioning the caregiver's available resources, the degree of caregiver burden, perceived public opinion toward institutionalization, and precipitating events on the likelihood of institutionalization among Taiwanese male and female caregivers. Women were more likely to institutionalize the older adult for whom they cared. The proposed model correctly predicted the likelihood of institutionalization of an elderly adult based on male versus female caregivers at the 92% level. Perceived public opinion toward institutionalization was the most significant predictor of institutionalization for both genders. Perceived public opinion toward institutionalization has a strong influence on whether or not caregivers institutionalize an elderly relative. This is consistent with Chinese culture in which public opinion has a much stronger effect on individual behavior than in the United States. American concepts of "minding one's own business" do not exist in Taiwan. It is logical that the older adults' level of functioning would predict the likelihood of institutionalization regardless of caregiver gender. In terms of caregiver characteristics, working hours in male caregivers is more predictive, and the quality of the relationship with the older adult was more predictive of institutionalization for female caregivers.

Adult↗
PubMed2001

Direct and maternal genetic effects on birth and weaning traits in multibreed cattle data and predicted performance of breed crosses.

Direct and maternal additive effects and heterosis were estimated using data from straightbred Angus, Brahman, Charolais, Hereford, and four generations of rotational crosses among these breeds. Traits of interest were birth weight, Julian day of birth, average daily gain from birth to weaning, 205-d weight, and weaning weight per cow exposed. Complete data were available on 3,445 calves produced from 4,733 matings. Discrete generations of 4-yr duration were produced from 1970 through 1988. Brahman was included in each rotational crossbreeding system. Genetic effects were estimated by regression. Direct and maternal additive effects of Brahman, Charolais, and Hereford were estimated as deviations from Angus. Direct and maternal heterosis effects were assumed proportional to expected heterozygosity. The Brahman direct additive effect resulted in later-born calves (P < 0.01). Brahman, Charolais, and Hereford direct additive effects increased birth weight, and the Brahman maternal additive effect decreased birth weight compared with Angus (P < 0.05). Charolais direct and maternal additive effects were greater than Angus for average daily gain and 205-d weight (P < 0.01). The Hereford maternal additive effects on average daily gain and 205-d weight were less than those of the other breeds (P < 0.01). Breed combinations including Brahman had greater direct heterosis for birth weight, average daily gain, and 205-d weight than other combinations (P < 0.01). Angus, Charolais, and Hereford direct additive effects on weaning weight per cow exposed were greater than Brahman (P < 0.05). Predicted average daily gain, 205-d weight, and weaning weight per cow exposed were, on average, greater in four-breed rotation systems than in three- and two-breed systems. Among two-breed rotation systems, predicted average daily gain and 205-d weaning weight were greatest for Charolais-Brahman and least for Angus-Hereford. Calves from the Angus-Charolais-Hereford system weighed less at weaning than any other three-breed combination. However, weaning weight per cow exposed from the Angus-Charolais-Hereford system was greatest among three-breed systems. Within three- and four-breed rotation systems, ranges in predicted birth and weaning weights among generations varied by up to 10.0 and 25.2 kg, respectively. The choice of breeds affects performance, and the sequence of their use may affect intergenerational variation in performance.

Animals↗
PubMed1999

Salivary cortisol responses in prepubertal boys: the effects of parental substance abuse and association with drug use behavior during adolescence.

BACKGROUND: The purpose of this investigation was three-fold. First, we extended our original observation of decreased cortisol reactivity to an anticipated stressor in sons of fathers with a substance use disorder (SUD). Second, we examined the hypothesis that salivary cortisol underresponsivity in these high-risk prepubertal boys is an adaptation to the stress associated with having a father with a current, rather than remitted, SUD. Third, we tested the hypothesis that prepubertal cortisol underreactivity might be associated with subsequent drug use behavior during adolescence. METHODS: Preadolescent salivary cortisol responses were examined in the context of risk-group status, paternal substance abuse offsets, and subsequent adolescent drug use behavior. RESULTS: The results confirmed a decreased salivary cortisol response to an anticipated stressor among sons of SUD fathers in our expanded sample. In addition, sons of fathers with a current SUD and boys whose fathers had a SUD offset from their 3rd to 6th birthdays had lower anticipatory stress cortisol levels compared with sons of control fathers. Finally, lower preadolescent anticipatory cortisol responses were associated with regular monthly cigarette smoking and regular monthly marijuana use during adolescence. CONCLUSIONS: Hyporeactivity as an adaptation to chronic stress may be salient to the intergenerational transmission of substance abuse liability.

Adolescent↗
PubMed2006

Generational, ethnic, and national differences in attitudes toward the rights of children in Israel and Palestine.

With the nearly universal ratification of the Convention on the Rights of the Child, children's rights have become a cornerstone of discussions in relation to human rights and human services around the world. Although the concept of children's rights is now broadly established, the meaning of this concept and its significance for policies and programs are apt to vary across nations, cultures, religions, and age groups. With the close proximity of diverse national, ethnic, and religious groups and seemingly omnipresent political conflicts about the meaning of rights among them, the Middle East presents unusual opportunities to understand the effects of such variables on attitudes toward children's rights. Drawing from samples of Jews from Israel, Palestinian Muslims from Israel, and Palestinian Muslims from the Palestinian Authority, surveys were conducted of adolescents, young mothers (mothers of toddlers), middle-aged mothers (mothers of adolescents), and grandmothers. Attitudes toward children's rights were more strongly affected by the respondents' ethnicity and nationality than by their age.

Adolescent↗
PubMed1999

Primary socialization theory: comments on racism, sexism, generational neglect, abuse, and abandonment.

This article asks whether primary socialization theory adequately deals with the most distressed and disadvantaged members of society, whether for most of them the family, school, and peers are the primary sources of socialization. Children who are subjected to the effects of racism, sexism, physical and mental abuse, inferior dangerous schools, and abandonment to foster care from birth may find other sources of primary socialization which can be either negative and positive. "Nihilism" and "anomie" are used to describe such children's position in their societies, and the article asks if those without benefit of the three primary sources of socialization can find ways to create new and positive norms, or whether they are doomed to lives of hopelessness and deviance. [Translations are provided in the International Abstracts Section of this issue.]

Child↗
PubMed2003

Intergenerational transmission of tobacco use and dependence: a transdisciplinary perspective.

Numerous questions remain regarding the intergenerational transmission of tobacco use and dependence, and some of these questions are best approached from a transdisciplinary perspective. For example, considering both genetic and environmental influences on cigarette smoking promises to be a fruitful venue for future investigations. In this paper, we consider the evidence regarding intergenerational influences on the transmission of tobacco use and nicotine dependence in both humans and animal models; our focus will be on genetic influences, in utero exposure to nicotine, and some postnatal influences. Research gaps that exist between scientific disciplines are highlighted, and some directions for future research are suggested.

Adult↗
PubMed2004

Attachment representations of deaf adults.

The primary goal of this study was to examine the feasibility of using the Adult Attachment Interview (AAI) with 50 culturally Deaf adults. Modifications to the standard protocol included using a visual-spatial language (American Sign Language) rather than a spoken language (English), as well as coding and procedural variations from the standardized protocol. Results suggested that the adapted AAI interview and coding processes provided an effective assessment of the state of mind regarding the attachment of Deaf individuals. The expectation that Deaf participants would be less coherent in their AAI transcripts and therefore less likely than hearing individuals to be classified as Autonomous was not supported. The distribution of the classifications of this Deaf sample was not different from existing normative distributions. Moreover, there was no evidence that early separation from parents associated with attendance at a residential school for the Deaf resulted in attachment formations with residential counselors or teachers at the school.

Adult↗
PubMed1998

Gender, social mobility and psychiatric diagnoses.

Data from a Swedish cohort born in 1953 and studied through to 1983 is used to examine the relationship between the incidence of psychiatric disorder, parental socio-economic status and intergenerational social mobility. No difference is found in the over-all incidence of in-patient treatment between men and women, but there are considerable differences in the incidence of individual diagnoses. As found in other studies, rates of schizophrenia and substance abuse are greater among men than women, while rates of neurosis are greater among women. The data generally support the drift explanation of inequalities in health rather than the social causation hypothesis, but there is some variation by both gender and diagnosis. Little association is found between parental status, measured when cohort members were aged 10, and the incidence of disorder, except in the case of substance abuse, but there is a strong association between disorder and own status, measured at age 27 yr. By far the highest rates of disorder are found among those members of the cohort who are not in the workforce. Both schizophrenia and neurosis exhibit strong drift effects; there is some evidence that the children of higher status parents have a heightened risk of being diagnosed as schizophrenic; in the case of substance abuse both downwards social mobility and low class origins appear to be implicated in the cumulative incidence of in-patient treatment.

Adolescent↗
PubMed1992

Intergenerational studies of human birthweight from the 1958 birth cohort. II. Do parents who were twins have babies as heavy as those born to singletons?

OBJECTIVE: To ascertain whether maternal twinning influences the previously described association between the birthweight of singleton mothers and their infants. DESIGN AND SUBJECTS: The association between the birthweight of singleton parents and their offspring and that between twin parents and their offspring was compared using data from the 23-year-old sample of the 1958 British national birth cohort. The numbers available for full comparison were 1027 female and 611 male singleton cohort members, and 26 female and 17 male twin cohort members and their first singleton livebirths. RESULTS: Of the mothers who had been twins, half had been of low birthweight, and overall their mean weight was 700 g less than that of their singleton counterparts. Nevertheless, the mean birthweight of babies of twin mothers was 133 g, and of twin fathers 94 g, greater than of babies of corresponding singletons. For female, but not male, parents this difference persisted after adjustment for confounding variables. CONCLUSIONS: We suggest two possible reasons for the difference between the weight of babies of twin and singleton mothers. Firstly, the growth of twins becomes retarded late in pregnancy, possibly after a period critical in determining long-term reproductive effects. Secondly, the twin survivors were of higher birthweight than the original twin cohort, whilst the singleton survivors were more representative of all singleton births, thus introducing a possible bias.

Birth Weight↗
PubMed1996

Caregiving for parents and parents-in-law: is gender important?

This article analyzes cross-sectional data collected from 1,585 employed caregivers of parents and parents-in-law. Hierarchical regression models were used to examine the additive and multiplicative effects of relationship status (parent or parent-in-law) and gender on caregiving activities, resources, and costs. Findings indicate that both the caregiver's gender and the elder's gender are associated with care provided to and from parents and parents-in-law. Results also show that daughters-in-law are especially vulnerable because they receive few resources from elders. Practice implications and directions for future research are discussed.

Adult↗
PubMed1997

Building a theory of grandparent development.

A theory of grandparent development is described that includes the formulation of assumptions, goals for guiding instruction, curriculum design, and a measurement tool to assess learning needs and evaluate the effects of educational intervention. Cultural considerations are illustrated by a three generational study of African-American (n = 777), Caucasian (n = 1086), and Hispanic (n = 672) subjects who were administered the Grandparent Strengths and Needs Inventory. Perceptions of each generation about the attitudes and behaviors of grandparents were examined with multivariate analysis of variance and post-hoc comparisons to analyze the scores, confirm results, and facilitate interpretation of findings. Results showed significant differences between generations and within cultures. Each generation identified elements of grandparent success as well as issues that deserve consideration in building educational programs.

Attitude↗
PubMed2000

Matrilineal advantage in grandchild-grandparent relations.

This study examines the sources of matrilineal advantage in grandchild-grandparent relations using data from the Iowa Youth and Families Project. Results from fixed-effect models indicate that the observed matrilineal advantage in grandchild-grandparent ties arises from lineage differentials in the quality of relations between grandparents and the parents of grandchildren. Specifically, better relations between mothers and the maternal line facilitate closer ties between grandchildren and maternal grandparents. Fathers' closer ties with the paternal side also promote better relations between a grandchild and paternal grandparents, but the greater prevalence of matrilineal bias in parent-grandparent ties leads to an overall matrilineal advantage in grandchild-grandparent relations.

Adolescent↗
PubMed1994

[Family structure, parental support, and leaving home among young Americans in the twentieth century].

"This paper examines the effects of childhood family structure on patterns of home leaving (route and timing). The analysis uses data from the [U.S.] National Survey of Families and Households.... Family disruption is linked with leaving home via all routes except college attendance.... We interpret the results as indicating the ways the parental home provides the resources needed for a successful launching into adult independence or prompts leaving home either too early, or to new living arrangements likely to make establishing a stable independent adult role set more difficult." (SUMMARY IN ENG AND SPA)

Adult↗
PubMed2003

Family size and support of older adults in urban and rural China: current effects and future implications.

Change in China's age structure is creating concerns about whether reductions in family size undermine traditional support mechanisms for older adults. Future generations may expect less support as the availability of children declines. In this article, the association between number of children and the receipt of instrumental and financial support is examined for rural and urban populations. Probabilities are modeled as bivariate probits. Coefficients are used to conduct simulations in which support is examined across hypothetical distributions of number of children. The results show that the number of children is an important determinant of support, but future reductions in support may not be as dramatic as anticipated.

Activities of Daily Living↗
PubMed2005

Familial resemblance in eating behaviors in men and women from the Quebec Family Study.

OBJECTIVE: It is commonly recognized that genetic, environmental, behavioral, and social factors are involved in the development of obesity. The family environment may play a key role in shaping children's eating behaviors. The purpose of this study was to estimate the degree of familial resemblance in eating behavioral traits (cognitive dietary restraint, disinhibition, and susceptibility to hunger). RESEARCH METHODS AND PROCEDURES: Eating behavioral traits were assessed with the Three-Factor Eating Questionnaire in 282 men and 402 women (202 families) from the Quebec Family Study. Familial resemblance for each trait (adjusted for age, sex, and BMI) was investigated using a familial correlation model. RESULTS: The pattern of familial correlation showed significant spouse correlation for the three eating behavior phenotypes, as well as significant parent-offspring and sibling correlations for disinhibition and susceptibility to hunger. According to the most parsimonious model, generalized heritability estimates (including genetic and shared familial environmental effects) reached 6%, 18%, and 28% for cognitive dietary restraint, disinhibition, and susceptibility to hunger, respectively. DISCUSSION: These results suggest that there is a significant familial component to eating behavioral traits but that the additive genetic component appears to be small, with generalized heritability estimates ranging from 6% to 28%. Thus, non-familial environmental factors and gene-gene and gene-environmental interactions seem to be the major determinants of the eating/behavioral traits.

Adolescent↗