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Tracking of health and risk indicators of cardiovascular diseases from teenager to adult: Amsterdam Growth and Health Study.

Cardiovascular disease is recognized as a serious public health problem. Because the underlying pathological processes start shortly after birth, tracking of recognized cardiovascular disease indicators during childhood and adolescence can help in developing preventive pediatric strategies. A prospective follow-up of both genetic and behavioral lifestyle parameters (serum cholesterol, blood pressure, percentage body fat, maximal oxygen uptake (VO2max), smoking, physical inactivity, and type A behavior) was designed. In the Amsterdam Growth and Health Study a population of 93 males and 107 females was measured annually from 1977 to 1980 and a fifth measurement was made in 1985. In that way longitudinal data covering a period of 8 years was collected for a group of adolescents/adults between 13 and 21 years of age. Analyses of these parameters provided the following results: The stability over the 9 years of tracking cardiovascular disease indicators, measured as the interperiod correlations, is fairly high. It varies from 0.4 to 0.8 in percentage body fat, cholesterol, and VO2max. Blood pressure values are low (between 0.3 and 0.4). The probability of 13-year-olds having relatively high values of cardiovascular disease indicators on the basis of a quartile distribution with that at age 21 indicated a moderate to high predictive value. According to the literature, the levels of subjects that are continuously relatively high over the years are more in the direction of optimal health than risk values. The exception is for percentage body fat. Interrelation of the seven cardiovascular disease indicators in constantly relatively high-risk and relatively low-risk groups during the teenage period, measured during young adulthood (21.5 years), appeared to be weak: only males and females with a high percentage body fat and a low VO2max showed significantly high total cholesterol, low high-density lipoprotein cholesterol, and high total cholesterol/high-density lipoprotein cholesterol levels. From the three environmental cardiovascular disease indicators (smoking, physical activity, and type A/B behavior) measured in 1985, only physical activity was significantly correlated among males and females with high-density lipoprotein cholesterol, percentage body fat, and VO2max. It can be concluded that measurement of percentage body fat in the early teenage period seems to be the most important cardiovascular disease indicator in predicting risk levels in the young adult. The amount of physical activity measured at young adult age is the only behavioral parameter to show a significant interrelation with other cardiovascular disease risk indicators.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗

Reducing obesity and related chronic disease risk in children and youth: a synthesis of evidence with 'best practice' recommendations.

Childhood obesity is a global epidemic and rising trends in overweight and obesity are apparent in both developed and developing countries. Available estimates for the period between the 1980s and 1990s show the prevalence of overweight and obesity in children increased by a magnitude of two to five times in developed countries (e.g. from 11% to over 30% in boys in Canada), and up to almost four times in developing countries (e.g. from 4% to 14% in Brazil). The goal of this synthesis research study was to develop best practice recommendations based on a systematic approach to finding, selecting and critically appraising programmes addressing prevention and treatment of childhood obesity and related risk of chronic diseases. An international panel of experts in areas of relevance to obesity provided guidance for the study. This synthesis research encompassed a comprehensive search of medical/academic and grey literature and the Internet covering the years 1982-2003. The appraisal approach developed to identify best practice was unique, in that it considered not only methodological rigour, but also population health, immigrant health and programme development/evaluation perspectives in the assessment. Scores were generated based on pre-determined criteria with programmes scoring in the top tertile of the scoring range in any one of the four appraisal categories included for further examination. The synthesis process included identification of gaps and an analysis and summary of programme development and programme effectiveness to enable conclusions to be drawn and recommendations to be made. The results from the library database searches (13,158 hits), the Internet search and key informant surveys were reduced to a review of 982 reports of which 500 were selected for critical appraisal. In total 158 articles, representing 147 programmes, were included for further analysis. The majority of reports were included based on high appraisal scores in programme development and evaluation with limited numbers eligible based on scores in other categories of appraisal. While no single programme emerged as a model of best practice, synthesis of included programmes provided rich information on elements that represent innovative rather than best practice under particular circumstances that are dynamic (changing according to population subgroups, age, ethnicity, setting, leadership, etc.). Thus the findings of this synthesis review identifies areas for action, opportunities for programme development and research priorities to inform the development of best practice recommendations that will reduce obesity and chronic disease risk in children and youth. A lack of programming to address the particular needs of subgroups of children and youth emerged in this review. Although immigrants new to developed countries may be more vulnerable to the obesogenic environment, no programmes were identified that specifically targeted their potentially specialized needs (e.g. different food supply in a new country). Children 0-6 years of age and males represented other population subgroups where obesity prevention programmes and evidence of effectiveness were limited. These gaps are of concern because (i) the pre-school years may be a critical period for obesity prevention as indicated by the association of the adiposity rebound and obesity in later years; and (ii) although the growing prevalence of obesity affects males and females equally; males may be more vulnerable to associated health risks such as cardiovascular disease. Other gaps in knowledge identified during synthesis include a limited number of interventions in home and community settings and a lack of upstream population-based interventions. The shortage of programmes in community and home settings limits our understanding of the effectiveness of interventions in these environments, while the lack of upstream investment indicates an opportunity to develop more upstream and population-focused interventions to balance and extend the current emphasis on individual-based programmes. The evidence reviewed indicates that current programmes lead to short-term improvements in outcomes relating to obesity and chronic disease prevention with no adverse effects noted. This supports the continuation and further development of programmes currently directed at children and youth, as further evidence for best practice accumulates. In this synthesis, schools were found to be a critical setting for programming where health status indicators, such as body composition, chronic disease risk factors and fitness, can all be positively impacted. Engagement in physical activity emerged as a critical intervention in obesity prevention and reduction programmes. While many programmes in the review had the potential to integrate chronic disease prevention, few did; therefore efforts could be directed towards better integration of chronic disease prevention programmes to minimize duplication and optimize resources. Programmes require sustained long-term resources to facilitate comprehensive evaluation that will ascertain if long-term impact such as sustained normal weight is maintained. Furthermore, involving stakeholders in programme design, implementation and evaluation could be crucial to the success of interventions, helping to ensure that needs are met. A number of methodological issues related to the assessment of obesity intervention and prevention programmes were identified and offer insight into how research protocols can be enhanced to strengthen evidence for obesity interventions. Further research is required to understand the merits of the various forms in which interventions (singly and in combination) are delivered and in which circumstances they are effective. There is a critical need for the development of consistent indicators to ensure that comparisons of programme outcomes can be made to better inform best practice.

Body Mass Index↗

Health hazard appraisal in a family practice center: an exploratory study.

Health Hazard Appraisal (HHA), a tool of primary prevention, has been advocated for use in family practice. Yet little evidence exists regarding its effectiveness in clinical settings or its acceptability to practitioners or patients. In this study, 69 family practice patients completed a HHA questionnaire. Their responses were computer-analyzed and returned in two to three weeks. The patients were telephoned three to five months later to assess the effectiveness of HHA in terms of desired behavioral changes. Of the patients who were recommended to undertake specified behavioral changes, 41.3% reported that they had begun an exercise program, 27.8% had stopped smoking cigarettes, 20.0% had limited their alcohol intake, 23.5% had reduced their driving mileage to under 10,000 miles, and 75.0% of the women started breast self examinations. Although the patients' self-reports may have been exaggerated, they nonetheless represent encouraging results. Evaluations by patients revealed little objection to the personal questions, length of time to complete, or cost of the HHA form. Physician evaluations expressed the consensus that HHA was beneficial to the doctor-patient relationship, but a few indicated they did not feel comfortable discussing the HHA results with the patient.

Adolescent↗

Patient suffering and patient satisfaction among the chronically ill.

In a patient population with serious, debilitating chronic disease, the present study tested the hypothesis that a significant amount of variance in patient satisfaction ratings of provider behavior would be explained by patients' current assessment of their health and their social circumstances. More favorable patient ratings of the art, technical quality and efficacy of their care givers were found to be significantly associated with more positive general health perceptions, fewer days spent in bed due to health problems and lower scores on a widely used depression scale, as well as with age and ethnic background. These data provide evidence indicating that patient satisfaction measures are sensitive to and confounded by patients' perceived health, view of life and social circumstances. It is suggested that if patient satisfaction ratings are to be used as indicators of the quality of health care delivery, there is a need to account for the variance attributable to measurable psychological, social and demographic factors.

California↗

Organochlorine contaminant exposure and associations with hematological and humoral immune functional assays with dam age as a factor in free-ranging northern fur seal pups (Callorhinus ursinus).

Potential effects of organochlorine contaminant (OC) exposure on humoral immune function and health of free-ranging northern fur seals were investigated. Forty-two "neonates" were captured for blood sample collection and re-sampled as "pups" 29-51 days later. OCs were extracted from whole blood to identify polychlorinated biphenyl congeners and chlorinated pesticides by high performance liquid chromatography. Humoral immune function was assessed by antibody responses to vaccination and immunoglobulin concentrations. Additional health status indicators included leukocyte counts and haptoglobin concentrations. Mean OC concentrations were higher in neonates than at recapture. Neonates of young dams had higher mean OC concentrations than neonates of older dams. A higher proportion of old dam's pups developed a twofold or greater increase in antigen-specific antibodies compared to young dam's pups. Higher OC exposure and poor immune responses in first-born pups may indicate a higher risk of secondary morbidity and mortality than pups of multiparous dams.

Age Factors↗

Health diaries: strategies for compliance and relation to other measures.

This article described experience with the use of health diaries in a two-year prospective study of the influence of the psychosocial environment on the health status of 500 subjects in the Hamilton area. Three strategies were used to maintain compliance: 1) random sampling of three days within each two-week interval; 2) a lottery ticket incentive; and 3) telephone follow-up. The results of an initial telephone and lottery ticket study demonstrated a significant effect on compliance. The data from the two-year study were analyzed to characterize health change based on diary reports over successive six-month intervals and to determine the relationship of reported health to medical utilization data. The results indicated that subjects reported symptoms on about one third of the days surveyed but took no action on about one third of these symptom days. Only one quarter of the symptom days resulted in a change in usual activity, and fewer than one tenth of the symptom days resulted in time off from work or physician visits. The diary variable showed a low, positive correlation with health utilization.

Adult↗

[Health, work, and aging in Brazil].

The rapid aging process of the Brazilian population is accompanied by a similar change in the composition of the country's work force. The objective of this study is to determine health differentials in the elderly according to their insertion in the work market, after considering the influence of socio-demographic factors. This study included 2,886 males > or = 65 years residing in ten Brazilian metropolitan areas and included in the National Household Survey conducted by the National Institute of Geography and Statistics, or National Census Bureau (IBGE) in 1998. The analysis included the chi-square and odds ratios estimated by multiple logistic regression. More than a fourth of the elderly worked. Among the formally retired elderly, those who still worked were younger seniors, those with more schooling, and those with higher per capita family income; they reported fewer chronic diseases and presented less difficulty in performing their activities of daily living, but did not show any differences in relation to health services utilization. According to our results, health and especially indicators of autonomy and physical mobility are independent predictive factors for the elderly to remain active.

Aged↗

Examining the continuity of self-rated health.

BACKGROUND: The study examines whether self-rated health forms a continuum from poor through average to good health in terms of two groups of health-related variables. METHODS: The data come from the 1994 Finnish Survey on Living Conditions, a representative sample of Finnish men and women aged 25 years or older (n = 7290). Logistic regression analysis was used with two dependent variables: (1) average versus good/excellent self-rated health and (2) poor versus good/excellent self-rated health. Two groups of independent variables were used: (1) risk factors and (2) ill-health indicators. Separate analyses were made for men and women controlling for sociodemographic background variables. RESULTS: Of the risk factors, BMI and physical exercise were associated both with average and poor self-rated health whereas frequency of drinking was only associated with poor health. All used indicators of ill health were strongly associated with average as well as poor self-rated health. With the exception of BMI, the associations of both risk factors and ill health were stronger with poor than with average health. CONCLUSIONS: The study suggests that self-rated health forms a continuum from poor to good health when risk factors and indicators of ill health are considered, and that there are only minor differences in the continuity of self-rated health between men and women.

Adult↗

Factors associated with high-risk pregnancies in Canadian Inuit.

Antenatal risk factors and management problems during labour and delivery were examined for 141 consecutive deliveries in Canadian Inuit of the eastern Arctic. The applicability of three risk scoring systems for antenatal use was evaluated. Pregnancies were categorized as being at high, moderate or low risk according to the authors' published criteria. Only two of the systems gave statistically valid predictions of the outcome of pregnancy in terms of risk categorization. Sensitivity and uniformity of the systems were lacking: the risk scores were low in 32% to 58% of the pregnancies in which the mother or the infant or both had problems during labour or delivery or both, and in 27% to 36% of the pregnancies in which the infant alone had problems. Antepartum factors that indicated a significantly increased risk of problems during labour or delivery or both were maternal age less than 16 or more than 35 years, prevous stillbirth or neonatal death, previous birth weight of less than 2501 g, previous pastpartum hemorrhage or other problem in the third stage of labour, antituberculosis therapy in the mother, and any of antepartum hemorrhage, multiple pregnancy, breech delivery, malpresentation or long period between rupture of the membranes and delivery in the current pregnancy. The data indicate that scoring systems should take into account regional or population variations if they are to have reasonable sensitivity.

Adolescent↗

[Trends in birth rates, general, infantile and neonatal mortality in Chile from 1850 to date].

BACKGROUND: Chile has experienced great changes in its health conditions, due to economical, social and demographic phenomena. AIM: To underline the moment of the demographic transition in Chile by means of a chronological epidemiological study, using available information. MATERIAL AND METHODS: Data was obtained from registries of the National Statistical Office, General Statistics Direction and National Institute of Statistics. RESULTS: Birth rate was 41/1000 in 1850, remained stable until the thirties, decreased to 35/1000 in 1965, to 21.3/1000 in 1978 and to 20.5/1000 in 1994. The mortality rate increased from 20.3 to 37/1000 from 1850 to 1901 and the it descended to 5.50/1000 in 1993. The annual population growth was 1% in the forties, increased to 2.5% in 1965 and is 1.6% at the present. The population thus increased from 1,400,000 inhabitants in 1850 to 14,000,000 in 1994. The nuptial rate has remained between 7 and 8/1000 since 1934. Infantile mortality was 337 per 1000 newborns in 1950 and dropped to 12 in 1994. It represented 36% of the total mortality until the sixties, and now represents only 5%. This has contributed to the increase in life expectancy and ageing of our population. Neonatal mortality dropped from 136 per 1000 newborns in 1915 to 6.8 in 1994. Fetal mortality changed from 50 per 1000 newborns in 1936 to 5.3 in 1993. CONCLUSIONS: Several causes have contributed to the changes in the above mentioned indicators. Currently, we are in the third stage of a Demographic transition that began in the sixties.

Adolescent↗

Crew health status and monitoring summary: the second manned Skylab mission.

We have attempted to show that objective data used to assess crew health comes to the responsible physicians from the laboratories of the experimenters in sporadic and overwhelming amounts, but rarely in the real-time or near real-time frame which is preferred. The crew surgeon generates little hard data by his own efforts. Because of these factors, whenever an over-all clinical assessment of a particular crewman's fitness to continue a mission is an immediate necessity, it must too often be given on what the clinician would consider less than adequate data. Beginning on MD 28, weekly conferences were held with senior NASA management to make a "Go" or "No-Go" recommendation to continue or terminate the mission. In the absence of absolute indications of an unacceptable declining crew health, a clinical judgment was required. To tighten the criteria for decision-making, the authors selected factors that seemed indicative of overall health and plotted them both as real-time and percentage changes from preflight means. Other plots of the most readily available real-time and near real-time data were also developed for this purpose. The major success of this effort was the initiation of a method which indicated interesting and worthwhile possibilities if continued, refined, and computerized for more rapid availability. Correlation of actual post-flight findings with results anticipated from this method was gratifying but not statistically defensible. Whether or not this method would have forewarned of a serious decrement in crewmen's health cannot be known because, in fact, they were healthy and remain healthy.

Adult↗

Poverty is a predictor of non-communicable disease among adults in Peruvian cities.

BACKGROUND: Rapid health and nutrition transitional changes are resulting in greater prominence of non-communicable disease (NCD) in Latin America, particularly among the poor. OBJECTIVE: The study aims to examine the extent to which NCD pxfsrevails in Peru and the socioeconomic status (SES) as a risk factor. DESIGN: Between 1998 and 2000, health surveys and clinical assessments were completed on 2337 adults in six cities, 18 to 60 years of age. Stratified by social class, multi-staged random sampling was used. Anthropometric data, blood pressure and serum samples were collected. RESULTS: Adjusting for age, hypertension, low HDL cholesterol, high total cholesterol and diabetes was found in 47%, 40%, 21% and 17% of women and in 44%, 38%, 27% and 19% of men, respectively. Over one quarter of the population exhibited multiple risk factors, not including overweight and obesity. Across all study sites, lowest SES revealed highest burden of NCD and appeared as an independent risk factor for associated NCD indicators. CONCLUSION: The high prevalence of NCD in urban areas of Peru is not only associated with excess body weight, but also with poverty itself. The greater burden of NCD in the poorest areas of society requires a better understanding of causal determinants and may have implications in terms of public health policies and interventions.

Adolescent↗

[Applications of the OECD disability questions in the Netherlands (author's transl)].

In the Netherlands a research survey consisting of two main versions (self-administered and interview) was carried out in March'79, covering among other subjects the complete set of OECD items. A short description of the purposes, the survey design, the sampling method and the fieldwork is given in the paper. The sampling method and sample size only permit rather restricted comparisons between both versions and proxy and non-proxy respondents. Difficulties and alterations in the translation into dutch are mentioned. An outline is given of preliminary results, and a comparison is made with long-term disability indicators from other dutch surveys. The research survey appears to be of limited value for generalising to the whole population.

Activities of Daily Living↗

Disability indicators and WHO programme: "health for all by the year 2000".

The WHO worldwide policy "Health for all by the year 2000" has been adapted into "Targets for health for all by the year 2000" for Europe. The issue of the elderly is addressed by the slogan "Add life to years", the issue of the disabled by "Better opportunities for disabled persons". To support the monitoring process towards attainment of the regional targets, a list of regional indicators was proposed. These indicators are either parts of the national health information systems already, or are developed ad hoc through sample surveys. The indicators in care of the elderly and disabled are reviewed with regard to previous developments of data base on consequences of diseases, malformations and injuries.

Persons with Disabilities↗

Supplement use is associated with health status and health-related behaviors in the 1946 British birth cohort.

Use of dietary supplements may be one of a number of health-related behaviors that cluster together. The current study investigated the underlying diet, health-related characteristics, and behaviors of users and nonusers of dietary supplements in a longitudinal study of health. Participants (n = 1776) completed a 5-d food diary including information on dietary supplement use (vitamins, minerals, and nutraceuticals) at age 53 y. Sociodemographic information and data on smoking, alcohol, and physical activity were obtained along with anthropometric measurements, blood pressure, and a blood sample (nonfasting subjects). A significantly greater percentage of women reported supplement use compared with men (45.1 vs. 25.2%). Supplement use was associated with lower BMI, lower waist circumference, higher plasma folate and plasma vitamin B-12 concentrations, nonsmoking, participation in physical activity, and nonmanual social class in women and with plasma folate concentrations and participation in physical activity in men. Nonsupplement users tended to be nonconsumers of breakfast cereals, fruit, fruit juice, yogurt, oily fish, and olive oil and had lower dietary intakes of potassium, magnesium, phosphorus, iron, and vitamin C even after adjustment for sociodemographic and behavioral factors. Overall, supplement users tended to differ from nonsupplement users on a range of health-related behaviors and health status indicators, although there were fewer significant associations in men. Similarly, dietary supplements users tended to have underlying diets that, were healthier and those taking supplements may be the least likely to need them. These results support the notion of a clustering of healthy behaviors and cardiovascular risk factors, particularly for women.

Cohort Studies↗

Factors associated with poor general health after stem-cell transplantation.

AIMS: To describe functional status (FS), general health (GH) and symptom distress (SD) from admission to 1 year post-SCT and to identify medical, demographic, and/or patient-reported outcome variables associated with patient-perceived GH. MATERIAL AND METHODS: Forty-one patients (27 women) with a median age of 44 (18-65) years answered three questionnaires (SIP, SWED-QUAL, and SFID-SCT) from admission to 1 year post-SCT. RESULTS: At discharge, 59% of the patients reported poor FS and GH, and 24% reported > 10 simultaneous symptoms. After 1 year post-SCT, 22% still reported poor FS, 32% poor GH, and 12% > 10 simultaneous symptoms. Compared with admission, significantly larger proportions of the patients reported poor GH at discharge (20 vs 59%, p = .001), poor FS at 6 months (24 vs 59%, p = .004), and poor GH [The number of symptoms was found to be significantly associated with poor GH at discharge (OR 1.330, p = .009) and at 1 year post-SCT (OR 2.000, p = .010)]. Patients reporting "poor GH" at discharge and at 1 year post-SCT reported a median of 7 and 10 symptoms, respectively. Patients with "good GH" reported a median of three symptoms both at T1 and T4. "Tiredness", "anxiety", "mouth dryness", "loss of appetite", and "diarrhoea" were reported by a larger proportion of the patients reporting "poor GH". CONCLUSIONS: The results confirm that some patients who have undergone a SCT have a negatively affected life situation. The study indicates that actively asking for symptoms and applying the best treatment for symptom alleviation are among the most important measures that SCT teams can take to help the patients perceive better general health and an improved life situation.

Adolescent↗

Health indicators and risks among people experiencing homelessness in Melbourne, 1995-1996.

During the study's first stage, 284 homeless people from crisis and long-term accommodation sites were surveyed using stratified, systematic sampling. The second stage involved a survey of a convenience sample of 100 homeless people from squats and the streets. Participants completed a questionnaire, Mantoux testing was performed and blood taken for gamma-interferon assay, liver and renal function tests. The group's health status was poor, with 72% experiencing medical conditions in the preceding two years and 77% symptoms in the month prior to interview. Bronchitis, asthma and gastroenteritis were the most commonly reported conditions; productive and persistent coughing, shortness of breath and wheezing the commonest symptoms. Twenty-one per cent had Mantoux reactions 15 mm or greater, 28% a raised GGT and 19% a raised ALT. Seventy-seven per cent smoked, 74% were current drinkers, 28% had injected drugs at some time in their lives and 14% were regularly injecting drugs. Forty-four per cent had experienced mental illness, 49% of whom reported depression and 15% schizophrenia. Homeless people in Melbourne have poor health status and engage in behaviours that place their health at risk. The high number of respiratory and gastro-intestinal complaints, the high level of cigarette smoking and injecting drug use (IDU) and the proportion likely to be infected with Mycobacterium tuberculosis (MTb) are all issues with important health consequences. Participants recruited from the street had significantly poorer health and engaged in more risk behaviours than those from accommodation sites; those from the accommodated sample were more likely to be infected with Mtb.

Adolescent↗

[The effect of structural adjustment on health conditions in Latin America and the Caribbean, 1980-2000].

OBJECTIVE: To assess the impact of structural adjustment on health indicators in Latin America and the Caribbean during 1980-2000. METHODS: This was an ecological study. Public spending and per capita gross domestic product (pcGDP) figures were obtained from the World Bank, and life expectancy (LE) and infant mortality (IM) figures were obtained from the World Health Organization. Structural adjustment (government downsizing) was assessed by looking at the change in the amount of spending taken up by the government (or the reduction in public spending) in Latin American and Caribbean countries during 1980-1990. Changes in health indicators were measured in terms of the percentage variation in LE and IM. The variations found in Latin America and the Caribbean were compared to those seen in different groups of countries in other parts of the world during 1980-2000. Pearson's chi squared test was used to explore the associations between the decrease in public spending and health indicators. In order to estimate the health effects of such changes, a multivariate linear regression model was created, with adjustments for pcGDP. RESULTS: A deceleration in the rise of LE and in the decline of IM in Latin America and the Caribbean was noted, especially over the period from 1980 through 1990. Significant associations were observed between health indicators and the change in public spending in all groups of countries included in the study. When adjustments were introduced into the multiple regression model, the only associations that remained were seen in Latin America and the Caribbean. CONCLUSIONS: In the decade of 1980, adjustments in macroeconomic policies had a negative effect on social indicators, specifically those that had to do with health conditions in Latin America and the Caribbean. Such an effect lasted throughout the following decade.

Caribbean Region↗