Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “HYPNOTICS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 523 records · Page 29Linked to original sources
PubMed1995

Relationship between the provision of counselling and the prescribing of antidepressants, hypnotics and anxiolytics in general practice.

BACKGROUND: The provision of counselling in general practice is increasing, despite uncertainty concerning its effectiveness. Furthermore, the relationship between counselling and prescribing of antidepressants, hypnotics and anxiolytics in general practice is not known. AIM: This study set out to assess the relationship between provision of counselling and prescribing of antidepressants, hypnotics and anxiolytics in general practice. METHOD: An observational, cross-sectional study of general practices in Oxfordshire Family Health Services Authority was undertaken. Practices were surveyed on the availability of counselling services. The quantity and cost of prescribing of psychotropic drugs over one year (April 1992 to March 1993) were compared for practices with different levels of counselling provision. RESULTS: Of the 82 (96%) respondents, 74 (90%) referred patients for counselling; of these 74 practices, the highest levels of prescribing, in terms of number of items and net ingredient cost, were seen in those practices that employed a counsellor working on the premises. The lowest levels of prescribing were seen in those practices that referred their patients to a counsellor not working on the practice premises. CONCLUSION: The relationship between the provision of counselling and the level of prescribing of antidepressants, hypnotics and anxiolytics is complex. In this study lower levels of prescribing of these drugs in practices with higher provision of counselling were not observed.

Anti-Anxiety Agents↗
PubMed1995

[Pharmacotherapy of sleep disorders using benzodiazepine hypnotics and their analogs].

Benzodiazepine hypnotics and analogs promote the inhibitory neurotransmitter GABA in the brain. The individual substances of this class differ mainly with respect to their elimination half-life. They are all effective hypnotics, but exhibit a number of undesired effects. Hypnotics should be administered generally for the short-term treatment of insomnia, and they should be prescribed for a prolonged time period only exceptionally.

Benzodiazepines↗
PubMed1993

[Use of hypnotics by elderly patients admitted for rehabilitation].

60 persons (13 men, 47 women, median age 80 years) who were admitted to a nursing home for rehabilitation were studied with respect to sleep-related problems and consumption of hypnotic drugs. 25 patients (42%) used hypnotics regularly. The median time of drug use was 72 months. More users than non-users reported difficulty in falling asleep (OR 3.1) and were less likely to feel rested in the morning (OR 4.4). There was no difference between users and non-users with respect to sex, age, living condition, use of analgesics or drugs that can influence sleep. In general, drug consumption was significantly higher among users of hypnotics than among non-users, and more of the users drank coffee or tea in the afternoon or evening. Ten of the users did not want to discontinue their drug consumption.

Age Factors↗
PubMed1993

[Investigation on insomnia and use of hypnotics among an adult population].

An epidemiological enquiry about the sleep status and use of hypnotics in 1289 adults (742 men and 547 women), including 266 workers, 195 peasants, 275 intellectuals and 553 college students, was done in 1989. A questionnaire including 15 questions on sleep habits, sleep disorders and consumption of hypnotics was used. The response percentages were compared with chi-square test between different sexes, age groups, professions and places of residence. 52.9% and 5.4% of the sample complained of transient and persistent insomnia, respectively. Our data did not reveal sex difference as insomnia is concerned. The response percentages for transient insomnia did not correlate with age, while persistent insomnia definitely increased from middle age. Both transient and persistent insomnia were present much less in rural residents than in towns folks. No significant difference in the incidence of insomnia was found between intellectuals and workers. Only 1.1% of the sample used hypnotics regularly and 10.9% had ever taken sleeping pills.

Adult↗
PubMedDate not supplied

Effect of epidural bupivacaine block on midazolam hypnotic requirements.

BACKGROUND AND OBJECTIVES: The aim of the study was to determine the effect of epidural bupivacaine block on midazolam hypnotic requirements. METHODS: Sixty unpremedicated, ASA physical status I or II male patients, aged 45-65 years and scheduled for elective lower abdominal, pelvic, or lower limb surgery participated in this randomized, double-blind, placebo-controlled study. The study population was composed of three groups: Before administration of midazolam, patients in the first group received an intramuscular injection of 15 mL saline (M), those in the second group an intramuscular injection of 15 mL 0.5% bupivacaine (MIB), and those in the third group an epidural injection of 15 mL 0.5% bupivacaine at the L3-L4 level (MEB). Loss of the ability to respond to verbal command was used as an endpoint for the effect of midazolam injected intravenously in predetermined doses (five patients per dose) 30 minutes after a bupivacaine (or saline) injection. Midazolam dose-response curves were obtained by probit analysis. RESULTS: The midazolam median effective dose values for the hypnotic effect were 0.20 mg/kg (95% confidence limit, 0.10-0.27 mg/kg) in the M group; 0.10 mg/kg (0.06-0.22 mg/kg) in the MIB group; and 0.04 mg/kg (0.03-0.07 mg/kg) in the MEB group. The differences between the midazolam median effective dose values had high levels of significance: P < .00001 for MEB versus M, P < .002 for MEB versus MIB, and P < .01 for MIB versus M. CONCLUSIONS: Epidural bupivacaine block profoundly decreases midazolam hypnotic requirements. The most likely explanation for this effect is the reduction in afferent input induced by the block.

Aged↗
PubMed1998

[Hypnotic drugs in a population. Prescriptions by the specialist and the general practitioner].

The aims of our survey were to estimate the prevalence of hypnotic drug prescription in a representative sample of population in 5 cities of Northern Italy and to analyse the pattern of prescription of these drugs by general practitioners (GPs) and psychiatrists. The data were collected with the collaboration of pharmacists working in 145 pharmacies. All consecutive patients presenting a prescription for a hypnotic drug were interviewed by the pharmacists during a two-week period. The pharmacists interviewed 7744 consecutive patients. The highest prevalence of prescriptions for hypnotic drugs was found in the elderly and in women. The majority of prescriptions were for benzodiazepines (BDZ), with lorazepam and triazolam accounting for about 50% of the total prescriptions. Short-acting and ultra-short-acting BDZ were more frequently prescribed for sleep induction by GPs than by psychiatrists. Approximately 73% of subjects reported that they had been taking the prescribed drug for one year or more. The high proportion of long-term BDZ users may be a consequence of the short period surveyed, which produced data weighted toward long-term consumption. Our data, however, do not permit to establish whether long-term use is appropriate from a clinical point of view or is the consequence of a physical dependence. We must be aware that this practice needs to be studied more accurately, with the aim to assess the risk/benefit ratio of long-term BDZ use.

Adult↗
PubMedDate not supplied

Concomitant therapy with anxiolytics or hypnotics and maintenance of initial SSRI therapy.

We conducted a retrospective analysis to evaluate the relationship between anxiolytic or hypnotic therapy and maintenance of therapy with selective serotonin reuptake inhibitors (SSRIs). Subjects were 654 patients who received anxiolytics or hypnotics early in SSRI therapy (study group ) and 15,172 patients who did not (controls). Maintenance of SSRI therapy was evaluated during the 6 months after start of therapy and included days of initial SSRI therapy and rates of discontinuation, defined as a break of more than 30 days. Rates of discontinuation in study and control groups (84% and 77%, p=0.001) and average days of initial SSRI therapy (77 and 94 days, p<0.0001) were statistically different. Thus patients receiving anxiolytic or hypnotics in the first 60 days of therapy were less likely to continue initial SSRI therapy.

Adult↗
PubMed1983

Neuropsychological test performance and hypnotic susceptibility.

Treated 70 patients for alcohol dependency. Various degrees of cortical dysfunctioning were represented as measured by the Halstead-Reitan Neuropsychological Battery. The study's purpose was to determine whether there was a relationship between brain-behavior and hypnotic susceptibility as measured by the Stanford Hypnotic Susceptibility Scale and its Fromm-Weingarten modification. It was found that the two scales were interchangeable insofar as they measured the same ability. Results indicate that hypnotic susceptibility is related to cognitive ability independent of lateralization. Further studies that use the same instruments with more precisely neurologically impaired patients are needed.

Adult↗
PubMed1976

Hypnotic efficacy of lorazepam and flurazepam.

In a double-blind crossover study involving 15 insomniac subjects, the hypnotic efficacy of lorazepam, 2 and 4 mg, was compared with flurazepam, 15 and 30 mg, and placebo. Five subjective measures were used: onset, length, and depth of sleep, number of times awakened, and satisfaction with the hypnotic. Lorazepam in 2- and 4-mg doses was comparable in hypnotic efficacy to flurazepam, 30 mg, according to most parameters of measurement. Side effects were minor, although relatively numerous at the 4-mg doses.

Anti-Anxiety Agents↗
PubMed1983

Comparative hypnotic activity of single doses of loprazolam, flurazepam, and placebo.

Loprazolam is a benzodiazepine derivative which possesses, in animals, a potent hypnotic effect. In a double-blind single-dose study, three dose levels of loprazolam (0.5, 1.0, and 2.0 mg) were compared to each other as well as to 15 mg flurazepam and placebo in 60 insomniac outpatients. The 0.5- and 1.0-mg doses demonstrated hypnotic potency comparable to that of flurazepam, and all three treatments were superior to placebo. The hypnotic effect of the 2-mg dose of loprazolam was significantly greater than that of the other treatments, but at this dose, patients experienced significantly more side effects and morning hangover.

Adult↗
PubMed1980

Residual effects of hypnotics: triazolam, flurazepam, and nitrazepam.

The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 years. The number of total polygraphic records was 77. Triazolam 0.25 mg and 0.5 mg, flurazepam 30 mg, and nitrazepam 10 mg showed definited sleep inducing and sleep maintenance effects in night recordings. Flurazepam 15 mg and 30 mg and nitrazepam 5 mg and 10 mg were followed by residual effects in morning, afternoon and evening recording periods on the day after the administrations of the hypnotics. However, no effects were seen on the day after the administration of triazolam 0.25 mg and 0.5 mg except for some slight residual effects in the morning. Thus triazolam 0.25 mg and 0.5 mg produces less residual effect than do flurazepam 15 mg and 30 mg, and nitrazepam 5 mg and 10 mg, and 24-h polygraphy is useful for measuring the residual effects of hypnotics.

Adult↗
PubMed1979

Hypnotic susceptibility to various depressants in rats selected for differential ethanol sensitivity.

MA rats, bred for greater motor impairment following subhypnotic doses of ethanol, were found to be more sensitive to the hypnotic effects of phenobarbital and chloral hydrate than were LA rats. In addition, the previously reported finding of a difference between the two lines of rats in duration of loss of righting reflex following a hypnotic dose of ethanol was replicated. The results are discussed in terms of a phenotypic difference in central nervous systems sensitivity to a range of sedative-hypnotics.

Animals↗
PubMed1979

Hypnotic analgesia in conditions of stress is partially reversed by naloxone.

In this study the hypothesis that hypnotic analgesia under conditions of stress is mediated through a neurochemical mechanism involving the release of opioid peptides in the CNS was investigated. Ten highly hypnotizable subjects participated in a 2 x 2 factorial design, which involved hypnotic analgesia, stress and double blind administration of naloxone (an opiate antagonist) or placebo. Analysis of post-hypnosis results indicates that hypnotic analgesia was significantly reversed by the interactive effects of stress and naloxone. It is inferred that stress may be the common psychological denominator of the various analgesic methods which effectively engage this endogenous pain inhibitory system. Additional analyses of anxiety measures reveals no significant association between trait and state anxiety, but significant relationships between state anxiety and time tolerance to ischemic pain. These results suggest that anxiety remains a definitional problem and that previous conceptualizations may not have satisfactorily explained the affect's adaptive function.

Adult↗
PubMedDate not supplied

Blood pressure responses to hypnotic and nonhypnotic suggestions in normotensive subjects.

Forty normotensive subjects participated on a voluntary basis in a study designed to compare the effect of suggestions on blood pressure (BP). Two experimental groups received suggestions presumed to be specific in lowering or raising BP after simple relaxation (relaxation group) or hypnotic induction (hypnotic group). A control group was used to record the BP changes over time. The time variable was significant for both systolic (SBP) and diastolic blood pressure (DBP). Induction procedures (hypnosis or relaxation) resulted in significant decreases in DBP in both experimental groups. In the control group there was a significant decrease in SBP. A specific suggestion to increase the BP resulted only in DBP increase in the hypnotic group. This group also gave an increase of both SBP and DBP over the entire experiment, whereas the relaxation group resulted in a significant decrease in SBP. There was no significant group variable, indicating no differences between the groups. Further research is needed to enable firm conclusions of the effect of suggestions on BP.

Adult↗
PubMed2005

The dynamics of the spatial synchronization of brain biopotentials in conditions of intense attention in the hypnotic state.

Twelve mentally healthy women aged 21-38 years were studied in the state of consciousness and hypnosis. The main study method was electroencephalography with assessment of the spatial synchronization of brain biopotentials (SSBP). Suggestion of high-intensity attention delivered to subjects in the hypnotic state was found to lead to significant reorganization of SSBP, with increases in SSBP between both occipital areas, the right temporal area, and other parts of the brain. The dynamics of brain SSBP in intense attention were opposite in the hypnotic and conscious states, which appears to result from the temporary exclusion in the hypnotic state of the functions of the frontal areas of the cortex responsible for conscious control and regulation of ongoing activity.

Adult↗
PubMed2002

Flumazenil reduces the hypnotic dose of propofol in male patients under spinal anesthesia.

PURPOSE: Flumazenil has been reported to produce a partial benzodiazepine-agonist-like effect in some psychopharmacological examinations. This study investigated the effect of flumazenil on the hypnotic activity of propofol in 60 men scheduled for minor surgical procedures done under spinal anesthesia. METHODS: After a steady state of spinal anesthesia had been reached, patients were pretreated with saline or flumazenil, 5 microg.kg(-1), followed by the administration of saline or midazolam, 10 microg.kg(-1). Then, 250 microg.kg(-1).min(-1) of propofol was infused until hypnosis was achieved. Loss of response to a simple command with a slight stimulus, served as the end-point for hypnosis. Immediately after achievement of the end-point, propofol infusion was discontinued, and a 2-ml venous blood sample was obtained from the dorsal pedis vein to determine plasma propofol concentration. RESULTS: Flumazenil significantly decreased the dose of propofol required and the time required to achieve hypnosis compared with values in the control group (55 +/- 10 [mean +/- SD] vs 71 +/- 14 mg and 212 +/- 42 vs 268 +/- 48 s, respectively; P < 0.05), whereas flumazenil attenuated the effect of midazolam in reducing the plasma concentration of propofol at hypnosis (2.9 +/- 0.5 and 2.5 +/- 0.6 microg.ml(-1), respectively; P < 0.05). CONCLUSION: These results suggested that flumazenil may potentiate the hypnotic properties of propofol, despite flumazenil having an antagonistic effect on the enhanced hypnotic activity of propofol induced by the coadministration of midazolam.

Journal Article↗
PubMed1975

Hypnotic susceptibility and the Lamaze childbirth experience.

This study explored the relationship between childbirth training and hypnotic susceptibility. A multiple linear regression analysis was performed on the various medical and attitudinal variables related to the subjects' Lamaze childbirth experience and these were tested against hypnotic susceptibility. The results of the analysis indicate that hypnotic susceptibility is not significantly related to Lamaze training, nor is it significantly related to the type of childbirth experience that a Lamaze-trained woman has.

Adult↗
PubMed1990

Quantitative evaluation of hypnotically suggested hyperaesthesia and analgesia by painful laser stimulation.

The ability to reduce both clinically and experimentally induced pain by hypnotic suggestion of analgesia is well known. However, the nature of hypnotic analgesia still remains uncertain. Attempts to demonstrate and identify specific psychophysiological mechanisms have, so far, been unsatisfactory. Methodological problems in inducing pain and monitoring physiological responses may be the reason for this lack of success. In the present study, we have attempted to eliminate some of these methodological problems. The sensory and pain thresholds to laser stimulation were determined, and the laser-evoked brain potentials were measured for 8 highly hypnotically susceptible subjects in 3 conditions: (1) waking state, (2) suggestion of hyperaesthesia, (3) suggestion of analgesia. The thresholds were reduced during induced hyperaesthesia and increased during analgesia. During hyperaesthesia sensations could be evoked by laser intensities which were below intensities that could be perceived in the awake state. The amplitude of the evoked brain potentials increased during hyperaesthesia and decreased during analgesia. The latency of the potential remained constant. The perception of pain during hypnosis can change very fast, indicating that slow endogenous mechanisms may play only a minor role in suggested hyperaesthesia/analgesia.

Analgesia↗