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At least 523 records · Page 29Linked to original sources
PubMed2006

Models of perceived cycling risk and route acceptability.

Perceived cycling risk and route acceptability to potential users are obstacles to policy support for cycling and a better understanding of these issues will assist planners and decision makers. Two models of perceived risk, based on non-linear least squares, and a model of acceptability, based on the logit model, have been estimated for whole journeys based on responses from a sample of 144 commuters to video clips of routes and junctions. The risk models quantify the effect of motor traffic volumes, demonstrate that roundabouts add more to perceived risk than traffic signal controlled junctions and show that right turn manoeuvres increase perceived risk. Facilities for bicycle traffic along motor trafficked routes and at junctions are shown to have little effect on perceived risk and this brings into question the value of such facilities in promoting bicycle use. These models would assist in specifying infrastructure improvements, the recommending of least risk advisory routes and assessing accessibility for bicycle traffic. The acceptability model confirms the effect of reduced perceived risk in traffic free conditions and the effects of signal controlled junctions and right turns. The acceptability models, which may be used at an area wide level, would assist in assessing the potential demand for cycling and in target setting.

Accidents, Traffic↗
PubMed2005

Who, when, and how much? Epidemiology of walking in a middle-income country.

BACKGROUND: Physical inactivity is one of the leading causes of morbidity and mortality worldwide. Walking, an inexpensive and accessible activity, is protective against unhealthy outcomes. Little data on walking practices are available outside developed countries. This study estimated the prevalence and correlates of compliance with physical activity recommendations through leisure-time and all-domain (combined leisure time, commuting, and work-related) walking in individuals aged > or =20 years in a southern Brazilian city. METHODS: Data from two population-based surveys carried out in 2002 and 2003 in Pelotas, Rio Grande do Sul, were compared and analyzed in 2004. Multistage sampling procedures were undertaken in both surveys. Compliance with physical activity recommendations was defined as > or =150 minutes/week of walking during the previous week, although other cut-off points were estimated. The International Physical Activity Questionnaire was used in both studies. RESULTS: Samples comprised 3182 (2002 study) and 3100 (2003 study) individuals. Nonresponse rates were 5.6% and 3.5%, respectively. Both prevalence and correlates of leisure-time and all-domains walking were markedly different. Compliance with physical activity guidelines (> or =150 minutes/week) through walking was 40.6% (all domains) and 15.0% (leisure time). Poor and uneducated participants had a lower likelihood of walking than higher-income and more educated people, particularly in leisure time. Walkers were also more likely to practice other vigorous and moderate-intensity activities. CONCLUSIONS: Although the results derive from a single Brazilian city, they are likely to be relevant to similar environments/locales in middle-income countries, where the obesity epidemic is rapidly increasing. Due to the low levels of walking detected, particularly during leisure time, healthcare professionals are encouraged to recommend walking to their patients.

Adult↗
PubMed2005

Physical activity levels of children who walk, cycle, or are driven to school.

BACKGROUND: Active commuting to school by walking or bicycle is widely promoted to increase children's physical activity. However, there is little data to describe the impact that travel mode, and in particular cycling, may have on activity levels. METHODS: Primary school children wore an accelerometer recording minute-by-minute physical activity, and completed questions describing travel habits. Total volume of physical activity and hourly physical activity patterns were estimated and groups of children compared by mode of travel to school. Data were collected as part of the European Youth Heart Study. RESULTS: A total of 332 children (average age 9.7 years, standard deviation [SD] = 0.4 years) completed all measurements. Children who walked to school were significantly more physically active than those who traveled by car (accelerometer counts per minute [cpm]: 667.7, SD = 233.7 vs 557.3, SD = 191.4; p = 0.01). Those who cycled to school recorded higher accelerometer counts than those who traveled by car, but differences were not significant. Boys who walked or cycled to school were significantly more physically active than those traveling by car (walk: 732.2 cpm, SD = 253.1 vs 592.8 cpm, SD = 193.9; p=0.007; cycle: 712.6 cpm, SD = 249.1 vs 592.8 cpm, SD = 193.9; p = 0.013). In girls, walking but not cycling to school was significantly associated with higher daily physical activity levels (606.3 cpm, SD = 197.7, vs 523.4 cpm, SD = 185.0 cpm; p = 0.05). CONCLUSIONS: In primary school-aged children, walking to school is associated with higher levels of overall physical activity compared with those who travel to school by motorized transport. Cycling is associated with higher overall physical activity only in boys.

Anthropometry↗
PubMed2006

Trueness verification and traceability assessment of results from commercial systems for measurement of six enzyme activities in serum: an international study in the EC4 framework of the Calibration 2000 project.

BACKGROUND: The in vitro diagnostics directive of the European Union requires traceability to higher order reference measurement procedures and materials for analytes in assuring the result trueness and comparability of laboratory measurements. Manufacturers must ensure that the systems they market are calibrated against available reference systems. Validation of metrologically traceable calibrations is, however, required. METHODS: A commutable serum-based material was analyzed in three reference laboratories and target values for six enzymes (ALT, AST, CK, GGT, LD, amylase) were assigned using IFCC reference measurement procedures. 70 laboratories in Germany, Italy, and The Netherlands measured the same enzymes in the material using procedures from six commercial companies. A system for maximum allowable error was developed from the biological variation model and the results of the various procedures were tested on their compliance to trueness and between-laboratory and within-laboratory variations relative to the maximum allowable. RESULTS: For ALT results were relatively good. >95% of laboratories using systems from Dade, Olympus, Ortho and Roche are expected to comply traceability within the biologically derived limits, and 94% respectively 89% from Abbott and Beckman. For AST and GGT only Dade respectively Olympus fully complied. For CK all companies showed significant bias. Nevertheless >95% of laboratories applying Abbott, Beckman and Roche systems will comply. Finally, LD and amylase measurements require significant improvement. Some manufacturers continue to sell on the European market assays giving results which are not traceable to the internationally accepted reference systems. CONCLUSIONS: The traceability of enzyme measurements obtained with routine procedures to internationally accepted IFCC reference systems is not yet satisfactorily accomplished in clinical practice.

Biomedical Research↗
PubMed2004

Standardization of immunoassays for measurement of myoglobin in serum. Phase I: evaluation of candidate secondary reference materials.

BACKGROUND: Myoglobin is a low-molecular weight protein present in the cytosol of striated muscles. Its concentrations in serum can be measured by immunoassays and are used as an early indicator of myocardial necrosis. Since variability among commercial myoglobin assays exists, standardization of myoglobin assays is needed. METHODS: An international collaborative study was organized with the involvement of seven companies using 12 different automated platforms for measuring myoglobin. Five candidate secondary, i.e., matrixed, reference materials were assayed in relation to linearity, imprecision, recovery rate and commutability to demonstrate a possible identity between the materials and the usual routine serum samples. RESULTS: One lyophilized candidate material (human heart myoglobin in human serum) was selected as the most suitable secondary reference material, based on the criteria examined. Used as a calibrator a posteriori, the bias between the various myoglobin assays for a frozen human serum pool was reduced from 32% to 13%. CONCLUSION: This study provides the basis for the selection of an internationally recognized secondary reference material.

Animals↗
PubMed2004

Quality specifications in thyroid diseases.

BACKGROUND: Laboratory tests to support the diagnosis and management of thyroid diseases have undergone significant changes with the introduction of highly sensitive assays for thyroid stimulating hormone (TSH) and free T4 and T3 concentrations in plasma. Given the importance of these measurements, quality specifications are needed to ensure accurate results. Goals for precision and accuracy are available based on known intraindividual and interindividual biological variation. METHODS: Results of external quality assurance (EQA) schemes are sufficient to document precision goals but survey materials are not commutable for use in determining bias or detect the presence of unusual antibodies on a case-by-case basis. Because TSH concentrations are inversely related to free T4, this physiologic relationship can be exploited for quality assurance purposes. RESULTS: Significant discordance between this relationship can be caused by subclinical and potentially unrecognized disease, dysequilibrium caused by recent therapy, the presence of abnormal binding proteins or protein binding competitor drugs, and antibody interferences such as human antimouse antibody (HAMA) or rheumatoid factor. CONCLUSION: A mechanism to automatically track discordances for subsequent follow and investigation can be an effective part of a quality assurance program for thyroid hormone measurements.

Antibodies, Heterophile↗
PubMed2005

Indoor air and human exposure assessment--needs and approaches.

The Commission launched on June 9, 2004 the Environment and Health Action Plan to reduce diseases caused by a polluted environment. The plan would develop an EU system integrating information on the state of the environment, the ecosystem and human health. The action plan identifies 13 actions (including an action on indoor air quality), which refer to initiatives on how to better understand the environment-health link and establish how environmental exposure leads to epidemiological effects. The ultimate goal of the proposed "Environment and Health Strategy" is to develop an environment and health "cause-effect framework" that will provide the necessary information for the development of Community policy dealing with sources and the impact pathway of health stressors. The need for policy-science interface in the EU guided in the last few years the research on indoor air pollution. In particular, the lack of information regarding human exposure to air pollutants makes it necessary, in line with the Environment and Health Action Plan, to develop targeted strategies to evaluate the impact of indoor air pollution on human health. This includes apart from specific measurements in selected confined spaces (homes, schools, public buildings, etc.), large-scale monitoring campaigns at European level, specifically designed to assess indoor and outdoor air quality and personal exposure to pollutants in combination with micro-environmental activity patterns. Information from these studies will be considered as crucial for a first evaluation of the overall situation in indoor environments and the possible sources and source strengths of pollutants to which humans are exposed during working, commuting and rest time. As a first approach to systematically evaluate the relationship between indoor air pollution and human (chronic) exposure to pollutants, we started at the end of 2003 with the AIRMEX project (Indoor Air Monitoring and Exposure Assessment Study). In the frame of AIRMEX, measuring campaigns in various cities in Southern and Central Europe were carried out to estimate indoor/outdoor relationships and personal exposure concentrations for selected volatile organic compounds (aromatics, carbonyls, terpenoids). In agreement with the overall scope of the project, the measuring objects included public buildings (town halls, guild halls), schools and kindergartens. Personal exposure measurements were conducted with employers and/or teachers working in the selected occupational environments. Preliminary results indicate that personal exposure concentrations are higher than the indoor/outdoor concentrations. In most cases they are twice as high (or even higher) as indoor concentrations and significantly higher than outdoor concentrations.

Air Pollutants↗
PubMed2006

BMI, auto use, and the urban environment in San Francisco.

The epidemic of overweight and obesity has sparked interest in urban planning circles. Many believe the built environment directly influences physical health, and recent empirical evidence supports this notion. Cross-sectional survey data was collected from a sample of San Francisco residents (n=670) in the summer of 2005. Body mass index (BMI) served as the dependent variable. Independent variables included population density and auto use. Results indicate an inverse relationship between density and auto use as well as higher BMI scores for respondents reporting high levels of auto use for the work/school commute and trips to the grocery store.

Adolescent↗
PubMed2007

Securing electronic health records without impeding the flow of information.

OBJECTIVE: We present an integrated set of technologies, known as the Hippocratic Database, that enable healthcare enterprises to comply with privacy and security laws without impeding the legitimate management, sharing, and analysis of personal health information. APPROACH: The Hippocratic Database approach to securing electronic health records involves (1) active enforcement of fine-grained data disclosure policies using query modification techniques, (2) efficient auditing of past database access to verify compliance with policies and track security breaches, (3) data mining algorithms that preserve privacy by randomizing information at the individual level, (4) de-identification of personal health data using an optimal method of k-anonymization, and (5) information sharing across autonomous data sources using cryptographic protocols. CONCLUSIONS: Our research confirms that policies concerning the disclosure of electronic health records can be reliably and efficiently enforced and audited at the database level. We further demonstrate that advanced data mining and anonymization techniques can be employed to analyze aggregate health records without revealing individual patient identities. Finally, we show that web services and commutative encryption can be used to share sensitive information selectively among autonomous entities without compromising security or privacy.

Access to Information↗
PubMed2006

Physical activity: what do high school students think?

PURPOSE: To explore the views high school students have about various physical activity contexts and their ideas of potential physical activity promoting strategies. METHODS: Forty-four students from New Zealand high schools with a low decile rating participated in one of nine focus groups. All groups were separated by gender and ethnicity (Maori, New Zealand European). A standardized semi-structured schedule that included key questions and prompts was used. Thematic induction of the raw data was conducted using the long table approach. RESULTS: Perceived benefits of physical activity participation centered on fun, achievement, and physical-related factors. Key barriers to physical activity engagement included lack of peer social support and low accessibility to, and availability of, physical activity opportunities. The structure of physical education (PE) classes was a barrier noted by females. Distance was consistently articulated as a barrier to commuting actively to school. Reflective of the barriers raised by participants, self-identified strategies to promote physical activity participation included environmental modifications such as (1) increasing social support from peers, (2) improving availability of, and accessibility to, activities at school and in their neighborhood, (3) providing organized activities at school, and (4) restructuring physical education classes. CONCLUSION: In line with the current understandings of barriers to physical activity participation, youth perceptions were focused toward environmental factors, both social and physical, thereby supporting further development of environment-focused interventions. The potential of the peer, school, neighborhood, and home strategies reported in our study need to be considered in future initiatives targeting youth physical activity.

Adolescent↗
PubMed2006

Rural versus urban inpatient case-mix differences in the US.

BACKGROUND: Preparation of surgeons for practice in rural settings is hindered by limited knowledge of case-mix differences between rural and nonrural surgical practices. Although surgical practice in isolated rural areas is believed to be very different from urban practice, little is known about actual inpatient case-mix differences. STUDY DESIGN: We performed a retrospective, descriptive comparison of inpatient general surgical procedures performed at rural versus urban hospitals in the US using the Nationwide Inpatient Sample database (2000 to 2001). Rural versus urban geographic designations were based on Rural-Urban Commuting Area codes developed by the Rural Health Research Institute. Inpatient surgical procedures were aggregated by the Clinical Classifications Software based on ICD-9-CM procedure codes. RESULTS: Operations on the bowel, appendix, and gallbladder constitute 61% of general surgical inpatient procedures in rural hospitals, compared with 46% in urban hospitals. Compared with urban general surgery practices, rural practices include substantially fewer operations on the stomach and esophagus (6% versus 11%), liver and pancreas (0% versus 1%), spleen and thyroid (3% versus 10%), and bowel (17% versus 19%). General surgical procedures constitute 42% of inpatient procedures in rural hospitals versus 25% in urban hospitals. A rural general surgeon more broadly trained in selected obstetric and gynecologic operations could potentially perform 66% of all inpatient procedures in rural hospitals. Addition of simple vascular cases (eg, arteriovenous fistula, vascular access), head and neck operations, amputations, and nephrectomies could increase this potential to 71% of all cases. CONCLUSIONS: Rural and urban general surgical inpatient case-mixes differ from each other substantially. Additional competence in a few surgical areas that are not currently emphasized in general surgical training could result in an increased role for general surgeons practicing in rural areas.

Diagnosis-Related Groups↗
PubMed2005

MathNMR: spin and spatial tensor manipulations in Mathematica.

Spin and spatial tensor manipulations are frequently required to describe the theory of NMR experiments. A Mathematica package is presented here, which provides some of the most common functions for these calculations. Examples are the calculation of matrix representations of operators, commutators, projections, rotations, Redfield matrix elements, matrix decomposition into basis operators, change of basis, coherence filtering, and the manipulation of Hamiltonians. The calculations can be performed for any spin system, containing spins 1/2 and quadrupolar spins alike, subject to computational limitations. The package will be available from upon acceptance of the article.

Magnetic Resonance Spectroscopy↗
PubMed2005

Long-term spinal reflex studies in awake behaving mice.

The increasing availability of genetic variants of mice has facilitated studies of the roles of specific molecules in specific behaviors. The contributions of such studies could be strengthened and extended by correlation with detailed information on the patterns of motor commands throughout the course of specific behaviors in freely moving animals. Previously reported methodologies for long-term recording of electromyographic activity (EMG) in mice using implanted electrodes were designed for intermittent, but not continuous operation. This report describes the fabrication, implantation, and utilization of fine wire electrodes for continuous long-term recordings of spontaneous and nerve-evoked EMG in mice. Six mice were implanted with a tibial nerve cuff electrode and EMG electrodes in soleus and gastrocnemius muscles. Wires exited through a skin button and traveled through an armored cable to an electrical commutator. In mice implanted for 59-144 days, ongoing EMG was monitored continuously (i.e., 24 h/day, 7 days/week) by computer for 18-92 days (total intermittent recording for 25-130 days). When the ongoing EMG criteria were met, the computer applied the nerve stimulus, recorded the evoked EMG response, and determined the size of the M-response (MR) and the H-reflex (HR). It continually adjusted stimulation intensity to maintain a stable MR size. Stable recordings of ongoing EMG, MR, and HR were obtained typically 3 weeks after implantation. This study demonstrates the feasibility of long-term continuous EMG recordings in mice for addressing a variety of neurophysiological and behavioral issues.

Animals↗
PubMed2003

Phylogenetic invariants for the general Markov model of sequence mutation.

A phylogenetic invariant for a model of biological sequence evolution along a phylogenetic tree is a polynomial that vanishes on the expected frequencies of base patterns at the terminal taxa. While the use of these invariants for phylogenetic inference has long been of interest, explicitly constructing such invariants has been problematic. We construct invariants for the general Markov model of kappa-base sequence evolution on an n-taxon tree, for any kappa and n. The method depends primarily on the observation that certain matrices defined in terms of expected pattern frequencies must commute, and yields many invariants of degree kappa+1, regardless of the value of n. We define strong and parameter-strong sets of invariants, and prove several theorems indicating that the set of invariants produced here has these properties on certain sets of possible pattern frequencies. Thus our invariants may be sufficient for phylogenetic applications.

Base Sequence↗
PubMed2006

Borrelia burgdorferi--traveling incognito?

We outline in this review how Borrelia burgdorferi, the causative agent of Lyme disease, moves from the tick to the vertebrate host, and what molecules are potentially involved in this challenging commute. The survival strategies utilized by the spirochete during transmission and the initial stages of infection are discussed.

Animals↗
PubMedDate not supplied

Physical activity policy and program development: the experience in Finland.

This article describes the development of sports and physical activity policies and programs in Finland during the past 30 years. The past two decades have been marked by a shift in emphasis from competitive and elite sports to health-enhancing physical activity for all, as seen most clearly in two successive sports acts and a government resolution. The new, increasingly multisectoral policies have led to substantial changes in the public funding of sports organizations, services, and construction of sports sites. Furthermore, three successive five-year national physical activity promotion programs have been launched. As a result, increased and new types of opportunities to participate in physical activity have become available, and the infrastructure and networks for provision of services have been strengthened. Until the mid 1990s, leisure time physical activity increased in Finland, but during the last seven to eight years, both leisure time and commuting physical activity have been stable. This finding may be an indication of the difficulty to increase physical activity in an industrialized country with already relatively high levels of physical activity even when systematic, long-term policies and measures are applied.

Exercise↗
PubMed2006

Monoamine and motor responses to cocaine are co-deficient in the Fawn-Hooded depressed animal model.

The Fawn-Hooded (FH) genetic animal model of depression continues to be of interest because the FH model has limited biochemical and immune function. The FH animal has an inherited trait, platelet storage pool deficiency (PSPD), an hemorrhagic disorder that is also a component of Chediak-Higashi syndrome (CHS). CHS is a pyrogenic infectious childhood disease; few patients live past the age of 20. Our hypothesis was that FH animals may exhibit different monoamine and motor responses to cocaine versus the Sprague-Dawley (SD) "normal" animal strain, which does not have the FH trait. Therefore, selective neuromolecular imaging (NMI) of the monoamines, dopamine (DA) and 5-HT within nucleus accumbens (NAcc) of behaving male FH versus SD rats was performed in vivo with BRODERICK PROBE sensors and a semiderivative voltammetric circuit. Each animal was placed in a faraday chamber and electrochemical signals were detected via a mercury commutator and flexible cable. Baseline values for neurotransmitters and behavior were derived during the last half-hour of habituation behavior. Release of DA and 5-HT was detected selectively, at separate oxidation potentials, within seconds, before and after intraperitoneal administration of the psychostimulant, cocaine (10 mg/kg). At the same time, frequencies of ambulations and central ambulations were separately monitored with infrared photobeams, which surrounded the faraday chamber. Data were compared by ANOVA analysis followed by Tukey's post hoc test. The data showed that (1) DA release in NAcc of behaving FH animals did not respond to cocaine; neither first hour nor second hour values significantly differed from baseline (both hours, p>0.05), whereas SD animals exhibited a significant increase in cocaine-induced DA release in NAcc (both hours, p<0.001). The ability for acute cocaine to increase DA release in NAcc was significantly greater in SD than in FH animals (p<0.001). (2) 5-HT release in NAcc of behaving FH animals was not significantly increased by cocaine (both hours, p>0.05), whereas 5-HT release in NAcc of SD animals was significantly increased after cocaine (both hours, p<0.001). The ability for acute cocaine to increase 5-HT release was significantly greater in SD than in FH animals (p<0.001). (3) Ambulations in the FH strain were modestly, yet significantly, enhanced after cocaine during both hours of study (p<0.05, p<0.001, respectively) as were ambulations in the SD strain. Nonetheless, the ability for acute cocaine to increase ambulations was significantly greater in SD than in FH animals in the first hour (p<0.001). (4) Central ambulations in the FH strain was not affected by cocaine (both hours, p>0.05), whereas SD animals showed a significant increase in central ambulatory activity in both hours of the cocaine study (p<0.001). The ability for acute cocaine to increase central ambulations was significantly greater in SD than in FH animals (p<0.001). Thus, this is the first study to determine in vivo the neurochemical response to acute cocaine in the behaving FH animal. Moreover, this is the first study to determine in vivo and simultaneously the neurochemical and behavioral response to acute cocaine in the FH strain in comparison with SD animals, a "normal" strain. Remarkable deficiencies in the ability for acute cocaine to alter neurochemistry and behavior in animals with the FH trait are shown. These studies emphasize the need to look differentially at cocaine effects in biochemically and immune-compromised subjects versus "normal" subjects.

Animals↗
PubMed2005

Prehospital management of sarin nerve gas terrorism in urban settings: 10 years of progress after the Tokyo subway sarin attack.

Chemical agents have been used previously in wartime on numerous occasions, from World War I to the Gulf War. In 1994 and 1995, sarin nerve gas was used first in peacetime as a weapon of terrorism in Japan. The Tokyo subway sarin attack was the first large-scale disaster caused by nerve gas. A religious cult released sarin gas into subway commuter trains during morning rush hour. Twelve passengers died and about 5500 people were harmed. Sarin is a highly toxic nerve agent that can be fatal within minutes to hours. It causes the clinical syndrome of cholinergic hyperstimulation by inhibition of the crucial enzyme acetylcholinesterase. Therapy of nerve agent toxicity is divided into three categories, decontamination, respiratory support, and antidotes. All of these therapies may be given simultaneously. This article reviews toxicology and management of this acute chemical emergency. To help minimize the possible catastrophic impact on the public, we make several recommendations based on analysis of the Tokyo subway sarin attack and systematically review the current scientific literature.

Antidotes↗