Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Colonic Neoplasms”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 523 records · Page 29Linked to original sources
PubMed2002

A multi-centre North Italian prospective survey on some quality parameters in lower gastrointestinal endoscopy.

BACKGROUND AND AIM: To record prospectively, in a multi-centre survey, the adherence to some quality parameters of lower digestive endoscopy in everyday practice, focusing in particular on sedation and monitoring; choice of extension of endoscopic examination by the operator and relative performance in intubation of the caecum; behaviour, in some particular clinical circumstances, such as fresh haematochezia, screening and surveillance situations, functional symptoms, management of polyps. PATIENTS AND METHODS: Twenty-five centres located in Lombardia, Italy took part in the study; the duration of the survey was 2 weeks. 1,406 consecutive cases were recorded. RESULTS: The main indications to colonoscopy were fresh haematochezia (21%). abdominal pain (11.7%) and surveillance after surgery for tumours or endoscopic polyp removal (24.3%). Screening examinations accounted for 7.1% of all examinations. Conscious sedation was administered in 63.9% of patients; pulse oxymetry and cardiac frequency monitoring was used in 44.2% of cases. Total colonoscopy was planned in 84.2% of cases; the actual rate of intubation of the caecum in the cases submitted to the procedure was 84.1%. Normal results were obtained in 24.3%. In 24.3% of patients, one or more polyps were identified; 84.2% of these were removed during the first examination. Four complications (accounting for 0.28% of cases) were recorded, all after polypectomy and all successfully treated conservetively. CONCLUSIONS: The present study has shown that some attitudes in lower digestive endoscopy are sub-optimal: in particular, screening examinations are still infrequent; conscious sedation and monitoring have probably been used too rarely; intubation of the caecum was achieved in <90% of cases; the endoscopic removal of many polyps has been delayed for unexplained reasons. On the other hand, timing of surveillance after surgery for tumours or endoscopic removal of polyps has, overall, been adequate; the rate of normal examinations and the rate of complications have been satisfactorily low.

Adolescent↗
PubMed1971

Mucosubstances in neoplasms of the human colon and rectum.

The patterns of mucosubstances secreted in the normal human colon and rectum, in benign tumours, and in and around malignant tumours of the colon and rectum have been studied. Very little neutral mucosubstance was seen in normal specimens; the secretion in these was made up of sulphated and nonsulphated acid mucosubstances, with the former predominating in the deeper half and the latter in the superficial half of the mucosa.Benign tumours contained moderate amounts of mucosubstance, predominantly acid nonsulphated mucosubstances. Differences in the pattern of secretion were observed between the adenomatous polyp on the one hand and the villous papilloma and the papillary parts of the papillary adenoma on the other. Carcinomas of colon and rectum contained very little secretion, with very scanty or no evidence of sulphation. The mucosa around carcinomas and in areas of non-polyploid hyperplasia in carcinoma-bearing colons showed two constant patterns, one consisting of very small amounts of secretion, with sulphated mucosubstance predominating, and the other showing normal or increased amounts of secretion almost entirely of the acid nonsulphated variety. The latter pattern extended for several centimetres from the tumour. The possibility that sulphated mucosubstance might have a role in controlling cell division and that a decrease in its secretion might initiate a sequence of changes leading to malignancy is discussed.

Adult↗
PubMed2006

Induction of the tumor-suppressor p16(INK4a) within regenerative epithelial crypts in ulcerative colitis.

p16(INK4a) is a major tumor-suppressor protein, but its regulation and settings of fuction remain poorly understood. To explore the notion that p16 is induced in vivo in response to replicative stress, we examined p16 expression in tissues from human ulcerative colitis (UC; n = 25) and normal controls (n = 20). p16 was expressed strongly in UC-associated neoplasms (n = 17), as seen previously in sporadic colonic neoplasms. In non-neoplastic UC epithelium, p16 was expressed in 33% of crypts (the proliferative compartment) compared to < 1% of normal controls. p16 expression did not correlate with degree of inflammation but did correlate with the degree of crypt architecture distortion (P = .002)-a reflection of epithelial regeneration. In coimmunofluorescence studies with Ki67, p16 expression was associated with cell cycle arrest (P < .001). Both UC and normal crypts displayed evidence for the activation of the DNA damage checkpoint pathway, and p16 was induced in primary cultures of normal epithelial cells by ionizing irradiation (IR). However, induction by IR displayed delayed kinetics, implying that p16 is not an immediate target of the checkpoint pathway. These findings support a model in which p16 is induced as an "emergency brake" in cells experiencing sustained replicative stress.

Colitis, Ulcerative↗