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At least 523 records · Page 29Linked to original sources
PubMed1998

Biochemical changes induced by intravitreally-injected doxorubicin in the iris-ciliary body and lens of the rabbit eye.

The aim of this study was to examine the chronic effects and mode of action of doxorubicin in ocular tissues. A dose of 10 microg (17.24 nanomoles) of doxorubicin hydrochloride in 20 microl sterile saline were intravitreally injected, under local anaesthesia, in one eye of 13 rabbits and 50 microg (86.20 nanomoles) were similarly injected in one eye of 3 rabbits. The contralateral eye received 20 microl of saline only. The dose of 50 microg induced initially mild uveal inflammation which became chronic and turned into circular iritis. Both doses of the drug induced cataract of the lens and clouding of the cornea within 2-3 months. The activity of superoxide dismutase, in iris-ciliary bodies and lenses treated with either 10 or 50 microg of the compound, was significantly lower relative to that in respective control tissues. In contrast to superoxide dismutase, catalase showed an increased activity in experimental tissues relative to control. The lysosomal hydrolases acid phosphatase, N-acetyl-B-D-glucosaminidase, aryl sulphatase and acid cathepsin, all showed significantly elevated activities in iris-ciliary body tissues one year after injection with the 50 microg doxorubicin. The reduction in superoxide dismutase activity may render ocular tissues susceptible to peroxidative attack and the increased activities of lysosomal hydrolases may contribute to chronic cell injury and inflammation.

Animals↗
PubMed2005

[Visual acuity after surgical management of ciliary body melanoma].

The aim was to evaluate the visual acuity after transcleral resection of ciliary body melanoma. 42 patients were treated by trans-scleral resection of melanoma between January 1995 and June 2001. Additional rutenium brachytherapy was performed in 29 cases. Cataract surgery and intraocular lens implantation was necessary in 7 cases. Postoperative filtration bleb appeared in 6 eyes. The evaluation of functional results has shown no impairment of visual acuity in 56% of cases and did not change during follow up. These observations show that functional results after trans-scleral resection with additional brachytherapy are satisfactory and stable during follow-up.

Adult↗
PubMed1998

Microcirculation architecture of metastases from primary ciliary body and choroidal melanomas.

PURPOSE: To describe the microcirculation architecture of metastatic choroidal and ciliary body melanoma. METHOD: Histologic sections of 35 metastases from 19 primary melanomas were stained to demonstrate microcirculation. RESULT: The appearance of microcirculatory networks in metastases is independent of the target organ but associated with the size of the metastatic deposit (estimated coefficient = 0.5959; SE = 0.3024; P = .0488). CONCLUSION: The microcirculatory patterns of primary uveal melanomas that are associated with metastatic behavior appear in foci of metastasis, regardless of the site of dissemination.

Choroid Neoplasms↗
PubMedDate not supplied

[Magnetic resonance imaging in the evaluation of malignant melanoma of the choroid and ciliary body].

We evaluated 16 patients with malignant melanomas of the choroid (11) or the ciliary body (5) by magnetic resonance imaging (MRI), using a 0.5 T magnet and a surface coil. The tumor was seen in all cases, hyperintense in T1-weighted images, and hypointense in T2-weighted sequences (80%). These images reflected the short T1 and T2 relaxation times caused by the presence of melanin in those tumors. This non-invasive method was superior to computed tomography (70%), and sometimes superior to fundoscopy (2 cases), angiofluorography (3 cases) or echography (1 case). MRI also proved valuable for differentiating uveal melanoma from associated subretinal effusion.

Adult↗
PubMed2000

Optimal methods for preparation and immunostaining of iris, ciliary body, and choroidal wholemounts.

PURPOSE: Investigations into the biology of resident and infiltrating immune cells in the uveal tract of the rodent eye have been greatly aided by the use of tissue wholemount methods. These methods offer a number of advantages over conventional histological and frozen section techniques. The purpose of this article is to provide a detailed step by step guide to aid others who may wish to use this method. METHODS: A detailed description of whole-body perfusion fixation, dissection and isolation of the iris-ciliary body from the anterior segment and the choroid from the posterior segment is provided. In addition, the techniques used to handle whole tissue pieces during single and double immunohistochemical staining protocols, as well as the staining protocols themselves, are described. RESULTS: In refining the techniques described, the author has catalogued a number of frequent problems which compromise immunohistochemical staining results. A troubleshooting guide aimed to help identify the cause of common problems and with some suggested remedies is provided. CONCLUSIONS: Although tissue wholemounts are frequently used in retinal research, a similar approach to investigating the components of the uveal tract has only recently been applied. The methods described in this article will provide sufficient detail for other investigators to obtain maximum benefit from this alternative approach and provide an additional technique to assist in their investigations of ocular immunobiology.

Animals↗
PubMed1988

[Homolateral episcleral metastasis or surgical seeding of a proton-irradiated ciliary body melanoma?].

In an eye with a proton beam-irradiated malignant melanoma of the ciliary body a second melanoma appeared episclerally on the opposite side of the globe. Microscopic examination did not show any connection to the primary tumor. The different possibilities of pathogenesis (bloodborn metastasis to the same globe, episcleral metastasis by conjunctival lymphatics, surgical dissemination due to the suturing of tantalum marks around the primary tumor) are discussed. The ciliary melanoma has spread over the iris despite the irradiation, probably as a result of insufficient irradiation of its anterior border. The results of histologic examination of the partially necrotic, partially viable irradiated tumor are considered with regard to the conservative tumor therapy administered.

Ciliary Body↗
PubMed1987

Astrocytoma of the ciliary body.

A healthy 24-year-old man was noted to have rubeosis iridis and a ciliary body mass. Iridocyclectomy successfully removed the lesion with preservation of vision and resolution of rubeosis. Histologic and immunocytochemical examinations revealed a glial tumor of the ciliary epithelium.

Adult↗
PubMed1982

The incidence of metastases from untreated ciliary body and choroidal melanoma.

A large survey was conducted to identify patients with choroidal and ciliary body melanomas in whom preoperative evaluation for the presence of metastases was performed. Twenty-nine (2.47%) of 1,214 patients were found to have metastases prior to surgical manipulation of the globe. Liver function enzymes combined with liver-spleen scanning is the most effective means for screening for the presence of metastases in these patients and should be performed in all cases in which surgical manipulation of the globe is anticipated.

Adult↗