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PubMed1993

Cat scratch disease and bacillary angiomatosis: aetiological agents and the link with AIDS.

The recent characterisation of a new species of the genus Rochalimaea is the culmination of a ten year search for the identity of the agent of bacillary angiomatosis, a condition that is increasingly recognised in association with AIDS. This work has also implicated Rochalimaea henselae in the aetiology of cat scratch disease contact with cats is a risk factor for both conditions. This report describes both diseases and reviews progress toward understanding their microbiology. R. quintana is also implicated as an agent of bacillary angiomatosis and was recognised much earlier as the cause of trench fever.

Acquired Immunodeficiency Syndrome↗
PubMed2001

Circulating cytokines in patients with cat scratch disease.

Levels of circulating interleukin (IL)-2, IL-6, and IL-10, measured by enzyme-linked immunosorbent assay, were significantly higher in patients with cat scratch disease (CSD) than in healthy control subjects; no induction of IL-12 was observed, and levels of interferon-gamma and IL-4 were generally not detectable. This is the first report showing increased circulating cytokine levels in patients with CSD. The induction of these mediators can partly explain some clinical and pathological features of the disease.

Antibodies, Bacterial↗
PubMed2002

[Usefulness of ultrasonography in the study of superficial lymph nodes. A case of cat scratch disease].

Ultrasonography is a wide spread, non-invasive and repeatable imaging methodology. It is able to evidence any type of lesion and to describe its extent, its site and its content. The ultrasound role in the diagnosis of a case of cat scratch disease in a 44 year old man is described. Symptoms included intermittent fever, pain and palpable tumefactions in right armpit and elbow. The patient underwent routine and lymphoadenopathy specific laboratory data. Ultrasound examination and echo-guided fine-needle biopsy of the evident lesions were performed. These exams, related to pathological clinical presentation, have shown a chronic granulomatous lymphadenopathy like cat scratch disease. This case provides further evidence that ultrasound procedures might play an important role in differential diagnosis of palpable lesions.

Adult↗
PubMedDate not supplied

Abscess-forming granulomatous lymphadenitis: histological typing of suppurative granulomas and clinicopathological findings with special reference to cat scratch disease.

In order to clarify the histological and immunohistochemical characteristics of suppurative granuloma in abscess-forming granulomatous lymphadenitis (AGL), and the relation between AGL and cat scratch disease (CSD), 36 cases of AGL were studied. The combined results showed that there were two types of suppurative granulomas. The suppurative granulomas histologically revealed small lymphocytes of predominantly T cell phenotype distributed among the epithelioid histiocytes bordering central necrotic areas in the suppurative granulomas. These suppurative granulomas could be further subdivided into two groups, mainly those with and without the intermingling of large transformed cells of B-cell phenotypes: Type B granuloma with large transformed B cells and Type A without large transformed B cells. Both types of granulomas were observed in a varying degree in most cases. According to the predominant type of granulomas, 36 patients with AGL were further classified into two groups: Group I of Type A dominance and Group II of Type B dominance. Warthin-Starry (WS) silver stain positive bacteria, which are said to be a causative agent of CSD, were present in about 50% of both groups. No Brown-Hopps' Gram-positive bacteria, fungus, toxoplasma, Chlamydia or Bacillus Calmette-Guérin antigen were found in any case. Clinically, there was no significant difference between these two groups. On the other hand, the detection of WS-positive bacteria seemed to have some relationship with the duration of disease and the history of exposure to cats, and 70% of AGL cases occurred in autumn without a single concurrent epidemic.

Adolescent↗
PubMed1979

Cat-scratch disease presenting as status epilepticus. A case report.

A 12-year-old Bedouin boy presented with sudden asymmetrical status epilepticus. The presence of a scalp wound, rubbery cervical lymphadenopathy and a history of contact with cats suggested the diagnosis of cat-scratch disease complicated by encephalopathy. The diagnosis was supported by histological examination of a cervical lymph node and a positive skin test with cat-scratch antigen. The rapid establishment of the diagnosis avoided the necessity of elaborate and complicated neuroradiological investigations.

Cat-Scratch Disease↗
PubMed1979

[Benign inoculation lymphoreticulosis or cat-scratch disease].

Discovered in 1950-51 by two great parisian medical teams, inoculation lymphoreticulosis, also called cat's scratch disease, is locoregional adenitis whose aetiology is imperfectly determined. Following, often bu not always, cat's scratch, it may evolve to suppuration. Pus is always aseptic. Attributed to Bedsonia's family micro-organism, no cultivation was possible up to date. Evolution is as a rule favourable, but disease is poorly accessible to tetracycline family's antibiotics. Diagnosis is possible by intradermoreaction. The antigen used is tyndallised pus of homologous infection. The role of the cat, still healthy, has not yet been explained.

Animals↗