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At least 523 records · Page 29Linked to original sources
PubMed2005

Improved hypercalcemia after debulking of uremic tumoral calcinosis in a parathyroidectomized patient.

Uremic Tumoral Calcinosis (UTC) is a rare complication of chronic kidney disease on dialysis, characterized by large periarticular calcification. Among some cases, hypercalcemia with no conventional etiologies has been reported. We present a case of UTC in which hypercalcemia occurred after parathyroidectomy and introduction of low-calcium containing dialysate. Work-up of hypercalcemia did not reveal any conventional etiology, but hypercalcemia resolved after debulking of the tumor. This change in serum calcium gives us an insight into the mechanism of hypercalcemia, occasionally seen among cases with UTC.

Calcinosis↗
PubMed2005

Scrotal calcinosis: pathogenesis and case report.

Scrotal calcinosis (SC) is a rare and benign condition defined as the existence of multiple calcified nodules within scrotal skin. We report the case of a 39-year-old male patient with a three-month history of scrotal tumours that increased rapidly in number and size. Histopathological and immunohistochemical investigations showed no evidence of epithelial structure. Whether SC is idiopathic or the result of the calcification of pre-existing cysts is still a controversial issue. In some cases, as well as in our case, no evidence of cystic structure was found around calcified material, despite minutely careful studies. This suggests that SC might be truly idiopathic.

Adult↗
PubMed2006

Uremic tumoral calcinosis in hemodialysis patients: clinicopathological findings and identification of calcific deposits.

OBJECTIVE: Extraskeletal calcifications generally develop in uremic patients. Periarticular massive calcifications, referred to as uremic tumoral calcinosis (UTC), represent solitary or multifocal calcium phosphate deposits. Our objectives were to clinically analyze a series of 8 patients with UTC undergoing hemodialysis, and to characterize calcium deposits in UTC. METHODS: The clinical, radiological, and pathological features of 8 consecutive patients (4 men and 4 women, mean age 49 yrs) with UTC were analyzed, and treatment and outcome were evaluated. Calcific specimens from the 8 patients were analyzed by x-ray diffraction, Raman spectroscopy, and infrared spectroscopy. RESULTS: Unifocal UTC was observed in 5 patients, whereas multifocal lesions occurred in 3 patients. The most common sites of UTC were the shoulders, elbows, and hands. Elevated serum calcium and phosphorus and intact parathyroid hormone were detected in 63% (n = 5), 100% (n = 8), and 63% (n = 5) of the patients, respectively. An increased calcium-phosphorus (Ca P) product was observed in 6 patients. Medical intervention to decrease the Ca P product achieved complete remission in 3 of 5 patients with solitary UTC, whereas this treatment was ineffective for multiple UTC. The 8 calcium deposits were identified as carbonate apatite. CONCLUSION: The most important pathogenic factors in UTC are an increased Ca P product and hyperphosphoremia, which is not necessarily related to hyperparathyroidism. Medical intervention is effective for solitary UTC, but combined treatment (surgery and medical therapy) is required for multiple UTC. Calcium deposits in UTC are composed of carbonate apatite.

Adult↗
PubMed2006

Tumoral calcinosis: a series of six cases with review of pathogenesis and histopathological diagnosis.

Six cases of tumoral calcinosis detected in a short period of time are reported. All the cases were in late adults and mostly in females. Most lesions were in inactive late stage. Available published literature on this rare interesting lesion has been reviewed. The etiopathogenesis and pathological features are discussed. It appears that the strict compartmentalization of lesions into different stages depending on the histological features and the importance of proliferating areas as a marker for progression and recurrence has been over emphasized.

Aged↗
PubMed2006

Tumoral calcinosis--clinicopathological study of five cases.

Five cases of tumoral calcinosis were studied during the period of January-february 1999 in MIMER medical college, Talegaon, a rural place 35kms. from Pune. All the Five patients were females residing in nonendemic area for Dracunculosis. They were from 5th-6th decade. They were otherwise healthy and had normal serum calcium and phosphorus levels and no eosinophilia. All had large, hard subcutaneous lump around hip joint. The skin overlying the swelling was normal. Histologically all cases showed similar morphology, the lesions were composed of large and small deposits of calcium. The foreign-body giant cell reaction was seen in two cases. There were no eosinophils and lymphocytes. On multiple sectioning none of the cases revealed any evidence of dead or living parasite. Old and recent necrosis was absent. These cases are presented since the condition is comparatively rare and it appeared in crops in our Institute.

Calcinosis↗
PubMed1991

[An experimental study of biomaterials resistant to calcinosis and thrombosis].

Creation of hemocompatible materials resistant to calcinosis for plastic cardiosurgery call for employment of combined methods of their evaluation in experiment. The present study deals with some biochemical and physico-chemical aspects of biomaterial calcification inhibition on reduction of their porosity by means of N-vinylpyrrolidone, and also on immobilization of diphosphonates, phosphonates, and anti-aggregants. The method of radiation copolymerization was employed for immobilization of active agents. The effects of different biotissue specimens of varying modifications (pig aortal valves and cattle pericardium) and of Lavsan (polyethyleneterephthalate) on coagulation factor activation were studied in vivo (in goat) and in vitro. The specimen surface was inspected prior to and after the contact with blood and plasma using the techniques of scanning electron microscopy and photoelectron spectroscopy. The influence of the modifications on the calcium and phosphorus accumulation were studied after subcutaneous implantation of the specimens to rats, and the aggregating capacity of blood platelets was determined in incubation of Lavsan treated with an anti-aggregant. Combined studies revealed the optimal modification routine and the most active agents enabling one to obtain biomaterials that not only are resistant to calcification but also possess good hemocompatibility.

Aortic Valve↗
PubMed1991

[A case of idiopathic calcinosis of the scrotum].

We report a case of idiopathic calcinosis of the scrotum. The patient was a 33-year-old male with a complaint of multiple scrotal nodules, from which white chalky materials occasionally broke out. The nodules were first noticed 17 years ago, and since then gradually increased in size and number. Sometimes he had felt itching on the scrotum, but otherwise he had been in good health. Blood analysis and biochemical analysis revealed normal findings. In addition, there were no abnormal findings in serum electrolyte analysis including calcium and phosphate concentrations. Analysis of the intra-nodular content by infrared spectrophotometry showed that it consisted of calcium phosphate (52%) and magnesium ammonium phosphate (48%). We reviewed the literature and discuss the etiology of this disease.

Adult↗
PubMed1991

[Tumoral calcinosis with superinfection and sepsis].

Tumoral calcinosis (TC) is a rare syndrome involving ectopic calcifications in the vicinity of the large joints. In about one third of patients the disorder is familial and is associated with hyperphosphatemia, elevation of 1,25-dihydroxy-vitamin-D levels and peculiar dental lesion. TC is inherited in an autosomal-recessive manner. In a normophosphatemic male patient with alcoholic cirrhosis of the liver, TC occurred first in the thoracic wall. Seven years after excision of the first lesion, a large tumor mass around the right hip developed. Infection of the calcified masses with Staph. aureus led to extensive abscess formation, septicemia and death at the age of 64. Clinical, dental and biochemical examination of the 7 descendants of the patient revealed no constitutional signs of the disease, thus identifying our patient as a sporadic case. Clinical and pathological findings in the patient are discussed and the literature is reviewed.

Abscess↗
PubMed1991

[Tumoral calcinosis. A case report].

A case of tumoral calcinosis of the hand is reported. The lesion was localized at the fifth digit of the right hand and caused pain and disability. The clinical, diagnostic and therapeutic problems of this rare soft tissue disease are discussed.

Adult↗
PubMed1990

[Idiopathic tumoral calcinosis. A clinical case].

A 25-year-old Chilean woman of Jewish ancestry developed subcutaneous nodules at the thighs, axillae, elbows and coccygeal areas. X rays disclosed heavily calcified lesions at these levels. The patient's father had Whipple's disease, her mother and one brother had early hip osteoarthrosis and one son had idiopathic pancreatitis. Laboratory studies ruled out hyper or hypoparathyroidism. Electromyogram showed evidence of mild myopathy and inflammatory elements were present on muscle biopsy. However, the diagnosis of polymyositis associated to calcinosis was ruled out. Skin biopsy disclosed calcifications and fat necrosis. After 20 years of follow up, an increase in calcification specially at the pelvis and periarticular regions has been observed. Etiology, differential diagnosis and treatment are discussed.

Arthrography↗
PubMed1990

Dystrophic cardiac calcinosis in mice: abnormal myocardial response to freeze-thaw injury.

Dystrophic cardiac calcinosis (DCC) is a frequent finding in DBA/2, C3H and BALB/c mice and its etiology is not known. Previous studies have speculated that myocardial necrosis is involved in the pathogenesis of DCC. In this study, cardiac necrosis was induced in DBA/2, C3H and C57BL/6 mice by freeze-thaw injury through the abdominal diaphragm. Four weeks after freeze-thawing, the mice were sacrificed and the hearts and diaphragms were examined. In response to injury, cardiac mineralization was present only in DBA/2 and C3H mice. The myocardium of C57BL/6 mice (control strain) healed by fibrosis without mineralization, the normal response of the myocardium to injury. Calcified diaphragms also were present at the site of freeze-thaw injury in DBA/2 and C3H mice, which is supportive evidence that a systemic abnormality is involved in the pathogenesis of DCC. The conclusion from this study is that the pathogenesis of DCC in DBA/2 and C3H mice is multifactorial and involves both myocardial necrosis and an abnormal response to injury.

Animals↗
PubMedDate not supplied

Tumoral calcinosis of the foot: case report and literature review.

Soft tissue tumors occur in all parts of the body. Once identified, they must be thoroughly evaluated and treated. Tumoral calcinosis is a metabolic disorder that presents as a soft tissue deposit near large joints in the body. Occasionally, it may occur in the foot and become symptomatic. Once the etiology and pathophysiology is understood, the proper course of treatment may begin.

Adult↗
PubMedDate not supplied

Tumoral calcinosis with extensive pedal involvement.

Tumoral calcinosis is characterized by excessive calcified masses in the soft tissues of young adult extremities. The histologic and radiologic appearances are discussed. A 56-year-old female pathologic case is reviewed.

Calcinosis↗
PubMed1979

[Tumoural calcinosis in a white male (author's transl)].

A case of tumoural calcinosis in a 61-years-old man. This is a rare condition (60 published cases), affecting above all black subjects. It takes the form of hard rounded masses which progressively increase in size and vary in their location (hips, elbows, shoulders, periscapular region). On X-rays, the tumour is rounded, consisting of a mass of several calcified small nodules. On technetium pyrophosphate isotope scanning, there is very marked and periarticular uptake. There is often hyperphosphoraemia associated with normal blood calcium levels, without any abnormality in the hormones controlling calcium and phosphate metabolism. Treatment usually consists of the excision of the tumour masses. More recently, the reduction of hyperphosphoraemia by the prescription of aluminium salts and a reduction in phosphorus intake has been suggested.

Bone Neoplasms↗
PubMed1989

Calcinosis circumscripta: indications for surgery.

Five patients with calcinosis circumscripta were treated, four of them surgically. The indications for surgery included painful lumps, recurrent infection of the calcified masses, secreting ulcers, functional disorders, severe esthetic problems, and pressure on nerves. One patient showed permanent improvement; four gained temporary relief.

Adult↗
PubMed1989

Prevention of experimental calcinosis by salmon calcitonin in rats.

The effects of salmon calcitonin on calcium overload and its deposition in the rat aorta was studied. Calcitonin administered 4 days to rats i.p. in doses of 10 IU/kg body weight blocked the development of calcinosis induced by a single dose of vitamin D3 (300,000 IU/kg body weight, orally). This was demonstrated biochemically, histochemically and by electron microscopic methods.

Animals↗