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Results for “Alcoholic Intoxication”

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PubMedDate not supplied

[The effect of chronic alcoholic intoxication on the level and metabolism of glycolipids in the rat brain].

The chronic alcohol intoxication has been studied for its effect on the content of glycolipids in the rat brain and incorporation of [I-14C]acetate into them. It is established that administration of ethanol to animals (2 g per 1 kg of body weight daily for 7 days) rises the content of cerebrosides I in the brain tissue. The specific radioactivity of sulphatides I falls as a result of a decrease of the [I-14C]acetate into fatty acids and galactose. The specific radioactivity of sulphatides II, cerebrosides II and III falls as a result mainly of a decrease of the specific radioactivity in the galactose components.

Alcoholism↗
PubMed1987

[Psychopathological and hormonal manifestations of alcoholic intoxication and emotional stress in monkeys].

Ethological approach to studying mature P. hamadryas and M. mulatta males has revealed a wide spectrum of changes in individual and zoosocial behaviour in response to the administration of different alcohol doses and stress stimuli. It has been established that neuroendocrine basis for the depression of psychic and locomotor activities developing in conditions of alcohol intoxication and emotional stress is an extremely high release of catecholamines and the increase of glucocorticoid secretion accompanied by a sharp decrease in androgen products. It should be noted that the exposure to stress stimuli during consumption of small alcohol doses intensifies depression-like stress-induced behaviour of monkeys.

Alcoholic Intoxication↗
PubMed2000

Effects of acute alcohol intoxication on pituitary-gonadal axis hormones, pituitary-adrenal axis hormones, beta-endorphin and prolactin in human adolescents of both sexes.

Teenage drinking continues to be a major problem in industrialized countries, where almost 35% of alcohol drinkers are under 16 years old. In the present paper we studied the effects of acute alcohol intoxication (AAI) on the pituitary-gonadal (PG) axis hormones, and the possible contribution of pituitary-adrenal (PA) axis hormones, beta-endorphin (BEND), and prolactin (PRL) to the alcohol-induced dysfunction of PG axis hormones. Blood samples were drawn from adolescents that arrived at the emergency department with evident behavioral symptoms of drunkenness (AAI) or with nil consumption of alcohol (controls [C]). Our results demonstrated that AAI produces in adolescents a high increase in plasma PRL, ACTH, and cortisol (F), and a contradictory behavior of testosterone (T) according to gender: plasma T was increased in females and decreased in males. ACTH and PRL correlated positively with F, dehydroepiandrosterone-sulphate (DHEAS) and T in females, which suggests that PRL and ACTH could synergistically stimulate adrenal androgen production. In contrast, the decrease in T and increase in BEND in males suggests that AAI could have an inhibitory effect on testicular T, perhaps mediated by BEND. The hormones studied are involved in the development of secondary sexual characteristics and the growth axis during adolescence. The deleterious effects of alcohol abuse should be made known to adolescents and the appropriate authorities.

Acute Disease↗
PubMedDate not supplied

[Action of analeptics in acute alcoholic intoxication].

Tests conducted on rabbits in a state of acute ethanol poisoning (2.5 g/kg per os) of a medium degree demonstrated that caffein (10 mg/kg) and bemegride (5 mg/kg) introduced one time intravenously at the height of alcoholic intoxication raise the activity of aerobic oxidative processes, but fail to eliminate metabolic acidosis and do not accelerate the excretion of ethanol. Unlike caffein, bemegride shows a tendency toward respiratory compensation of metabolic acidosis and lowers the activity of the alcohol-dehydrogenase.

Acid-Base Equilibrium↗
PubMed2004

[Clinical characteristics and management of adolescents admitted to the emergency ward for alcohol intoxication in the region of The Hague during the period 1999-2001].

OBJECTIVE: To analyse the findings in adolescents between the ages of 12 and 17 who were admitted to the emergency ward as a result of excessive alcohol consumption. DESIGN: Retrospective. METHOD: The clinical characteristics, laboratory findings and treatment policy were studied in adolescents between the ages of 12 and 17 who were admitted for alcohol intoxication (> or = 1/1000) to the emergency wards of Leiden University Medical Centre, Juliana Children's Hospital, Haaglanden Medical Centre (Westeinde location) or the Leyenburg Hospital (all hospitals in the area of The Hague, The Netherlands) during the period 1999-2001. RESULTS: In the three successive years, the number of patients was 19, 18 and 51, respectively; there were a total of 58 boys and 30 girls. Laboratory determinations and other investigations were carried out and/or recorded in varying numbers of patients. The cause of the intoxication was usually the consumption of spirits together with friends; 60% of the patients had a Glasgow coma score < 15 and 30% were admitted to hospital. In 25% the visit to the emergency ward was preceded by an accident in which alcohol played a part. Little attention seems to have been paid to aftercare in the form of a follow-up visit.

Adolescent↗
PubMed1989

The effect of repeated occasions of alcohol intoxication on two processes involved in the visual discrimination of movement.

The focus of this study was the effect of repeated episodes of alcohol intoxication on two processes involved in visual movement discrimination: visual sensitivity and decision-making. Four female subjects were asked to discriminate between a stationary light signal and one that changed position in the center of a dark visual field. Prior to each of 15 alcohol testing sessions, a dose of .66 ml of 95% USP ethanol per kg body weight was administered to each subject and BAL was sampled frequently within sessions. Differences in subjects' pre- and postalcohol performance were evaluated within the framework of a psychophysical model that mathematically characterizes the problem of movement discrimination and yields independent estimates of visual sensitivity and decisional aspects of subjects' performance. Evidence for specificity in the development of sensory versus decisional process tolerance to intoxication effects was found. The major result was that each subject made large and statistically reliable shifts in decisional criteria during the time course of the blood alcohol curve within alcohol testing sessions, even when visual sensitivity had adapted to alcohol intake effects. The results of this study illustrate the utility of tracing acute intake effects over repeated occasions of intoxication, and empirically testing subjects' assumed decisional strategies when modeling these effects.

Adult↗
PubMed2005

[Role of S-100B for evaluation of traumatic brain injury in patients with alcohol intoxication].

The neuroprotein S-100B was identified as a possible marker for primary brain damage. The objective of this prospective study was to determine the diagnostic validity of plasma measurements of S-100B in patients with minor head injury and acute alcohol intoxication. The results of S-100B plasma levels were compared to the Glasgow-Coma-Scale score, the neurological examination and the CCT data. Median S-100B levels of the CCT+ patients were significantly increased compared to those of the CCT- patients without being influenced by alcohol. Increased S-100B plasma levels seem to indicate a primary brain damage.

Adult↗