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PubMedDate not supplied

Preparation of an intravenous infusion admixture nursing reference.

There has been a growing concern over the increasingly complex problem of incompatibility between intravenous drugs mixed extemporaneously by nursing staff. A considerable amount of data has been published although much of it has not included background on the criteria and conditions under which it was collected. The compatibility/incompatibility of a number of admixtures is known to depend on these conditions. The purpose of the present work was to compile and evaluate data on drugs which were most frequently requested to be mixed at the author's hospital. The results are presented in a chart with an accompanying guide to its use for the nursing staff. Use of the chart may require reference to more detailed information kept in the Pharmacy, although restrictions outlined in the guide minimize this.

Drug Information Services↗
PubMed1982

A first-phase quality assurance program for intravenous admixture aseptic technique.

Results of initial departmental quality assurance audits revealed noncompliance with the intravenous admixture service criteria concerning aseptic technique. In order to better assess this problem, a quality assurance program for aseptic technique was developed. The criteria consisted of 16 characteristics and/or functions that are indicative of aseptic technique. An audit of 13 technicians revealed a number of problems (noncompliance) related to aseptic technique. An educational program was developed and implemented on an individual basis. A reaudit two to four weeks later revealed compliance with the aseptic technique criteria. This study indicates that the audit method is effective in determining compliance to the aseptic technique criteria and standards.

Antisepsis↗
PubMed1983

Using a microcomputer to support an I.V. admixture service.

Acquisition of a microcomputer and a high-speed printer enabled the authors' pharmacy to automate the production of I.V. additive labels. This automation freed 0.5 FTEs of pharmacy personnel time for other duties. This low-cost microcomputer and printer has proven to be sufficient equipment for the support of an I.V. admixture program with time-saving and cost-saving applications.

Computers↗
PubMed1989

Intravenous admixture service: implementation of service in a complex ICU patient population.

An aggressive IV admixture program in a 600 bed tertiary care teaching institution was implemented. Four intensive care units primarily caring for cardiology patients are the responsibility of a satellite pharmacy, which in January of 1986 began preparation of intravenous infusion medications (IVIMs), commonly referred to as "drip medications." By adopting this service, the pharmacy helped reduce workloads of nursing at a time of increasing demand owing to a rising acuity level of the patient population. The predominance of labor was shifted to less expensive and more available pharmacy technicians. Increased quality control and flexibility in constituents were also achieved. The satellite pharmacists became recognized as "expert" in the compatibility and administration of the IVIMs they prepared expanding their role in the ICU. The service demonstrates the ability of the pharmacy to prepare IV products even under the most critical circumstances.

Drug Therapy, Combination↗
PubMed1999

The 5/2,3/2 Spin Admixture in the Chloroiron(III) Derivative of the Sterically Crowded 2,3,7,8,12,13,17,18-Octaethyl-5,10,15,20-tetraphenylporphyrin.

Despite similar ring deformations in solution and in the solid state, the chloroiron(III) derivative of 2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetraphenylporphyrin ([FeCl(oetpp)], shown schematically) prepared in this study exhibits only a very weak quantum-mechanical admixture of spin S=3/2 (only 4-10 %) with spin S=5/2. In contrast, for the variety of [FeCl(oetpp)] studied earlier by other researchers a 40 % contribution of the S=3/2 state was found.

Journal Article↗
PubMedDate not supplied

[The determination of lipopolysaccharide admixtures in protein preparations].

A new method for the determination of lipopolysaccharide (LPS) admixtures in protein solutions has been developed. The method includes the periodate oxidation of LPS, biotinylation with biotin hydraside, immobilization on a nitrocellulose membrane and the development of biotinylated LPS in the streptavidin--alkaline phosphatase system. Proteins are previously removed from the solution by treatment with hot phenol. Development with the use of 5-bromoinodyl phosphate and nitrotetrazolium blue makes it possible to detect about 30 pg of LPS immobilized on the nitrocellulose membrane.

Biotinylation↗
PubMed1975

Recommended methods for compounding intravenous admixtures in hospitals.

Recommendations regarding (1)hospital receipt and storage of large-volume parenterals and (2)hospital compounding of intravenous admixtures are presented. The recommendations are presented in a stepwise manner, and a self-evaluation form is included. Also included is a pictorial illustration of a suggested dressing change for an i.v.catheter.

Drug Compounding↗
PubMed2001

Sensory nerve somatosensory evoked potentials (SEP) in the evaluation of patients with sciatica: false P1 latency prolongation may be due to admixture of dermatomal SEP.

Patient-reported stimulus-related radiating sensory symptoms within the territory of the stimulated nerve have been used to verify stimulation in sensory nerve scalp recorded somatosensory evoked potentials (SEP). The main aim of the present study of false positive P1 latency prolongation in lumbosacral sensory nerve SEP was to investigate whether elicitation of such symptoms secures adequate sensory nerve stimulation. Nerve roots were studied on the asymptomatic side in 64 patients with unilateral sciatica. Saphenous (L4), superficial peroneal (L5), and sural (S1) nerve SEP were registered in all patients. Pretibial dermatomal SEP were registered in ten of them. Stimulation was equidistant from the registration electrode in all SEP registrations. The false positive rate was lower in saphenous nerve SEP with than without verified supramaximal stimulation (1/30 vs. 6/22, P = 0.03) in spite of radiating stimulus-related sensory symptoms in both groups. This difference was not caused by subclinical myelographic nerve root compression or general peripheral nerve dysfunction. The P1 latency was longer in the pretibial dermatomal SEP than in the saphenous and superficial peroneal nerve SEP with the same conduction distance (mean difference 4.7 (95% CI = 3.8 to 5.6) and 4.4 ms (95% CI = 3.4 to 5.4), respectively). It is concluded that dermatomal SEP have longer P1 latency than sensory nerve SEP. Verified supramaximal nerve simulation is recommended to avoid false results due to admixture of dermatomal to sensory nerve SEP.

Adult↗
PubMed1975

Pharmacy-nursing communications in an intravenous admixture program.

A centralized pharmacy admixture program is discussed, with emphasis on the forms used to communicate between pharmacists and nurses. Aspects of the programs described include the patient intravenous profile folder, preparation and delivery of i.v. solutions, preparation of piggyback solutions and prefilled syringes of reconstituted antibiotics, and emergency intravenous solution stock.

Communication↗
PubMed1976

[Purification of antibiotic solutions of finely dispersed admixtures].

A possibility of complete separation of fine disperse admixtures from antibiotic fermentation broth filtrates by filtration with the use of special additives was shown. The purity of the filtrates and filtration rate depended on the procedure of addition, amount and average size of the particles of the filtration material.

Anti-Bacterial Agents↗
PubMed2003

[Experimental study of total nutrient admixture promoting transfection of plasmid DNA mediated with liposomes to colorectal cancer cells].

OBJECTIVE: To study total nutrient admixture (TNA) promoting plasmid DNA transfection mediated with liposomes to colorectal cancer cells. METHODS: Dispensing varied transfection agents of liposome + DNA plasmid pEGFP-N(1), TNA + liposomes + pEGFP-N(1), TNA + pEGFP-N(1), liposomes merely, and TAN sole. Human colorectal cancer cell LoVo and HR-8348 were treated with the agents respectively. Green fluorescence protein (GFP) gene as a report gene was detected. RESULTS: GFP was not detected in cancer cells treated with agents of merely liposomes and TAN. Transfection rates of GFP in two groups of cancer cells treated with agent of TNA + liposomes + pEGFP-N(1) were 33%, 38% respectively. With liposome + pEGFP-N(1), the rates of transfection in two cells were 22%, 24% respectively. The expression of GFP was 1% in the two groups of tumor cells treated with TNA + pEGFP-N(1). With agent of TNA + liposomes + pEGFP-N(1), a high transfection rate of GFP gene was obtained. And no negative effect was observed to stabilization of TAN solution. CONCLUSION: TNA may enhance transfection rate of plasmid DNA mediated with liposome, and may be beneficial to the treatment of cancer.

Colorectal Neoplasms↗
PubMedDate not supplied

[Determination of phenotypes of haptoglobin and GLM(1) factor of human GM system in stains with admixtures of blood of some fish strains].

It was shown that the phenotypes of haptoglobin (Hg) can not be detected in stains of dried blood of salmon, roach and bream. The results of experimental research of blood of the above fish species are described according to the Cm system. It was proven as possible to identify the human blood in stains with admixtures of blood of the above fish by using the Hp and Cm systems.

Agglutination Tests↗
PubMed2004

Effects of a midazolam-ketamine admixture in human volunteers.

As the ideal sedative does not exist for all situations, we examined the effect of a midazolam-ketamine sedoanalgesic admixture in human volunteers. Ten ASA physical status I volunteers were administered loading doses of 0.07 mg/kg of midazolam followed by 0.7 mg/kg of ketamine. The same amount of midazolam and ketamine was then infused constantly over 1 hour via a 60 drops (gtts)/mL i.v. infusion set. Blood samples were analyzed for plasma catecholamine levels. Respiration rate and oxygen saturation did not alter significantly from baseline levels. Heart rate and systolic blood pressure remained stable with an increase of 15% in heart rate and 6% in systolic blood pressure only at 10 minutes following the bolus loading. Diastolic blood pressure did not alter significantly from baseline levels (P < .05). Plasma catecholamines levels remained stable except for an increase in epinephrine (38%) and norepinephrine (19%) 10 minutes following the bolus injections. Plasma dopamine levels remained unchanged. There were no cases of unpleasant dreaming, dysphoria, or emergence-type reactions. This combined nonnarcotic sedoanalgesic technique maintains spontaneous ventilation and stable cardiorespiratory parameters and may be considered as an alternative to traditional conscious sedation or general anesthesia.

Adult↗
PubMed1992

Biological activity of recombinant interleukin-2 in intravenous admixtures containing antibiotic, morphine sulfate, or total parenteral nutrient solution.

The biological activity of recombinant interleukin-2 in intravenous admixtures containing gentamicin sulfate, tobramycin sulfate, amikacin sulfate, ticarcillin disodium, piperacillin sodium, morphine sulfate, or total parenteral nutrient (TPN) solution was investigated. Recombinant interleukin-2 in a formulation containing human serum albumin was diluted to a therapeutic dose and mixed with the other drugs in test tubes to simulate mixing distal to the Y-site of an i.v. administration set. All test tubes were visually observed for precipitates. Triplicate test samples of recombinant interleukin-2 and interleukin-2 with drug were added to microplate wells containing lymphocyte tissue culture media (an interleukin-2-dependent murine cytotoxic T cell line, CTLL-2) using serial dilutions. The microplates were incubated then pulsed with mouse lymphocyte media containing tritiated thymidine (3H-thymidine). The amount of 3H-thymidine incorporated into lymphocyte DNA was measured using a beta counter. The average counts per minute (cpm) of a sample was analyzed as a function of the logarithm of sample dilution; one interleukin-2 unit was defined as 50% of the maximum cpm measured in the samples. At minimum dilutions, ticarcillin disodium reduced the effect of interleukin-2 on CTLL-2 growth; the other antibiotics and morphine sulfate had no effect. Interleukin-2 mixed with TPN solutions showed slightly enhanced growth of the CTLL-2 line compared with the interleukin-2 standard. Mixtures of multiple antibiotics, morphine, and TPN solutions with and without 20% fat emulsion had no effect on interleukin-2 activity.(ABSTRACT TRUNCATED AT 250 WORDS)

Anti-Bacterial Agents↗
PubMed2005

Peroxidative protection of parenteral admixture by D-alpha-tocopherol.

High lipid:low dextrose (HL:LD) parenteral admixtures (PAs) are becoming commonplace in the nutritional support of veterinary patients. Lipid peroxidation before administration appears to be an unwanted sequela of high lipid content in PAs that can lead to oxidative injury of biologic membranes in vivo. The purpose of this in vitro study was to measure hydroperoxides in HL:LD PAs and to determine the optimal dose of d-alpha-tocopherol to minimize peroxidation in these PAs during a 24-hr period. Detectable concentrations of hydroperoxides were present in all PAs. D-alpha-tocopherol appeared to significantly minimize peroxidation of HL:LD PAs in vitro. These results have clinical implications for parenteral feeding in critically ill patients.

Animals↗
PubMed2006

Studies on the compressibility of wax matrix granules of acetaminophen and their admixtures with various tableting bases.

Matrix granules of acetaminophen have been formed by a melt granulation process whereby the acetaminophen powder was triturated with the melted wax--goat wax, glyceryl monostearate or carnuba wax. The compressibility of the matrix granules and their admixture, with diluent granules (lactose, alpha-cellulose or microcrystalline cellulose) was investigated. The granules were compressed to tablets at a constant load (30 arbitrary units on the load scale) of a manesty single punch machine. Resulting tablets were evaluated for tensile strength (T) and disintegration times (DT). Granule flow was determined by measuring their angle of repose when allowed to fall freely on a level surface. Matrix granules prepared by melt granulation with goat wax or glyceryl monostearate were too sticky and therefore did not flow at all. They were also poorly compressible (T values = 0.20MN/m2). Inclusion of the diluent remarkably improved granule flow property and compressibility. The T values of the tablets (measure of compressibility) increased from about 0.24 to 0.65 MN/m2 during increase in diluent (lactose) content from 20 to 80 %w/w. Microcrystalline cellulose and alpha-cellulose were more effective than lactose in promoting compressibility of the granules. By contrast the matrix granules formed with carnuba wax were free flowing (angle of repose, 18.60). Addition of the diluent further improved flowability slightly. The matrix granules (without a diluent) were readily compressible (T value, 1.79MN/m2). Addition of the diluent (80%w/w) reduced T values (MN/m2) slightly to 1.32 (lactose), 1.48 (alpha-cellulose) and 1.74 (microcrystalline cellulose). Tablets of the matrix granules only, disintegrated rapidly within 3 minutes. DT was further reduced to <30 s by addition of any of the diluents. The indication is that the inclusion of the diluents studied can be used to improve the compressibility of the otherwise poorly compressible matrix granules. Based on the flowability, compressibility, and disintegration data, carnuba wax proved most promising in the melt granulation of the test drug for sustained release applications.

Acetaminophen↗