VITAMIN UNRESPONSIVENESS. PROGRESSION OF CLASSIC SIGNS OF NEUROPATHY AND PELLAGRA DURING THERAPY.
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Feeding a diet deficient in nicotinamide, nicotinic acid, and tryptophan to pregnant rats causes death and resorption of all fetuses. This effect can be prevented by administration of either chlorpromazine or imipramine. Analysis of maternal liver at the time of fetal resorption indicates that the observed effects may be mediated through modification of the concentration of the pyridine nucleotide coenzymes.
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