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Evidence for hydrogen desorption through both interdimer and intradimer paths from Si(100)-(2 x 1).

Despite intensive work there are still controversial issues about desorption and adsorption of hydrogen on Si(100)-(2 x 1). In particular, the relative importance of the various interdimer- and intradimer-desorption paths is not clear. Nanosecond-pulse-laser desorption data have been used to argue that the 4H interdimer path is important, while data from thermal-desorption time-of-flight measurements suggest a large translationally hot contribution which cannot arise from the 4H interdimer path. The observation of a translationally hot desorption fraction at low to medium coverage can be accounted for by including the 2H interdimer path in quantum dynamical calculations. In this paper we investigate this issue further and present evidence that supports the inclusion of the intradimer path. Specifically, our results show that the intradimer and 3H interdimer paths provide the major contributions to the translationally hot fraction in the desorbate. Our conclusions are based on density-functional calculations of hydrogen translational excitation, mean-field analysis of thermal-desorption experiments over a range of ramp rate, and Monte Carlo simulations of nanosecond-pulse-laser experiments.

Journal Article↗

Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.

A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age (P < 0.00032) and may contribute to the epidemiological observation that the higher risk for prostate cancer in African Americans is greatest in younger men (and attenuates with older age). The same region was recently identified through linkage analysis of prostate cancer, followed by fine-mapping. We strongly replicated this association (P < 4.2 x 10(-9)) but find that the previously described alleles do not explain more than a fraction of the admixture signal. Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it.

Black or African American↗

Characterization of the metabolic demands of simulated shipboard Royal Navy fire-fighting tasks.

The purpose of this study was to quantify the metabolic demand of simulated shipboard fire-fighting procedures currently practised by men and women in the Royal Navy (RN) and to identify a minimum level of cardiovascular fitness commensurate with satisfactory performance. Thirty-four males (M) and 15 females (F) volunteered as subjects for this study (n=49). Maximal oxygen uptake (VO2max) and heart rate (fcmax) of each subject was assessed during a standardized treadmill test. During the main trials, volunteers were randomly assigned to complete several 4-min simulated shipboard fire-fighting tasks (boundary cooling (BC), drum carry (DC), extinguisher carry (EC), hose run (HR), ladder climb (LC)), at a work rate that was endorsed as a minimum acceptable standard. Heart rate (fc) and oxygen uptake (VO2) were recorded at 10-s intervals during rest, exercise and recovery. Participants completed all tasks within an allocated time with the exception of the DC task, where 11 subjects (all females) failed to maintain the endorsed work rate. The DC task elicited the highest (p<0.01) group mean peak metabolic demand (PMD) in males (43 ml min(-1) kg(-1)) and females (42 ml min(-1) kg (-1)) who were able to maintain the endorsed work rate. The BC task elicited the lowest PMD (23 ml min(-1) kg(-1)), whilst the remaining three tasks elicited a remarkably similar PMD of 38-39 ml min(-1) kg(-1). The human endurance limit while wearing a self-contained breathing apparatus (SCBA) dictates that RN personnel are only able to fire-fight for 20-30 min, while wearing a full fire-fighting ensemble (FFE) and performing a combination of the BC, HR and LC tasks, which have a group mean metabolic demand of 32.8 ml min(-1) kg(-1). Given that in healthy subjects fire-fighting can be sustained at a maximum work intensity of 80% VO2max when wearing SCBA for this duration, it is recommended that all RN personnel achieve a VO2max of 41 ml min(-1) kg(-1) as an absolute minimum standard. Subjects with a higher VO2max than the above quoted minimum are able to complete the combination of tasks listed with greater metabolic efficiency and less fatigue.

Energy Metabolism↗

Ergonomics and safety in societies in transfer.

In Central Europe, the influence of transformation on science and practice in both ergonomics and occupational safety has been positive. The opening of markets has automatically resulted in the quality of products of various countries being compared. The comparison of the state of science has been equally revealing. The spontaneous willingness of leading world centres to co-operate in both occupational safety and ergonomics has resulted in positive changes, e.g. intensive work on creating the instruments for: implementing ILO conventions and EU directives into national laws; implementing international and European standards into national standards; accrediting testing laboratories in the field of occupational safety and ergonomics; accrediting centres for product certification for the safety mark (obligatory) and for conformity with ergonomic parameters (voluntary); and computer-aided designing and creating databases in occupational safety and ergonomics conforming to international standards. These are the laws of the emerging common market for products and services. There is still a much more difficult area of necessary changes in the approach to: the value of life and health; the belief in the possibilities and the effectiveness of initiatives towards changing the working and life environment; and the form and content of the information in occupational safety and ergonomics taught from school to adult education. Transformation has led to a renaissance in which man has become the subject of all aspects of life and activity. There is also a renaissance of occupational safety and ergonomics. The fields of research that have gained importance in this new approach in Central Europe are discussed.

Accidents, Occupational↗

Effects of endurance training and heat acclimation on psychological strain in exercising men wearing protective clothing.

Two experiments examined the influences of endurance training and heat acclimation on ratings of perceived exertion (RPE) and thermal discomfort (RTD) during exercise in the heat while wearing two types of clothing. In experiment 1, young men underwent 8 weeks of physical training [60-80% of maximal aerobic power (VO2max) for 30-45 min day-1, 3-4 days week-1 at 20-22 degrees C dry bulb (db) temperature] followed by 6 days of heat acclimation [45-55% VO2max for 60 min day-1 at 40 degrees C db, 30% relative humidity (rh)] (n = 7) or corresponding periods of control observation followed by heat acclimation (n = 9). In experiment 2, young men were heat-acclimated for 6 or 12 days (n = 8 each). Before and after each treatment, subjects completed bouts of treadmill exercise (1.34 m s-1, 2% grade in experiment 1 and 0% grade in experiment 2) in a climatic chamber (40 degrees C db, 30% rh), wearing in turn normal light clothing (continuous exercise at 37-45% VO2max for a tolerated exposure of 116-120 min in experiment 1 and at 31-34% VO2max for 146-150 min in experiment 2) or clothing protective against nuclear, biological, and chemical agents (continuous exercise at 42-51% VO2max for a tolerated exposure of 47-52 min in experiment 1 and intermittent exercise at 23% VO2max for 97-120 min in experiment 2). In experiment 1, when wearing normal clothing, endurance training and/or heat acclimation significantly decreased RPE and/or RTD at a fixed power output. There were concomitant reductions in relative work intensity (% VO2max) [an unchanged oxygen consumption (VO2) but an increased VO2max, or a reduced VO2 with no change of VO2max], rectal temperature (Tre), mean skin temperature (Tsk), and/or heart rate (HR). When wearing protective clothing, in contrast, there were no significant changes in RPE or RTD. Although training and/or acclimation reduced %VO2max or Tre, any added sweat that was secreted did not evaporate through the protective clothing, thus increasing discomfort after training or acclimation. Tolerance times were unchanged in either normal or protective clothing. In experiment 2, when wearing normal clothing, heat acclimation significantly decreased RPE and RTD at a fixed power output, with concomitant reductions in Tre, Tsk, and HR; the response was greater after 12 than after 6 days of acclimation, significantly so for RPE and HR. When wearing protective clothing, the subjects exercised at a lower intensity for a longer duration than in the moderate exercise trial. Given this tactic, either 6 or 12 days of heat acclimation induces significant reductions RPE and/or RTD, accompanied by reductions in Tre, Tsk, and/or HR. Tolerance times in protective clothing were also increased by 11-15% after acclimation, despite some increase of sweat accumulation in the protective clothing. The results suggest that (1) neither endurance training nor heat acclimation reduce psychological strain when protective clothing is worn during vigorous exercise, because increased sweat accumulation adds to discomfort, and (2) in contrast to the experience during more vigorous exercise, heat acclimation is beneficial to the subject wearing protective clothing if the intensity of effort is kept to a level that allows permeation of sweat through the clothing. This condition is likely to be met in most modern industrial applications.

Acclimatization↗

Perception of surface pressure applied to the hand.

The study aimed to determine the relationship between the physical magnitude and the subjective perception of applied pressure, and to determine discomfort and pain thresholds. Free modulus magnitude estimation of the subjective pressure level was made on three points: on the finger, the palm and the thenar area. The pressure was judged to be higher at the thenar point than at the finger and palm points. The slopes of the linear functions (log magnitude estimates as a function of log pressure) were 0.66, 0.78 and 0.76 for the finger, palm and thenar points respectively. The discomfort threshold was 38% of the pain pressure threshold at the finger point, 40% at the palm and 22% at the thenar point. The results are probably of importance in the performance of hand-intensive work, in particular in the design of hand tools.

Adolescent↗

Ratings of perceived exertion by women with internal or external locus of control.

Ratings of perceived exertion are frequently used to estimate the strain and effort experienced subjectively by individuals during various forms of physical activity. A number of factors, both physiological and psychological in origin, have been suggested to work as modifiers of the exertion perceived by the individual. It has been reported in nonsport-related research that individuals with an internal locus of control seem to pay more attention to relevant information and use the available information more adequately than individuals with an external locus of control. The reputed inferior information-processing abilities of externals compared with internals could possibly also influence the ratings of perceived exertion, with externals being less accurate in their ratings. Whether locus of control might be such a factor was investigated. Fifty women worked on an ergometer cycle at four different work loads. The results showed statistically significant differences in subjective ratings of perceived exertion between externals and internals, especially at heavier work loads. Such differences might be because of unequal information-processing abilities, as the observed discrepancies occurred at higher work intensities, when more cues are available for processing.

Adult↗

Plasma testosterone and cortisol responses to prolonged sculling in male competitive rowers.

In this study, we examined anabolic and catabolic hormone responses to a single endurance rowing training session in 12 male competitive single scull rowers. A work intensity eliciting a blood lactate concentration of 4 mmol(-1) was determined on a rowing ergometer during an endurance rowing training session lasting about 2 h (7891+/-761 s; distance covered 22.6+/-2.5 km; heart rate 136+/-7 beats x min(-1); intensity 77.4+/-3.8% of anaerobic threshold; mean +/- s). Venous blood samples were obtained before and after on-water rowing. Cortisol, testosterone and sex hormone binding globulin were measured and free testosterone and the free testosterone: cortisol ratio calculated. Blood lactate concentration did not change significantly during training (from 1.7+/-0.4 to 1.9+/-0.4 mmol x l(-1)); however, body mass was reduced (from 82.0+/-10.8 to 80.6+/-11.2 kg) and was related to the distance covered (r = -0.75). The concentrations of cortisol and testosterone did not change significantly during rowing or in the first 2 h of recovery. Free testosterone was reduced in the first 2 h of recovery, but no significant changes were observed in the free testosterone: cortisol ratio. Immediately after rowing, the concentrations of cortisol (r = 0.49) and free testosterone (r = -0.58) were related to the distance covered. Our findings indicate that a prolonged low-intensity training session results in a similar anabolic and catabolic hormone stimulus for trained rowers.

Adolescent↗

Physiological profile and incidence of injuries among elite figure skaters.

The physiological responses to skating and the incidence of injuries were recorded in young, Danish elite figure skaters (n = 8) over a 1-year period. The skaters' maximum oxygen uptake (VO2 max) ranged from 54.7 to 68.8 ml kg-1 min-1, and work intensity during simulated competitive figure skating corresponded to 89% VO2 max. Before the onset of competitive skating, but after a warm-up, blood lactate (BLa) concentration was measured as 2.0 +/- 0.05 mM (means +/- S.E.). After a 4-min run, BLa increased to 8.0 +/- 0.6 mM. The subjects' resting heart rates were measured each morning over a 1-year period and corresponded to 53 +/- 2 and 58 +/- 3 beats min-1 for the males and females respectively, with no systematic season-related variations. The skaters trained for 15-41 h per week, 60-95 min of this time being spent on warm-up activities. The injury incidence rate during competitive skating was recorded as 1.4 injuries per 1000 h of training, 56% of these being acute and 44% chronic injuries. Of those injuries registered, 83% were recalled by the skaters when a retrospective questionnaire was given to them at the end of the observation period. This study indicates that ice figure skating is associated with high aerobic power. Furthermore, Danish skaters spend large amounts of time on training, including warm-up and stretching. Despite the amount of training and the intensity of ice-skating programmes, injury rates are low compared with other sporting events.

Adolescent↗

Rate of accumulation of blood lactate during graded exercise as a predictor of 'anaerobic threshold'.

The subject group comprised 35 endurance-trained males: 11 young adults, 11 seniors and a control group of 13 young adults. A graded submaximal exercise test on a treadmill was performed by 22 of the subjects. The exponential function [La-] = a.ebx + c (where x = running velocity) showed a high degree of correlation with the experimental results (mean r = 0.997) and had randomly distributed residuals. Twenty-two subjects performed a series of running sessions at constant speed to establish the highest working intensities that could be endured without an increase in blood lactate (BLa) - the maximal steady-state workload (MSSW). The observed velocities of MSSW were related to the BLa vs velocity curves from the graded test. The graded submaximal exercise tests yielded mean derivatives from the BLa vs velocity relationship curves equal to 0.089 and 0.083 mM per m.min-1 for the young and senior groups, respectively. The derivatives had moderate inter-individual variations. In reversing the procedure, MSSW was estimated for all of the subjects using a common slope of 0.086. Only small individual variations were found between observed and estimated MSSW. The mean BLa value f (x), calculated using exponential functions where x = individual observed MSSW, was 3.0 mM. Thus, for endurance-trained athletes, a BLa accumulation rate of 0.086 mM per m.min-1 or, alternatively, a fixed BLa concentration of 3 mM, is recommended as a predictor of MSSW when analysing the BLa-velocity profiles from a graded submaximal test.

Adolescent↗

A descriptive analysis of elite-level racquetball.

The results of the three experiments provide insight into the time/motion characteristics of racquetball and the physiological responses of elite-level racquetball players during competition. The maximum oxygen uptakes of the male and female athletes tested were relatively low in comparison to those of other elite-level sports, suggesting that aerobic demand, although necessary, is probably not a limiting factor at this level of racquetball play. Racquetball games at the elite level last from 10 to 15 min, and the distance covered by each player during this time is minimal. Even though the rest periods between rallies are from one to two times as long as the work intervals, the work intensity during the rallies is sufficient to produce an average heart rate of between 75 and 95% of maximum throughout most of a game. Although some lactic acid accumulates in the blood, the concentration remains at a steady state during a game (10 to 30% of maximum).

Adult↗

Work performance of high-altitude Aymara males.

The sample for this study consisted of 28 Aymara males between the ages of 15 and 43 years. The subjects were rural high-altitude natives who were temporarily working as porters in La Paz, Bolivia (3700 m). Mean VO2max was 46 X 5 ml/kg/min. There was a significant negative relationship between VO2max and age in adult porters . However, there was also a significant positive relationship between maximal work output and age and a significant negative relationship between VO2 during submaximal exercise and age. Relative work intensity (VO2/VO2max) during submaximal exercise did not change significantly with age. Thus, even though VO2max decreased significantly with age, these data suggest that there may not be a substantial decrease with age in the adaptive status of these men. Minimal support was found for the hypothesis that chest size in Andean highlanders influences the effectiveness of the oxygen transport system.

Acclimatization↗

Exertional symptoms and exercise capacity in individuals with brain injury.

PURPOSE: To examine factors affecting cycling exercise performance in individuals with acquired brain injury. METHODS: Thirty individuals with acquired brain injury and 18 sedentary controls (SC) participated. Heart rate, bicycle power output and rating of perceived exertional (RPE) were recorded, throughout incremental cycle ergometer exercise. The SC group and 18 moderately impaired individuals from the ABI group performed a 25-W (B25) protocol. The remaining 12 individuals performed a 10-W protocol (B10). RESULTS: The B10 group terminated exercise at the lowest RPE, percentage age predicted maximal heart rate (% APMHR) and bicycle power output, followed by the B25 and then the SC group (RPE: Kruskal - Wallis test P < 0.001, %APMHR and bicycle power output: one-way ANOVA P < 0.01). RPE was correlated with %APMHR and percentage of peak bicycle output (B10 group: R2 0.1 to 0.67; B25 group: 0.69 - 0.83; SC group: 0.76 - 0.91). There was no difference in RPE at the same relative work intensity between the B25 and the sedentary control group (P > 0.05). Forward regression analysis revealed fatigue levels were predictive of %APMHR at test termination (beta = -0.411, P < 0.05) and quadriceps strength was predictive of peak bicycle power output (beta = 0.612, P < 0.05). CONCLUSIONS: Individuals with brain injury terminated exercise at lower exercise intensities but rated exertion no differently from healthy individuals. General fatigue levels predicted %APMHR and quadriceps strength predicted peak bicycle power output.

Adult↗

Reflections concerning biochemical parameters of androgenicity.

Due to the highly variable concentration of sex hormone binding globulin (SHBG) and the many factors affecting it, the evaluation of the androgen status may require the measurement of a parameter of bioactive plasma testosterone. As, however, no practical, clinical useful direct method for measurement of plasma androgen bioactivity is available, indirect biochemical parameters are used. All have their limitations and pitfalls. In this paper are discussed some of the factors influencing the values obtained with different methods (direct measurement of free testosterone by analog radioimmunoassay, dialysis, ammonium sulfate precipitation, free testosterone index, calculated free and bioavailable testosterone), all of which may explain the variability of data reported in the literature. It is concluded that, whereas determination of bioavailable testosterone by dialysis or ammonium sulfate precipitation of SHBG-bound testosterone is work-intensive and not really suitable for clinical routine, while direct measurement of free testosterone by analog immunoassay yields unreliable results, only the free testosterone index and calculated bioavailable testosterone are adapted for clinical routine. The limitations of the free testosterone index, a dimensionless parameter which does not reflect a defined bioavailable testosterone concentration, are discussed. As the same measurements of testosterone and SHBG required for determination of the free testosterone index permit the calculation of bioavailable testosterone, which yields a defined androgen concentration, it is advisable to prefer the latter over the free testosterone index, which should no longer be used.

Age Factors↗

Comparative physiological responses of exercising men and women to 5 ppm hydrogen sulfide exposure.

A study compared the effects of inhalation of 5 ppm hydrogen sulfide (50% of its occupational exposure limit) on the physiological and hematological responses of healthy men and women during exercise. Subjects were 13 men (mean +/- SD for age, height, and weight = 24.7 +/- 4.6 yr, 173 +/- 6.6 cm, 73.1 +/- 8.1 kg, respectively) and 12 women (mean +/- SD for age, height, and weight = 22.0 +/- 2.1 yr, 165 +/- 8.2 cm, 63.4 +/- 8.6 kg, respectively). Subjects completed two 30-minute exercise tests on a cycle ergometer at 50% of their predetermined maximal aerobic power while breathing medical air or 5 ppm H2S from a specially designed flow system. The results indicated that there were no significant differences between the two exposures for the metabolic (oxygen uptake, carbon dioxide production, respiratory exchange ratio), cardiovascular (heart rate, blood pressure, rate pressure product), arterial blood (oxygen and carbon dioxide tensions, pH), and perceptual (rating of perceived exertion) responses in either sex. None of the subjects reported any adverse health effects subsequent to the H2S exposure. These results suggest that healthy men and women can safely perform moderate intensity work in environments contaminated with 5 ppm H2S.

Adult↗

Efficacy of the customized employment supports (CES) model of vocational rehabilitation for unemployed methadone patients: preliminary results.

This article presents initial efficacy data for an innovative vocational rehabilitation model designed for methadone-maintained patients--the Customized Employment Supports (CES) model. In this model, a CES counselor works intensively with a small caseload of patients in order to overcome the vocational as well as nonvocational barriers that hinder their employment, with the goal of attaining rapid placement in competitive employment. The CES model was implemented at two Manhattan methadone treatment programs as part of a randomized clinical trial comparing the model's employment outcomes with those of standard vocational counseling. The study tested the hypothesis that patients in the experimental group will have better employment outcomes than those in the comparison group. The data were collected from May 2001 through September 2003. The sample consisted of the first 121 patients who had completed their 6-month follow-up interviews. The preliminary results supported the hypothesis for two indices of paid employment, i.e., the CES group was more likely to obtain both competitive employment and informal paid employment. The clinical trial is continuing.

Adult↗

Simplified user poll and experience report language (SUPER): implementation and application.

Biological computing is generally organized as standalone implementation on a PC-type computer or on a central facility (e.g. a university computer center). Services provided by central facilities need to be tailored to the user community. Unless very work-intensive individual contacts are used, the feedback must be collected with generalized tools, such as questionnaires distributed in the form of a newsletter. We have developed a method to have such polls automated and tailored, as well as having multiple-choice questions combined with branching after fundamental questions. As the evaluation of the results needs to know the questions asked, we have also included a method to process the answers and give detailed tables on the answers. SUPER was applied in a poll to query the academic usership in Switzerland on the usage of molecular biology databases.

Biology↗

Simplified user poll and experience report language (SUPER): implementation and application.

Biological computing is generally organized as stand-alone implementation on a PC-type computer or on a central facility (e.g. a university computer center). Services provided by central facilities need to be tailored to the user community. Unless very work-intensive individual contacts are used, the feedback must be collected with generalized tools, such as questionnaires distributed in the form of a newsletter. We have developed a method to have such polls automated and tailored, as well as having multiple-choice questions combined with branching after fundamental questions. As the evaluation of the results needs to know the questions asked, we have also included a method to process the answers and give detailed tables on the answers. SUPER was applied in a poll to query the academic usership in Switzerland on the usage of molecular biology databases.

Evaluation Studies as Topic↗