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Noise exposure among construction electricians.

Data-logging noise dosimetry was used to assess the exposure levels of electricians working for a major electrical subcontractor in Washington State at five sites using four types of construction methods. Subjects documented activities and work environment information throughout their work shift, resulting in an activity/exposure record for each of the 174 full-shift samples collected over the 4-month duration of the study. Over 24% of the TWA samples exceeded 85 dBA; 5.2% exceeded the federal Occupational Safety and Health Administration permissible exposure limit of 90 dBA. The National Institute for Occupational Safety and Health exposure metric, which specifies a 3-dB ER, was also utilized; using this metric, 67.8% of the samples exceeded 85 dBA and 27% exceeded 90 dBA. Subjects were directly observed for a subset of 4469 min during which more detailed activity and environmental information was recorded. Linear and logistic regression models using this subset were used to identify the determinants of average exposure, and exposure exceedences, respectively. These models demonstrated the importance of multiple variable modeling in interpreting exposure assessments, and the feasibility and utility of modeling exposure exceedences using logistic regression. The results further showed that presumably quiet trades such as electrician are at risk of exposure to potentially harmful noise exposures, and that other workers' activities and the general environment contribute substantially to that risk. These results indicate that noise control strategies will have to address the construction work environment as an integrated system.

Adult↗

Rapid freezing of whole blood or buffy coat samples for polymerase chain reaction and cell culture analysis: application to detection of human immunodeficiency virus in blood donor and recipient repositories. The Transfusion Safety Study Group.

Storage of lymphocytes for later use in prospective epidemiologic studies of blood donors and transfusion recipients has been limited by the cost of separating peripheral blood mononuclear cells (PBMCs). When the Transfusion Safety Study began in 1985, it was decided to establish a cell repository of cryopreserved buffy coat (BC) samples, and thus far over 20,000 samples have been accumulated from enrolled subjects. To determine if these specimens could be used for polymerase chain reaction, a simple thawing and pelleting technique for recovering hemoglobin-free total white cells (WBCs) was developed. To validate the technique, parallel analysis was conducted of BCs, whole blood (WB), and PBMC samples from human immunodeficiency virus type 1 (HIV-1)-seropositive subjects. Immediate postthaw cell courts of 29 frozen-thawed (F-T) WB and BC samples averaged 90 percent of the prefreeze (input) values. Representative WBC populations were obtained by immediate pelleting. Amplification of HIV-1 gag sequences from F-T BCs and F-T WB was 94 and 75 percent, respectively, which is as sensitive as that obtained with freshly separated PBMC lysates. Quantitative HIV-1 proviral load analysis by serial dilution of 23 F-T BCs and 8 WB lysates showed results comparable to those obtained with lysates of fresh PBMCs. Values for WBC differential and immunophenotyping could be applied to express viral load relative to total WBCs, PBMCs, or CD4+ cells. These results establish the basis for simplified virologic analysis of cryopreserved BC or WB specimens.

Blood Donors↗

Food fears: a national survey on the attitudes of Australian adults about the safety and quality of food.

A national telephone survey of a representative sample of 1200 Australian adults was conducted in March 2002 in order to identify the factors of greatest concern to consumers in relation to the safety and quality of food, to measure recent trends in views about hazards in the food supply, to explore beliefs about the safety of additives and to discover whether consumers use food labels to check for ingredients of concern. Forty five percent of Australians responded that they were more concerned about the safety and quality of food than they were five years previously, while only 5% were less concerned. The most common potential hazards volunteered were additives and chemical residues (28%), followed by food processing/handling/freshness (21%), food hygiene or contamination (14%), and also genetic modification (14%). More than half of the respondents believe that additives and preservatives are harmful to your health and that many foods contain high levels of pesticides. A greater proportion of consumers claimed to be conscious of checking for additives, either general or specific, on food labels than for information on the salt or sugar content of products. Food regulators, journalists, the food industry and health professionals need to work together to correct misconceptions about the risks to health posed by common food additives and pesticide residues.

Adolescent↗

Association of pesticide safety beliefs and intentions with behaviors among farm pesticide applicators.

Telephone interviews were conducted on a random sample of 164 dairy farmers knowledge and beliefs about pesticide hazards, intentions to use precautions, perceptions of pesticide safety peer norms, perceived self-efficacy to prevent personal exposure, and use of protective equipment. Self-efficacy and risk perception appear less relevant to safety behavior than other variables. Future research should focus prospectively and on national samples.

Adult↗

Characterization of AUCs from sparsely sampled populations in toxicology studies.

PURPOSE: The objective of this work was to develop and validate blood sampling schemes for accurate AUC determination from a few samples (sparse sampling). This will enable AUC determination directly in toxicology studies, without the need to utilize a large number of animals. METHODS: Sparse sampling schemes were developed using plasma concentration-time (Cp-t) data in rats from toxicokinetic (TK) studies with the antiepileptic felbamate (F) and the antihistamine loratadine (L); Cp-t data at 13-16 time-points (N = 4 or 5 rats/time-point) were available for F, L and its active circulating metabolite descarboethoxyloratadine (DCL). AUCs were determined using the full profile and from 5 investigator designated time-points termed "critical" time-points. Using the bootstrap (re-sampling) technique, 1000 AUCs were computed by sampling (N = 2 rats/point, with replacement) from the 4 or 5 rats at each "critical" point. The data were subsequently modeled using PCNONLIN, and the parameters (ka, ke, and Vd) were perturbed by different degrees to simulate pharmacokinetic (PK) changes that may occur during a toxicology study due to enzyme induction/inhibition, etc. Finally Monte Carlo simulations were performed with random noise (10 to 40%) applied to Cp-t and/or PK parameters to examine its impact on AUCs from sparse sampling. RESULTS: The 5 time-points with 2 rats/point accurately and precisely estimated the AUC for F, L and DCL; the deviation from the full profile was approximately 10%, with a precision (%CV) of approximately 15%. Further, altered kinetics and random noise had minimal impact on AUCs from sparse sampling. CONCLUSIONS: Sparse sampling can accurately estimate AUCs and can be implemented in rodent toxicology studies to significantly reduce the number of animals for TK evaluations. The same principle is applicable to sparse sampling designs in other species used in safety assessments.

Animals↗

Hospital safety climate and its relationship with safe work practices and workplace exposure incidents.

BACKGROUND: In the industrial setting, employee perceptions regarding their organization's commitment to safety (i.e., safety climate) have been shown to be important correlates to both the adoption and maintenance of safe work practices and to workplace injury rates. However, safety climate measures specific to the hospital setting have rarely been evaluated. This study was designed to develop a short and effective tool to measure hospital safety climate with respect to institutional commitment to bloodborne pathogen risk management programs and to assess the relationship between hospital safety climate and (1) employee compliance with safe work practices and (2) incidents of workplace exposure to blood and other body fluids. METHODS: A questionnaire, which included 46 safety climate items, was developed and tested on a sample of 789 hospital-based health care workers at risk for bloodborne pathogen exposure incidents. RESULTS: A 20-item hospital safety climate scale that measures hospitals' commitment to bloodborne pathogen risk management programs was extracted through factor analysis from the 46 safety climate items. This new hospital safety climate scale subfactored into 6 different organizational dimensions: (1) senior management support for safety programs, (2) absence of workplace barriers to safe work practices, (3) cleanliness and orderliness of the work site, (4) minimal conflict and good communication among staff members, (5) frequent safety-related feedback/training by supervisors, and (6) availability of personal protective equipment and engineering controls. Of these, senior management support for safety programs, absence of workplace barriers to safe work practices, and cleanliness/orderliness of the work site were significantly related to compliance (P<.05). In addition, both senior management support for safety programs and frequent safety-related feedback/training were significantly related to workplace exposure incidents (P<.05). Thus the most significant finding in terms of enhancing compliance and reducing exposure incidents was the importance of the perception that senior management was supportive of the bloodborne pathogen safety program. CONCLUSIONS: Hospital safety climate with regards to bloodborne pathogens can be measured by using a short, 20-question scale that measures 6 separate dimensions. Whereas all 6 dimensions are essential elements of overall safety climate, 3 dimensions are significantly correlated with compliance, and 1 dimension (senior management support) is especially significant with regard to both compliance and exposure incidents. This short safety climate scale can be a useful tool for evaluating hospital employees' perceptions regarding their organization's bloodborne pathogens management program. In addition, because this scale measures specific dimensions of the safety climate, it can be used to target problem areas and guide the development of intervention strategies to reduce occupational exposure incidents to blood and other body fluids.

Adult↗

Arsenic in breast milk during the first 3 months of lactation.

Increased concentrations of arsenic were found in soil and ground water from a military training area in Munster, Lower Saxony, Germany, where chemical weapons were dumped after World War II. In order to assess the possible impact of this contamination for nursing new-borns and infants, samples from breast milk of 36 women were analysed with respect to arsenic content. Study participants came from three different regions: the city of Hamburg, the rural area of Soltau, Lower Saxony, and from Munster, the potentially contaminated area. Breast milk samples were collected immediately before and after nursing on days 2, 5, 15, 30, 45, 60, 75, and 90 post partum. At least 10 ml were required for measurements of arsenic, and 187 samples were of that volume. Samples were analysed with a Perkin-Elmer Type 403 hydride-generation atomic absorption spectrometer, equipped with an arsenic EDL-lamp. Arsenic was not detectable, i.e. below 0.3 microgram/l, in 154 of 187 samples. The highest concentration of 2.8 micrograms/l was measured in a sample from the rural area of Soltau. Geometric means of arsenic concentrations were comparable in the three regions. Concentrations did neither differ in samples obtained before and after nursing nor with respect to age of the infant. The calculated daily intake of arsenic was in the range of 0.02 to 0.06 microgram per kg body weight, which is far below the lower limit of daily permissible intake for adults (WHO/JECFA recommendation 1993) of 15 micrograms/kg/wk. In conclusion, we found concentrations of arsenic in breast milk within the reported safety limits. This was also true for samples from women living in a region which has previously been shown to be contaminated with arsenic from chemical weapons.

Adult↗

Apparent high tritium intake by a radiation worker at the University of Rochester.

On 20 September 1999, a urine sample submitted by a University of Rochester radiation worker was noted to have a count rate of about 759,500 disintegrations per minute (dpm) per milliliter as analyzed on the Radiation Safety Unit (RSU) Packard liquid sintillation counter. The sample was recounted that day with variable results but each time indicating several hundred thousand dpm of activity present. Calculations indicated this corresponded to a whole-body uptake of about 518 MBq (14 nmCi) and a whole-body dose of about 10 msv (1 rem). An investigation indicated it was unlikely for these analytical results to indicate an actual uptake of tritium and suggested the results were most likely due to chemical luminescence in the sample. Accordingly, no dose was assigned to this worker from the exposure.

Artifacts↗

Potential exposure to metal fumes, particulates, and organic vapors during radiotherapy shielding block fabrication.

The shielding-block fabrication areas of three hospitals were surveyed to assess inhalation exposure to lead (Pb), cadmium (Cd), bismuth (Bi), and tin (Sn) fumes, as well as styrene and methyl chloride vapors. Area and personal breathing zone samples were collected for various steps in the block fabrication process. Only 3 of 16 air samples for metals resulted in detectable levels of Pb and/or Cd. The levels were well below the Occupational Safety and Health Administration (OSHA) Permissible Exposure Limits, excluding a sample which contained a visible metal fragment. Bi and Sn were not detected in any samples. Methyl chloride and styrene vapors were not detected in any air samples during foam cutting procedures. Total particulates (TP) were measurable in 11 of 17 air samples (ranging from 0.01 to 2.1 mg/m3). TP values were below the OSHA federal standard for nuisance particulates, which is 15 mg/m3. The data suggest that the materials and procedures sampled do not present an inhalation hazard to employees who construct shielding blocks. Precautions should, however, be exercised to prevent exposure under extreme procedural conditions such as soldering or overheating of alloy, and by other means such as ingestion. Care should also be taken during cleanup or housekeeping to prevent re-entrainment into the work atmosphere of mechanically generated metal particles or materials condensed within melting pots (which may be high in metal content).

Air Pollutants, Occupational↗

Public health issues in aquaculture.

The authors address the public health issues associated with the consumption of aquacultural products using numerous examples from the United States of America. As with other foods, public health risks exist but these mostly involve open water environments or products which are consumed raw or undercooked. Unlike wild fisheries, inland aquaculture systems can minimise public health risks by proper site evaluation and good aquacultural practices. Responsible use of pesticides and therapeutants can prevent violative residues to assure product safety and wholesomeness. The implementation of hazard analysis and critical control point regulations will further enhance the preventive approach to hazards control. The most challenging public health risks arise from shellfish production in open, surface waters, where both naturally-occurring and trace environmental residue contaminants can bioaccumulate in tissues and may cause disease outbreaks (and, in severe cases, death). Water quality certification programmes and field surveillance efforts including product sampling, testing and monitoring can address critical safety criteria. This paper focuses primarily on public health risks associated with production: however, the fact that consumer risks also occur as a result of the processing of aquacultural products and that foodborne diseases arise additionally from unsanitary handling or preparation and storage at incorrect temperatures (as is the case for food products from other animals) must also be taken into consideration.

Animals↗

Preventability of percutaneous injuries in healthcare workers: a year-long survey in Italy.

The aim of the study was to examine the preventability of percutaneous injuries either through the adoption of correct behaviour or by the use of needles with safety features. We analysed the report forms of occupational needlestick or sharps injuries in a sample of healthcare workers exposed to the risk of percutaneous injuries in the period between 1 June 2000 and 31 May 2001; the forms were returned to the regional SIROH (Italian Study on Occupational Exposure to HIV) centre in which all hospitals of the Piemonte region (Italy) participate. Percutaneous injuries caused by needles (injection, phlebotomy, infusion), suture needles and scalpels were analysed; three samples were extracted according to the type of device that caused the injury. In the sample of 439 needlestick-related percutaneous injuries, 74% were caused by incorrect health worker behaviour and 26% were unpreventable, seventy-nine percent of accidents caused by incorrect behaviour and 24% of accidents could have been prevented by using needles with safety features. In the sample of 221 suture needle and 114 scalpel injuries, incorrect health worker behaviour was identified in 26.2% and 14%, respectively, and unpreventable causes in 73.8% and 50.9%, respectively. A high rate of percutaneous injuries, especially those involving needles for injection, phlebotomy, infusion, and scalpels, could be prevented by adopting safe work behaviour practices and using personal protection equipment. The introduction of devices with safety features could lead to a significant reduction in the number of injuries from needles.

Health Personnel↗

Liberation of hydrogen cyanide and hydrogen chloride during high-temperature dispersion of CS riot control agent.

High temperature dispersion (greater than 700 degrees C) of the riot control agent orthochlorobenzylidenemalononitrile (CS) has previously been shown to produce a number of organic thermal degradation products through rearrangements and loss of cyano and chlorine substituents present on the parent CS compound. Until now the possibility that HCN and HCl might also be air contaminants produced during high temperature CS dispersion has not been examined. Air samples were collected to detect HCN and HCl as air contaminants released during high-temperature CS dispersion indoors. Sampling and analysis based on National Institute of Occupational Safety and Health methods 7904 and 6010 for HCN, and 7903 for HCl, showed evidence that both compounds were present in air samples collected. A reassessment of human health risks associated with exposure to CS riot control agent dispersed at high temperature should be conducted, and should consider the full range of contaminants produced during the dispersion process.

Environmental Exposure↗

Evaluation of a school-based education program to promote bicycle safety.

Of the 500,000 children in the United States who are injured in bicycle crashes annually, 252 die--97% of whom were not wearing a helmet. Although many intervention programs promote the use of helmets by children, a paucity of school-based evaluation studies exist that report students' knowledge retention or behavioral changes. The purposes of this study were to identify associations between student-reported knowledge of safety-related behaviors, reports of current safety-related practices, and students' participation in the Safety Central program while in the 4th grade. The sample consisted of 284 students currently enrolled in 5th and 6th grades. Findings showed a statistically significant association between participation in the Safety Central program and retention of knowledge and enactment of safety messages after a 1- and 2-year period. Motivators and barriers for helmet use were also identified. Implications for modifications to the content and delivery of the program and future evaluations are addressed.

Accident Prevention↗

Reducing exposures to airborne lead in a covered, outdoor firing range by using totally copper-jacketed bullets.

A study was conducted to evaluate the feasibility of reducing or eliminating airborne lead concentrations at a covered, outdoor firing range by using totally copper-jacketed ammunition. Used in the study were 38-caliber-special police revolvers, and firings were conducted with 38-caliber, totally copper-jacketed bullets. The mean lead levels in general area air samples and personal breathing zone samples were 9.53 micrograms/m3 and 5.88 micrograms/m3, respectively, calculated as an 8-hr, time-weighted average (TWA). The mean copper levels in general area samples and personal breathing zone samples were 0.8 micrograms/m3 and 1.43 micrograms/m3, respectively. These concentrations in general area air samples and personal breathing zone samples were well below the current Occupational Safety and Health Administration (OSHA) permissible exposure limit (PEL) for occupational exposure to inorganic lead (50 micrograms/m3) and for copper (100 micrograms/m3). No significant difference was found between blood lead levels before and after firing totally copper-jacketed bullets. Based on comparison with results from a comparable study using nonjacketed lead ammunition, it was concluded that the use of totally copper-jacketed bullets significantly reduced airborne lead levels by a factor of 21 in the personal breathing zone samples and by a factor of 7.5 in the general area air samples.

Air Pollutants, Occupational↗

The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693.

AIM: The aim was to assess the central nervous system (CNS) effects, pharmacokinetics and safety of GPI 5693, an inhibitor of a novel CNS-drug target, NAALADase which is being evaluated for the treatment of neuropathic pain. METHODS: This was a double-blind, placebo-controlled, exploratory study in healthy subjects receiving oral GPI 5693 single ascending doses of 100, 300, 750, 1125 mg with a placebo treatment randomly interspersed. An open-label, parallel extension examined the effects of food and sex on the pharmacokinetics of 750, 1125 and 1500 mg doses. Blood samples were collected for pharmacokinetic and biochemical/haematological safety analysis, vital signs, ECG and adverse event checks were performed regularly up to 48 h postdose. Postdose CNS effects were assessed using eye movements, adaptive tracking, electroencephalography (EEG), body sway and Visual Analogue Scales (VAS). RESULTS: CNS effects were mainly observed after the 1125 mg dose, showing a significant decrease of adaptive tracking performance, VAS alertness and VAS mood, and an increase of EEG occipital alpha and theta power. Gastro-intestinal (GI) adverse effects were frequent at higher doses. No clinically significant changes in vital signs or ECG were noted during any of the treatments. The therapeutically relevant concentration range (950-11 100 ng ml(-1)) as determined from animal experiments was already reached after the 300 mg dose. C(max) after the 300 mg and 750 mg dose was 2868 and 9266 ng ml(-1) with a t(1/2) of 2.54 and 4.78 h, respectively. Concomitant food intake (with the 750 mg and 1125 mg doses) reduced C(max) by approximately 66% and AUC by approximately 40%. With concomitant food intake, the dose-normalized C(max) also decreased significantly by -5.6 (CI: -2.6 to -8.7) ng ml(-1) mg(-1). The pharmacokinetic variability was largest after the 300 mg and 750 mg dose, resulting in a SD of approximately 50% of the C(max). CONCLUSION: NAALADase inhibition with GPI 5693 was safe and tolerable in healthy subjects. Plasma concentrations that were effective in the reversal of hyperalgesia in the chronic constrictive injury animal model of neuropathic pain were obtained at doses of 300, 750 and 1125 mg in the fasted state. Comcomitant food intake reduced C(max) and AUC. CNS effects and GI AEs increased in incidence over placebo only at the 1125 mg dose.

Administration, Oral↗

Field evaluation of a sampling and analytical method for environmental levels of airborne hexavalent chromium.

Hexavalent chromium, Cr(VI), has been classified as a human respiratory carcinogen. Airborne Cr(VI) emissions are associated with a number of industrial sources including metal plating, tanning, chromite ore processing, and spray painting operations; combustion sources such as automobiles and incinerators; and fugitive dusts from contaminated soil. There has been considerable interest within industry and the regulatory community to assess the potential cancer risks of workers exposed to Cr(VI) at levels substantially below the threshold limit value (TLV) of 50 micrograms/m3. To date, only the workplace sampling and analytical method (National Institute for Occupational Safety and Health [NIOSH] Method 7600) has been validated for measuring airborne Cr(VI), and it can accurately measure concentrations only as low as 500 ng/m3. This paper describes the field evaluation of a sampling and analytical method for the quantitation of airborne Cr(VI) at concentrations 5000 times lower than the current standard method (as low as 0.1 ng/m3). The collection method uses three 500-mL Greenberg-Smith impingers in series, operated at 15 Lpm for 24 hr. All three impingers are filled with 200 mL of a slightly alkaline (pH approximately 8) sodium bicarbonate buffer solution. The results of validation tests showed that both Cr(VI) and trivalent chromium, Cr(III), were stable in the collection medium and that samples may be stored for up to 100 days without appreciable loss of Cr(VI). Method precision based on the pooled coefficient of variation for replicate samples was 10.4%, and method accuracy based on the mean percent recovery of spiked samples was 94%. Both the precision and accuracy of the impinger method were within NIOSH criteria. This method could be used to measure ambient concentrations of Cr(VI) in the workplace caused by fugitive emissions from manufacturing processes or chromium-contaminated soils at workplace concentrations well below the current TLV (50 micrograms/m3) or permissible exposure limit (100 micrograms/m3).

Air Pollutants, Occupational↗

Illnesses and injuries reported by Latino poultry workers in western North Carolina.

BACKGROUND: Poultry processing is the largest sector of the meat products industry. Many workers are immigrants; few data exist on their illness and injury rates and the impact of workplace safety environment. METHODS: Survey interviews were conducted with a representative sample of 200 Latino poultry workers employed by three different companies in western North Carolina; topics included symptoms, work-related illnesses and injuries, and plant safety climate. RESULTS: Most respondents were <35 years of age and had been in the US <10 years. Frequency of self-reported symptoms was high, particularly for musculoskeletal symptoms. Despite symptoms, workers reported not missing work or seeking medical care. Occupational injuries and illnesses and symptoms varied by company. Between-company differences in injury and illness rates were consistent with perceived safety and company provision of personal protective equipment. CONCLUSIONS: Symptoms reported exceeded rates reported by other community, clinical, and occupational samples. Findings suggest policy changes and research are needed to reduce the high rates of occupational illnesses and injuries in this vulnerable population.

Adult↗

Workers' safety in milking premises.

Dairy cattle rearing techniques have evolved, and milking has moved from stalls to specialized premises. A survey was carried out on a representative sample of dairy farms in central Italy to investigate workers' safety in milking premises. Results indicated acceptable sound level and microclimatic conditions, whereas repetitive motion of the upper limbs should be carefully monitored for the possible effects it can induce on the milkers, who were devoid of adequate personal protective equipment (PPE). Floor antislipping characteristics represented a major deficiency in the building material, in spite of its strength and durability.

Adult↗