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Hyperuricemia in diarrheal dehydration.

Serum uric acid levels were measured in 133 dehydrated patients admitted with diarrhea. Elevated levels were found in 80% of the patients; the highest was 38 mg/dL. Serum uric acid was correlated with serum urea nitrogen and the levels tended to be higher in patients with hypernatremia. The serum uric acid levels returned toward normal with rehydration, and no specific therapy was necessary.

Blood Urea Nitrogen↗

X-linked glycogen storage disease. A cause of hypotonia, hyperuricemia, and growth retardation.

Seven male members of one family had a form of glycogen storage disease that was inherited in an X-linked recessive pattern. The clinical manifestations included hepatomegaly, delay in growth and sexual maturation, muscular weakness in childhood, and gouty arthritis. The cause of the glycogen accumulation did not appear to be a deficiency of glucose 6-phosphatase, debrancher enzyme, phosphorylase, or phosphorylase kinase. Prognosis appeared to be good although there was significant disability during childhood.

Adolescent↗