Abnormal visual pathways in the brain of a human albino.
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We have measured thresholds for bichromatic test-mixtures in red/green dichromats. Our results provide strong evidence for cone-antagonistic coding along the dichromats' detecting pathways. The threshold behavior of the isolated dichromatic pathways is consistent with that predicted by Opponent Colors Theory. We compare these threshold data with the dichromats' judgments of "blue/yellow" hue equilibria, which we obtained in supra-threshold color-cancellation experiments. The results are consistent with the hypothesis that both sets of data are mediated by the same dichromatic cone antagonistic pathway.
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Photophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from multiple studies have shown the significance of the trigeminal system and the pretectal nuclei in its pathophysiology. The authors report on a rare case of a blind patient who presented with photophobia without evidence of light perception. They also review the literature and early experimental data in an effort to understand the possible neuronal pathways and structures involved in photophobia.
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