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Is there a substitute for Structured Interview assessments of type A behaviour?

Discriminant analyses, attempting to predict the Type A behaviour categorization achieved by means of the Structured Interview (SI), were carried out on the responses of 93 British males to the Jenkins Activity Survey and the Framingham Scale, together with information regarding their smoking habits, alcohol consumption, tea and coffee drinking and obesity levels, all of which have been suggested as risk factors for coronary heart disease. Where classification agreements with the SI were found to be above 50 per cent, classification functions based on the discriminant analyses were calculated from the responses of 36 additional male subjects. The actual SI categories were compared with the predicted categories for this second subject group. The results indicated that no reliable and robust alternative was available to predict the SI categorization. The implications of these results for the substitution of the SI by self-report questionnaires are discussed.

Adult↗

Taste responses in patients with Parkinson's disease.

OBJECTIVE: Preclinical studies indicate that dopaminergic transmission in the basal ganglia may be involved in processing of both pleasant and unpleasant stimuli. Given this, the aim of the present study was to assess taste responses to sweet, bitter, sour, and salty substances in patients with Parkinson's disease (PD). METHODS: Rated intensity and pleasantness of filter paper discs soaked in sucrose (10-60%), quinine (0.025-0.5%), citric acid (0.25-4.0%), or sodium chloride (1.25-20%) solutions was evaluated in 30 patients with PD and in 33 healthy controls. Paper discs soaked in deionised water served as control stimuli. In addition, reactivity to 100 ml samples of chocolate and vanilla milk was assessed in both groups. Taste detection thresholds were assessed by means of electrogustometry. Sociodemographic and neuropsychiatric data, including cigarette smoking, alcohol consumption, tea and coffee drinking, depressive symptoms, and cognitive functioning were collected. RESULTS: In general, perceived intensity, pleasantness, and identification of the sucrose, quinine, citric acid, or sodium chloride samples did not differ between the PD patients and controls. Intensity ratings of the filter papers soaked in 0.025% quinine were significantly higher in the PD patients compared with the control group. No inter-group differences were found in taste responses to chocolate and vanilla milk. Electrogustometric thresholds were significantly (p = 0.001) more sensitive in the PD patients. CONCLUSIONS: PD is not associated with any major alterations in responses to pleasant or unpleasant taste stimuli. Patients with PD may present enhanced taste acuity in terms of electrogustometric threshold.

Aged↗

Consumption of aspartame-containing beverages and incidence of hematopoietic and brain malignancies.

BACKGROUND: In a few animal experiments, aspartame has been linked to hematopoietic and brain cancers. Most animal studies have found no increase in the risk of these or other cancers. Data on humans are sparse for either cancer. Concern lingers regarding this widely used artificial sweetener. OBJECTIVE: We investigated prospectively whether aspartame consumption is associated with the risk of hematopoietic cancers or gliomas (malignant brain cancer). METHODS: We examined 285,079 men and 188,905 women ages 50 to 71 years in the NIH-AARP Diet and Health Study cohort. Daily aspartame intake was derived from responses to a baseline self-administered food frequency questionnaire that queried consumption of four aspartame-containing beverages (soda, fruit drinks, sweetened iced tea, and aspartame added to hot coffee and tea) during the past year. Histologically confirmed incident cancers were identified from eight state cancer registries. Multivariable-adjusted relative risks (RR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards regression that adjusted for age, sex, ethnicity, body mass index, and history of diabetes. RESULTS: During over 5 years of follow-up (1995-2000), 1,888 hematopoietic cancers and 315 malignant gliomas were ascertained. Higher levels of aspartame intake were not associated with the risk of overall hematopoietic cancer (RR for >/=600 mg/d, 0.98; 95% CI, 0.76-1.27), glioma (RR for >/=400 mg/d, 0.73; 95% CI, 0.46-1.15; P for inverse linear trend = 0.05), or their subtypes in men and women. CONCLUSIONS: Our findings do not support the hypothesis that aspartame increases hematopoietic or brain cancer risk.

Aged↗

[Bursting risk of capped PET bottles with leftover contents caused by yeast growth].

Accidents caused by the bursting of capped PET bottles with leftover contents have increased in Japan. Therefore, the bursting risk of capped PET bottles with leftover contents was investigated. The ratios of distension, after 10 days at 25 degrees C, of capped PET bottles with leftover orange juice were approx. 70% in the case of drinking while eating Kimuchi, and approx. 6% in the case of drinking but not eating. Among 58 distended bottles, none burst spontaneously, but 4 bottles (6.9%) burst upon physical shock (dropping onto a concrete floor from 1.5 m height). The greatest distensions of capped PET bottles were observed with leftover orange juice, apple juice and soured milk after 10 days at 25 degrees C. No distensions were observed in bottles containing leftover sports drink and green tea under the same conditions. Identified organisms from distended bottles were almost all Candida spp. When those Candida spp. strains were inoculated individually into PET bottles half full of orange, apple or sour milk, all bottles were distended after 7 days at 25 degrees C. From the above results, it appears that there is a risk that capped PET bottles with leftover contents, especially sour fruit juice or soured milk, may burst owing to high gas pressure caused by yeast growth during storage at room temperature for over 1 week.

Accidents↗

Study of the colors and retention of over-the-counter cosmetic veneers.

The purpose of this study was to observe the tooth colors and retention of a cosmetic veneer Fiche Pearl On containing shellac and five experimental formulations containing benzoin gum and ethyl cellulose. Tooth color was measured with a spectrophotometer before and after application of the veneers to the buccal or labial surface of experimental teeth. Through both in vitro and in vivo studies, the retention rates of veneers were assessed. In terms of color difference (deltaE*ab) between before and after veneer application, it ranged from 4.3 (Fiche Pearl On) to 15.0 (experimental formulation White Plus). In terms of retention rate, in vitro test found the retention rate of experimental formulation White Plus was significantly higher than that of Fiche Pearl On. In in vivo test where subjects were permitted to drink water and tea, it was found that the retention rate after two hours ranged from 94.0 to 98.5%. In conclusion, teeth applied with the experimental cosmetic veneer formulations showed better color and retention than teeth with Fiche.

Analysis of Variance↗

Are our people health conscious? Results of a patients survey in Karachi, Pakistan.

BACKGROUND: Life style is known to influence health and may be responsible for certain diseases. There is a need to document the life style on health among the Pakistani population. METHODS: The study was conducted on patients visiting the Family Practice Center, the Aga Khan University, Karachi. A questionnaire was used to collect information on the demographic profile, and the life style on health. The ethical requirements for conducting the study were met. RESULTS: 393 patients were surveyed. The majority were young married men, in either private or government service. Preference for consumption of fats/oils, sweets, spicy foods, salt, fruits/vegetables, tea, coffee, cola drinks and alcohol was found among 103 (26%), 84 (22%), 86 (22%), 110 (28%), 239 (61%), 319 (81%), 117 (30%), 253 (64%) and 13 (03%) respondents respectively. Hand washing after defecation, before eating food and after work was seen among 341 (87%), 296 (75%) and 256 (65%) respondents respectively. Brushing of teeth after eating food, before breakfast and bedtime was seen in 56 (14%), 346 (88%) and 176 (45%) respondents respectively. Preventive dental check-up was practiced by 102 (26%) of the respondents. Sleep of less than 6 hours per day among 74 (19%), water consumption of less than 1 liter daily among 84 (21%) and fish consumption on once a week basis among 173 (44%) respondents was found. Tobacco and betel nuts use was found among 69 (17%) and 79 (20%) respondents. CONCLUSIONS: We have documented a clear need to raise public awareness on the issue of life style on health. There is a need and we strongly recommend debate and further research, along with interventional strategies in line with the available evidence on healthy life style.

Adult↗

Postural fall in blood pressure in the elderly in relation to drug treatment and other lifestyle factors.

In a study of 843 independent-living men and women aged between 60 and 87 in Perth, Western Australia, stepwise multiple regression, after correction for initial levels of systolic blood pressure, showed that postural fall in systolic blood pressure was positively related to alcohol intake of more than 20 ml/day, the use of sleeping tablets and higher levels of anxiety on the Spielberger state-trait scale, and negatively related to body mass index. Postural fall in blood pressure was not significantly related to treatment for hypertension, age, sex, patterns of usual physical activity, tea or coffee drinking, or the diagnosis of diabetes mellitus. This analysis is the first to examine the relationship between lifestyle factors and the magnitude of the fall in systolic blood pressure on standing after adjustment for the association between the change in a variable and its initial level. Our analysis suggests the need for further study of the possible role of lifestyle factors such as the use of sleeping tablets and alcohol in postural hypotension in the elderly.

Aged↗

[A case-control study on the relationship between methyl-tetra-hydrofolic acid reductase 677 gene polymorphism and the risk of stomach cancer].

OBJECTIVE: To explore the relationship between methyl-tetra-hydrofolic acid (MTHFR) 677 gene polymorphism and the risk of stomach cancer. METHODS: A population based case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect its genotypes. RESULTS: Among cases with stomach cancer, the frequency of C/C, C/T, T/T genotype were 25.8%, 54.6%, 19.6%, compared with controls as 34.5%, 50.9%, 14.6% respectively. Using C/C genotype as reference, the OR of C/T or T/T genotype was 1.52 (95% CI: 1.04 - 2.23). 53.3% C and 46.7% T allele were distributed in stomach cancer cases, while 60.0% C and 40.0% T in controls. The OR for T allele in relation to C allele was 1.31 (1.02 - 1.69) when C allele was used as reference. In addition, the present study showed that MTHFR677 AnyT genotype might interact with smoking, moldy food intake, wheat porridge intake, eating salty food and Hp CagA infection to increase the risk of stomach cancer. No interaction was observed between MTHFR677 AnyT genotype and alcohol drinking or green tea intake. CONCLUSION: MTHFR677 AnyT genotype, might increase the risk of stomach cancer development and the genotype might also interact with other environmental risk factors to increase the risk of stomach cancer.

Adult↗

Prevalence and precipitating factors of gastroesophageal reflux disease in a young population of Tabriz, Northwest of Iran.

OBJECTIVE: To estimate the prevalence and clinical spectrum of gastroesophageal reflux disease (GERD) in a young population and evaluate the risk factors. METHODS: This cross-sectional study using a reliable and valid questionnaire was performed during June and July 2005, on randomized selection of 620 students form Azad University of Tabriz. Gastroesophageal reflux disease was defined as at least weekly heartburn and/or acid regurgitation. RESULTS: Mean age (+/- SD) of the responders was 22.48 +/- 1.98 years. The prevalence of heartburn and/or acid regurgitation experienced at least weekly was 6.3% and monthly was 13%. The severity of symptoms was mainly of a mild to moderate degree. There was no difference in prevalence of any GERD symptom between 2 genders and it was not associated with age of the study population. A frequent symptom of GERD was reported more among subjects with atypical symptoms. There was no relation between marriage status and prevalence of GERD. On the other hand, GERD was less common among subjects with no family history of upper gastrointestinal disease and students in higher rank fields. Increased body mass index (but no recent weight gain or lose) and drinking coffee and tea was associated with higher prevalence of GERD symptoms. CONCLUSION: This study as the first study using a valid questionnaire reveals a high prevalence of frequent GERD symptoms in a young population of Tabriz. Atypical symptoms should be considered in this area.

Adult↗

Comparison of the dental health status of 8 to 14-year-old children in France and in Jordan, a country of endemic fluorosis.

In the present paper, data obtained from a survey dealing with dental carie, dental fluorosis and gingival health, involving 2618 Jordanian schoolchildren, aged 8 to 14, were compared with data from another survey dealing with 1058 schoolchildren of the same age groups living in a non-fluoridated area in the west of France. As regards dental carie in temporary teeth, up to the age of 12, the dft and dfs scores were higher in France than in Jordan. Over the age of 12, the difference was no longer significant. As regards dental carie in permanent teeth, the data showing that Jordanian children are less subject to caries than the French were very highly significant. Also, it was shown that caries index in girls was higher than in boys. These data were not significant in the French survey, but highly significant in the Jordanian investigation. A possible explanation is that, due to the custom of the country, boys in Jordan drink much more tea (with high fluoride content) than girls. As regards gingival health, an interesting finding was that, compared to the French children, the percentage of Jordanian children presenting gingivitis is remarkably low. The fluoride content of the dental plaque might play a restricting and preventing role.

Adolescent↗

Reverse phase liquid chromatographic determination of aspartame in beverages and beverage mixes.

A method is described for determining the artificial sweetener aspartame in beverages and beverage mixes by liquid chromatography. Aspartame is separated on a microC18 column, using a mobile phase of acetic acid, water, and isopropyl alcohol at pH 3.0 and UV detection at 254 nm. Beverages are filtered through 0.45 micron filters and injected directly into the chromatograph. Aspartame is eluted in approximately 7 min. Detection of aspartame is confirmed by a UV scan of the trapped peak. Aspartame is quantitated in the presence of other beverage additives such as saccharin, caffeine, sodium benzoate, artificial colors, and artificial flavors. Results are presented for spiked soda beverages, beverages from fruit-flavored mixes, instant tea, reconstituted presweetened drink mixes, and a powdered tabletop sweetener.

Aspartame↗

[Coffee and caffeine. Various selected aspects for everyday practice].

Moderate consumption of methylxanthines, for example in coffee, tea, cola-drinks and other foodstuffs containing caffeine, is probably without particular health risks, insofar as other risk factors (smoking, alcohol, nutrition in general) can be kept under control. To avoid prohibition on one hand and to evaluate necessary restrictions concerning caffeine consumption individually on the other hand is an artful task in daily medical practice. Coffee is one of the chemically most complex consumables, and its physiologic effects are accordingly complex and to a great deal still unknown. Caffeine in moderate amounts has practically neither a negative effect on health nor does it promote pathogenesis of disease. Only excessive use may induce problems. Therefore, excessive use of caffeine is assumed in those persons, in which withdrawal is followed by withdrawal symptoms (41). Many aspects of caffeine and biomedical caffeine effects cannot yet be explained. Nevertheless, from the medical point of view, there are no objections to a moderate use of caffeine with one exception: if the coffee break is used as a pretext for smoking.

Arrhythmias, Cardiac↗

Monitoring of pesticide residues in fresh vegetables, fruits, and other selected food items in Belgium, 1991-1993.

To estimate the exposure of the Belgian population to food contaminated with pesticide residues and to determine what pesticides people are actually consuming, a total diet study-individual approach-was performed. Fourteen kinds of fruits, 22 kinds of vegetables, and 7 other food items (coffee, drinking water, rice, tea, wine, bran, and wheat flour) were selected as major representatives of the Belgian diet. During the 2 years of study (April 1991-March 1993), about 3,698 samples were analyzed and 21 163 analyses were performed. The first part of this study demonstrates that no residues are found in 31.3% of leafy vegetables, 72.3% of other vegetables, 51.4% of fruits, and 67.2% of other samples. In particular cases, some critical situations still exist, especially for leafy vegetables. Also, contamination of foreign samples is not easy to determine, because origins are not always traceable.

Belgium↗

Tea flavonoids may protect against atherosclerosis: the Rotterdam Study.

BACKGROUND: Epidemiological studies have indicated a protective role of dietary flavonoids in cardiovascular disease, but evidence is still conflicting. Tea is the major dietary source for flavonoids in Western populations. We studied the association of tea intake with aortic atherosclerosis in a general population. METHODS: The present analysis formed part of the Rotterdam Study, a prospective study of men and women 55 years and older. Dietary intakes were assessed at baseline by a trained dietician who used a semiquantitative food frequency questionnaire. Calcified plaques in the abdominal aorta were radiographically detected after 2 to 3 years of follow-up. Aortic atherosclerosis was classified as "mild," "moderate," or "severe," according to the length of the calcified area (<1 cm, 1-5 cm, and >5 cm, respectively). The association of tea intake with severity of aortic atherosclerosis was studied in 3454 subjects who were free of cardiovascular disease at baseline. Data were analyzed by logistic regression, adjusting for age, sex, body mass index (calculated as weight in kilograms divided by the square of height in meters), smoking, education, and intake of alcohol, coffee, vitamin antioxidants, total fat, and total energy. RESULTS: Multivariable analyses showed a significant, inverse association of tea intake with severe aortic atherosclerosis. Odds ratios decreased from 0.54 (95% confidence interval [CI], 0.32-0.92) for drinking 125 to 250 mL (1-2 cups) of tea to 0.31 (CI, 0.16-0.59) for drinking more than 500 mL/d (4 cups per day). The associations were stronger in women than in men. The association of tea intake with mild and moderate atherosclerosis was not statistically significant. CONCLUSION: This study indicates a protective effect of tea drinking against ischemic heart disease.

Arteriosclerosis↗

The effect of Mentha spicata Labiatae on uterine tissue in rats.

The plant Mentha spicata, or peppermint, is commonly used in the treatment of loss of appetite, common cold, bronchitis, sinusitis, fever, nausea and vomiting, and indigestion as a herbal agent. In this study, we aimed to investigate the biochemical and histological effects of M. spicata Labiatae, growing on the Anamas high plateau of Yenisarbademli town, on rat uterine tissue. Twenty female Wistar albino rats weighing 160+/-10 g were used for this study. Rats were divided into two groups of ten animals: group I received no herbal tea (control group) and group II received 20 g/L M. spicata tea. Control group rats were given commercial drinking water (Hayat DANONESA water). Herbal tea was prepared daily and provided at all times to the rats over 30 days as drinking water. Plasma malondialdehyde (MDA) levels were determined. In addition, uterine tissues were submitted for histopathologic examination. MDA levels were increased in group II when compared with the control group. The difference between group II and the control group was statistically significant (P<0.01). In the M. spicata Labiatae-treated group, histopathological changes like apoptosis and diffuse eosinophil leucocyte infiltration in surface and stromal glandular epithelium were observed in both endometrium and endocervix. It was concluded that lipid peroxidation and uterine damage occurs after M. spicata administration in rat uterus. Despite the beneficial effects of M. spicata Labiatae in indigestion, we should also be aware of the toxic effects when it is not used in the recommended fashion, at the recommended dose.

Animals↗

Effects of hunger state on flavour pleasantness conditioning at home: flavour-nutrient learning vs. flavour-flavour learning.

UNLABELLED: This study examined acquired liking of flavour preferences through flavour-flavour and flavour-nutrient learning under hungry or sated conditions in a naturalistic setting. Each participant consumed one of three versions of a test drink at home either before lunch or after lunch: minimally sweetened ( CONTROL: 3% sucrose, 40 kcal), artificially sweetened (3% sucrose 40 kcal plus artificial sweeteners ASPARTAME) and sucrose-sweetened (SUCROSE: 9.9% sugar, 132 kcal). The test drink was an uncarbonated peach-flavoured iced tea served in visually identical drink cans (330 ml). Participants preselected as "sweet likers" evaluated the minimally sweetened flavoured drink (conditioned stimulus, CS) in the same state (hungry or sated) in which they consumed the test drink at home. Overall, liking for the CS flavour increased in participants who consumed the SUCROSE drink, however, this increase in liking was significantly larger when tested and trained hungry than sated, consistent with a flavour-nutrient model. Overall increases in pleasantness for the CS flavour in participants who consumed the SUCROSE drink when sated or the ASPARTAME drink independent of hunger state, suggest that flavour-flavour learning also occurred. These results are discussed in light of current learning models of flavour preference.

Adult↗

[Bradycardiac atrial fibrillation after consuming herbal tea].

HISTORY AND CLINICAL FINDINGS: One day after drinking what she thought to be a tea made from borage leaves a 72-year-old woman developed nausea, vomiting and diarrhoea, later also flickering in her eyes and palpitations. She was in a good general state with a blood pressure of 120/75 mm Hg and an irregular heart rate of 52/min. Physical examination was otherwise unremarkable. She had not been on any medication. INVESTIGATIONS: The usual laboratory tests were normal. The electrocardiogram showed atrial fibrillation with a slow ventricular rate with pauses of up to 1.5s. intermittently type I and II 2 degrees AV block, and depressed concave ST segments. The level of digoxin was 3.93 ng/ml, that of digitoxin 133.5 ng/ml. TREATMENT AND COURSE: The patient's symptoms quickly improved under symptomatic treatment. Further questioning suggested that she had probably mistaken foxglove leaves for those of borage when picking them to make a brew. CONCLUSION: If cardiac arrhythmias have occurred after intake of self-picked herbal leaves one should consider digitalis intoxication resulting from misidentification.

Acute Disease↗

Unsafe abortions: methods used and characteristics of patients attending hospitals in Nairobi, Lima, and Manila.

Using quantitative and qualitative data, the authors present selected characteristics of 626 women who reported complications of induced abortion in five hospitals: one in Nairobi, two in Lima, and two in Manila. Although there are some similarities, the findings show some marked differences in demographic characteristics. In Nairobi nearly all respondents were single, nulliparous, and 25 years or younger; in Lima and Manila most were either married or in union, usually aged 25 years or older and had at least 1 child. There was evidence of repeat abortions, especially in Nairobi where 26% had had at least one previous abortion. Access to safe abortions is severely restricted and is obtained through a secret referral system. A list of potentially hazardous local abortifacients range from the drinking of strong Kenyan tea to dangerous practices such as insertion of sharp objects into the uterus or drinking chemicals and toxic substances.

Abortion, Illegal↗