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At least 505 records · Page 28Linked to original sources
PubMed2005

Substance-dependent women attending a de-addiction center in North India: sociodemographic and clinical profile.

BACKGROUND: Treatment-seeking is limited in women substance abusers. Studying the sociodemographic and clinical profile of treatment-seeking substance-dependent women can help us to understand the problem better and respond appropriately in terms of primary and secondary prevention strategies. AIM: To study the sociodemographic and clinical profile of women attending a de-addiction centre in North India. DESIGN AND METHODOLOGY: Retrospective structured chart review of 35 women substance abusers. RESULTS: The results indicated that a typical subject was urban (86%), married (63%), nuclear family (60%), based housewife (57%), educated up to school completion (54%), and having poor social support (57%). The common substances were opioids (60%), followed by alcohol (17%), and tobacco and benzodiazepines (11.5% each). The mean age at onset of substance use was 30.5 years, the mean duration of use was 9 years and mean duration to develop dependence was 5.5 years. The common reasons for initiating use were medical (63%) and curiosity (34%). Comorbidity profile was: physical illness (34%), psychiatric illness (23%) and dependence on another substance (14%). Only 20% had a family history of substance dependence. The social impairment ranged from 77% for social to 40% for financial and none for legal aspects. A typical subject had followed up 4.2 times in 8.4 months, while 54% were abstaining, 40% were continuing their substance dependence at the last follow up. CONCLUSIONS: The results suggest that the development of substance dependence in women is a combination of genetic, personal, and social vulnerability factors, including the drug culture of the social milieu and the poor social support. Comorbidity and impairment are common features.

Adult↗
PubMed1996

Establishing and using a community inter-agency client monitoring system to develop addictions treatment programs.

The Substance Abuse Monitor is a comprehensive community-based addictions information system that forms the basis for an innovative approach to community needs assessment. This paper describes: (1) the conditions that created the need and support for the monitoring system; (2) the community development strategy that was employed to secure the commitment of agencies to the project; (3) the specifics of the needs assessment procedures; (4) some of the theoretical, clinical and methodological issues on which the procedures are based; (5) the practical applications of the system; and (6) the limitations of the system. The establishment of the database was based upon the idea that there would be benefits at several levels: the community, the participating agencies, the individual counsellors and the clients. The realization of these benefits requires that the information collected and the results generated must be capable of addressing specific service delivery problems with practical and tangible solutions. It is argued that the project has been successful in generating such solutions, and has considerable potential as an ongoing needs assessment tool.

Adult↗
PubMedDate not supplied

[Nicotine addiction and current therapy of smoking cessation].

Nicotine is defined as substance which provokes addiction because it creates both physiological and biochemical modifications in the nervous system stimulating the activity of dopaminergic neurons releasing dopamine in the areas of the brain that control pleasure. In this paper, after a short overview of neurobiological and cellular mechanisms involved in the pathway of nicotine addiction, the main therapies, used in order to provide support to smokers who decide to reduce their cigarette consumption or to quit smoking, are examined. These therapies can be enclosed in the following categories: nicotine replacement therapy (NRT), non-nicotine pharmacological therapy (NNPT), psychological-behavioural therapies (PBT), alternative therapies (AT). In this work the advantages and disadvantages of various therapies are analysed, assessing the criteria found in literature. Results from randomised and controlled clinical studies which examine some of these therapies, alone or in association, also related to relapse time are reported. In conclusion, results of this analysis confirm that, as well as therapies and their treatment time, psychological support and personal motivation are indispensable for successful smoking cessation.

Adolescent↗
PubMed1992

[The efficiency of vestibular organs in persons addicted to opioids, barbiturates and volatile organic substances examined during the period of abstinence].

Opioids, barbiturates and volatile organic substances are the most common drugs used in Poland by addicts. In the literature there are no data concerning efficiency of vestibular organs of addicted persons examined during abstinence period. 74 drug addicts and 50 healthy persons were subjected to ENG examinations (spontaneous nystagmus, positional ny gaze ny, eye-tracking test, optokinetic test, rotatory test and caloric test were evaluated). ENG showed abnormal records in all tests performed in the addicted persons. This study has revealed that addicts have insufficiency of vestibular organs, which is probably a result of central lesions.

Adolescent↗
PubMed1991

[Analytical exploration of drug addiction].

The natural and synthetic substances most frequently leading to drug addiction are described. They include cannabis, opium and cocaine with their respective derivatives. The authors insist on the problems encountered by analytical chemists when they examine urine samples containing these substances, owing to their metabolic degradation and to interferences between lawful and unlawful drugs. The limitations imposed by these problems to an unambiguous interpretation of the results obtained are defined, but they do not throw any doubt on the value of these investigations.

Chromatography, Gas↗
PubMed2003

Addiction: a disease of volition caused by a cognitive impairment.

The common etiology of substance and behavioural addictions is one that suggests faulty volition caused by a cognitive impairment. A cognitive impairment that minimizes the recall of the negative effects of the addictive behaviour is viewed as necessary and causal to all addictions. The proposed definition for addiction clarifies the confusion associated with addictive disorders, explains the many variable presentations, and provides an explanation of comorbidity and treatment outcomes. In addition, this paper suggests why this process has not been previously identified.

Attitude↗
PubMed2006

Monitoring of alcohol and drugs under scrutiny: output and shortcomings.

A major focus of Dutch addiction policy is to improve the monitoring of substance use and addiction - which surveys and registrations are important for the monitoring of alcohol and drugs problems, and what information is generated or needs to be generated by these monitors? Three methods were used: an inventorisation of existing monitoring projects, a survey among experts in the field of alcohol and drugs to study the information needs, and a study on the output and shortcomings of the existing monitors. Sixty monitors and 13 'umbrella' monitors were found. Experts formulated the needs of 11 topics which were matched with the output of the monitors. Coverage of the nature and extent of use in general is good. Shortcomings apply to the use and accessibility of the monitors, as well as to their completeness, standardisation and content. Especially questions with respect to problem use, treatment demand/need of help and user careers cannot be answered sufficiently with the existing information.

Humans↗
PubMed1975

[Analysis of motivation in attempted suicides of sniffing addicts].

The authors examined a group of 30 addicts, each of whom had attempted a suicide, once at least, irrespective of the mode of performance. They analysed the motivation and the causes leading the adolescent addicts to suicidal attempts. The suicidal attempts were shown to occur under acute intoxication in 83.3 per cent of cases. Most frequently, the mode of the suicidal attempt was drastic, as e.g. cutting the antebrachial and the wrist veins in 56.6 per cent of cases. In 43.3 per cent of cases there occurred mild encephalopathies. A history of delinquent behaviour was recorded in 63.3 per cent of cases. Eighty per cent of the addicts originated from defective families or had other adverse social conditions. In 80 per cent addiction of psychotropic substances of more than one year duration was noted. Addiction of more than one drug was recorded in 90 per cent of cases. Most probably, volatile psychotropic substances act as "accelerators" in this connection, deteriorating the personality alterations of encephalopathic and psychopathic origin already present, thus conditioning the motivation of suicidal attempts. This finding may be of significance in aiding the forensic psychology and the medicolegal expertise of realized suicides.

Adolescent↗
PubMed2001

Onset and pattern of substance use in intravenous drug users of an opiate maintenance program.

OBJECTIVES: To assess the initiation of substance use of participants in an opiate maintenance program by a cross-sectional survey. METHOD: Participants (n=184) filled out a questionnaire assessing age at initial substance use and age at onset of regular drug use. RESULTS: Of 15 substances investigated, alcohol, nicotine, analgesics and marijuana were initiated and consumed regularly before the age of 18 years. Barbiturates, benzodiazepines, cocaine, and opiates were begun later. The time gap between initial and regular use varied depending on the substance. Regular use exceeded 50% for alcohol, benzodiazepines, cocaine, heroin, marijuana and nicotine. CONCLUSIONS: Specific knowledge about the age of onset and sequence of substances used by drug addicts may help to prevent substance use more age specifically.

Adult↗
PubMed1990

[Substitute drug-assisted treatment of drug dependent patients in general practice].

An evaluation carried out on 15. 12. 1989 of the treatment of drug addicts with substitute substances in my practice, confirms the palliative effect of a substitute substance reported in other countries. The mortality rate of substituted addicts is below that of untreated patients. Compliance with treatment using dihydrocodeine is lower than that seen with methadone, which, at least in part, is probably due to the fact that the patients have to pay for the substitute substance themselves. Voluntary acceptance of inpatient long-term treatment was 3% a year, and was thus better by a third in my patients as compared with untreated drug addicts.

Ambulatory Care↗
PubMed1994

Psychologic principles of substance abuse: a brief overview.

In this paper, a brief overview of the psychology of addictions was presented. It was emphasized that physicians should initiate treatment by first diagnosing their addicted patients with "substance dependence." This paper also emphasized the significance of relapse and relapse prevention, and a model of motivation and behavior change was presented. CT was described as a useful approach for understanding the psychology of addictions. And finally, the treatment of addictions was briefly discussed.

Cognitive Behavioral Therapy↗
PubMed1998

Screening for addiction in patients with chronic pain and "problematic" substance use: evaluation of a pilot assessment tool.

Assessing for the presence of addiction in the chronic pain patient receiving chronic opioid analgesia is a challenging clinical task. This paper presents a recently developed screening tool for addictive disease in chronic pain patients, and pilot efficacy data describing its ability to do so. In a small sample of patients (n = 52) referred from a multidisciplinary pain center for "problematic" medication use, responses to the screening questionnaire were compared between patients who met combined diagnostic criteria for a substance use disorder and those who did not, as assessed by a trained addiction medicine specialist. Responses of addicted patients significantly differed from those of nonaddicted patients on multiple screening items, with the two groups easily differentiated by total questionnaire score. Further, three key screening indicators were identified as excellent predictors for the presence of addictive disease in this sample of chronic pain patients.

Adult↗
PubMed1997

Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors.

Abnormalities in the dopaminergic reward pathways have frequently been implicated in substance abuse and addictive behaviors. Recent studies by Self and coworkers have suggested an important interaction between the dopamine D1 and D2 receptors in cocaine abuse. To test the hypothesis that the DRD1 gene might play a role in addictive behaviors we examined the alleles of the Dde I polymorphism in three independent groups of subjects with varying types of compulsive, addictive behaviors-Tourette syndrome probands, smokers and pathological gamblers. In all three groups there was a significant in the frequency of homozygosity for the DRD1 Dde I 1 or 2 alleles in subjects with addictive behaviors. The DRD1 11 or 22 genotype was present in 41.3% of 63 controls and 57.3% of 227 TS probands (P = 0.024). When 23 quantitative traits were examined by ANOVA those carrying the 11 genotype consistently had the highest scores. Based on these results, we examined the prevalence of the 11 genotype in controls, TS probands without a specific behavior, and TS probands with a specific behavior. There was a progressive, linear increase, significant at alpha < or = 0.005 for scores for gambling, alcohol use and compulsive shopping. Problems with three additional behaviors, drug use, compulsive eating and smoking were significant at alpha < or = 0.05. All six variables were related to addictive behaviors. In a totally separate group of controls and individuals attending a smoking cessation clinic, and smoking at least one pack per day, 39.3% of the controls versus 66.1% of the smokers carried the 11 or 22 genotype (P = 0.0002). In a third independent group of pathological gamblers, 55.8% carried the 11 or 22 genotype (P = 0.009 vs the combined controls). In the TS group and smokers there was a significant additive effect of the DRD1 and DRD2 genes. The results for both the DRD1 and DRD2 genes, which have opposing effects on cyclic AMP, were consistent with negative and positive heterosis, respectively. These results support a role for genetic variants of the DRD1 gene in some addictive behaviors, and an interaction of genetic variants at the DRD1 and DRD2 genes.

Adult↗
PubMed1996

[The hospital, a site for prevention? From prevention of drug dependence to general drug promotion].

1. Hospital centres should develop into pilot centres of health promotion. This would require hospitals to undergo a change in their self-awareness and self-understanding. The target groups of health prevention measures are the co-workers and staff, patients and hospital visitors. 2. Prevention of addiction should be integrated into an overall health promotion concept. 3. Prevention of addiction and dependence should cover all psychoactive substances, not only alcohol. Alcohol dependence prevention programmes should not be unhesitatingly transposed to drug medication and drugs causing addiction. 4. Primary prevention must focus on preventing addiction by measures that are person-related, workplace-related and employer-related, as well as on measures preventing that addictive substances are within easy reach of the patients.

Alcoholism↗
PubMedDate not supplied

Adolescent pregnancy and substance use.

OBJECTIVE: To review the literature on adolescent pregnancy and substance use for the purpose of identifying practice and research implications. DATA SOURCES: Computerized searches were done using MEDLINE and CINAHL, as well as references cited in the articles reviewed. Key words used in the search were adolescent pregnancy and substance use; teen pregnancy and substance abuse; adolescent risk behaviors; pregnant adolescent and drug addiction; and perinatal substance use. STUDY SELECTION: Articles and comprehensive works from indexed journals in the English language published after 1986 were reviewed. DATA EXTRACTION: Data were extracted and organized using these headings: motivation for drug use; common drugs used; cigarette smoking; alcohol; and other drugs. DATA SYNTHESIS: This review identifies factors associated with drug use in adolescent pregnancy, risk factors for the teenaged mother and her developing fetus, and suggestions of health care providers who have studied adolescent pregnancy and substance use. CONCLUSIONS: Nurses who care for pregnant adolescents are in an ideal position to assess for signs and symptoms of substance abuse, provide education, initiate interventions and referrals, and provide follow-up care. Early identification of substance abuse is a key factor in the prevention of pregnancy complications and poor fetal outcome.

Adolescent↗
PubMedDate not supplied

Rapid detox: understanding new treatment approaches for the addicted patient.

TOPIC: Despite substantive advances in understanding of genetic and biochemical basis of substance abuse and addiction in the last decade, little information has been translated into alternative treatment models for the addicted patient. Rapid detox, an alternative form of detox treatment, is gaining in both acceptance and popularity. PURPOSE: To increase readers' understanding of the neurobiology of addiction and the mode of action of new detox approaches for patients addicted to opiate drugs. SOURCES: A review of the current literature pertaining to rapid detox. CONCLUSIONS: Rapid detox is a viable alternative for selected patients attempting to detox from opiate agents of abuse. Increasing knowledge of new treatment approaches allows nurses working to assist addicted patients in planning and receiving treatment based on new awareness of the neurobiology of addiction.

Anesthesia, General↗
PubMed2000

Motivations for use of opiates among addicts seeking treatment in Shiraz.

This study assessed the characteristics and motivation for substance use among addicts referred to the Shiraz Self-identified Center, an out-patient treatment facility. Data were gathered by a semistructured interview from 306 consecutive addicts seeking treatment and referred from July to September, 1998. Their mean age was 37 yr., and the majority (73.9%) were married. Of these addicts, 28.4% were workers, 13.4% drivers, and 11.4% were unemployed. Modeling or social pressure (43.1%) was identified as the first and enjoyment (fun) was the second most common reason given for opiate use. The majority (97.1%) used opium and 71.9% used alcohol; however, only 2.6% reported current use of alcohol. Other subjects were current users of cigarettes (72.2%), opium (67%), heroin (35%), hashish (2%), hallucinogens (0.3%), and cocaine (0.3%). The most common reason given for currently using opiates was habit (56.5%). About 36% of the subjects reported that they had frequently used opiates for more than a decade. These findings are quite different from those carried out in the West, although there is some overlap. Cultural attitudes toward drug use likely affect the types and amount of use.

Adolescent↗