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PubMed2001

Simple office spirometry.

Spirometric measurements are as fundamental to medicine as are measurements of pulse, blood pressure, temperature, height, and weight. Spirometric measurements should be considered important vital signs. Any deviations from "normal" measurements can point primary care physicians toward the use of behavioral modification or effective pharmacologic agents to prevent or forestall their patients' premature morbidity and mortality from many disease states, including premature deaths from all causes.

Forced Expiratory Volume↗
PubMed1984

[So-called pocket-sized spirometry versus respiratory function tests: a comparative study of vital capacity, forced expiratory volume in 1 second and Tiffeneau's coefficient].

A simplified preoperative respiratory assessment was carried out in order to assess the reliability of a pocket-sized spirometer. 30 patients were each tested using two methods: 1) the traditional extensive laboratory lung function tests and 2) a bedside test using a pocket-sized spirometer, which measured the vital capacity (VC), the forced expiratory volume in 1 second (FEV1), the peak flow (PEF) and the ratio of FEV1 to VC. The correlation between the two series of VC and FEV1 measurements was highly significant (p less than 0.001). Therefore, these two parameters could be considered as reliable when testing was performed at the bedside. However, the sensitivity of the FEV1/VC ratio was decreased; in three of the patients, the significance of this third parameter was not the same with the two methods. Measurements of peak flow were only collected at the bedside, and a statistical comparison was not established. Analysis of this last parameter always allowed us to confirm or not an obstructive syndrome when the values of FEV1 or FEV1/VC were in disagreement. The pocket-sized spirometer would seem to be a simple and reliable means of diagnosing respiratory insufficiency, its type (obstructive or restrictive) and its seriousness.

Aged↗
PubMed1996

A long-term study of symptoms, spirometry and survival amongst home nebulizer users.

Although home nebulizers are widely used to deliver bronchodilator medication to patients with asthma and chronic obstructive pulmonary disease (COPD), the long-term benefits and hazards are unknown. The present authors have previously reported a prospective 12-month study of home nebulizer use involving 49 patients (15 asthma, mean forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) 1.3/2.1 1; 34 COPD, mean FEV1/FVC 0.7/1.8 1). Thirty-two of these patients were treated with long-term domiciliary nebulized bronchodilator treatment, the other 17 patients chose metered dose inhaler (MDI) therapy. The present paper reports the progress of these patients over 5 yr. Five-year survival was similar in both groups (nebulizer users 56%, MDI users 53%). Most deaths were due to respiratory failure (14 deaths) or lung cancer (four deaths). Survival was determined mainly by FEV1 (R = 0.54, P = 0.0001) and age (R = -0.47, P = 0.0007). Laboratory lung function tests (16 nebulizer users) showed that FEV1 and FVC were still higher than pre-nebulizer baseline measurements after 36 months of nebulizer use, but PEFR had fallen by 7%. Twenty-one of 23 surviving nebulizer users completed a questionnaire after 36 months of treatment. All used their nebulizer at least once per day and 20 of 21 patients reported that they still obtained full benefit from each nebulized treatment. The morning peak flow response to nebulized treatment was the same at baseline and at 36 months (48 1 min-1). All patients remained breathless (mean subjective score 4.8 on seven-point scale) but the subjective response to nebulized treatment was unchanged at 36 months. Tachyphylaxis did not develop among 13 patients who underwent repeated reversibility studies using 200 micrograms of salbutamol at 6, 12 and 36 months. It is concluded that home nebulizer therapy is safe and effective for a small number of carefully selected patients with severe asthma or COPD, who have been evaluated by a rigorous home nebulizer assessment protocol prior to commencing home nebulizer therapy.

Adult↗
PubMed1999

Agreement between spirometry and tracheal auscultation in assessing bronchial responsiveness in asthmatic children.

We have recently found that changes in lung sounds correspond well with a 20% fall in the forced expiratory volume in 1 s (FEV1) after methacholine challenge in asthmatic children. Up to now, little was known about the agreement between a 20% fall in FEV1 and a change in lung sounds after repeated bronchial challenge. In this study we investigated the agreement between the total cumulative histamine dose causing a fall in FEV1 of 20% or more (PD20) and the detection of a change in lung sounds (PDlung sounds) after two bronchial challenges on different occasions in asthmatic children. Fifteen asthmatic children (nine boys), mean age 10.8 years (range 9-15), were studied. All performed two histamine challenge tests on 2 days, with a 24 h to 1 week interval. Lung sounds were recorded over the trachea for 1 min and stored on tape. Lung sounds were analysed directly and also scored from the tape-recording by a blinded second investigator. Wheeze, cough, and an increase in respiratory rate were assessed. The relationship between PD20 and PDlung sounds was calculated by Bland and Altman's measurement of agreement. Eleven children had a positive challenge test (PD20 < or = 16.0 mg ml-1) on both test days; four had a positive challenge on one test day. In 24 out of 26 positive challenges, wheeze, cough, prolonged expiration and/or increased respiratory rate were detected one dose-step before, or at the dose-step of histamine that induced a fall in FEV1 of 20% or more. In two challenges, PD20 was not detected by a change in lung sounds. In four out of four negative challenges (PD20 > 16.0 mg ml-1) no change in lung sounds could be detected. Good agreement between the logarithm of PD20 and the logarithm of PDlung sounds was found on both test days. The mean difference was 0.04 and the limits of agreement (d +/- 2 SD of the differences) were 0.04 +/- 0.41. A good agreement was found between the total cumulative histamine dose causing a fall in FEV1 of 20% or more and the detection of a change in lung sounds after two bronchial challenges on different occasions in asthmatic children.

Adolescent↗
PubMed2002

Spirometry values in Himalayan high altitude residents (Sherpas).

We compared the spirometric values of the isolated racial group of Himalayan Sherpas with those predicted for the European Coal and Steel Community (EC&S). 146 normal adult Sherpas (64 males, 82 females) and 103 adolescents (37 females and 66 males, age 10-18 years) resident at an altitude of 3,840 m were studied. Predicted values for each adult individual were calculated using the EC&S reference equations and separate Caucasian values for children were used, and new predictive equations for the Sherpa population derived. The FEV(1) of boys, adult male and female Sherpas are all significantly greater than predicted (% Predicted (PP) (95% Confidence Interval (CI)), 113% (110-116), 110% (107-114) and 116% (112-121), P < 0.0001 for all groups) as is forced vital capacity (FVC) (112% (111-119), 113% (109-117) and 121% (117-125) respectively, P < 0.0001 for all groups). Sherpa girls displayed a smaller difference in FEV(1) and FVC (PP(CI), 104% (99-109) P<0.1 and 108% (103-114) P = 0.005, respectively). We conclude that the Sherpa race has significantly larger spirometric values than Caucasians. We speculate that this is an adaptation in response to chronic hypoxia and high levels of habitual exercise.

Adaptation, Physiological↗
PubMed2002

[Stability of lung function parameters: spirometry, body plethysmography and mouth occlusion pressure (p0.1)].

Spirometric, bodyplethysmographic and mouth occlusion results of 9 healthy probands were measured 9 - 11 times over a total of 28 - 39 days. Interindividual predicted values based on large studies show SDs of +/- 20 %, which is not acceptable for the judgement of individual values. Individual values are much less scattered (SD +/- 10 %). Each test person showed a differing individual range of 75 - 140 %. Functional basic facts can be derived from the different levels of individual values. Early changes in the individual range are of special interest. For the evaluation of individual results the earliest possible basic values are of importance.

Adolescent↗
PubMed1998

[Value of spirometry-gated high resolution computerized tomography of the lung during inspiration and expiration].

PURPOSE: To compare mean lung density (MLD) of paired inspiratory and expiratory thin-section CT scans acquired after patient instruction or using spirometric gating. MATERIALS AND METHODS: 21 patients (13 m, 8 f. median age 59 years, two with normal lung function, 15 with obstructive, 4 with restrictive impairment) underwent thin-section CT. Paired inspiratory and expiratory scans were performed in the upper, middle and lower lung fields. They were acquired after automatic patient instruction with constant intervals between instruction and scan. Spirometrically gated scans were acquired within 4 days at 80% and 20% of vital capacity (VC) which has been determined on the CT scanner in supine position directly prior to the examination using the built-in spirometric option. Semiautomatic segmentation of the lung was performed and MLD was calculated. VC of pulmonary function testing was available for correlation. RESULTS: Inspiratory MLD was -828 +/- 71 HU with spirometric gating and -818 +/- 87 HU without. Expiratory MLD was -750 +/- 119 HU (increase 78 +/- 58 HU) with spirometric gating and -748 +/- 119 HU (increase 70 +/- 46 HU) without. All differences were non-significant. Intraindividual differences were 10 +/- 21 HU for inspiration and 2 +/- 36 HU for expiration. VC under CT-conditions was significantly smaller than that known from pulmonary function tests (1.9 +/- 0.71 vs. 2.7 +/- 0.81, p < 0.005). CONCLUSION: Spirometric gating does not lead to different results for MLD as compared with acquisition of paired inspiratory and expiratory thin-section CT after automatic patient instruction.

Absorptiometry, Photon↗