Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Sexual Development”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 505 records · Page 28Linked to original sources
PubMed1989

Urinary immunoreactive androgen levels during sexual development in the male tree-shrew (Tupaia belangeri).

1. Immunoreactive androgens were measured in the urine of individual male tree-shrews throughout post-natal development. 2. Urinary androgens were low during the infantile phase and then rose significantly between the 36-45 and 46-55 day age groups, in association with the onset of pubertal development. 3. Androgen excretion increased linearly during the pubertal period in parallel with the progressive development of the testes and reproductive tract. 4. The precise endocrine correlates established in the present work suggest that serial determination of urinary androgens provides a reliable method of monitoring male reproductive development which may be applied to small, sensitive species.

Aging↗
PubMed1990

[Delay in sexual development secondary to juvenile nasopharyngeal angiofibroma].

The angiofibroma of the nasopharynx is a benign tumor, sitting in the epipharynx of adolescents, but considered malignant owing to its local spreading power. Aside from the characteristics symptoms -nose bleeding and nasal obstruction- the A. of the paper has signaled a certain delay in the secondary sexual maturity of 2 of the 6 youth in all studied. In these 2 the tumor was detected at 9 and 12 years-of-age, respectively. Furthermore, these 2, showed destruction of inner structures of the nose when surgery was undertaken; adversely the other 4 showed normal inner nasal structures. The whole group was followed up for ten years, and only those 2 needed a treatment with chorionic gonadotrophin for the completeness of secondary sexual aspects.

Adolescent↗
PubMed1995

Involvement of N-methyl-D-aspartate receptor using excitatory amino acid neurotransmitters in control of pulsatile secretion of LH during sexual development in Holstein bull calves.

The neuroendocrine mechanisms underlying the development of pulsatile release of LH in bull calves are poorly understood. The hypothesis that endogenous excitatory amino acids, working through N-methyl-D-aspartate (NMDA) receptors, are involved in the generation of pulsatile LH release during sexual maturation of bull calves was tested. Holstein bull calves were administered i.v. 0.001, 0.01 and 0.1 mg kg-1 body mass of MK-801, a specific noncompetitive NMDA receptor antagonist, on alternate days at 1, 12 and 24 weeks of age (n = 6 per dose), using a replicated 3 x 3 latin square design. Blood samples were obtained from jugular catheters at intervals of 10 min for 2 h before and 2 h after MK-801 treatment at 1 week and for periods of 4 h before and after MK-801 administration at 12 and 24 weeks of age. Plasma concentrations of LH were measured by a specific radioimmunoassay and pulsatile LH secretion was analysed using the Pulsar algorithm. Basal LH secretion at 1 week of age was low but was increased by 12 weeks (0.38 +/- 0.01 versus 1.38 +/- 0.11 ng ml-1; P < 0.001) with the establishment of frequent high amplitude pulses. Mean LH concentrations and pulse amplitude, but not frequency, were lower at 24 than at 12 weeks of age (0.88 +/- 0.08 versus 1.38 +/- 0.11 ng ml-1: P < 0.001, 1.74 +/- 0.14 versus 2.82 +/- 0.36 ng ml-1: P < 0.01, and 1.70 +/- 0.30 versus 1.70 +/- 0.41 in 4 h: P > 0.05, respectively). Administration of MK-801 did not affect LH secretion in 1- and 12-week-old calves.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed2003

Puberty, sexual development and eating disorders in adolescent outpatients.

This study examined puberty and psychosexual state in a clinical sample of adolescents attending for assessment because of eating disorders (ED). A total of 57 adolescents (girls) aged 14-21 years (mean age 16.9 years) having either anorexia nervosa (AN) or bulimia nervosa (BN) were studied by semi-structured interviews and structured self-report questionnaires considering the timing of menarche, dating and attitudes to sexuality. The age at menarche did not differ statistically significantly between AN and BN. It was significantly lower in the BN group than in the normal population, but no statistically significant difference was found between the AN group and normal population. The general attitudes to sexuality were more negative in the AN group than in the BN group. In the AN group, there were also fewer dating experiences and interest in dating than in the BN group. After controlling for the effect of age, age at menarche and duration of ED, negative attitudes to sexuality and no dating experiences were still best predicted by AN. The results suggest different ways of coping with the developmental challenges in sexuality in AN and BN during adolescence.

Adolescent↗
PubMed2003

[Effects of valproate on sexual development].

INTRODUCTION: Valproate use in young girls has been associated with the adverse endocrinological effects of weight gain and hyperandrogenism. Furthermore, polycystic ovaries and hyperinsulinism have been described in adult women. In men and young boys, however, the possible adverse endocrinological effects of valproate have scarcely been analyzed. OBJECTIVES: The aim of this study was to evaluate the effects of valproate treatment on pubertal development, especially the possible hyperandrogenic effects, in girls and boys with epilepsy. MATERIAL AND METHODS: Twenty-three girls and 15 boys (aged 8-16 years old) who were undergoing valproate treatment for epilepsy were compared with 15 control girls and 10 control boys of the same age range. Anthropometric indexes, sexual maturation, and hirsutism scores were evaluated. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, androstenedione, dehydroepiandrosterone, estradiol, and insulin were measured. Ultrasound examination of ovaries and estimation of bone age through X-ray of the left hand were also performed. RESULTS: Valproate did not affect pubertal development in the study group. No hirsutism or polycystic ovaries were found. Increases in weight, relative weight, and body mass index were observed in the group undergoing valproate treatment, but no statistically significant differences compared with the control group were found. Plasma testosterone was higher in valproate-treated girls (0.71 0.51 ng/ml) than in control girls (0.35 0.15) (p 0.001). This finding was independent of valproate dose and treatment duration. Hyperandrogenism was not found in valproate-treated boys. CONCLUSIONS: Valproate may induce hyperandrogenism in epileptic girls but not in boys. This is an early adverse effect and is independent of the dose used. No changes in normal pubertal development or physical repercussions were found in epileptic patients.

Age Determination by Skeleton↗
PubMed2004

Socio-cultural influences on young people's sexual development.

Emerging evidence indicates that the mechanisms that create health (or ill health) at the population level exist at the intersection between the individual and more "upstream" forces that shape our social contexts. To investigate this proposition, we collected detailed descriptions of youth's perceptions about the socio-cultural and other structural aspects of their contexts that shape their sexual behaviour patterns, and ultimately their health outcomes. In this paper, we examine how social context shaped experiences and perceptions pertaining to sexual behaviour among 18-24 year olds living in two Canadian communities (one rural and one urban). We investigate explanations for the struggle that youth engage in as they attempt to situate their emergent sexual behaviour patterns within community, family, peer, and broader social contexts. Two central processes appeared to be important to the experiences of youth in the current study and their recollections about their adolescent sexual experiences. These processes are embedded in social norms and structures and are directed at pathologizing sex and silencing meaningful discussion about sex. Together, they interact to create a climate of sex-based shame. The findings of this qualitative study add to previous sociological and feminist research that has also demonstrated how traditional approaches to understanding youth sexual behaviour tend to ignore or discount the "embeddedness" of young people in their social structures and contexts.

Adolescent↗
PubMed2000

Characterization of the period of sensitivity of fetal male sexual development to vinclozolin.

Vinclozolin is a fungicide whose metabolites are androgen receptor (AR) antagonists. Previous work in our laboratory showed that perinatal administration of vinclozolin to rats results in malformations of the external genitalia, permanent nipples, reduced anogenital distance (AGD), and reduced seminal vesicle, ventral prostate, and epididymal weights. The objectives of this study were to determine the most sensitive period of fetal development to antiandrogenic effects of vinclozolin and to identify a dosing regime that would induce malformations in all of the male offspring. Pregnant rats were dosed with 400 mg vinclozolin/kg/day on either GD 12-13, GD 14-15, GD 16-17, GD 18-19, or GD 20-21, or with corn oil (2.5 ml/kg) from GD 12 through GD 21 (Experiment 1). All 2-day periods in which significant effects were produced were included in an extended dosing period, GD 14 through GD 19, in which pregnant rats were dosed with 200 or 400 mg vinclozolin/kg (Experiment 2). In Experiment 1, significant effects of vinclozolin were observed in rats dosed on gestation days (GD) 14-15, GD 16-17, and GD 18-19, while the most significant effects were observed in rats treated on GD 16-17. These effects include reduced AGD; presence of areolas, nipples, and malformations of the phallus; and reduced levator ani/bulbocavernosus weight. In contrast, ventral prostate weight was reduced only in the GD 18-19 group. The expanded dosing regime (Experiment 2) increased the percentage of male offspring with genital malformations (> 92%), and retained nipples (100%), further reduced the weight of the ventral prostate, and reduced the weight of the seminal vesicles. In addition, malformations were more severe and included vaginal pouch and ectopic/undescended testes. The latter was induced only in the 400 mg/kg group. These data indicate that the reproductive system of the fetal male rat is most sensitive to antiandrogenic effects of vinclozolin on GD 16 and 17, although effects are more severe and 100 % of male offspring are affected with administration of vinclozolin from GD 14 through GD 19.

Androgen Antagonists↗
PubMed1977

[Sexual development of boys, treated surgically for dystopia of testicles (author's transl)].

A clinical follow-up examination was made in a group of 208 children and adolescents who had undergone surgical treatment for congenital cryptorchid testis (unilateral or bilateral) between 2 and 10 years before. The puberal growth and maturing process of the primary and secondary sex characteristics of this morbidity group was compared to that of normal juveniles. The examination was made according to clinical criteria: length and circumference of the penis, volume of testes, general development of the genitals, pubic hair. Compared to normal juveniles, the genital development of the children and adolescents of the follow-up examinations series was retarded.

Adolescent↗
PubMed2000

Cloning and expression studies during vegetative and sexual development of Pbs1, a septin gene homologue from Pyrenopeziza brassicae.

A septin gene homologue designated Pyrenopeziza brassicae septin 1 (Pbs1) has been identified and cloned from the plant pathogenic fungus Pyrenopeziza brassicae and its expression analysed. Pbs1 is present in both mating types and in a single copy within each genome and is transcribed in proportionate levels during both vegetative and sexual growth.

Amino Acid Sequence↗