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494 records · Page 28Linked to original sources
PubMed1994

[Cataract extraction and intraocular lens implantation in patients with uveitis].

Thirty two patients with uveitis had a posterior chamber intraocular lens implantation after extracapsular cataract extraction. After a mean follow-up period of 5.4 months (range 3 to 29 months), the corrected visual acuity in 93.7% of the patients reached to 0.5 or better. Postoperative complications included posterior capsule opacification and iris posterior synechiae. The results suggest that careful selection of candidates for IOL implantation be crucial for successful cataract surgery in uveitis patients.

Adolescent↗
PubMed1993

[Humoral and cellular immune responses to retinal S-antigen in uveitis patients].

Humoral and cellular immune responses to purified S-Ag were determined in 73 patients with anterior-, intermediate- and pan-uveitis and in 55 healthy subjects by ELISA and leucocyte migration inhibition test. The positive rates of humoral immune response to S-Ag in patients and controls were comparable; however, the positive rate of cellular immune response to S-Ag in the patients (54.6%) was significantly higher than that in the controls (3.3%), and that in pan-uveitis patients (69.4%) was significantly higher than in patients with anterior uveitis (15.4%), highly suggesting that the cellular immune response to S-Ag was involved in the onset of uveitis, especially when the choroid and retina were affected. The breakdown of anterior chamber associated immune deviation and abnormal expression of intraocular MHC-II antigens may contribute to the development of cellular immune response. More studies are needed.

Adolescent↗
PubMed1995

Lymphocyte proliferation response to S antigen in patients with uveitis and optic neuritis.

PURPOSE: To evaluate the autoimmunity which may play a major role in the etiology of certain forms of uveitis and optic neuritis. METHODS: Lymphocyte proliferation response to retinal soluble antigen in vitro by incorporation 3H-thymidine with DNA was tested in 115 patients with anterior uveitis, posterior/pan-uveitis, optic neuritis, and 50 volunteers with unrelated diseases such as congenital ptosis, strabismus, or completely healthy persons as control. RESULTS: The positive rate of lymphocyte stimulation was 34% (18/53) in anterior uveitis, 41.5% (17/41) in posterior/pan-uveitis, and 57.1% (12/21) in optic neuritis. The results in the experimental groups were significantly different from those of the control group (X2 = 14.76, P < 0.05, x2 = 19.14, P < 0.005, x2 = 26.38, P < 0.005, respectively). CONCLUSION: The autoimmunity plays a role in the pathogenesis in certain forms of uveitis and optic neuritis. Such immune responses may be secondary to the exposition or release of retinal antigens by various causes, leading to activation or augmentation of meager or low-affinity S antigen specific lymphocytes which may pre-exist in the circulation and starting the pathogenic autoimmune process.

Adolescent↗
PubMed1996

Identification, quantitation, and purification of a 36 kDa circulating protein associated with active pars planitis.

PURPOSE: To establish a correlation between the presence of a 36 kDa protein in the blood of patients with pars planitis and to characterize and purify this protein. METHODS: Blood samples were obtained from patients with pars planitis and other types of uveitis and from various controls. Samples were treated with polyethelene glycol and protein A and were analyzed on 10% SDS-PAGE for the presence of a 36 kDa protein. Quantitative estimation of the level of this protein was determined by densitometric tracing of the stained gels. Polyclonal antibodies were raised by immunizing New Zealand White rabbits with a mixture of the gel fragment containing the 36 kDa protein (p-36) and complete Freund's adjuvant. These antibodies were used in the immunoaffinity purification of this protein. RESULTS: The levels of p-36 were sixfold to eightfold higher in 81% of the patients with active pars planitis than in controls (P < 0.05). Furthermore, the levels of this protein correlated with disease activity. A partial amino terminal sequence analysis revealed that p-36 may be a novel protein. It has been purified from the patient's blood using affinity chromatography. CONCLUSIONS: A 36 kDa protein (p-36) is found in elevated concentrations in the blood of many patients with active pars planitis. Its putative role in the etiopathogenesis of pars planitis is unknown.

Amino Acid Sequence↗
PubMed1996

[Intravenous corticosteroid megadose treatment in ocular Behçet disease].

Ocular Behçet's disease is characterized by a very poor visual prognosis. Twelve patients which had a maintenance treatment with immunosuppressors received 30 intravenous i.v. bolus of corticoids for uncontrolled severe retinal vasculitis (macular edema 58% of cases) and papillitis (100% of cases) (1 bolus treatment = 0.5-2 g of i.v. methylprednisolone once a day, for 3 days). In addition, oral immunosuppression was moderately increased in order to prevent further recurrences. Tolerance was good in all cases. Visual acuity (VA) remained stable or improved after one month in 87% of cases following the bolus treatment. In 92%, the VA remained stable or improved for a mean follow-up of 6 years. These good results suggest that intravenous bolus of steroids is a safe and efficient therapy which may prevent further decrease of the visual acuity and may reduce the side effects of the immunosuppressive treatment needed to control severe posterior uveitis in Behçet's disease.

Adult↗