[CIRCULATION OF PENICILLIN AND TETRACYCLINE IN THE RABBIT ORGANISM FOLLOWING THEIR ADMINISTRATION SIMULTANEOUSLY WITH CORTICOSTEROID HORMONES].
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A new occlusive X-Ray opaque antibacterial substance of biological origin was experimented on rats and dogs. The substance was administered intraperitoneally, intrahepatically and on the soft tissues of the limbs. Morphological studies conducted showed accumulation of macrophages.
Our study showed that synthetic glucocorticoids are potent mediators of vWF-reactivity in rat fetal placental, liver and lung vascular elements. However, it is not yet possible to draw final conclusions from these results obtained only by immunohistochemical studies using antibody against vWF, since the mechanisms in factor VIII/vWF are highly complex. Further investigations for example with anti-vW AgII and measurements of blood vWF levels after treatment with synthetic glucocorticoids may deliver more insight into the mechanisms of action of these drugs. Investigations after treatment of pregnant rats with methylprednisolone might help, in addition, to find out whether the increased vWF-reactivity in caused by special substituents in the steran ring of the glucocorticoids.
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