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PubMedDate not supplied

[The methodology for the rapid experimental validation of hygienic standards for xenobiotics in different environments (2)].

Based on standards set up in the 1990s correlation and regression analyses were performed of relationship between maximum permissible concentration (MPC) of xenobiotics in the air of the working environment and their MPCs in the atmospheric air, water bodies (with these being recognized as health hazard from hygienic-and-toxicological standpoints) or allowable diurnal dose. Highly reliable equations of regression were obtained that rely on preliminary determination of safe level of exposure in the air of the working environment and oral-and-inhalation coefficient on the level of standards set up by results of acute and subacute experiments.

Air Pollutants, Occupational↗
PubMed1996

[Toxicologic evaluation of pyrethroids in indoor air: demonstrated with the example of cyfluthrin and permethrin].

Pyrethroids have varying activities depending on vehicle or route of administration (oral, dermal, inhalational). Specific features like the sensory irritation potential of the alpha-cyano-pyrethroids on the respiratory tract can only be quantified adequately by inhalation testing. Thus equitoxic dosages can vary between inhalative and oral application, especially for alpha-cyano-pyrethrolds. The no-effect values for chronic exposures derived for permethrin (type I pyrethroid) and cyfluthrin (type II pyrethroid) show clearly, that each pyrethroid has to be considered as an individual substance toxicologically, and that any extrapolation from the oral to the inhalative route should only be done after a thorough assessment of the specific toxicological profile. The study of simulated pest control measures on carpets pretreated with permethrin showed, that no significant enrichment of permethrin in total dust could be seen from a carpet additionally treated with pyrethroids. The missing correlation between absolute (mg pyrethroid/m3 air) and relative (mg pyrethroid/kg dust) concentrations in air-borne dust as well as the low degree of translocation of pyrethroids from carpets (only about 0.044% x m(-2) x h(-1) of the cyfluthrin applied to the carpet can be regarded as possibly respirable) prove, that analyses of pyrethroids in household sedimented dust ("vacuum cleaner bag analyses") without knowing the absolute surface concentration and respective air concentrations are of little value for risk assessment. The data allow the conclusion, that a scientific assessment of health risks is only possible based on absolute concentrations of pyrethroids in indoor air.

Air Pollution, Indoor↗
PubMed1984

[Evaluation of the degree of protection provided by a cartridge-mask system during working with asbestos].

During removal of sprayed-on asbestos coating workers are exposed to high airborne fiber concentrations. The true protection of negative pressure respirators under working conditions was evaluated during an asbestos abatement project. A modification allowing air sampling inside the mask is described. The values for samples collected inside a full-face mask ranged between 0.4 and 5% of the concentrations measured outside. These values were considerably lower than those found inside a half-mask.

Asbestos↗