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Three-dimensional sonographic determination of normal fetal mandibular and maxillary size during the second half of pregnancy.

OBJECTIVE: To explore the various ways of obtaining fetal maxillary and mandibular size with three-dimensional (3D) ultrasound, with a view to developing a tool for identifying minor anomalies in the lower facial region. METHODS: Serial 3D sonographic measurements of the fetal jaws were made in 126 normal singleton pregnancies at 18-34 weeks of gestation for determination of degree of maxillary and mandibular protrusion, maxillary and mandibular corpus lengths, mid- and lower facial depths and maxillary and mandibular curvature. In a sub study the reproducibility of the measurements was evaluated. RESULTS: The coefficient of variation in the reproducibility study varied between 7.1 and 10.5%. For all parameters except maxillary and mandibular protrusion, there was a significant gestational age-related increase. Ratios of maxillary/mandibular protrusion, maxillary/mandibular corpus lengths, mid-/lower facial depths and maxillary/mandibular curvature all showed a significant gestational age-related decrease, with the most distinct decrease in the mid-/lower facial depth ratio. CONCLUSIONS: 3D sonographic measurement of the fetal maxilla and mandible demonstrated an acceptable intraobserver variability for all measurements. The mid-/lower facial depth ratio appears to be most valuable in determining abnormal mandibular development.

Adult↗

Treating Class II patients with removable plates and functional orthopedic appliances-the importance of anterior tooth inclination and direction of growth on treatment outcome.

OBJECTIVE: To determine the influence of physiological growth pattern and anterior tooth inclination on the outcome in Class II patients treated with removable orthodontic plates and functional orthodontic appliances. PATIENTS AND METHODS: After recruiting 50 patients with an upper anterior proclination of 1-SN >or= 107 degrees for this retrospective study, another 50 patients with a retroclination of 1-SN <or= 95 degrees were also included. All patients initially presented a skeletal Class II relationship with a distoclusion of at least one premolar width in the region of the first molars. All patients were evaluated separately by gender and additionally subdivided into three subgroups with a horizontal, neutral, or vertical craniofacial configuration. Treatment with removable orthodontic plates (pretreatment) and functional orthodontic appliances was initiated in mixed dentition. Pre- and post-treatment lateral cephalograms were evaluated for each patient. RESULTS: Dento-alveolar analysis showed that the inclination of the upper incisors changed in the direction of the clinical standard value independent of the craniofacial configuration, although full correction using removable orthodontic plates and functional orthodontic appliances was not always achieved. Similarly good treatment outcomes were achieved with regard to overjet and overbite. The lower incisors of all patients were in proclination after treatment. The ANB angle was reduced in both groups. Nevertheless, on average a skeletal Class II persisted in the Class II, Division 2 patients, while Class II, Division 1 patients with horizontal craniofacial configurations attained skeletal Class I. CONCLUSIONS: Treatment of Class II patients with removable appliances resulted in differences depending on anterior tooth inclination (Class II, Division 1 and II, Division 2) and craniofacial configuration. These differences must be taken into account during treatment planning. Complete treatment success with regard to sagittal jaw balance is very difficult to achieve with removable orthodontic plates (pre-treatment) and functional orthodontic appliances alone in Class II, Division 1 cases with a vertical craniofacial configuration and generally in Class II, Division 2 cases. A particularly favorable constellation for removable treatment is a Class II, Division 1 situation with a horizontal craniofacial configuration and retroclined or orthognathic mandibular anteriors.

Bone Development↗

Growth of mandibular prognathism after pubertal growth peak.

This study deals with the growth changes of the Japanese face associated with mandibular prognathism during 3 years after the pubertal growth peak. The investigation was based on the serial lateral cephalometric roentgenograms of prognathic and normal males and females, respectively. Maturational stages of the pubertal growth were determined individually by the ossification events taken from hand-wrist radiographs. Results indicate that the morphologic characteristics of the mandibular prognathism, which are established before the pubertal growth peak, are strongly maintained during the period studied. However, mandibular prognathism seems to show a manner of growth change fairly similar to that of the normal after the pubertal growth peak.

Adolescent↗

Skeletal maturation evaluation using cervical vertebrae.

Lateral cephalometric and left hand-wrist radiographs from the Bolton-Brush Growth Center at Case Western Reserve University were reviewed a posteriori to develop a cervical vertebrae maturation index (CVMI). By using the lateral profiles of the second, third and fourth cervical vertebrae, it was possible to develop a reliable ranking of patients according to the potential for future adolescent growth potential.

Adolescent↗

Interpretation of the vertical and longitudinal growth of the human skull.

Our model describes asymptotic growth as a time-dependent process which expresses a quantitative change in individual morphological factors. The development and growth of the face are intimately connected with the cranial base, which undergoes only minor changes between the ages of 0 to 25 years. The difference in growth of the neuro- and viscerocranium is evident in that the dimensions and angles of the viscerocranium undergo greater changes than those of the neurocranium. The anterior cranial base lengthens until the end of normal growth via bone apposition at the nasion. This elongates the cranial base. The nasion influences the sagittal maxillary relationships. The posterior cranial base shows a constant growth rate up to ca. 15 years of age. The face and dentition develop along the nasion-gonion and sella-gnathion distance, which demonstrates the greatest absolute growth rate. During growth, the viscerocranium increases principally in height.

Adolescent↗

Genetic and teratogenic approaches to craniofacial development.

Craniofacial malformations are the most common birth defects that occur in humans, with facial clefting representing the majority of these defects. Facial clefts can arise at any stage of development due to perturbations that alter the extracellular matrix as well as affect the patterning, migration, proliferation, and differentiation of cells. In this review, we focus on recent advances in the understanding of the developmental basis for facial clefting through the analysis of the effects of gene disruption experiments and treatments with teratogens in both chickens and mice. Specifically, we analyze the results of disruptions to genes such as Sonic hedgehog (Shh), epidermal growth factor receptor (EGFR), Distal-less (Dlx), and transforming growth factor beta 3 (TGFbeta3). We also describe the effects that teratogens such as retinoic acid, jervine, and cyclopamine have on facial clefting and discuss mechanisms for their action. In addition to providing insight into the bases for abnormal craniofacial growth, genetic and teratogenic techniques are powerful tools for understanding the normal developmental processes that generate and pattern the face.

Animals↗

Comparisons between cervical vertebrae and hand-wrist maturation for the assessment of skeletal maturity.

It was claimed that, skeletal maturity could be determined by using anatomical changes of the cervical vertebrae observed on the lateral cephalometric radiographs. In this method of assessment cervical vertebrae C2, C3, and C4 are observed and each patient is placed in a cervical vertebrae maturation index (CVMI). Fishman developed a system of hand-wrist skeletal maturation indicators (SMI), using four stages of bone maturation at six anatomic sites. The purpose of this study was to analyze associations between cervical vertebrae maturation index (CVMI) and skeletal maturation index (SMI). The second objective was to determine the reproducibility of the identifications on the lateral cephalograms and hand-wrist films. Lateral cephalometric and left hand-wrist radiographs of 180 untreated subjects (99 girls and 81 boys) aged from 8 to 18 years were obtained from the files of the Marmara University School of Dentistry, Department of Orthodontics. The results of this study indicated that cervical vertebrae maturation and hand-wrist skeletal maturation were significantly related.

Adolescent↗