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At least 505 records · Page 28Linked to original sources
PubMed1984

[Current aspects of xeroderma pigmentosum: apropos of two new cases].

Two recent cases of children treated for xeroderma pigmentosum are reported, and knowledge of the disease updated based on numerous reports published over the last few years, particularly by french authors ( Vaillant et al., 1979 and Mouly , Dufourmentel and Papadopoulos , 1980). Points discussed include the similarity of histology and course of the malignant cutaneous lesions with those of adult outdoor workers (co- carcinogenic role of ultraviolet rays ?), and the effect of the introduction of vitamin A acid into treatment on the course of the general and cutaneous lesions (immunocompetence, tumoral growth rate). A further feature discussed is the question raised by the surgical attitude: radical, extensive and mutilating as in the first case, or limited and conservative, with consequent long-term inconveniences, as in the second case. The persistence of an extremely poor prognosis after more than a century of study of the disease (it received its name from Kaposi as early as 1882. . . !!) is a strong argument for imposing the preventive measures which are still applied with difficulty at the present time.

Child↗
PubMed1984

[Osteoma cutis].

Explore the source record for details and available documents.

Adult↗
PubMed1980

A dermatologist's approach to the management of skin cancer.

The foregoing statements may invite controversy. At the same time, I hope they will be stimulating enough to lead many physicians to explore the various modalities open to them. Each case of skin cancer is an individual therapeutic problem, and the final decision as to what method should be used can be made only after every factor listed in Table 1 has been carefully weighed.

Cheek↗
PubMed1977

Modern radiotherapy for malignant epitheliomas.

There are exceptional cases of malignant epitheliomas in which radiotherapy is at once or eventually becomes a treatment of last resort. We recount the clinical facts, histologic findings, radiotherapeutic techniques, and results of treatment of seven such cases.

Adult↗
PubMed1996

[Autofluorescence diagnosis of malignant tumors of the head and neck].

A new method for diagnosing human malignant tumors is dealt with, which is based on fluorescence of malignant neoplasms and their adjacent normal tissue. To measure the fluorescence spectra, a fiber optic system and a multi-channel optic spectral analyser have been designed. While analysing the resultant spectra, a greater fluorescence excess was observed in the red wave band in the tumors than in normal tissue. Further investigations are required in order to use the method in question in clinical diagnosis.

Biopsy↗
PubMed1996

Incidence of post-transplant malignancy among 674 solid-organ-transplant recipients at a single center.

We evaluated the post-transplant course of the entire solid-organ-transplant population at our institution to determine the frequency, incidence and specific type of post-transplant malignancies which occurred at a single center. Of 674 solid-organ-transplant recipients (305 renal, 307 heart, 54 lung, 8 heart/lung), we detected 79 malignancies (48 heart, 28 renal, 2 lung, 1 heart/lung), representing an overall cancer frequency of 11.7%, 15.6% for heart and 9.2% for renal transplant recipients. The frequency in both transplant groups was higher than that reported previously in the multicenter data in the literature (about 6%); we also noted a shorter interval to malignancy (27 vs. 61 months). The most common malignancies overall were skin/lip carcinomas and post-transplant lymphoproliferative disorder (PTLD). The frequency of PTLD was higher in non-renal (6.5%) than renal (0.7%) transplant recipients and statistical analysis confirmed a significant higher incidence of all malignancies (p = 0.0032) and of PTLD (p = 0.0001) in heart and lung recipients as opposed to renal transplant recipients. The frequency of total skin/lip carcinomas was essentially equal in the heart and renal transplant groups (6%), and statistical analysis showed no significant difference in incidence of this general type of malignancy; however, there was a marked disparity in interval to squamous cell carcinoma (SCC) between renal and heart transplant recipients (27 versus 59 months). This was associated with an apparent increase in the rate of occurence of SCC after 60 months in heart transplant recipients, a finding not previously reported in the multicenter data in the literature. We did not demonstrate a significant effect of the withdrawal of prophylactic OKT3 from the immunosuppression regimen of heart transplant recipients on the incidence of all tumors, PTLD or skin/lip tumors.

Aged↗
PubMedDate not supplied

New trends in skin tumor surgery.

Over 8 years, 1700 patients were referred from the Mohs' Surgery and Cutaneous Laser Unit after Mohs micrographic skin tumor excision to the Division of Plastic and Reconstructive Surgery. Preoperative coordination between the two divisions was emphasised in wound preparation and timing of reconstruction for maximized patient convenience and outcome. Most repairs of facial and extremity defects were carried out under local anesthesia. Techniques of repair were selected based upon algorithmic priorities emphasizing simple techniques over complex ones. Direct closure, skin grafts and flaps were used. Preference for aesthetic subunit reconstruction of the face and the use of particular flap techniques including the O-to-S, O-to-T, V-to-Y island advancement, islandized nasolabial flap for alar reconstruction and the forehead flap for nasal dorsum and tip repair are illustrated.

Basal Cell Carcinoma↗
PubMed1998

[Advanced epitheliomas of the face: when to stop?].

Progress in plastic surgery has allowed an ever increasing extension of the indications for facial reconstruction. Although carcinomas are now detected earlier and earlier, the practitioner is nevertheless faced, several times during his working life, with "historical" cases. Although it is fairly rare to observe long-term progression of squamous cell carcinomas, basal cell carcinomas can take on considerable proportions due to their very low metastatic risk. In these situations, the dilemma between conservative management and performing an inevitably major procedure is never easy to resolve. Moreover, it is often the discomfort experienced by the patient's family which encourages him to accept the operation. The objective of the procedure is more often aesthetic rather than curative, although this latter objective must always be attempted. Consequently, the practitioner should never hesitate to defer reconstruction for several months in order to ensure reliable local surveillance. The value of epitheses is clearly established in this situation. When a reconstruction can be performed, "major" measures are generally necessary, making use of all of the regional or even distant plastic surgery techniques used for facial surgery. However, microsurgery is a last resort indication, which should only be used when the various pedicle flaps have been exhausted. The microsurgical delay technique (Jean-Marie Servant's "apple turnover" technique) is particularly useful in these situations. In the light of seven clinical cases, the authors try to define the essential concepts of this type of management. In fact, the respective limits of active intervention and conservative management are defined by each surgeon's common sense and experience. The constant improvement of the quality of epitheses make them the current treatment of choice for the restoration of extensive defects. Lastly, one of the main factors to be considered before taking any treatment decision is the psychology of these patients, as it is always difficult to explain the discovery of lesions at this advanced stage.

Aged↗