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Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation.

We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg x kg(-1)) and nicardipine (15 or 30 microg x kg(-1)). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg x kg(-1) and nicardipine 30 g x kg(-1) showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).

Adrenergic beta-Antagonists↗

The effect of single use laryngoscopy equipment on illumination for tracheal intubation.

We measured the illumination generated by all 30 Macintosh size 3 laryngoscopes in our department with a lux-meter and a standardised laryngoscope holding tube. We found a large range in illumination generated (65-3130 lx). We then measured the effect on the illumination for each laryngoscope by covering the blade with a cover (LaryGard). In every case, the illumination was reduced by the LaryGard, the mean (SD) reduction was 67 (19)%. When we compared the illumination generated by a disposable laryngoscope blade with the same power source, we found that the illumination was reduced less than with the standard Macintosh covered by a LaryGard.

Cross Infection↗

Difficult paediatric intubation when fibreoptic laryngoscopy fails.

We report an unusual problem with fibreoptic bronchoscopy in an 8-year-old girl with Negar syndrome. She had a history of difficult airway since birth, and had undergone mandibular distraction for severe obstructive sleep apnoea when she was aged 2 years. Nagar syndrome is a Treacher-Collins like syndrome with normal intelligence, conductive bone deafness and problems with articulation. The patients have malar hypoplasia with down slanting palpebral fissures, high nasal bridge, micrognathia, absence of lower eyelashes, low set posteriorly rotated ears, preauricular tags, atresia of external ear canal, cleft palate, hypoplasia of thumb, with or without radius, and limited elbow extension. Protracted attempts with a fibreoptic bronchoscope failed to visualize the glottis, and this was only possible when the tube was guided to the larynx by blind nasal intubation. Apparently, the healing of the wounds for the mandibular distraction in the mandibular space on the inside of the rami of the mandible had caused differential fibrosis on either side of the hyoid, leading to a triplane distortion of the larynx with a left shift, clockwise rotation to a 2-8 o'clock direction and a slight tilt towards the left pharyngeal wall. The large epiglottis overlying this had precluded a view of the larynx. Finally, the older technique of breathguided intubation facilitated fibreoptic bronchoscopy to achieve tracheal intubation.

Bronchoscopy↗