[Multiple primary malignant tumors of the large intestine].
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An attempt has been made to estimate the correlation of oncological illnesses in the families within the limits of segregational and correlational analyses, considering the fact of accumulation in the families of probands with autosomal-dominant polyposes of colon of the cases of primary (without preceding polyposes) colon cancer. Significant correlation was found between the hereditary polyposes and primary colon cancer in the families studied. Based on these data, a hypothesis is discussed of the main gene and its modifications on the phenotypical version in the form of primary benign (polyposes) and malignant (cancer) pathology. No significant correlation was found between colon polyposes and cancer of stomach in the families.
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Based on the study carried out, we have suggested a populational-genetical model of hereditary polyposes with frequencies of some parameters, such as frequency of mutation, gene's (allele's) frequency, frequency of heterozygotes (general and for separate groups), fertility, fittnes and selection efficiency.
Carcinoembryonic antigen was studied in 241 controls--patients with different diseases, 121 cases of intestinal polyp, 69 cases of large bowel carcinoma, 28 cases of stomach cancer and 65 patients with malignancies at other sites (total-524). Significantly high levels were found in large bowel and stomach cancer as well as cases of extensive tumor growth, relapse or metastases.
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