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PubMed1964

INHIBITORS OF HISTAMINE CATABOLISM AND THE ACTION OF GASTRIN IN THE RAT.

A method is described for the partial purification of hog's antral gastrin by gel filtration and ion-exchange chromatography. Gastrin was assayed by its effect on the pH of the effluent fluid from the perfused lumen of the stomach of the anaesthetized rat. The latency of the response to gastrin given intravenously was shorter than the latency to a similar dose of histamine. The response to gastrin injected into the arterial circulation of the stomach appeared sooner than the response to gastrin injected intravenously. Iproniazid and aminoguanidine potentiated responses to gastrin. Incubation in vitro with monamine oxidase or diamine oxidase did not inactivate gastrin. Chlorpromazine and bromolysergic acid diethylamide, in doses which enhance the effects of histamine on acid gastric secretion, did not affect responses to gastrin.

Administration, Intravenous↗
PubMed1964

EFFECTS OF CHLORPROMAZINE AND BROMOLYSERGIC ACID DIETHYLAMIDE ON GASTRIC SECRETION OF ACID INDUCED BY HISTAMINE IN RATS.

In anaesthetized rats in which the lumen of the stomach was perfused with 0.001 to 0.00025 N-sodium hydroxide solution and the pH of effluent fluid was recorded continuously, intravenous administration of chlorpromazine caused transient inhibition of acid secretion. After acid secretion had returned to the control level the responses to histamine were greater than those before chlorpromazine was given. Aminoguanidine, iproniazid and bromolysergic acid diethylamide also potentiated the effect of histamine on acid secretion but the initial inhibition was absent. Indirect evidence from experiments in which mixtures of aminoguanidine with chlorpromazine or bromolysergic acid diethylamide and of iproniazid with chlorpromazine or bromolysergic acid diethylamide were given, suggests that chlorpromazine and bromolysergic acid diethylamide enhance responses to histamine by inhibition of imidazole-N-methyl transferase.

Amine Oxidase (Copper-Containing)↗
PubMed1965

TRYPTAMINE OXIDATION BY EXTRACTS OF PEA SEEDLINGS: EFFECT OF GROWTH RETARDANT BETA-HYDROXYETHYLHYDRAZINE.

beta-Hydroxyethylhydrazine forces flowering of pineapple plants, possibly by reducing auxin concentration. A specific and sensitive assay showed that beta-hydroxyethylhydrazine (3.3 x 10(-7)M) inhibits noncompetitively and almost completely the oxidation of tryptamine to indoleacetaldehyde by extracts of pea-seedling (Pisum sativum L. var. Alaska). The relative rate of oxidation of putrescine to Delta(1)-pyrroline compared to that of tryptamine by these extracts and the inhibition of both reactions by beta-hydroxyethylhydrazine suggest that diamine oxidase is inhibited. beta-Hydroxyethylhydrazine is a potent inhibitor in vivo of animal diamine oxidase.

Alaska↗