Allergic contact dermatitis due to ranitidine.
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Thin-layer chromatography, column chromatography, mass spectrometry and nuclear magnetic resonance were used to investigate the chemical constituents and haptens responsible in 2 different circumstances where allergic contact dermatitis from composite materials was suspected. In an aircraft factory where epoxy resins were used, tetraglycidyl-4,4'-dimethyl dianiline and phenylglycidyl ether were identified as the haptens responsible for an outbreak of contact dermatitis. The role of abietic acid as the main sensitizer in colophony was confirmed in a case of contact dermatitis occurring in a sportsman with an acute eczematous reaction due to a leg bandage. Identification of the chemical sensitizers was possible only by using the aforementioned laboratory methods.
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Practising dental surgeons are now wearing gloves for longer periods of time than any other comparable group. As part of a study to assess dentists' attitudes to cross-infection, a questionnaire was sent to 1950 randomly selected general dental practitioners in England and Wales, with information being requested concerning the incidence of skin irritation of the hands considered to be associated with glove wearing. The response to the questionnaire was 61%, with 29% of respondents indicating that they experienced skin irritation. A strong association was identified between pattern of glove wearing and incidence of skin irritation, with routine glove wearers being more likely to suffer skin irritation than occasional glove wearers. Female respondents were also more likely to have experienced skin irritation than male respondents. No association was identified between reported incidence of skin irritation and practising arrangements, years since graduation and number of years of glove wearing.
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