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PubMed1995

[Fatigue properties of gallium alloy].

Gallium alloys that have been developed as a substitute for dental amalgam were investigated for fatigue properties and the effects of environmental factors were also examined. Cylindrical specimens were fatigue-tested employing cyclic tensile loading. Statistical definition of the fatigue limit at 10(5) cycles was obtained according to the staircase method. The significance of environmental factors were evaluated by analysis of variance using the orthogonal table L8 (2(7)). The fatigue limit of gallium alloys was higher than that of a conventional high copper amalgam and was influenced by the experimental environment such as temperature and water. The fatigue fracture occurred in the matrix and the interface between the matrix and the core. Gallium alloys have excellent fatigue properties as a filling material.

Analysis of Variance↗
PubMed1987

Gallium nitrate for treatment of refractory hypercalcemia from parathyroid carcinoma.

Intractable hypercalcemia is the major cause of morbidity and mortality in patients with parathyroid carcinoma. Because gallium nitrate previously was shown to inhibit the bone resorptive activity of parathyroid hormone (PTH) in vitro, we used it to treat two patients with parathyroid carcinoma and resistant hypercalcemia. In both patients, total serum calcium levels were reduced from initial values of 3.62 and 3.77 mmol/L to posttreatment values of 2.32 and 1.45 mmol/L, respectively. Urinary excretion of calcium and hydroxyproline also declined significantly. Serum PTH levels were lower in both patients after therapy, although all levels remained markedly elevated. Nephrogenous cyclic adenosine monophosphate and tubular reabsorption of phosphate remained unchanged. These data indicate that treatment with gallium nitrate can control hypercalcemia in patients with high circulating levels of PTH. Gallium nitrate antagonizes the bone resorptive activity of PTH without altering renal effects of the hormone.

Adult↗
PubMed1990

Gallium nitrate for advanced Paget disease of bone: effectiveness and dose-response analysis.

OBJECTIVE: To evaluate whether a brief course of treatment with gallium nitrate can reduce biochemical parameters of accelerated bone turnover in patients with advanced Paget disease. DESIGN: Unblinded trial, decreasing dose schedules of gallium nitrate. SETTING: University hospital with primary orthopedic and metabolic bone disease specialty. PATIENTS: Ten patients with advanced Paget disease who had previously received conventional therapy consisting of calcitonin, etidronate, or mithramycin. INTERVENTIONS: Five patients were entered into each of three dose schedules: 2.5 mg/kg body weight per day by continuous intravenous infusion for 7 days; 0.5 mg/kg per day for 14 days by subcutaneous injection; and 0.25 mg/kg per day for 14 days by subcutaneous injection. Several patients were treated with different dose schedules. Patients were followed until relapse. RESULTS: Fifteen courses of treatment were administered to ten patients. Reductions in serum alkaline phosphatase and urinary hydroxyproline excretion were observed after treatment with each dose schedule. After treatment with high, intermediate, and low doses, the median maximum decreases in serum alkaline phosphatase activity were 49%, 39%, and 18%, respectively. The median maximum decreases in urinary hydroxyproline excretion were 50%, 52%, and 16%, respectively. The maximum decrease in urinary hydroxyproline excretion occurred within a median of 2 weeks from the start of treatment, whereas the maximum decrease in serum alkaline phosphatase activity occurred substantially later at a median of 6 weeks. All treatment schedules were well tolerated. Response duration was highly variable (range, 6 to 42 weeks). CONCLUSIONS: Short-term treatment with gallium nitrate can reduce biochemical parameters of disease activity in patients with advanced Paget disease of bone. Larger trials using low-dose intermittent treatment schedules are required to evaluate the safety and effectiveness of this therapy.

Aged↗
PubMed1976

Gallium-67 scintigraphy and intraabdominal sepsis. Clinical experience in 140 patients with suspected intraabdominal abscess.

In 140 patients with suspected intraabdominal abscess, studies were made using gallium-67 citrate and technetium-99m labeled radiopharmaceuticals. Gallium-67 scintigrams correctly localized 52 of 56 intraabdominal abscesses confirmed at surgical operation or necropsy. In an additional 20 patients in whom findings on scintigrams were abnormal, there were clinically established infections. Sixty-one patients in whom findings on scintigrams were normal were conservatively managed and discharged from the hospital; none proved to have an abscess. Four false-negative and three false-positive studies were recorded. Gallium-67 scintigraphy is a useful noninvasive diagnostic adjunct that should be employed early in the evaluation of patients with suspected intraabdominal sepsis.

Abdomen↗
PubMed1975

Psoas abscess localization by gallium scan in aplastic anemia.

Gallium 67 scanning is an effective method of detecting inflammatory lesions, especially abscesses. A 10-year-old boy with aplastic anemia and severe leukopenia and granulocytopenia had a psoas abscess diagnosed by gallium scan. The patient died with Candida spesis 18 days after bone marrow transplantation. At autopsy, a chronic psoas abscess with Candida was found. The gallium scan offers a clinically effective and noninvasive means of evaluating suspected infection in the granulocytopenic patient.

Abscess↗
PubMed1975

Gallium-67 for the diagnosis and localization of subphrenic abscesses.

Four septic patients with suspected subphrenic abscess were evaluated with gallium-67 citrate and technetium-99m labeled radiopharmaceuticals. Gallium-67 scintigraphs proved instrumental in correctly diagnosing and localizing one left and three right subphrenic abscesses. Gallium-67 scintigraphy can be a useful noninvasive technique for evaluating patients with suspected subphrenic abscess.

Adult↗
PubMed2000

Multiple skeletal metastases of Ewing's sarcoma demonstrated on FDG-PET and compared with bone and gallium scans.

Bone and gallium scans have been shown to be useful in imaging Ewing's sarcoma. Here we report on a case of recurrent Ewing's sarcoma with multiple skeletal metastases demonstrated by the FDG-PET whole body scan, while the bone scan revealed fewer lesions and a non-remarkable finding was found on the gallium scan. The following pathologic examination showed bone marrow involvement. This case demonstrated that the FDG-PET could detect more lesions of metastatic Ewing's sarcoma than bone and gallium scans, especially for those with bone marrow involvement.

Adult↗
PubMed1975

Gallium citrate Ga 67 scans in febrile patients.

Scanning with gallium citrate Ga 67 is a sensitive technique for the detection of localized inflammatory disease. In a group of 22 febrile patients, 17 had one or more abnormal areas of radioactive gallium localization. Eight patients showed localized areas of inflammation; five showed no area of local inflammation within the field of the scan. The remaining patients had excellent clinical and laboratory confirmation of neoplastic or inflammatory disease. These cases illustrate the usefulness of radioactive gallium in febrile patients in whom the cause of the fever cannot be otherwise determined.

Abscess↗
PubMed1975

Usefulness of gallium scintigraphy in primary and metastatic breast carcinoma.

Gallium-67-citrate whole-body scintigraphy was incorporated into the evaluation of 125 patients with primary and metastatic breast carcinoma. A prospective analysis of these patients demonstrated gallium scanning to be limited in its corroborative value and of practical use only in detecting metastatic breast carcinoma in the mediastinum. Since the extent of tumor involvement is a significant prognostic factor, the gallium scan merits consideration for the detection of mediastinal metastases.

Adult↗
PubMedDate not supplied

Studies on the antitumor activity of gallium nitrate (NSC-15200) and other group IIIa metal salts.

Several group IIIa metal salts, eg, aluminum nitrate, gallium nitrate, indium nitrate, and thallium chloride, have been evaluated for in vivo toxicity in mice and rats, for cytotoxicity in tumor cells in vitro, and for activity against a broad spectrum of experimental rodent tumors. The position of these agents in the periodical table roughly parallels their toxicity, the LD50s decreasing with increasing atomic weights. This parallel also exists with regard to in vitro cytotoxicity to Walker 256 carcinosarcoma cells. Although all of the metal salts had activity against the ascites Walker 256 carcinosarcoma, they were ineffective in ascites leukemias, plasma cell tumors, or Ehrlich carcinoma. Gallium nitrate was particularly active against solid tumors transplanted subcutaneously, suppressing the growth of six of eight tumors more than 90%. Because of its demonstrated antitumor activity in rodents and its uptake and concentration by various animal and human tumors, gallium nitrate has potential usefulness in the treatment of solid tumors in man and has been entered into a phase I study at the National Cancer Institute.

Aluminum↗
PubMed2003

[Use of combined gallium-technetium scintigraphy to determine the interval before second-stage prosthetic reimplantation in hip arthroplasty infection: a consecutive series of 30 cases].

PURPOSE OF THE STUDY: We report a series of 30 consecutive patients with chronically infected total hip replacement in a prospective treatment protocol that included two-stage revision surgery and scintigraphic monitoring. The serial bone scans were used to evaluate the course of infection, but not for diagnosis. Negative scintigraphic results were required before the second-stage prosthesis reinsertion after laboratory, clinical, and radiographic normalization were achieved. MATERIAL AND METHODS: Between 1987 and 1997, we prospectively followed thirty patients, who had a chronically infected hip arthroplasty treated by the conventional two-stage revision procedure using scintigraphic verification. For the present series, negative bone scan results were achieved in the resected hip before reinsertion of the prosthesis in all patients except one. The labels used were in every case gallium-67 and technetium-99m MDP with early and late (after 30 hours) scans. A scintigraphic result was considered positive if more gallium than technetium was fixed at a site. Our conventional medical and surgical protocol consisted of an initial complete excision of all foreign bodies with systematic parenteral administration of two antibiotics after having searched for the causative organism. A spacer was never used. Tibial pin traction was always applied during the duration of drainage of the wound. The antimicrobial regimen was administered to all of these patients for 3 months. The prosthesis was reinserted when C-reactive protein (CRP) levels returned to normal and negative scintigraphic results were obtained after a period with no antibiotic therapy. Reimplantation of the prosthesis was always performed with preventive antibiotic therapy selected according to the susceptibility of the initial organisms and begun after collecting new intraoperative bacteriological culture specimens. This antibiotic therapy was pursued only for the duration of the postoperative drainage. RESULTS: This follow-up based on combined technetium-gallium bone scans demonstrated two major advantages. First, no recurrence of infection was observed except in the single patient for whom the protocol was not observed. The second advantage was to permit nonarbitrary determination of the moment of reimplantation of the prosthesis, as there is no clear consensus regarding the interval before reinsertion in the literature. The patients underwent the second-stage of hip reconstruction after a mean interval of 9 months. The mean delay before negative scintigraphic results was 7 months. DISCUSSION: This method, which determines the optimum delay before reimplantation reducing the risk of reinfection to a minimum, gave promising results in this prospective study of 30 patients.

Adult↗
PubMed2006

[The role of gallium scintigraphy in the diagnosis of sarcoidosis and in monitoring treatment effectiveness].

Sarcoidosis is an inflammatory disorder of unclear origin that can affect many organs. The hallmark of sarcoidosis is formation non-caseating epithelioid cell granulomas. The aetiology and the pathogenesis of the disease are not well understood, therefore in the absence of specific histopathology distinguishing marks the diagnosis is established by exclusion. In this case, the authors present a unique case of Boeck sarcoidosis with pulmonary manifestation and pleural involvement. They would like to draw attention to the importance of gallium scintigraphy in the diagnostic workup of the disease. During the diagnostic process, the exact diagnosis could be established with the help of gallium scintigraphy. Gallium scan also played an important role in identifying extrapulmonary manifestations. Serial control examinations--as being the only sensitive non invasive diagnostic test method- provided valuable help in estimating the activity of the inflammatory process and monitoring therapeutic efficacy.

Gallium Radioisotopes↗
PubMed1991

[Preparation and analysis of hydroxycarboxylic acid, sugar acid and amino acid complexes of gallium(III)].

Neutral, stable in water and not hydrolysing gallium(III) complexes were prepared and analysed by instrumental analytical methods. Nine hydroxy-carboxylic acids, four sugar acids and four amino acids were used as ligands. The chemical and physical characteristics of complexes (composition, stability, water solubility, pH in aqueous solution) significantly depend on the quality of gallium salt and ligand, the ratio of gallium and ligand, the medium used during the preparation (pH and temperature).

Amino Acids↗
PubMed1991

Inflammatory pseudotumor: a gallium-avid mobile mesenteric mass.

An 8-yr-old boy with a 1-mo history of culture-negative fever and anemia underwent gallium, ultrasound, and computed tomography studies as part of the evaluation of a fever of unknown origin. These studies revealed a mobile gallium-avid solid abdominal mass subsequently proven to be an inflammatory pseudotumor of the mesentery, a rare benign mass. This report documents the gallium-avid nature of this rare lesion and discusses associated characteristic clinical, pathologic, and radiographic features.

Child↗
PubMed1976

[Study of gallium-67 citrate distribution in rat tumors].

In rats with transplantable tumors of different histological structure the authors have studied the dynamics of gallium-67 citrate distribution in tumors, adjacent tissues and blood. It has been found that gallium-67 is able to be accumulated in increased amounts in all tumors irrespective of their histological type. Tumor image in scannograms was mostly distinct on the 2--3d day after injection of gallium-67 citrate, when there was the greatest difference in accumulation of the isotope in the tumor and surrounding "intact" tissues.

Animals↗
PubMed1991

Metabolic imaging with gallium-68- and indium-111-labeled low-density lipoprotein.

Low-density lipoprotein (LDL) labeled with either gallium-68 (68Ga) or indium-111 (111In) was evaluated as a potential PET or SPECT radiopharmaceutical for determination of hepatic lipoprotein metabolism in rabbits. Gallium-68 or 111In was linked to LDL via diethylenetriaminepentaacetic acid (DTPA) with a 25-70% radiochemical yield. Studies in vivo that compared 68Ga- or 111In-DTPA-LDL with dilactitol-[125I]-tyramine LDL and 131I-LDL showed that both 68Ga- and 111In-labeled LDL behaved as residualizing radiotracers. Localization of radioactivity within the liver of normal rabbits was visualized clearly with [68Ga]DTPA-LDL by PET and with [111In]DTPA-LDL by gamma scintigraphy. Significant differences were observed in hepatic uptake of normal compared with hypercholesterolemic rabbits in which low-capacity LDL receptor-mediated catabolism was saturated. Gallium-68 and 111In-DTPA-LDL are attractive radiopharmaceuticals for noninvasive delineation of tissue LDL metabolism under normal and pathophysiologic conditions.

Animals↗
PubMed1991

Gallium-67 imaging in retroperitoneal fibrosis: significance of a negative result.

A patient with retroperitoneal fibrosis and right peritracheal and hilar lymphadenopathy was studied using gallium-67-citrate. No abnormal uptake was seen in the regions of retroperitoneal fibrosis, while there was avid uptake in chest lesions later shown to represent small cell lung carcinoma. Retroperitoneal fibrosis which does not show gallium uptake is most likely mature, with few inflammatory elements. In patients with multiple retroperitoneal and/or mediastinal masses, gallium imaging may be useful in identifying the most active sites of disease for possible biopsy and for subsequent monitoring of response to therapy.

Aged↗
PubMedDate not supplied

[Decreased 67-gallium plasma protein binding in senile dementia of the Alzheimer type].

We examined the plasma-protein-binding of 67-gallium in 10 patients with probable dementia of the Alzheimer-type (DAT), diagnosed according to NINCDS-ADRDA-criteria, and in 10 healthy controls matched for age (mean: 82 and 83 years) and sex (2m:8f). In comparison to the control group, the percentage of 67-gallium bound in the plasma of DAT-patients was significantly decreased (10.6% vs 15.5%; p less than 0.05). As gallium and aluminum show corresponding biochemical characteristics, these results may indicate a potential contribution of a disturbed peripheral transport in DAT, leading to the intracerebral deposition of neurotoxic aluminum levels.

Aged↗