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PubMed2006

Guanosine 3',5'-bispyrophosphate coordinates global gene expression during glucose-lactose diauxie in Escherichia coli.

Guanosine 3',5'-bispyrophosphate (ppGpp), also known as "magic spot," has been shown to bind prokaryotic RNA polymerase to down-regulate ribosome production and increase transcription of amino acid biosynthesis genes during the stringent response to amino acid starvation. Because many environmental growth perturbations cause ppGpp to accumulate, we hypothesize ppGpp to have an overarching role in regulating the genetic program that coordinates transitions between logarithmic growth (feast) and growth arrest (famine). We used the classic glucose-lactose diauxie as an experimental system to investigate the temporal changes in transcription that accompany growth arrest and recovery in wild-type Escherichia coli and in mutants that lack RelA (ppGpp synthetase) and other global regulators, i.e., RpoS and Crp. In particular, diauxie was delayed in the relA mutant and was accompanied by a 15% decrease in the number of carbon sources used and a 3-fold overall decrease in the induction of RpoS and Crp regulon genes. Thus the data significantly expand the previously known role of ppGpp and support a model wherein the ppGpp-dependent redistribution of RNA polymerase across the genome is the driving force behind control of the stringent response, general stress response, and starvation-induced carbon scavenging. Our conceptual model of diauxie describes these global control circuits as dynamic, interconnected, and dependent upon ppGpp for the efficient temporal coordination of gene expression that programs the cell for transitions between feast and famine.

Bacterial Proteins↗
PubMed2002

Food security and nutrition -- the Ethiopian case for action.

OBJECTIVE: To assess the 1999-2000 food security situation and the food relief programmes in Ethiopia, and evaluate the need for a national food and nutrition policy. DESIGN: A systematic search of data sources from the Ethiopian Disaster Prevention and Preparedness Commission (DPPC), the Ethiopian Central Statistical Authority, the World Food Programme (WFP) and United Nations Children's Fund (UNICEF), the bibliographic database Medline and direct contacts with associations, institutions and people concerned with food security in Ethiopia. SETTING: Consultations to WFP Ethiopia. RESULTS: Food availability was severely restricted due to recurrent disasters such as drought, flood, war and a lack of diversity of food items. Food accessibility was limited due to a weak subsistence-agriculture-based economy, depletion of assets, absence of income diversity and a lack of alternative coping mechanisms. Food intake adequacy was rarely achieved due to food shortages, improper diet and poor sanitary conditions. There was a lack of early warning data to monitor food security indicators. Food aid programmes did not meet the requirements for food quantities and composition, and faced major obstacles in logistics and targeting of the vulnerable population. CONCLUSIONS: Improvements in food security and the eradication of famine will require investment in sustainable projects. There is an immediate need for better planning and targeting of food aid and a national food security monitoring system. A national food and nutrition policy is recommended, focusing both on relief efforts and on underlying factors contributing to the famine.

Adolescent↗
PubMedDate not supplied

Population crises and population cycles.

To prevent a population irretrievably depleting its resources, mammals have evolved a behavioural and physiological response to population crisis. When a mammalian population becomes dangerously dense, there is a reversal of behaviour. Co-operation and parental behaviour are replaced by competition, dominance and aggressive violence, leading to high mortality, especially of females and young, and a reduced population. The stress of overpopulation and the resulting violence impairs both the immune and the reproductive systems. Hence epidemics complete the crash of the population, and reproduction is slowed for three or four generations, giving the resources ample time to recover. In some mammal species, crisis and crisis response recur regularly, leading to cycles of population growth and relapse, oscillating about a fixed mean. Population crisis response and population cycles have been equally prominent in the history of human societies. But in man successive advances in food production have made possible growing populations, though with every such advance population soon outgrew resources again. Hence human cycles have been superimposed on a rising curve, producing a saw-tooth graph. Because advances in food production amounted to sudden disturbances in the relations between human populations and their environments, the crisis response in man has failed to avert famine and resource damage. In the large human societies evolved since the coming of settled agriculture and cities, the basic effects of violence, epidemics, famine and resource damage have been mediated by such specifically human disasters as inflation, unemployment, and political tyranny. An account of past crises, periods of relative relief from population pressure, and resulting cycles, is given for a number of regions: China, North Africa and Western Asia, the northern Mediterranean, and north-western Europe. The paper ends with an account of the present world-wide population crisis, and the solution made possible by Malthus's discovery that, unlike animals, we can choose to check population growth by reducing the birth-rate, instead of raising the death-rate, as in other mammals, by the population crisis response.

Animals↗
PubMedDate not supplied

The consumption bomb.

The explosion of the population bomb has long been predicted to cause massive famine in overpopulated countries. Rising consumption, even in a time of decreasing population growth rates, now threatens adverse global health effects more severe than localised famines. The world faces potential ecological entrapment. This has two dimensions: planetary eco-impoverisation and planetary eco-pathology. Eco-impoverisation, the depletion of natural capital, arises as the limit of the global human carrying capacity approaches. Eco-pathology, the disruption of ecological support systems, arises because of the way the biosphere has been modified by human activity and is caused particularly by unsustainable consumption for human purposes. Despite encroaching ecological entrapment, the dominant economic paradigm claims record levels of growth; a paradox that needs recognition. Reasons for denial of the gravity of ecological entrapment are discussed. Ways are suggested to defuse the consumption bomb and avert ecological entrapment.

Conservation of Natural Resources↗
PubMed1982

Prenatal starvation and maternal blood pressure near delivery.

Maternities in cities exposed to the Dutch famine of 1944 to 1945 and in control cities were compared. Systolic blood pressure near the time of delivery was significantly reduced by exposure to famine late in the 2nd trimester and early in the 3rd trimester. Blood pressure correlated best with caloric rations in the 3rd month before delivery, and this relationship holds consistently below a ration level of 1900 cal. Above 1900 cal and up to 2200 cal (the upper limit of rations for the data analyzed) the relationship is inconsistent across cities. Edema, analyzed in one city, varied in a manner similar to blood pressure.

Blood Pressure↗
PubMed1991

Maternal weight gain, infant birth weight, and diet: causal sequences.

The causal sequence maternal nutrition----maternal weight gain----infant birth weight is not sustained by available evidence except under extreme nutritional deprivation. For maternal weight change, diet effects of near starvation are unequivocal. With chronic undernutrition or social deprivation, diet effects are inapparent or modest (conditional on pregnancy stage, diet supplement, and prepregnancy weight). For birth-weight change, diet effects of near starvation are likewise unequivocal and modest with chronic undernutrition or social deprivation. The complete causal sequence has been demonstrated only below a famine threshold. Outside famine, effects are modest (conditional on baseline nutrition, timing, and content of diets, possibly also on infant sex and energy expenditure). High-protein concentrations have produced adverse effects. Micronutrients and consequent fluid retention could have favorable effects. Diet effects on birth weight apparently bypass maternal weight change. Hence, to enhance birth weight, maternal diet appears to deserve more attention than does weight gain.

Birth Weight↗
PubMed1997

Intra-household correlations of nutritional status in rural Ethiopia.

BACKGROUND: It is commonly believed that households are relatively homogeneous with respect to nutritional status and occurrence of diseases. We therefore examined how anthropometric measurements are correlated between different household members in famine-prone Ethiopian communities. METHODS: We studied 1147 people in the Elka village in the Rift Valley. RESULTS: The results show that the correlations between the state of nutrition among household individuals are weak. Thus, anthropometric indices of young children, older children and adult men are an inefficient means of screening for maternal malnutrition. The low sensitivity and high specificity suggest that intra-household members may not fully share risk factors for malnutrition. CONCLUSIONS: We question the commonly held view on the use of childhood nutritional indicators as proxies of household nutritional risks. Our study may have practical implications for screening programmes and interventions during famines. There is no short cut to separate screening of population subgroups.

Adolescent↗
PubMed2000

Multiple paths of sugar-sensing and a sugar/oxygen overlap for genes of sucrose and ethanol metabolism.

The two-fold purpose of this work is, first, to review current hypotheses for multiple paths of sugar-sensing in an oxygen-responsive context, and second, to present evidence for the extent of sugar/oxygen overlap regulating genes for sucrose and ethanol metabolism. Current data indicate that sugar signals in plants may be initiated by (a) hexokinases, (b) membrane sensors, (c) acetate and/or respiratory metabolites, and (d) other signals and/or crosstalk. Responses may also involve concurrent input along transduction paths by effectors such as energy charge, P status, and phytohormones. Prime candidates for initiation and/or integration of such signal integration include SNF1- and SCF-like, multi-enzyme complexes. In addition, different paths of sugar signal transduction may be linked to contrasting roles of responsive genes during feast, famine or pathogen attack. Oxygen can potentially alter sugar signals at several points, so its influence on feast and famine responses was initially tested with genes for sucrose metabolism in maize root tips. The Sus1 and Sh1 sucrose synthases in maize (typically up-regulated by carbohydrate abundance and deprivation, respectively) showed parallel responses to hypoxia (3% O2 [0.03l l-1 O2]) and anoxia (0% O2 [0l l-1 O2]) that were consistent with involvement of similar signals. In contrast, the differential sugar-responses of the lvr1 and lvr2 invertases were not evident under low oxygen, and both genes were rapidly repressed. A third response was evident in the marked, sugar-regulation of an oxygen-responsive Adh1 gene for alcohol dehydrogenase, which was sensitive to sugar availability from deficit to abundance, regardless of oxygen status (anaerobic to fully aerobic [40% O2 (0.04l l-1 O2)]. A clear interface is thus evident between sugar and oxygen signals, but this varies markedly with the genes involved and probable differences in respective transduction paths.

Carbohydrate Metabolism↗
PubMed1997

Offspring birth weights after maternal intrauterine undernutrition: a comparison within sibships.

The authors examined the effects of maternal intrauterine undernutrition on offspring birth weights in a cohort of women born between August 1944 and April 1946 in Amsterdam, The Netherlands. This period included the Dutch Hunger Winter, a war-induced famine. Undernutrition was defined separately for each trimester of pregnancy as an average supply of less than 1,000 calories per day from government food rations. For maximum control of potential maternal confounding factors related to offspring birth weight, the authors performed a within-family analysis, including 437 families with two siblings and 107 families with three siblings born between 1960 and 1985. As in other studies of the famine, maternal birth weight itself was decreased after third trimester intrauterine exposure but not after first trimester exposure. The expected increase in offspring birth weights with increasing birth order was not seen after maternal intrauterine exposure in the first trimester of pregnancy. In this group, second born infants weighed, on average, 252 g less at birth than their firstborn siblings (95% confidence interval (CI) -419 to -85), and thirdborn infants weighed 419 g less (95% CI -926 to 87), even after adjustment for trimester of maternal intrauterine exposure, maternal birth weight, smoking during pregnancy, and sex of infants in the sibling pairs. Additional adjustment for the birth weight of the elder sibling did not materially change this abnormal pattern. There were no abnormal patterns in offspring birth weights after maternal intrauterine exposure in the second or third trimester of pregnancy. The study outcomes could not be explained by other selected determinants of birth weight, by lack of control for socioeconomic status, or by loss to follow-up of the 1944-1946 birth cohort. This study suggests that there may be long-term biologic effects, even into the next generation, of maternal intrauterine undernutrition which do not correspond to the effects on the mothers' own birth weights.

Birth Order↗
PubMed1997

Knowledge and power: a critique of an international relief operation.

Exploring an alternative way to approach famine relief interventions, this paper draws on the work of French philosopher Michel Foucault and David Keen's recent work on south-west Sudan. It suggests that different discourses on 'famine' can lead to the dominance of certain kinds of institutional practices, and the prioritisation of special kinds of knowledge, at the expense of other modes of understanding and action. Using the case of the relief operation to Tigrayan refugees in eastern Sudan in 1984/5, the paper examines the specific ways in which 'power' was elaborated in the midst of the operation, and the manner in which institutional practices-designed to save as many lives as possible-influenced the reaction of international agencies to the spontaneous repatriation of the Tigrayans back to Ethiopia.

Ethiopia↗
PubMed2002

The Ethiopian crisis of 1999-2000: lessons learned, questions unanswered.

During 1999-2000, Ethiopia was brought to the edge of a major disaster, with some 10 million people estimated to be in need offood assistance at the height of the crisis. A repeat of the catastrophic famine of 1984-5 was avoided, but the numbers of people affected, the loss of life and the destruction of livelihoods made this one of the most serious crises in the Horn of Africa in the past 15 years. The humanitarian community has been slow to recognise the lessons of 1999-2000, and there have been surprisingly few attempts to conduct a serious, post-event evaluation of the overall crisis and response. The label famine averted' seems to summarise the crisis to the satisfaction of most parties involved. This paper reviews the crisis, the events that led up to it and the response effort. It examines thefactors that contributed to making this crisis so serious, in order to draw conclusions and note issues that are relevant to current thinking about disaster preparedness and response - in Ethiopia and elsewhere. Some of the lessons learned from the 1999-2000 crisis are not new. However, the veryfact that mistakes have been repeated should be a lesson to the humanitarian community.

Agriculture↗
PubMed2006

A teleological view of obesity, diabetes and hypertension.

1. The current worldwide epidemic of obesity and its major complications, namely type 2 diabetes and hypertension, is well documented. The present mini-review develops the thesis that 'thrifty' metabolic traits, evolved in the setting of intermittent famine, contribute to the obesity pandemic. 2. These thrifty traits, namely a decreased capacity for dietary thermogenesis and an increased resistance to insulin-mediated glucose uptake in skeletal muscle, would prolong survival during famine but predispose to obesity and diabetes in the face of abundance. The regulation of dietary thermogenesis by the sympathetic nervous system also explains the well-established association between obesity and high blood pressure. 3. These observations provide a deep-seated rationale for the efficacy of lifestyle interventions in the treatment of obesity and its complications and may also provide a predicate for the development of new therapeutic strategies aimed at neutralizing the impact of these thrifty traits. Such strategies may entail, for example, therapeutic agents that enhance metabolic rate during low-energy diets, thereby reversing the physiological impediment imposed by suppression of the sympathetic nervous system.

Diabetes Mellitus↗
PubMed1992

Nutrition mission to Iraq for UNICEF.

At the request of UNICEF, the authors conducted a rapid nutritional assessment of children from birth to five years of age in southern Iraq during the second half of June 1991. With support from local UNICEF staff, the nutrition team examined 680 children, measuring weight, height, and mid-upper arm circumference and observing clinical signs of anemia, vitamin A deficiency, and dehydration. These measurements and observations were performed in 14 rural, urban, and periurban settings in Basrah and Amarah governorates. Evidence of both acute and chronic malnutrition was found in large numbers of the children examined. However, the acute nutritional signs of impending famine were not evident at the time of the survey. This is true notwithstanding epidemic levels of infectious disease, market prices for basic food items three to 20 times prewar levels, and a reported crisis in mothers' ability to breastfeed. Other signs of impending famine (distress sales of family assets, disintegration of social structures, etc.) may have existed, but were not evident to the team.

Child Nutritional Physiological Phenomena↗
PubMed2001

Maternal nutrition and perinatal survival.

The simple relationship between maternal macronutrient status and perinatal survival (increased macronutrient intake --> increased maternal weight and/or weight gain --> increased fetal growth --> improved survival) that is usually posited is no longer defensible. First, maternal weight and weight gain are remarkably resistant to either dietary advice or supplementation; further, increased birth weight attributable to maternal nutrition does not necessarily increase perinatal survival (because prepregnant weight is positively associated with both birth weight and higher perinatal mortality). Finally, whereas dietary supplements during pregnancy may have a modest effect on birth weight in nonfamine conditions (by contrast with a large effect in famine or near-famine conditions), their impact is not mediated by maternal energy deposition. Rather, the component of maternal weight gain associated with accelerated fetal growth is maternal water (presumably plasma) volume.

Birth Weight↗
PubMed1980

Are voluntary agencies helping to improve health in Bangladesh?

Since independence in 1971, a large number of health programs run by local and foreign voluntary organizations have been started in Bangladesh. This paper is the result of a survey undertaken on behalf on the Oxford Famine Relief Committee of ten of the most interesting of these projects. On the basis of an analysis of the underlying causes of ill health in Bangladesh, a criterion for the assessment of these health programs is developed. Following an overview of the performance of these "innovative" projects, the pertinent issues which have been and have to be dealt with by appropriate projects are addressed by means of a case study of one of the best of these projects. A basic premise of this analysis is that ill health in particular communities is not simply a result of local conditions; rather, the structural determinants of ill health are frequently national and even international in scope. The effect of these structural determinants of the presence and funding policies of the many voluntary agencies in Bangladesh is assessed by analyzing the performance of the Oxford Famine Relief Committee, one of the more enlightened of these agencies.

Bangladesh↗
PubMed1999

Characteristics of insulin requiring diabetes in rural northern Ethiopia--a possible link with malnutrition?

We have examined 100 consecutive insulin-treated diabetic patients from the Diabetic Clinic at Mekelle Hospital in Tigray, Northern Ethiopia; an area of low socio-economic status recently affected by severe famine. The study was conducted over a six month period (1997). Mean age of onset of diabetes was 27 +/- 10 y (SD) and there was a male excess (3.1:1.0). Body Mass index (BMI) at diagnosis was very low at 15.8 +/- 2.8. Because of erratic insulin supply 48 (48%) had interrupted insulin treatment in the past for a mean duration of 9 +/- 12 weeks (range 1-78). Despite this, only 2 (4%) developed ketoacidosis (DKA). The patients thus have features suggestive of malnutrition-related diabetes mellitus (MRDM) possibly of the "malnutrition-modulated" (MMDM) type in view of the apparent absence of overt exocrine pancreatic disease. The famine in this area 10 years previously may be of relevance to the aetiology of diabetes in these patients.

Adult↗
PubMed2002

Modelling of activated sludge processes with structured biomass.

Bacterial communities when subjected to feast-famine conditions as occurring in many wastewater treatment systems store substrates as reserve polymers. Including storage polymers in a description of microbial growth processes makes important the choice of kinetic relations. Presently there is no sound description for the diversion of substrate towards biomass growth or substrate storage. Based on observations with pure cultures and mixed cultures growing under dynamic conditions a model is proposed to describe such behaviour. This description is based on the observation that bacteria in order to grow fast have to induce a high level of RNA and proteins in order to allow fast growth. We assume that this protein synthesising system is only induced in the presence of external substrates. Based on this assumption a model structure is proposed and evaluated. It seems that this model can predict the turnover of PHA in the cells correctly, and describes well the overall behaviour mixed culture SBR systems. However especially the growth rate in the famine phase seems to be overestimated. The model defined here is a contribution to a further development of mechanistically based models for activated sludge processes.

Biomass↗
PubMed2002

[Practical management of nutritional and food problems in crisis situations].

This article deals with one of the most consistent problems arising during crisis situations, i.e., food shortage. The author first presents the international context conducive to natural or man-made famine. He emphasizes the importance of early detection and the need for an evaluation phase using public health survey skills to determine the objectives of relief. He then describes strategies for management of alimentary and nutritional requirements in famine-stricken populations in function of the different types of malnutrition encountered. The article ends with a presentation of preventive measures that must be implemented in association with crisis management.

Adult↗