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[Is insufflation with carbon dioxide as an ambulatory procedure for evaluating tubal patency obsolete today?].

UNLABELLED: Tubal insufflation with carbon dioxide is one of the ambulatory and non-invasive procedures in use for the evaluation of tubal patency. The aim of the present study was to investigate whether the findings obtained at tubal insufflation are reliable enough to avoid laparoscopy with instillation of dye for its inherent risk of severe operative complications. Diagnostic accuracy, positive and negative predictive value of tubal insufflation were compared with that of the reference method (laparoscopy) in 107 infertile patients of childbearing age without previous pelvic inflammatory disease, tubal or ovarian surgery. No result was obtained from tubal insufflation in 13 patients for intolerance or technical problems. The positive predictive value (percentage of correct positive findings, i.e., tubes patent) was 0.79 (130/165 tubes), the negative predictive value (percentage of correct negative findings) 0.43 (10/23) with an overall diagnostic accuracy (percentage of correct findings) of 0.74. If both tubes were reported patent on insufflation (68 patients), this finding was confirmed in 82% (56/68) on laparoscopy. The remaining 18% also include the rate of false negative findings (tubes falsely reported as occluded) on laparoscopy which may account for up to 10% according to the literature. False negative findings on insufflation were reported at a frequency of 21% (35/165 tubes). COMMENT: The diagnostic accuracy of tubal insufflation with carbon dioxide is definitely inferior to that of laparoscopy. In view of the frequency of false negative findings, its use as a screening procedure should be restricted to young patients with a low probability of tubal occlusion.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

[Early diagnosis of heterotopic pregnancy with viability of the intrauterine fetus. Report of two cases and review of the literature].

Heterotopic pregnancy, or coexistence of intrauterine and extrauterine pregnancy, is a rare entity, with a difficult pre-operative diagnosis, and potentially dangerous for the mother and for the intrauterine pregnancy. There are risk factors that are increased by this entity, so it should be taken into consideration if assisted reproduction techniques are used. The use of ultrasonography and laparoscopy is fundamental for detection, in order to implant an opportune treatment. Two cases of heterotopic pregnancy with viability of intrauterine gestation, are presented.

Adult↗

Hysteroscopic cannulation for proximal tubal obstruction: a change for the better?

OBJECTIVE: To compare overall the results of hysteroscopic tubal cannulations and resection anastomosis for proximal tubal occlusion. DESIGN: Nonrandomized retrospective analysis of patients operated on by two surgeons. SETTING: University and large tertiary referral private practice. PATIENTS: Seventy-four patients over a 10-year period, with bilateral or unilateral proximal occlusion of a single tube. INTERVENTIONS: Hysteroscopic cannulation, resection anastomosis, or both. MAIN OUTCOME MEASURES: Intrauterine and ectopic pregnancy rates, long-term tubal patency, and pathology of tubal segments. RESULTS: In patients with normal distal tubes, intrauterine pregnancy rates were similar (12/21, 57% versus 12/24, 50%) and ectopic pregnancy rates were lower (0/21, 0% versus 7/24, 29.1%) in the cannulation group. One-year patency rates in nonpregnant patients was higher in the anastomosis group (12/15, 80% versus 3/8, 33%). CONCLUSIONS: Hysteroscopic cannulation should be first choice in the management of proximal tubal obstructions in selected patients. It may be a treatment option for delayed occlusion after successful cannulation or resection anastomosis.

Anastomosis, Surgical↗

Anastomosis of the freshly divided uterine horns of rats with the CO2 laser vs. microsurgery.

We used the CO2 laser (group 1) and conventional microsurgery (group 2) for anastomosis of the freshly divided uterine horns of rats and compared the two methods. Each group was then compared with a control group in whom only exploration was carried out at laparotomy. Comparison was done regarding the clinical and histologic results. In addition, serum levels and tissue concentrations of alkaline phosphatase (ALP) and lactic dehydrogenase (LDH) were measured, and the three groups were compared. No significant difference was found between the mean adhesion scores of groups 1 and 2; however, when the control group was compared with the other groups, the differences were statistically significant. The tubal patency rates in groups 1 and 2 and the control group were 83.3%, 79.2% and 100%, respectively, and the pregnancy rates in those groups were 54.5% (6/11), 45.5% (5/11) and 100% (10/10). The differences in tubal patency and pregnancy rates between groups 1 and 2 were not significant, but when each was compared with the control group, the differences were significant. The mean scores for mucosal regeneration and disruption of the muscularis layer in group 1 were significantly lower than those in group 2. Serum levels and tissue concentrations of ALP and LDH in the control group were lower than in groups 1 and 2, and the differences between the control group and each of the other groups were significant; however, no significant difference was found between groups 1 and 2.(ABSTRACT TRUNCATED AT 250 WORDS)

Anastomosis, Surgical↗

Hysteroscopic tubal catheterization and hydrotubation for treatment of infertile women with tubal obstruction.

We reported the efficacy of interval hysteroscopic tubal catherization and hydrotubation for three months in 54 infertile women with tubal obstruction (102 fallopian tubes). By comparison of HSGs before and after treatment, 86 of 102 tubes (84%) showed the improvement of tubal patency (P < 0.01). 56 tubes were patent (54.9%). This method is effective for partially patent tubes (87.5%), intramural tubal obstruction (62.5%), and the obstruction at the distal portion of the fallopian tube (13.3). One -12 month follow-up after treatment, 12 of 35 women whose tubes became completely patent achieved intrauterine pregnancies.

Adult↗

Unexpected pregnancies after tubal recanalization failure with selective catheterization.

OBJECTIVE: To evaluate selective salpingography sensitivity. DESIGN: Retrospective study. SETTING: Obstetrics and Gynecology Department, University of Genoa, Italy. PATIENTS: One hundred seventeen patients previously submitted to selective salpingography because of unilateral or bilateral proximal tubal injection failure. RESULTS: Seven pregnancies, one of which was ectopic, were obtained in 17 patients who had only recanalized tubes available for conception; 15 pregnancies were obtained in 39 patients who had one tube recanalized and one already patent; 3 tubal pregnancies were obtained in 12 patients who had only one tube already patent; 4 pregnancies, one of which was ectopic, were obtained in 19 patients who had neither patent nor recanalized tubes. CONCLUSIONS: Selective salpingography can give false-positive results; therefore, it is possible to obtain a pregnancy even after selective salpingography failure.

Abortion, Spontaneous↗

[Diagnosis and treatment of cornual obstruction by transcervical fallopian tube cannulation under hysteroscopy].

Transcervical cannulation of the proximal oviduct was performed with a tube catheter and flexible guidewire under hysteroscopic guidance to evaluate and treat intramural fallopian tube obstruction in 37 patients. Hysteroscopic cannulation with direct visualization by laparoscopy was successful in 69.2% of the obstructed tubes, 77.4% of the cases. 74% of the obstructed tubes diagnosed by HSG and/or laparoscopy was patent after hydrotubation and cannulation by hysteroscopy. Transcervical cannulation of the proximal oviduct is an effective method for evaluation and treatment of cornual obstruction.

Adult↗

[Contrast hysterosalpingography (or HyCoSy)].

A new echogenic contrast medium, SHU-454 is a new method for direct imaging of fallopian tube passage in tubal diagnostics using transvaginal B-mode echography. Clinical studies in over 1,600 patients have shown that this product offers a reproducible echogenic contrast, significantly amplifies Doppler signal and is well tolerated. SHU-454 is injected through the cervix into the uterus and fallopian tubes using the same technique as for radiologic hysterosalpingography. This examination is easily performed in 5 to 10 minutes. Results, compared with two conventional methods, hysterosalpingography and chromolaparoscopy, in 115 women show that HyCoSy is a reliable procedure for detecting tubal patency. HyCoSy results totally agree with the results from the conventional methods in case of tubal patency. This technique may be suitable as an easy, quick and low-risk outpatient examination. It does not involve radiation exposure and is unlikely to cause allergic reactions such as those known to occur with iodinated contrast media. Transvaginal HyCoSy can be used to assess tubal patency early in sterility diagnostics, before adnexal or uterine (myoma) surgery or when tubes and uterine appendages cannot be seen during chromolaparoscopy.

Contrast Media↗

[HSG--usefulness in diagnosing infertility].

HSG examination was performed on 363 female patients diagnosed because of infertility. In 258 (71.8%) women primary infertility was recognized and in 105 (28.9%) secondary infertility. Normal anatomical state of Fallopian tube was observed in 65 (77.4%) patients with primary infertility and only in 19 (22.6%) with secondary infertility. Abnormal results of examination were discovered in altogether 279 (76.9%) diagnosed patients. Taking into consideration Fallopian tube factor in secondary infertility, it was discovered in as many as 81.9% of cases.

Adult↗