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Anti-fasciola IgG isotypes among patients with fascioliasis before and after treatment.

Stool examination using modified Kato thick smear method was performed to detect Fasciola eggs and other parasites. Abdominal pain was the major presenting symptom (83.3%) followed by pallor (71.6%) and fever (16.7%). Anaemia and hepatomegaly were recorded in 70% of patients compared to 25% with splenomegaly. Abdominal ultrasonography revealed hepatomegaly and common bile duct dilatation in 70% of patients. Moreover, 6 cases showed Olympic game rings which is diagnostic. All of patients had positive IgG4 levels, 58 cases were found positive for specific total IgG and IgG1, whereas, only 36 cases had positive IgG2 levels (60%). All negative control group showed no cross reactions. On the other hand, ELISA detecting IgG4 showed the highest specificity (95%), followed by IgG2 (85%) and the least specific test was obtained with detection of IgG (70%) and IgG1 (65%). One week after treatment, 90% of patients were completely cured. One and 3 months after treatment, the cure rate was 83.3%. In completely cured patients, none of anti-Fasciola isotypes was significantly changed.

Adolescent↗

Triclabendazole in the treatment of human fascioliasis: a community-based study.

The efficacy of triclabendazole in the treatment of chronic Fasciola infection was assessed. A total of 134 asymptomatic cases of established Fasciola infection were treated: 68 individuals received a single dose of 10 mg/kg and 66 individuals received 2 doses of 10 mg/kg on 2 consecutive days. Cure was assessed 5 weeks after treatment and 79.4% of the first group and 93.9% of the second group were cured. The drug was well tolerated; no serious side-effects were noted. One patient developed biochemical cholestasis the third day after treatment, but her enzyme profiles returned to normal after 2 months. We conclude triclabendazole is a safe and potent fasciolicidic drug.

Adolescent↗

[Human fascioliasis symptoms. A case report with review of the literature].

We present the case of a 17 years old man with fasciola hepatica infection. After initial therapy with Praziquantel and Metronidazole abdominal pain as well as eosinophilia persisted. The diagnosis was made by ERC and examination of the bile, where typical ovulas were found. An analysis of faeces and the serology (ELISA, IFAT) were not diagnosticated. After papillotomy, extraction of the parasites and therapy with Triclabendazole the patient became asymptomatic, the serology turned to negative and the haematology was normalised.

Abdomen, Acute↗

[The diagnosis of fascioliasis of the biliary tract by imaging].

Three patients with abdominal pain were studied and through ultrasonography, it was suspected that they had Fasciola hepatica in their gallbladder and choedochio. By using endoscopic retrograde cholangiopancreatography (ERCP), the presence of parasites in extrahepatic biliary passages of the cases was confirmed and then, it was taken out with a Dormia basket. It was concluded that imaging is a diagnostic means to be considered in this parasitosis.

Adult↗

[The effectiveness of the drugs Dovenix and Bilevon(R)-Injection against liver fascioliasis (Fasciola hepatica, Linné 1758) in cattle].

Dovenix and Bilevon-injection (manufactured by SPECIA, France and BAYER, West Germany, respectively) were tested for their anthelmintic efficacy against Fasciola hepatica in cattle. The drugs proved highly effective against both adult and immature flukes. The faeces of the treated animals were negative for F. hepatica eggs when examined 91 days after the treatment. In experiments with rats Dovenix and Bilevon-injection were tolerated up to eight times and ten times higher doses than the normal therapeutic dose, respectively.

Animals↗

[Fascioliasis of the common bile duct: endoscopic ultrasonographic diagnosis and endoscopic sphincterotomy].

Two cases of biliary fasciolasis are reported. The patients presented with biliary pain and/or acute pancreatitis. Pre-operative ultrasound endoscopy showed main bile duct dilation and linear elongated echogenic structures in the common bile duct lumen. Endoscopic retrograde cholangiography and endoscopic sphincterotomy were performed. Parasites were endoscopically removed resulting in disappearance of symptoms and biological abnormalities. Serological tests and pathological examination confirmed the presence of Fasciola hepatica. During follow-up, stool examination failed to show any Fasciola hepatica eggs, and in one case, serology became negative. This report emphasizes the value of ultrasound endoscopy in the diagnosis of unsuspected biliary fasciolasis. This report also confirms the therapeutic role of endoscopic sphincterotomy in patients with obstructive biliary fasciolasis.

Acute Disease↗

[Hepatic hematoma caused by fascioliasis].

The clinical presentation of two patients was carried out, with the history of having consumed in their diet watercress, and presented digestive and general symptoms. One of the patients presented hepatomegalia; but both presented jaundice and eosinophilia; CAT scan was suggestive in both cases of the presence of hepatic hematomas, confirmed by laparoscopic study and surgical intervention. The definitive diagnosis of hepatic hematoma by fasciolasis was obtained during the operation and the postoperative study, added to the other important complementary exams in this entity.

Emergencies↗

[Hepatic fascioliasis: a diagnosis problem?].

Human fasciolasis is an infection caused by the liver fluke Fasciola hepatica that predominantly affects cattle and sheep, man being an accidental host. The epidemiological situation has changed in the last few years, reporting an increase in the number of new cases in different countries around the world. In the majority of cases, diagnosis of infection in the acute or invasive phase or in chronic or state phase, is difficult because the symptoms of both phases overlap or due to the lack of symptoms or the intermittent elimination of eggs by the adult worm. Determining the phase will depend on clinical suspicion and on the selection of adequate serological and coprological methods in the acute or chronic stages, respectively, as well as determining whether the patient comes from an endemic area. In this study, we reported six cases of patients that were hospitalized at the Arzobispo Loayza Hospital in Lima, Peru, from 1990 to 1999, whose diagnoses were different from the final ones and which evidenced diagnosing problems. The important correlation between the place of origin, the physical and laboratory findings to diagnose this parasitic disease were emphasized.

Adult↗