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At least 505 records · Page 28Linked to original sources
PubMed1995

Compatibility of morphine, baclofen, floxuridine and fluorouracil in an implantable medication pump.

Studies were performed with a pump designed as a flow regulated implantable pump with a reservoir of 30 ml (VIP 30) for the continuous long term drug application in out-patients. The device consists of a gas driven two-chamber system containing the drug solution in one chamber and the propellant in the other. At body temperature the propellant underlies an isobaric expansion, thus creating pressure towards the impermeable, flexible membrane that separates the two chambers. Subsequently the pharmaceutical preparation is transported via a catheter to the target organ. With regard to its use as an implantable medication pump, four such devices were filled with solutions of morphine, baclofen, floxuridine, and fluorouracil, while one blank was filled with sterile water. The stability of the solutions and their compatibility with the pump materials was then examined. With a delivery rate of 1 ml/24 h, the pump is completely emptied after 30 days. Storage was at 37 degrees C and a number of values were obtained during the twice-normal period of 8 weeks; the content of active substances as well as any other products that had developed was determined with an optimized HPLC method. The chromatographic separations were done with two different eluents per substance. For each substance, individual samples from different periods of time were also chromatographed for up to 1 h and scanned at different wavelengths. All four pharmaceutical solutions were found stable after 30 days, only floxuridine showed a decomposition product after 7 weeks' storage.(ABSTRACT TRUNCATED AT 250 WORDS)

Baclofen↗
PubMed1993

Taxol: a history of pharmaceutical development and current pharmaceutical concerns.

Taxol, a unique diterpene anticancer compound derived from the bark of the Taxus brevifolia (Pacific yew) tree, induces cytotoxicity by a novel mechanism of action. An antimicrotubule agent, Taxol promotes the formation and stabilization of the tubulin polymer unlike other anticancer agents that induce microtubule disassembly. Because of its poor aqueous solubility, Taxol is formulated as a solution in 50% Cremophor EL and 50% dehydrated alcohol, USP. The Cremophor EL and dehydrated alcohol vehicle used in the formulation of Taxol creates some interesting challenges for its preparation and administration. The pharmaceutical concerns associated with the preparation and administration of Taxol are discussed.

Animals↗
PubMed1994

[Effects of compatibility of radix Ginseng with faeces Trogopterori on toxicity in experimental animals].

The acute toxicity test in mice revealed no toxic effects after oral administration with mixed decoction of Radix Ginseng and Faeces Trogopterori. But a tendency of increasing toxicity was found with intraperitoneal injection. The subacute toxicity test in rats showed no obvious effect on white blood cell count (WBC), differential count (DC), platelet count (Pt), hemoglobin amount (Hb), serum glutamic pyruvic transaminase (SGPT), blood urea nitrogen (BUN), body weight (BW), and so on after oral administration with the above-said mixed decoction.

Animals↗
PubMed1994

[Influence of combined Salvia miltiorrhiza and Ligusticum wallichii on pharmacokinetics of tetramethylpyrazine in rats].

Influence of Salvia miltiorrhiza (SM) and/or Ligusticum wallichii (LW) on pharmacokinetics of tetramethylpyrazine (TMP) was observed in rats. The content of TMP in LW and LW-SM decoctions were 375.8 and 236.2 micrograms/ml respectively. The rat serum components after oral administration of LW were analyzed by modified HPLC. One of 3 compounds was detected, which was identified as TMP by the comparison of the parameters of 4 spectrums (UV, IR, MS and NMR) with those of TMP in literature. Pharmacokinetics of TMP in rats after the oral administration of LW and LW-SM decoction respectively showed that: (1) both of the data fitted adequately to two-compartment open model; (2) Ka, AUC and serum concentration were higher (P < 0.05-0.01) for LW decoction than that for LW-SM decoction, indicating a higher bioavailability. It demonstrated that the absorption of TMP of LW-SM decoction was slower and the bioavailability of TMP of LW-SM decoction reduced. Contents of TMP in LW and LW-SM decoction and serum concentration of TMP were determined by HPLC method.

Animals↗
PubMed1994

Stability and compatibility studies of cefaloridine, cefuroxime and ceftazidime with PVC infusion bags.

A rapid isocratic technique was developed for the analysis of three cephalosporins: cefaloridine, cefuroxime and ceftazidime in parenteral solutions using high-performance liquid chromatography (HPLC) with UV detection and C18 column. The availability and compatibility of drugs from solutions infused via plastic infusion bags through plastic administration sets have been examined. No significant drugs loss was observed during the simulated infusions (n = 4) for 1 h using PVC infusion bags and administration sets. No significant difference was found between infusion solutions (5% glucose or 0.9% NaCl). The stability of drugs was also studied in solution in PVC bags after storage at room temperature and at +4 degrees C without protection from light. The results show the stability of drugs during 24 h at room temperature and 7 d storage at +4 degrees C to be satisfactory, irrespective of the infusion solution (5% glucose or 0.9% NaCl).

Ceftazidime↗