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PubMed2003

A technique to improve the spelling suggestion rank in medical queries.

Correct spelling is crucial for online search engines to function well, and health information is highly sought after online. We propose a technique for increasing the effectiveness of spell-checking tools for use with medical queries. Our results show a marked improvement in the ranking of the correct term within the suggestion list returned by the spelling correction tool, as well as a lessening of the drawbacks associated with using larger dictionaries.

Dictionaries, Medical as Topic↗

PubMed2003

A "systematics" tool for medical terminologies.

Finding the hierarchical relations amongst multiple terms within medical terminologies that support multiple parents to a term is a common task, especially for trainees and knowledge engineers implementing or maintaining medical logic modules or guidelines. Examples of such terminologies include the UMLS and the Medical Entity Dictionary (MED). In addition, the task of identifying and discriminating amongst some common ancestors to a list of terms is a recurrent theme. This is also a common concern in the science of classification (systematics). Some nearest common ancestors have distinct valuable properties for classification and simplification of lists. Although there exist some visualized navigating and editing tools for the UMLS and the MED, they are browsers that show a large number of unrelated and irrelevant relationships to the task at hand. While algorithms have been well studied in computer science to solve such a problem over semantic networks and trees, to our knowledge, they have not been used with a visualization tool in biomedicine. We developed a visualized tool that graphically displays the hierarchical relations of multiple terms, and helps identifying the nearest common ancestors of these terms.

Classification↗

PubMed2004

Mapping various information sources to a semantic network.

Giessen Data Dictionary Server (GDDS) provides context sensitive information services to disparate clinical applications by automatically navigating a semantic network that stores medical knowledge. Mapping multiple information sources to single clinical application becomes a challenge due to different organization of semi-structured information sources. Linking huge unstructured information sources such as medical literature is even more challenging because we need to develop a mechanism to organize unstructured information and take into account the scalability issue. In this paper, we have successfully mapped two drug information sources by developing an independent subnet for each source and linking them at proper nodes. For medical literature, we have demonstrated that the semantic network of the Unified Medical Language Systems and human assigned topics to each document can be used to organize the large amount of medical literature into the framework of the GDDS service.

Dictionaries, Medical as Topic↗

PubMed2005

Of mice and men: aligning mouse and human anatomies.

This paper reports on the alignment between mouse and human anatomies, a critical resource for comparative science as diseases in mice are used as mod-els of human disease. The two ontologies under investigation are the NCI Thesaurus (human anatomy) and the Adult Mouse Anatomical Dictionary, each comprising about 2500 anatomical concepts. This study compares two approaches to aligning ontologies. One is fully automatic, based on a combination of lexical and structural similarity; the other is manual. The resulting mappings were evaluated by an expert. 715 and 781 mappings were identified by each method respectively, of which 639 are common to both and all valid. The applications of the map-ping are discussed from the perspective of biology and from that of ontology.

Anatomy↗

PubMed2006

[The Unión Médica Hispano-Americana (1900) and its contribution to scientific internationalism].

The Unión Médica Hispano-Americana was founded during the XIII International Congress of Medicine of Paris in 1900. Its main aim was to strengthen the cultural and scientific ties among Spanish speaking countries. The first assembly took place in Madrid in the Spring of 1903. The most interesting paper presented was undoubtedly that of Manuel Tolosa Latour. He suggested creating a Diccionario Tecnológico Médico Hispano-Americano. The society had no continuity and neither did the dictionary. The reasons for this failure must be seen in the absence of economic support by political authorities in Spain and America, the organizational weakness of the Unión and the poverty of its action program, which was imbued with a triumphalist rhetoric, empty of content and highly paternalistic in its relations with the American world.

Americas↗

PubMed1995

Managing vocabulary for a centralized clinical system.

The clinical computing environment at Columbia-Presbyterian Medical Center is organized around a centralized database of coded patient information collected from various ancillary sources. The Medical Entities Dictionary (MED) is the central repository for the controlled vocabulary used to encode the patient data. The MED is composed of terms used in the ancillary departments and, as such, changes in the source vocabularies must be maintained in the MED. The MED also contains some basic knowledge about the terms, and sophisticated maintenance tools have been developed that take advantage of this knowledge. This paper describes the success of the knowledge-based approach by describing the techniques used in two tasks: addition of a new vocabulary and maintenance of an existing one.

Clinical Laboratory Information Systems↗

PubMed1996

A glossary of managed care terms.

With health care changing by the nanosecond and managed care entities growing, mixing and mutating even more quickly, the words used to describe, distinguish and categorize various entities and activities are confusing even the most sophisticated professionals. This "article" provides a much-needed dictionary of managed care terms.

Humans↗

PubMed1998

Snake oil for the 21st century.

Dermatology has been associated with quackery for at least a century. The dictionary defines a quack as "a pretender to medical knowledge or skill; ignorantly or falsely pretending to cure." The term quack is derived from quacksalver, or one who quacks like a duck in promoting his salves. Quacksalvers hacked many potions, including snake oil, with claims that it cured everything from dermatitis to rheumatism. With the current promulgation of skin "products" and their promotion and even sale by dermatologists, and the use of treatments of no proven efficacy, this association between dermatology and quackery is set to continue well into the 21st century. The list of offending treatments includes silicone gel sheets and onion extract cream (Mederma) for keloids, alpha-hydroxy acid creams and peels, topical ascorbic acid and phytonadione, "laser resurfacing," and cimetidine for warts, to name only a few.

Clinical Trials as Topic↗

PubMed1991

Allochiria vs allesthesia. Is there a misperception?

Allochiria is the mislocation of sensory stimuli to the corresponding opposite half of the body or space. Obersteiner (1882) introduced the term allochiria (Greek allos = other + chiria = hand), and more than 20 authors employed it in this context over the next 25 years. Stewart (1894) described a related phenomenon in which stimuli are displaced to a different point on the same extremity. He noted that the displacements were different than allochiria and coined the term allachaesthesia (ie, allesthesia) (Greek allaché = elsewhere + aisthésis = perception). Despite this historical background, Jones (1907) redefined both terms in an attempt to increase diagnostic specificity and attributed allochiria to hysteria. Jones' reinterpretation does not appear to be justified historically, etymologically, or scientifically and has resulted in contradictory definitions of allochiria and allesthesia in present-day medical dictionaries and neurologic textbooks. We advocate a return to usage consistent with the original descriptions and word derivations.

Europe↗

PubMedDate not supplied

Automatic annotation of BIND molecular interactions from three-dimensional structures.

Software to automate the process of extracting molecular interactions from three-dimensional (3D) structures has been developed that records these as Biomolecular Interaction Network Database (BIND) pairwise interaction records. Full annotation of BIND records is provided through a database processing tool called MMDBind, including detailed atom-atom and residue-residue level interaction information. BIND three-dimensional interaction annotation is synthesized by combining information from the Molecular Modeling Database (MMDB), and the HET (heterogen) group dictionary of small molecules in the macromolecular Crystallographic Information Format (mmCIF). Interactions are validated using the Protein Quaternary Structure (PQS) system. A total of 18,166 interactions were removed as being redundant or biologically irrelevant after PQS validation. This first pass MMDBind annotation creates two new divisions of BIND, 3D Biopolymers (BIND-3DBP) comprising 16,737 initial interaction records, and 3D Small Molecules (BIND-3DSM) comprising 48,219 records. Visualization of interacting residues and nucleotides within a macromolecular structure is possible directly from the BIND database owing to added 3D feature annotation within the BIND records that can be conveniently seen using Cn3D ("see-in-3D") after query from the BIND Data Manager. These interaction records provide a further demonstration of the completeness of the BIND data specification and its capabilities as storage and exchange format for all kinds of molecular interactions, including RNA, DNA, protein, and small molecules. Data from the 3DBP and 3DSM sets are available for downloading in Abstract Syntax Notation.1 (ASN.1) or Extensible Markup Language (XML) formats at ftp://ftp.bind.ca/DB/MMDBBind. Data from the 3DBP set is available for interactive query from the BIND Data Manager at www.bind.ca.

Crystallography, X-Ray↗

PubMed1984

Lexical differences between working and resistance sessions in psychoanalysis.

Divided 25 psychoanalytic sessions with a single patient into 10 working sessions, 5 neutral sessions, and 10 resistance sessions on the basis of ratings by psychoanalysts. Using the Regressive Imagery Dictionary on keypunched transcripts of these sessions, significantly more primary process content and less secondary process content was found in the patient's working-session speech, as opposed to resistance-session speech. Lexical diversity was also higher during working sessions. Results are compared with those obtained with other types of verbal material and are discussed in terms of psychoanalytic views on the process of psychotherapy.

Humans↗

PubMed1997

Language as a psychological adaptation.

Language is the remarkable faculty by which humans convey thoughts to one another by means of a highly structured signal. Language works by two principles: a dictionary of memorized symbols, that is, words, and a set of generative rules organized into several subsystems, that is, grammar. The machinery of language appears to have been designed to encode and decode propositional information for the purpose of sharing it with others. Language is universally complex and develops reliably throughout the species, partly independently of general intelligence. I suggest that language is an adaptation for sharing information. It fits with many other features of our zoologically distinctive 'informavore' niche, in which people acquire, share and apply knowledge of how the world works to outsmart plants, animals and each other.

Adaptation, Psychological↗

PubMed1991

Human spinal arachnoid septa, trabeculae, and "rogue strands".

This study was undertaken because of confusion arising from a diversity of names, descriptions, and drawings of the human spinal subarachnoid septa and trabeculae in the standard texts and dictionaries. Sixty-two complete human cords were examined under the dissecting scope. The finely "woven" adult arachnoid membrane was two-layered, and there were essentially no connecting septa or trabeculae between the cord and the arachnoid membrane anteriorly. Posteriorly, in the upper cervical region there is a scanty series of connecting fibers and fenestrated sheets 1 or 2 mm on either side of the midline; these become progressively more extensive in the lower cervical region, remain extensive to the lumbar enlargement, beyond which they progressively dwindle to end abruptly at the filum terminale origin. Throughout the cauda equina, strands are haphazardly arranged connecting the roots and supporting blood vessels. These occasionally become tangentially adherent to the arachnoid membrane. Throughout the length there are many unexplained, redundant, nonbranching, beaded, thicker "rogue strands". All of the above are of a different character from the right-angle fiber arrangement of the denticulate ligament, the two leaves of which are often separated form segmental longitudinal tunnels. The nerve rootlets (fila radicularia) for each dermatome are joined by strands and webs to each other. There was no evidence of change in number or type of connection with age.

Adolescent↗

PubMed1993

Estimating historical exposure to silica among mine and pottery workers in the People's Republic of China.

A quantitative retrospective exposure assessment method was developed for use in a nested case-control study of lung cancer among mine and pottery workers exposed to silica dust in the People's Republic of China. Exposure assessment was carried out in 20 mines (10 tungsten, 6 iron/copper, and 4 tin) and nine pottery factories. A job title dictionary was developed and used in both the collection of historical exposure information and work histories of 1,668 (316 cases and 1,352 controls) study subjects. Several data abstraction forms were developed to collect historical and current exposure information and employees' work histories, starting in 1950. A retrospective exposure matrix was developed on the basis of facility/job title/calendar year combinations using available historical exposure information and current exposure profiles. Information on the amount of respirable, thoracic, and free silica content in total dust was used in estimating exposure to silica. Starting in 1950, 6,805 historical estimates had been carried out for 14 calendar-year periods. We estimated the average total dust concentration to be 9 mg/M3, with a range from 28 mg/M3 in earlier years to 3 mg/M3 in recent years. Several exposure indices [such as cumulative dust, average dust, cumulative respirable (< 5 mu in particle size) and thoracic (< 10 mu in particle size) silica dust, average respirable and thoracic silica dust, exposure-weighted duration, and the highest/longest exposure] were calculated for individuals by merging work history and historical exposure matrix for each study subject. We developed these various measures of exposure to allow investigators to compare and contrast different indices of historical exposure to silica.

Case-Control Studies↗

PubMed1986

Updating McKusick: an educational exercise for medical students.

An educational module is described in which first-year medical students were assigned different entries from the 1983 edition of McKusick's Mendelian Inheritance in Man to revise and update. Following review and discussion in small group sections, the entries were reproduced to provide each student with an updated compendium of the selected genetic disorders. The important principles of Mendelian inheritance could be readily illustrated by the entities assigned to each discussion group. Students learned to use the library and how to understand and integrate clinical and experimental papers. More than half the students reported spending 11-20 h to complete the assignment and reviewed from six to ten articles in detail. The caliber of the entries was found to be significantly correlated with the time students reported they spend on the exercise, but not with the number of papers reviewed, prior knowledge of the disease entity, the frequency of dictionary usage, or undergraduate exposure to genetics.

Education, Medical, Undergraduate↗

PubMed1978

Automatic indexing of pathology data.

A procedure for automated indexing of pathology diagnostic reports at the National Institutes of Health is described. Diagnostic statements in medical English are encoded by computer into the Systematized Nomenclature of Pathology (SNOP). SNOP is a structured indexing language constructed by pathologists for manual indexing. It is of interest that effective automatic encoding can be based upon an existing vocabulary and code designed for manual methods. Morphosyntactic analysis, a simple syntax analysis, matching of dictionary entries consisting of several words, and synonym substitutions are techniques utilized.

Abstracting and Indexing↗

PubMed1994

[Not Available].

In most instances, knowledge is passed on through the medium of language. The author tries to demonstrate to what extent the Latin present in early medieval Latin medical treatises failed to fulfill its role as an efficient medium of communication, which factors may account for this failure and how scholars in the middle ages strove to restore sense in texts in various stages of corruption, an attempt that was bound to be unsuccessful in many cases owing to a lack of reliable dictionaries.

Europe↗

PubMed2006

Toxicity and outcome of a phase II trial of taxane-based neoadjuvant chemotherapy and 3-dimensional, conformal, accelerated radiotherapy in locally advanced nonsmall cell lung cancer.

BACKGROUND: The objective of this study was to evaluate prospectively the acute and late adverse effects of taxane/carboplatin neoadjuvant chemotherapy and 3-dimensional, conformal radiotherapy in patients with locally advanced nonsmall cell lung cancer (NSCLC). METHODS: Forty-two patients were entered into a nonrandomized Phase II study of continuous, hyperfractionated, accelerated radiotherapy (CHART) week-end less (CHARTWEL) to a dose of 60 grays (Gy). Three cycles of chemotherapy were given over 9 weeks before radiotherapy. Dose escalation with paclitaxel was from 150 mg/m2 to 225 mg/m2. Systemic toxicity to chemotherapy was monitored throughout. Radiation-induced, early, adverse effects were assessed during the first 9 weeks from the start of radiotherapy, and late effects were assessed from 3 months onward. Overall survival, disease-free survival, and locoregional tumor control also were monitored. RESULTS: Twenty percent of patients failed to receive chemotherapy as planned, primarily because of neutropenia. The incidence of Dische Dictionary Grade >or=2 and Grade >or=3 dysphagia was 57.5% and 10%, respectively, with an average duration of 1.2 weeks and 1.5 days, respectively. By 9 weeks, <3% of patients were symptomatic; and, eventually, all acute reactions were healed, and there has been no evidence of consequential damage. At 6 months, the actuarial incidence of moderate-to-severe pneumonitis was 10%. During this time, all patients were free of severe pulmonary complications. Actuarial estimates of Grade >or=2 late lung dysfunction were 3% at 1 year, 10% at 2 years, and remained at this level thereafter. The actuarial 3-year locoregional control and overall survival rates were 54% and 45%, respectively. CONCLUSIONS: Neoadjuvant chemotherapy followed by 3-dimensional, conformal CHARTWEL 60-Gy radiotherapy in patients with advanced NSCLC was feasible and was tolerated well. Historic comparisons indicated that locoregional tumor control is not compromised by the use of conformal techniques.

Aged↗