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PubMed1991

Analysis of the frequency and duration of freeway accidents in Seattle.

Accidents occurring on congested urban freeways can have enormous impacts in terms of lost commuter time. This paper presents an appropriate statistical analysis of urban freeway accident frequency and duration and discusses how this analysis can be used to guide management strategies that seek to reduce the traffic-related impacts of accidents. The findings and demonstration of analysis procedures should be of considerable value to ongoing and future studies in this area.

Accidents, Traffic↗
PubMed1978

What the passenger contributes to passenger comfort.

An individual's reaction to a vehicle environment depends not only on the physical inputs but also on the characteristics of the individual. Surveys of airline passengers were conducted on board regularly scheduled commuter flights. Sex of the respondent and attitude toward flying were found to have import nt influences on passenger comfort. Individual differences were also found regarding (1) perceptions of environmental variables, (2) the importance of factors as determinants of comfort, and (3) the ease of and frequency of performing activities in flight.

Journal Article↗
PubMed1996

The impact of shift and night work on health.

Shift work, in particular night work, can have a negative impact on health and well-being of workers as it can cause: (a) disturbances of the normal circadian rhythms of the psychophysiological functions, beginning with the sleep/wake cycle; (b) interferences with work performance and efficiency over the 24 hour span, with consequent errors and accidents; (c) difficulties in maintaining the usual relationships both at family and social level, with consequent negative influences on marital relations, care of children and social contacts; (d) deterioration of health that can be manifested in disturbances of sleeping and eating habits and, in the long run, in more severe disorders that deal prevalently with the gastrointestinal (colitis, gastroduodenitis and peptic ulcer), neuro-psychic (chronic fatigue, anxiety, depression) and, probably, cardiovascular (hypertension, ischemic heart diseases) functions. Besides, shift and night work may have more specific adverse effects on women's health both in relation to their particular hormonal and reproductive function, and their family roles. It has been estimated that about 20% of all workers have to leave shift work in a very short time because of serious disturbances; those remaining in shift work show different levels of (mal)adaptation and (in)tolerance, that can become more or less manifest in different times, and with different intensity. In fact, the effects of such stress condition can vary widely among the shift workers in relation to many 'intervening variables' concerning both individual factors (e.g. age, personality traits, physiological characteristics), as well as working situations (e.g. work loads, shift schedules) and social conditions (e.g. number and age of children, housing, commuting).

Journal Article↗
PubMed1988

The place of reference materials in clinical enzymology.

Standardization embraces two concepts: achievement of a uniform standard of practice, or comparison with a standard of known or defined properties. In clinical enzymology the former concept can be equated with the adoption of recommended standardized methodology, which has had noteworthy successes in improving comparability of results. The use of enzyme standards or calibrators has received relatively little attention so far, but is increasingly important with the introduction of analysers which cannot readily utilize recommended methods. The main factor in the use of calibrators is that of commutability of calibrators and patients' samples between methods, which must be the subject of thorough experimental tests.

Calibration↗
PubMed1988

CYP1 (HAP1) regulator of oxygen-dependent gene expression in yeast. II. Missense mutation suggests alternative Zn fingers as discriminating agents of gene control.

In the accompanying paper, we present and analyse the sequence of a "superactivator" mutant allele of the CYP1 (HAP1) gene. This locus encodes a trans-acting pleiotropic positive regulator of the transcription of both isocytochrome c structural genes. In this paper, we present the genetic localization of the mutation and the sequence of the wild-type fragment that includes the mutation. The mutated phenotype that commutes the expression of the two isocytochrome structural genes (superactivation of CYP3 and inhibition of CYC1) results from a transversion in an AGT codon (serine) in the wild-type to an AGG codon (arginine) in the mutant. Moreover, we show that the missense mutation that affects the amino acid preceding the first cysteine of the "Zn finger" is responsible on its own account for the entire mutated phenotype. In all seven yeast regulatory proteins analysed so far, this position is occupied by a neutral amino acid (serine, alanine or glycine), thus the serine-arginine replacement is a radical one. This result is consistent with the hypothesis of alternative and mutually exclusive Zn fingers, formed either at low or high redox potential, recognizing the target sequences identified in the upstream regions of the CYC1 and CYP3 isocytochrome c structural genes.

Alleles↗
PubMed1989

Biological growth and spread modeled by systems of recursions. I. Mathematical theory.

We study the asymptotic behavior of solutions to a system of recursions u in+1 = Qi[mu n], i = 1, ..., k. The vector operator Q has the origin theta and a positive vector beta as fixed points and is defined for vector-valued functions bounded between theta and gamma where gamma greater than or equal to beta. In addition, Q is order-preserving, commutes with translation, and is continuous in the topology of uniform convergence on compact subsets. Let theta less than or equal to pi much less than beta, and suppose that for all pi much less than alpha much less than beta, Q(n) alpha]----beta as n----infinity. If u0 much greater than pi on a sufficiently large ball and has bounded support, then un propagates with a speed c*(xi) in the direction of the unit vector xi as n----infinity. In certain cases, c*(xi) can be calculated explicitly. The results generalize those of a scalar equation studied by Weinberger.

Genetics, Population↗
PubMed1993

Women's opinion on withdrawal bleeding with hormone replacement therapy.

The objective of the study was to assess the opinion of women about the use of hormone replacement therapy (HRT) in relation to continuation or re-induction of bleeding periods after menopause. The design was a population-based cross-sectional study using a postnatal questionnaire in Krimpen aan den IJssel, a commuter suburb of Rotterdam. The participants were all 2729 women living in Krimpen aan den IJssel aged 45-60 years, of whom 1947 (71.3%) responded. The main outcome measure was an opinion on monthly or trimonthly withdrawal bleedings with HRT. The results showed 16.9% of all women have no or little objection to use of HRT with monthly withdrawal bleedings. There is a marked difference between premenopausal women (32.4% have no or little objection) and postmenopausal women (only 9.2% have no or little objection). Trimonthly cycles during HRT tend to be perceived as more acceptable (41.4% of premenopausal women and 11.8% of postmenopausal women have no or little objection). It is concluded that a reasonable proportion of premenopausal women accept continuation of periodic bleeding with HRT. There is a preference for trimonthly cycles rather than monthly withdrawal bleedings. Most postmenopausal women object to having withdrawal bleedings with HRT, irrespective of a monthly or trimonthly cycle. Research should continue on schedules without withdrawal bleedings.

Estrogen Replacement Therapy↗
PubMed1984

An improved drug infusion pump for injecting nanoliter volumes subcortically in awake rats.

A new drug infusion pump capable of injecting nanoliter volumes of drug solution into the brains of awake rats has been constructed which incorporates a new "turntable" commutator and a compact tubing compressor mechanism requiring no gears. Injector cannulas inserted into guide cannulas permanently mounted in the rat's skull are connected to the drug pump by spring-protected, PE 10 tubing. Drug solutions are delivered when the pump rollers compress the drug-filled PE 10 tubing. An additional animal-activated switch and motorized mechanism rotates the drug pump in response to the animal's movements so that the PE 10 drug reservoir is not twisted. Testing the drug pump's performance in vivo with injections of 14C-nicotine into the caudate nucleus shows that drug delivery is both reliable and reproducible.

Animals↗
PubMed1995

A novel apparatus that permits multiple routes for infusions and body-fluid collections in a freely-moving animal.

A novel apparatus is described for simultaneous performance of multi-channel infusions/body-fluid collections and multichannel electrical recordings/stimulations in a freely behaving animals. This apparatus consists of a cylindrical cage and other devices described below. Electrical contacts are achieved via a slip-ring commutator. A rotation detector detects the turning of the animal in the cage, and a controller rotates the floor under the animal in the opposite direction by means of a stepping motor. Thus, excessive twisting of the fluid tubing between the animal and experimental equipment is released by rotation of the floor. Floor rotation starts when the animal turns in either direction and exceeds a present number of rotations. When the turning exceeds certain rates, the floor is rotated with higher angular velocities. This floor rotation little affected sleep-wake activities, brain temperature, food and water intake, and general behavior of the rat. Thus, multi-channel fluid routes have been realized; and by excluding the swivel apparatus from the fluid lines, advantages such as no fluid leakage at the swivel, no extra dead volume, and low torque to rotate the device have been gained.

Animals↗
PubMed1994

When is a move a migration?

"This paper extends the traditional theory of urban location to derive a consistent model of inter- and intra-regional mobility. It demonstrates that the two are behaviorally distinct. Workplace and residence relocations tend to be 'substitutes' in intra-regional mobility but are 'complements' in inter-regional mobility. Previous empirical papers have neglected the theoretical foundations of intra-regional mobility. In consequence, they have made four types of analytical compromises: defined 'migration' as any change in residence location, used job changes as proxies for workplace mobility, neglected commuting distances, and used estimation techniques that do not reveal the underlying behavior."

Demography↗
PubMed1995

Intracellular pH of Candida albicans blastospores as measured by laser microspectrofluorimetry and 31P-NMR.

The intracellular pH (pHi) of Candida albicans blastospores harvested from 8 h or 48 h cultures was determined under identical experimental conditions by two different techniques: 31P-NMR and laser microspectrofluorimetry. Time dependence of pHi was monitored by 31P-NMR on the whole cell population. Microspectrofluorimetry, after loading of the cells with SNARF-1, enabled the determination of pHi in isolated cells and its distribution among the cell population. By this method, the vacuolar pH could not be distinguished from the cytoplasmic pH in C. albicans blastospores, but alkalization of pHi was observed at the beginning of germ tubes. The absolute values of pHi determined by 31P-NMR were slightly different from those obtained by laser microspectrofluorimetry. However, the pH distributions in the cell population were converging. For blastospores in exponential phase a gaussian distribution of pHi was observed with both methods, the cells maintained a steady pHi value when the external pH was varied from 5.5 to 8.5. For cells in stationary phase two pools were identified: the combination of the two techniques demonstrated the presence of two different subpopulations. One of these population (with lower pH) was able to commute to the other one with time as shown by 31P-NMR kinetics. This information is reported here for the first time in C. albicans.

Benzopyrans↗
PubMed1996

Vasomotor symptoms and well-being in the climacteric years.

OBJECTIVES: To determine more closely the relationship between vasomotor symptoms, well-being and climacteric status according to the last menstrual bleeding and according to the women themselves. METHODS: A population-based cross-sectional study was executed using a postal questionnaire. Well-being of women with and without vasomotor symptoms was compared, for the different menopausal statuses. All 2729 women living in a commuter suburb of Rotterdam aged 45-60 years were approached of whom 1947 (71.3%) responded. Well-being was measured by the Inventory of Subjective Health (ISH) and three subscales of the Sickness Impact Profile (SIP). RESULTS: The results showed that the relationship between vasomotor symptoms and well-being was dependent on climacteric status. Pre- and (middle and late) postmenopausal women with vasomotor symptoms more often experienced a relatively lower level of well-being compared to women without these symptoms. However, when the prevalence of vasomotor symptoms is as its peak, i.e. in late perimenopause, a difference in the level of well-being between women with and without vasomotor symptoms was absent. CONCLUSIONS: It is concluded that well-being and vasomotor symptoms were inversely related in all menopausal statuses except for the (late) perimenopausal phase. For this no somatic explanation seems plausible. A more social scientific explanation is suggested.

Climacteric↗
PubMed1994

Imaginary constructions and forensic reconstructions of fatal violence against women: implications for community violence prevention.

The almost exclusive media focus on political violence in South Africa has deflected attention from the high levels of interpersonal violence in areas of socioeconomic deprivation. In order to explore the tension between an at-risk community's perspective and the current reality of violence against women, imaginary constructions of their own violent death produced by 45 African female interview respondents were examined in conjunction with forensic data relating to 73 African female homicide victims in Cape Town, South Africa. The prototypical account of an imagined homicide involved a female commuter being approached by a group of men, taunted and assaulted, raped and then killed. The majority of actual homicides occurred at or in the vicinity of the residence of the victim, with the attacker being known to the deceased. Whilst only 1 of the imagined homicide narratives depicted the use of alcohol by the victim, over half the actual homicides had elevated postmortem blood alcohol levels. These and other disjunctions and convergencies between lay and forensic constructions of violent female death should be viewed in the wider context of enmeshment in social circumstance, and could provide some understanding of how at-risk communities perceive violence against women, thereby providing a foundation for appropriate prevention programmes.

Adult↗
PubMed1995

Bridges, why and from where to where?

Therapeutic intervention for chronic diseases does not rely only on drugs but is also strictly dependent on how the patient has been informed about his disease and how he is able to master the various skills required by his treatment. Education therefore plays a fundamental role in the efficacy of control of those diseases. But what is education? Among the various possible definitions, one could be metaphorically illustrated by bridges. How to get the message across from the medical world to that of the patient, or, inside the medical professions from one group of providers to another. Different bridges may have different functions or roles. One is for commuting in the current daily life. Another one is to ensure vital needs. Bridges help also to discover new territories, but any new visitor may not always be welcomed in these new regions. Bridges need to be solidly constructed with a structure which can be methodologically described. This may help repair in case of problems. Patient education is a kind of bridge submitted to all sorts of forces and barriers which may interfere with the passage of knowledge and skills from the health care providers to the patient and his family.

Chronic Disease↗
PubMed1996

Distortions in multiple-pulse solid state NMR imaging: gradient decoupling, time-sequenced second averaging, and over-sampling.

Three approaches to reducing image artifacts are described that are specific to multiple-pulse line-narrowing methods of NMR imaging. Gradient decoupling avoids excess line broadening from off-resonance gradient phase evolution by restricting the gradient to selected windows in which the gradient Hamilton an commutes with the toggling frame state, and where the averaged Hamiltonian between gradient pulses is either cyclic or anti-cyclic. This forces the residual averaged dipolar Hamiltonian to be independent of the gradient evolution. Time-sequenced second averaging addresses the on-resonance broadening, where residual error terms dominate the spin dynamics (a lack of second averaging), by adding a second coherent averaging that retains part of the modulation associated with off-resonance terms, and thus smoothes out the line-narrowing efficiency with spatial offset. Over-sampling is useful to increase both the resolution and sensitivity of an image, but it introduces a sampling modulation that produces sidebands. These are eliminated by a series of prepulses in a fashion reminiscent of CYCLOPS phase cycling.

Magnetic Resonance Spectroscopy↗
PubMedDate not supplied

Freshmen baccalaureate nursing students' perceptions of their academic and nonacademic experiences: implications for retention.

As a component of the evaluation for a program designed to enhance recruitment and retention of disadvantaged nursing students, qualitative interviews were conducted, with a sample of 20 baccalaureate nursing students at the end of their freshman year. Students were asked to describe positive aspects of their academic and nonacademic experiences as well as problems that were experienced, with recommendations for resolving these problems. Positive aspects of the freshman experience that were identified included academic, social, familial, and financial support. Problems cited were related to two categories of factors, external and internal. Problems related to external factors included excessive academic loads, course-specific problems such as with the sciences, large class size, faculty inattentiveness, racial tensions, dorm/roommate problems, and parking or commuting time. Problems related to internal factors included poor study habits, loneliness, homesickness, family conflicts, and difficulties with peer relationships. The findings can be used by nursing faculty to determine the extent to which programs address students' perceived needs and to identify innovative retention strategies that would enhance students' perceptions of their college experience.

Alabama↗
PubMed2005

Is rigorous punishment effective? A case study of lifetime license revocation in Taiwan.

This study investigated the effectiveness of administrative lifetime driver's license revocation (ALLR) and its impact on offenders, based on a two-stage survey of 768 offenders. It was found that after ALLR had been imposed, 23.4% of these offenders were still driving almost the same as before, 59.8% drove significantly less frequently, and only 16.8% of the offenders gave up driving completely. The results of logistic regression models showed that offenders' compliance with ALLR was significantly correlated with their personal characteristics (age, income), penalty status (incarceration, duration of ALLR), and the need to drive for working, commuting and shopping. Elderly and low-income offenders were more likely to abide by the ALLR restriction. The application of the generalized estimating equations (GEE) model was used to identify the determinant factors affecting offenders' driving mileage, and to effectively estimate the driving mileage reduction as a result of the ALLR. It was found that ALLR is fairly effective in keeping offenders off the road, but that it may reduce their ability to make a living, resulting in the less fortunate becoming more helpless.

Adult↗