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PubMed1979

[Surveillance of cephalosporins therapy in therapeutic practice of 15 Italian hospitals (author's transl)].

A retrospective review and evaluation of systemic cephalosporin therapy in 15 hospitals of various italian Regions was conducted. In any hospital the Pharmacy Service has examined a random sample of medical records of hospitalized patients exposed to cephalosporin therapy over a twelve month period (January-December 1976). In the years 1974-1976 were also examined the consumption and cost for Penicillin G, Ampicillin and Cephalosporins. A standard protocol and methodology for homogeneous collection of data was developed. On the base of collected data, the patterns of choice, the rational and irrational use, the role of cephalosporins in hospital practice are discussed.

Ampicillin↗
PubMed1981

Pharmacokinetics of cefapirin in patients with normal and impaired renal functions.

The pharmacokinetics of 3-hydroxymethyl-7-[2-(4-pyridyl-thio)acetamido]-2-cephem-2-carboxylic acid acetate (cefapirin) was evaluated after 1.0 g i.m. to 14 patients with different glomerular and tubular functions. Peaks in normal renal function ranged between 9--17 micrograms/ml and was 3--4 times higher in patients with glomerular filtration rates below 30 ml/min. The serum half-life in normal renal function was 0.8 h and was somewhat increased in renal impairment. The distribution volume was little influenced by renal capacity. Recommendations for dosage are given.

Adolescent↗
PubMed1981

Kidney transport of cefapirin in normal and impaired renal function.

The renal transport of cefapirin has been assessed in thirteen patients after one dose of 1.0 g i.m. In normal glomerular filtration rate, approximately 50-60% of the dose is recovered in the urine in active form. The corresponding figure in functions below 30 ml/min was 10-30%. In normal function, tubular secretion accounts for ca. 1/4-1/3 of the amount appearing in the urine.

Biological Transport↗
PubMed1975

[Cephalosporins].

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Cefazolin↗
PubMedDate not supplied

Quantitation of penicillin G in medicated premix feeds by micellar electrokinetic capillary chromatography.

A micellar electrokinetic capillary chromatographic (MECC) method for quantitation of penicillin G in medicated premix feeds was compared with the AOAC microbiological cylinder plate method. Feed was extracted according to the AOAC method, enabling comparison of both methods with the same extract. The MECC method detected penicillin G within 20 min, using a 150 mM sodium dodecyl sulfate (SDS)-20 mM sodium borate run buffer and a UV photodiode array detector at 210 nm. Recoveries from 5 replicates of medicated feed containing 117 g penicillin G/kg and then spiked to give a concentration of 176 g/kg were 98.4-108%, with a relative standard deviation (RSD) of 3.76% for the MECC method, and 102-104% with RSD of 1.06% for the AOAC microbiological cylinder plate method. Using a 5-point calibration curve, the MECC method detected and quantitated penicillin G in medicated premix feeds within 3 h, versus 24 h for the AOAC microbiological cylinder plate method.

Amoxicillin↗