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PubMed2005

A multicompartmental model of in vivo adipose tissue glycerol kinetics and capillary permeability in lean and obese humans.

Lipolysis of adipose tissue triglycerides releases glycerol. Twenty-four volunteers, of whom 6 were obese and 13 were women, received a primed-constant infusion of 2H5-glycerol for 120 min during postabsorptive steady-state conditions. Arterial, abdominal venous, and interstitial (microdialysis) samples were taken, and a four-compartment model was applied to assess subcutaneous abdominal adipose tissue glycerol kinetics. Adipose tissue blood flow was measured using 133Xe washout. Venous glycerol concentrations (median 230 micromol/l [interquartile range 210-268]) were consistently greater than those of arterial blood (69.1 micromol/l [56.5-85.5]), while glycerol isotopic enrichments (tracer-to-tracee ratio) were greater in arterial blood (8.34% [7.44-10.1]) than venous blood (2.34% [1.71-2.69], P < 0.01). Microdialysate glycerol enrichment was 1.44% (1.11-1.79), indicating incomplete permeability of glycerol between capillary blood and interstitium. Calculated interstitial glycerol concentrations were between 270 micromol/l (256-350) and 332 micromol/l (281-371) (examining different boundary conditions). The calculated capillary diffusion capacity (ps) was between 2.21 ml . 100 g tissue(-1) . min(-1) (1.31-3.13) and 3.09 ml . 100 g tissue(-1) . min(-1) (1.52-4.90) and correlated inversely with adiposity (Rs< or = -0.45, P < 0.05). Our results support previous estimates of interstitial glycerol concentration within adipose tissue and reveal capillary diffusion capacity is reduced in obesity.

Adipose Tissue↗
PubMed1984

Capillary permeability in the isolated rabbit heart as measured by local tissue clearance.

The relatively simple method of local tissue clearance was used to measure capillary permeability-surface area products (PS) in the isolated, Ringer-perfused rabbit heart. Ten microliters of a mixture of [3H]inulin and [14C]sucrose was injected at a depth of 2 mm into the left ventricular myocardium and clearance rate constants (k in min-1) were determined by analyzing the draining perfusion fluid. PS (ml/min per 100 ml) for each solute was calculated by the following equation: PS = -F ln(1 - lambda k/F), where F is perfusate flow (ml/min per 100 ml) and lambda is the equilibrium tissue/Ringer partition coefficient. At a perfusion pressure of 40 mm Hg, F = 133 +/- 9.7 (mean +/- SEM), PSsucrose = 77 +/- 8.0, and PSinulin = 13.9 +/- 0.7. These PS products are within the range of values previously reported by others using several different techniques. The mean inulin/sucrose permeability ratio was 0.189 +/- 0.018 which is significantly less than the separately measured free diffusion coefficient ratio (= 0.41 +/- 0.005), thus indicating that sucrose and inulin crossed myocardial capillary walls by restricted diffusion. The reasons why some investigators did not find similar evidence of restricted diffusion are discussed.

Animals↗