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Survey on neurosurgery subspecialty fellowship training. Congress of Neurological Surgeons Education Committee.

BACKGROUND: The ongoing controversy on the certification of neurosurgery subspecialties has not been settled. There has been no detailed report on why a resident chooses to undergo further training in the form of a postgraduate fellowship. A survey was devised to investigate the reasons, as well as factors, that prompt the resident to pursue fellowship training. METHODS: The names of the surveyed residents were obtained from the Congress of Neurological Surgeons database, and the names of the neurosurgery fellows were obtained from individual program coordinators by phone. A survey, a cover letter, and a return envelope were mailed to each prospective respondent. The data were entered on the Paradox for Windows program, and multiple queries were run to obtain tabulated results. RESULTS: The overwhelming majority (84.6%) of the resident respondents considered fellowship a possibility. Academic medicine was also the choice of career for most (60.3%). The most popular reported fellowships were spine (25.6%), pediatric (16.5%), and vascular (16.1%). The three top reasons for pursuing fellowship training were "personal interest for knowledge," "job market demand," and "academic prestige." "Inadequate training during residency" was a distant fourth. For respondents citing "inadequate training during residency" as one of the top three reasons, there were proportionally higher respondents in the fields of peripheral nerve, endovascular, and skull base neurosurgeries. CONCLUSION: A significant number of residents consider fellowship a way to further their personal interest and knowledge, as well as increase their marketability. Relatively few from the surveyed group considered their residency training experience deficient in the subspecialty areas, with the exception of peripheral nerve, endovascular, and possibly skull base neurosurgery.

Career Choice↗

Conducting international research in midwifery: a workshop held at the ICM Congress, Vienna, April 2002.

A workshop on international research in midwifery was held at the triennial International Confederation of Midwives (ICM) Congress in Vienna, April 2002. Thirty-five participants from 12 countries took part. The participants themselves defined the agenda, and subsequent discussion addressed the following issues: international research relationships and collaboration; ethical conduct in international research in midwifery; the role of the ICM in international research; and identifying topics for an international midwifery research agenda. Recommendations arising from this workshop were: that guidelines and a code of ethics for the conduct of international research in midwifery be developed; that the ICM and national midwifery organisations continue to actively support research, and further develop that support; that the ICM support education and capacity building for research at basic and continuing education levels; and that the priorities identified for collaborative international studies be updated on a regular basis.

Education↗

Clinical trials update: highlights of the scientific sessions of the XXIII Congress of the European Society of Cardiology--WARIS II, ESCAMI, PAFAC, RITZ-1 and TIME.

This article continues a series of reports updating recent research developments of particular interest to personnel involved in the treatment and management of patients with heart failure. This is a summary of selected presentations made at the Scientific Sessions of the XXIII Annual Congress of the European Society of Cardiology. Summaries of the following clinical studies are included: WARIS-II, ESCAMI, PAFAC, RITZ-I and TIME.

Anticoagulants↗

Conducting international research in midwifery: a workshop held at the ICM Congress, Vienna, April 2002.

A workshop on international research in midwifery was held at the International Confederation of Midwives (ICM) Triennial Congress in Vienna, April 2002. Thirty-five participants from 12 countries took part. The participants themselves defined the agenda, and subsequent discussion addressed the following issues: international research relationships and collaboration; ethical conduct in international research in midwifery; the role of the International Confederation of Midwives in international research; and identifying topics for an international midwifery research agenda. Recommendations arising from this workshop were as follows: develop guidelines and a code of ethics for the conduct of international research in midwifery; continue to actively support research and further develop that support; support education and capacity building for research at basic and continuing education levels; and update on a regular basis the priorities identified for collaborative international studies.

Austria↗

10th International Congress on Antiphospholipid Antibodies--summary.

The 10th International Congress on Antiphospholipid Antibodies (Sicily, Italy, September 29-October 3, 2002) (Fig. 1) provided enlightening aspects on the recent developments in antiphospholipid syndrome (APS) and antiphospholipid antibodies in more than 150 lectures and posters. Researchers from all aspects of medicine attended the meeting, implicating the systemic characteristics of APS. The important breakthroughs are summarized.

Animals↗

Abstracts of trials presented at the Vth World Congress of Psychiatry (Mexico, 1971): a cohort study.

BACKGROUND: Systematic reviews should identify all relevant trials in order to minimize the potential for bias and the play of chance in their results. Other specialities have shown that conference proceedings are a rich source of trials, but many of these trials are never fully published. METHODS: All clinical trials presented at a single conference (Vth World Congress of Psychiatry, Mexico, 1971) were identified by hand searching. Full publications of these abstracts were then sought on five databases by searching for the authors or relevant key words. RESULTS: Full publications were found for 46% of the abstracts. The odds of publication decreased for abstracts that were from a non-Anglophone country or that failed to mention randomization. CONCLUSIONS: Anyone wishing to undertake a systematic review of a mental-health care topic should search relevant conference proceedings for trials.

Clinical Trials as Topic↗

Adolescent Health. Reflections on a report to the U.S. Congress.

The Office of Technology Assessment (OTA) found that the conventional wisdom that American adolescents are so healthy that they do not require health and related services is not justified; U.S. adolescents often face formidable barriers to obtaining needed health care, and relatively little appropriate attention has been paid to adolescents by the federal government. OTA suggested that Congress could act to (a) increase adolescents' access to health care by supporting comprehensive health services specifically for adolescents, (b) restructure the federal role in adolescent health by creating an office of adolescent health in the U.S. Executive Branch, and (c) improve adolescents' social environments by providing more support to families of adolescents, limiting adolescents' access to firearms, supporting the expansion of their recreational opportunities, and further increasing opportunities for community service. Federal actions taken since OTA's report are summarized.

Adolescent↗

A dual role for Bub1 in the spindle checkpoint and chromosome congression.

The spindle checkpoint ensures faithful chromosome segregation by linking the onset of anaphase to the establishment of bipolar kinetochore-microtubule attachment. The checkpoint is mediated by a signal transduction system comprised of conserved Mad, Bub and other proteins. In this study, we use live-cell imaging coupled with RNA interference to investigate the functions of human Bub1. We find that Bub1 is essential for checkpoint control and for correct chromosome congression. Bub1 depletion leads to the accumulation of misaligned chromatids in which both sister kinetochores are linked to microtubules in an abnormal fashion, a phenotype that is unique among Mad and Bub depletions. Bub1 is similar to the Aurora B/Ipl1p kinase in having roles in both the checkpoint and microtubule binding. However, human Bub1 and Aurora B are recruited to kinetochores independently of each other and have an additive effect when depleted simultaneously. Thus, Bub1 and Aurora B appear to function in parallel pathways that promote formation of stable bipolar kinetochore-microtubule attachments.

Animals↗

Publication bias in presentations to the Annual Scientific Congress.

BACKGROUND: Free papers presented to the Annual Scientific Congress (ASC) of the Royal Australasian College of Surgeons (RACS) were reviewed for the years 1994, 1995 and 1996. Reports were examined for evidence of publication bias. METHODS: Suitable free papers were identified from the proceedings of the meetings and authors were contacted to obtain information about the research reported and any publications resulting from it. RESULTS: Responses were obtained from 302 of 576 presentations considered suitable. A total of 55% of responding authors reported publication of their paper. Basic science papers were most likely to be published. There was a significant bias in favour of publication of positive results (98 of 139 positive vs 76 of 159 inconclusive or negative reports; P < 0.01). Retrospective data were as likely to be published as prospective (51% and 57%, respectively). Reports describing studies of high-level evidence were more likely to be published in journals with a high impact factor. CONCLUSION: The ASC is a comprehensive meeting that attracts a wide range of free papers from most sections of the RACS. There appears to be no evidence of bias in selection of papers for inclusion in the meeting but there is bias in the subsequent publication, which favours positive reports.

Australia↗

Hepatic encephalopathy--definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998.

Research on hepatic encephalopathy is hampered by the imprecise definition of this disabling complication of liver disease. Under this light, the Organisation Mondiale de Gastroentérologie commissioned a Working Party to reach a consensus in this area and to present it at the 11th World Congress of Gastroenterology in Vienna (1998). The Working Party continued its work thereafter and now present their final report. In summary, the Working Party has suggested a modification of current nomenclature for clinical diagnosis of hepatic encephalopathy; proposed guidelines for the performance of future clinical trials in hepatic encephalopathy; and felt the need for a large study to redefine neuropsychiatric abnormalities in liver disease, which would allow the diagnosis of minimal (subclinical) encephalopathy to be made on firm statistical grounds. In the interim, it proposes the use of a psychometric hepatic encephalopathy score, based on the result of 5 neuropsychologic tests. Finally, the need for a careful evaluation of the newer neuroimaging modalities for the diagnosis of hepatic encephalopathy was stressed.

Clinical Trials as Topic↗

Travelers' diarrhea in Mexico. A prospective study of physicians and family members attending a congress.

We conducted a prospective study of travelers' diarrhea on 73 physicians and 48 family members attending a medical congress in Mexico City, in October, 1974. Fecal and blood specimens were collected before, during and after their visit and examined for enteric bacterial pathogens, viruses and parasites. In 59 (49 per cent) participants travelers' diarrhea developed. Median duration of illness was five days. Onset occurred a median of six days after arrival. An etiologic agent was found in 63 per cent of ill participants. Enterotoxigenic Escherichia coli of different, non-"enteropathogenic" serotypes was the most common cause; other responsible pathogens included salmonellae, invasive Esch. coli., shigellae, Vibrio parahaemolyticus, Giardia lamblia and the human reovirus-like agent. Consumption of salads containing raw vegetables was associated with enterotoxigenic Esch. coli infection (P = 0.014). Travelers' diarrhea in Mexico is a syndrome caused by a variety of pathogens, the most common of which is enterotoxigenic Esch. col.

Diarrhea↗

Campaign contributions from the American Medical Political Action Committee to Members of Congress. For or against the public health?

BACKGROUND: The American Medical Political Action Committee (AMPAC), the political arm of the American Medical Association (AMA), contributed $2.4 million to candidates for Congress during the 1989-1990 campaign and $2.9 million during the 1991-1992 campaign. It is not known whether these funds preferentially benefited representatives who supported the AMA's positions on public health issues. METHODS: We analyzed AMPAC contributions to members of the House of Representatives during the 1989-1990 and 1991-1992 campaigns according to their votes on three health-related issues: the promotion of tobacco exports, the institution of a mandatory waiting period before a handgun purchase, and the so-called gag rule, which limited physicians' speech on abortion in federally funded clinics. For each issue, we determined whether AMPAC had contributed more on average to opponents or to supporters of the official AMA position. RESULTS: AMPAC contributed more on average to opponents of the AMA positions on all three public health issues. From 1989 to 1992, AMPAC gave significantly larger average contributions to House members who favored tobacco-export promotion than to those opposed it ($11,549 vs. $9,842, P = 0.04) and contributed significantly less on average to supporters of handgun control than to their opponents ($9,022 vs. $11,250, P = 0.001). During the same period, AMPAC's contributions revealed a marked preference for House members who supported the gag rule over those who opposed it ($10,961 vs. $9,611, P = 0.05). House members who supported the AMA positions on all three votes received an average of $8,800 from AMPAC from 1989 through 1992, whereas members who opposed all three positions received an average of $13,270 (correlation between the number of votes for AMA positions and AMPAC contributions, -0.21; P < 0.001). CONCLUSIONS: AMPAC's contributions to members of the House of Representatives belie the AMA positions on some important public health issues.

American Medical Association↗

Dynamic changes in histone H3 lysine 9 methylations: identification of a mitosis-specific function for dynamic methylation in chromosome congression and segregation.

Histone methylation is unique among post-translational histone modifications by virtue of its stability. It is thought to be a relatively stable and heritable epigenetic mark for gene-specific regulation. In this study, we use quantitative in situ approaches to investigate the cell cycle dynamics of methylated isoforms of histone H3 lysine 9. Contrary to the expected stability of trimethylated lysines, our results for trimethylated lysine 9 (tMeK9) of H3 demonstrate that the genomic content of this methylation undergoes significant changes as cells progress through mitosis. Unexpectedly, there is a loss of tMeK9 that appears to reflect a robust demethylase activity that is active during the period between anaphase and cytokinesis. Subsequent investigations of mitoses in tMeK9-deficient cells revealed defects in chromosome congression and segregation that are distinct from the increased cohesion at centromeres previously reported in association with the loss of tMeK9. Collectively, these results identify a mitosis-specific trimethylation of Lys9 in pericentromeric heterochromatin that functions in the faithful segregation of chromosomes.

Adenosine↗

Drug addiction and AIDS: highlights of the 1st European Congress.

The 1st European Congress on 'Drug Addiction and AIDS' was held in Vienna, Austria, February 21-23 1991. This conference represented scientists from all areas of Europe and North America. The co-ordinators and the international scientific board offered an exciting programme with eight workshops in clinical, medical and management tracts; there were four plenary sessions with international, national and local experts, exhibits and receptions. With the impact of AIDS and the changes in Eastern Europe, we must now, more than ever before, rethink our strategies to improve effective treatment for substance abusing patients.

Acquired Immunodeficiency Syndrome↗

The prolongevists speak up: the life-extension ethics session at the 10th annual Congress of the International Association of Biomedical Gerontology.

Life-extension was the focus for the 10th annual Congress of the International Association of Biomedical Gerontology, held last September at Cambridge University. This scientific convention included a panel of several bioethicists, including Art Caplan, John Harris, and others. The presentations on the ethics of life-extension are reviewed here.

Aging↗

The 17th International IRIST Congress Proceedings.

The 17th IRIST (International Research Group on Immunoscitigraphy and Therapy) meeting was held July 27-29, 2004, at the Ghent University Hospital, Ghent, Belgium. Cochairs Christophe Van de Wiele and Alberto Signore brought together basic researchers, clinicians, radiopharmacists, and nuclear medicine specialists to discuss progress in single photon emission computed tomography (SPECT) and positron emission tomography (PET), using radiolabeled antibodies and peptides for imaging biologic properties related to the effectiveness of available treatment options and for treatment of cancer patients. The format of the conference was the presentation of research that focused on the basic and translational biology of cancer and on current state-of-the-art radiopharmacy and related SPECT and PET imaging techniques for the purposes described above. This report summarizes the 17th International IRIST Congress.

Humans↗

The neglected global tuberculosis problem: a report of the 1992 World Congress on Tuberculosis.

Tuberculosis is the single leading cause of death from any single infectious agent. A world congress on tuberculosis was held to highlight the problem and to discuss recent scientific advances and global strategies for prevention and control. About one-third of the world population is latently infected with Mycobacterium tuberculosis. Over 8 million new cases and nearly 3 million deaths occur each year. The situation is deteriorating due, in part, to the human immunodeficiency virus pandemic and shifts in the age distribution of the population. Resistance to antituberculosis drugs has also emerged as an important obstacle to control. Tuberculosis control programs in many developing and some industrialized countries have inadequate resources to combat the problem. Despite these trends, successful strategies and programs have been developed that, if implemented, would likely significantly reduce morbidity and mortality. Furthermore, recent research findings suggest that technologic advances will soon lead to improved methods for prevention and control.

Humans↗