Investigation of the trace changes in the electroencephalogram in man during the formation of motor conditioned reflexes.
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The EEG of the cerebral cortex and the electrohypothalamogram (EHG) was recorded in cats with a salt load and water deprivation during the performance of runs conditioned to non-salty and salty food signals. The non-salty food signal against the background of thirst was accompanied only by the activation of the cerebral cortex, whereas the hypothalamus in addition to the cortex was involved in the activation in relation to the salty food signal. In those cases in which the non-salty signal was reinforced by salty food and the animal has eaten it (although it had rejected it in the presence of thirst), a strong activation of the cortex was observed, with involvement of the paraventricular divisions of the hypothalamus. The remodeling of the signal role of the conditional signals was achieved in accordance with the new quality of the food reinforcement. The hypothalamo-cortical mechanisms of the dominant motivation and its conditioned reflex effectuation are discussed.
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EEG power spectra of the sensorimotor area of the neocortex, the dorsal hippocampus, midbrain reticular formation and anteroventral thalamic nucleus, as well as corresponding coherence functions and phase spectra, undergo changes during formation and performance of defensive conditioned reflex in rabbit. The conclusion is draen that in the process of conditioning a morphofunctional system of brain structures is established including the above mentioned formations. Their functional integration occurs on the basis of theta-rhythm. The execution of a conditioned act requires isorhythmicity of electrical processes within the theta-range in the studied structures and an adequate level of their excitability, which is manifested in the dominance of 6,0 c/s frequency.
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Interrelations between projection (auditory), associative (parietal) and integrative-triggering (sensorimotor) cortical areas were studied in dogs by EP parameters and localization during formation of defensive conditioned reflex to clicks. These interrelations were studied in intact animals and after ablation of either T3 areas or PI2 area of the auditory cortex. It was found that in intact animals auditory cortical areas are constantly involved in brain integrations whereas parietal ones show periodical participation (EPs in the parietal cortical area accompany some pairings of signal stimulus with reinforcement). Integrative-triggering cortical structures are involved in the systemic processes in the period of stabilisation of defensive reaction. After ablation of T3 area integrative-triggering cortical structures are turned on within a large exitation system from the beginning of the defensive reaction formation. After ablation of PI2 area parietal areas constantly participate in brain integrations. The nature of their participation in the forming of a given functional system is determined by the state of the auditory system or location of its injury.
In experiments on 66 albino rats an electrolytic coagulation of the basolateral amygdala caused facilitation while that of the corticomedial amygdala caused inhibition of alimentary conditioned reflexes. The corticomedial amygdala forms a part of the excitatory and the basolateral amygdala--of the inhibitory system of the rat's brain. In intact rats the basolateral amygdala function dominates over the corticomedial amygdala activity in feeding behaviour.
In experiments with dogs was shown the role of motivational and emotional structures of the hypothalamus in reproduction of the adaptive motor reaction both in classical and instrumental conditioned reflexes (alimentary and defensive). Change of parameters of electrostimulation gave a possibility to activate differentially the motivational, emotional negative, and emotional positive structures of the hypothalamus. Electrostimulation of the motivational structures reproduced alimentary but not defensive adaptive motor reaction and decreased the threshold of the motor reaction which was used as a signal during classical alimentary conditioning. Electrostimulation of the emotional negative structures reproduced defensive adaptive reaction and inhibited alimentary unconditioned response. Elaboration of the avoidance of the stimulation of the lateral hypothalamus was a proof for the activation of the emotional negative structures. Electrostimulation of the emotional positive structures which was used as an unconditioned stimulus during self-stimulation conditioning reproduced neither defensive nor alimentary conditioned response.
Adrenolytic heart defect (AHD) proceeds with the breaking of higher adaptational reactions, i.e. the change of latent period of conditioned active prevention reaction and arising of retrograde amnesia. alpha-Tocopherol--antioxidant prevents the breaking of conditioned reflex activity and sharply reduces the mortality rate in AHD. More effective is the prophylaxis of the brain function breaking and lethality.
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Relationships of symmetrical systems of reflexes organized by rhythmic and random presentation of unilateral stimuli were traced in dogs on the Abuladze model of unilateral conditioned reflexes. Rhythmic (counter-phasic) oscillations of the excitability level on two sides have appeared in the process of integration of different systems. Their integration at short intervals (4 min) leads to an experimental neurosis. If, however, the intervals between the systems amount to 24 hours, no disturbances are observed in higher nervous activity. The data obtained are considered in the light of the concept of experimental informational neuroses.